| PDF (2MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-309279
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.30927
Zusammenfassung
In contrast to the corresponding mouse and rat orthologs, the human histamine H4 receptor (hH4R) shows extraordinarily high constitutive activity. In the extracellular loop, replacement of F169 by V as in the mouse H4R significantly reduced constitutive activity. Stabilization of the inactive state was even more pronounced for a double mutant, in which, in addition to F169V, S179 in the ligand ...
Nur für Besitzer und Autoren: Kontrollseite des Eintrags
Downloadstatistik