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Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists

Weiss, Stefan ; Keller, Max ; Bernhardt, Günther ; Buschauer, Armin ; König, Burkhard



Zusammenfassung

According to a 'bivalent ligand approach' to increase the affinity of the potent argininamide-type NPY Y(1) receptor antagonist BIBP-3226, dimeric ligands were synthesized in which two molecules of the parent compound were linked by different spacers via N(G)-acylation at the guanidino groups. A synthetic route for the preparation of the title compounds was developed, which includes a ...

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