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Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics.

Appl, Heidrun ; Holzammer, Tobias ; Dove, Stefan ; Haen, Ekkehard ; Strasser, Andrea ; Seifert, Roland



Abstract

Antidepressants and antipsychotics affect multiple molecular targets. Consequently, these drugs exhibit not only unique profiles of therapeutic effects but also several undesired effects. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the large family of G protein-coupled receptors and are very important drug targets. All four HxR subtypes are expressed in the CNS. Interactions of ...

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