Go to content
UR Home

The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists

Birnkammer, Tobias ; Spickenreither, Anja ; Brunskole, Irena ; Lopuch, Miroslaw ; Kagermeier, Nicole ; Bernhardt, Günther ; Dove, Stefan ; Seifert, Roland ; Elz, Sigurd ; Buschauer, Armin



Abstract

Bivalent histamine H-2 receptor (H2R) agonists were synthesized by connecting pharmacophoric 3-(2-amino-4-methylthiazol-5-yl)-, 3-(2-aminothiazol-5-yl)-, 3-(imidazol-4-yl)-, or 3-(1,2,4-triazol-5-yl)propylguanidine moieties by N-G-acylation with alkanedioic acids of various chain lengths. The compounds were investigated for H2R agonism in GTPase and [S-35]GTP gamma S binding assays at guinea pig ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons