Go to content
UR Home

The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists

Birnkammer, Tobias ; Spickenreither, Anja ; Brunskole, Irena ; Lopuch, Miroslaw ; Kagermeier, Nicole ; Bernhardt, Günther ; Dove, Stefan ; Seifert, Roland ; Elz, Sigurd ; Buschauer, Armin



Abstract

Bivalent histamine H2 receptor (H2R) agonists were synthesized by connecting pharmacophoric 3-(2-amino-4-methylthiazol-5-yl)-, 3-(2-aminothiazol-5-yl)-, 3-(imidazol-4-yl)- or 3-(1,2,4-triazol-5-yl)-propylguanidine moieties by NG-acylation with alkanedioic acids of various chain lengths. The compounds were investigated for H2R agonism in GTPase and [35S]GTPγS binding assays at guinea pig (gp) and ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons