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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-289835
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.28983
Alternative Links zum Volltext:DOI
Zusammenfassung
Premedication with a combination of histamine H1 receptor (H1R) and H2 receptor (H2R) antagonists has been suggested as a prophylactic principle in anesthesia and surgery. Aiming at pharmacological hybrids combining H1R and H2R antagonistic activity, a series of cyanoguanidines (14-35) was synthesized by linking mepyramine-type H1R antagonist substructures with roxatidine-, tiotidine-, or ...
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