Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin

URN to cite this document:: urn:nbn:de:bvb:355-epub-339335
DOI to cite this document:: 10.5283/epub.33933

Schlossmann, Jens ; Wetzl, Veronika ; Schinner, Elisabeth ; Kees, Frieder K. ; Hofmann, Franz ; Faerber, Lothar

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Date of publication of this fulltext: 24 Jun 2016 08:50

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Abstract

Introduction: Kidney fibrosis has shown to be ameliorated through the involvement of cyclic guanosine monophosphate (cGMP) and its dependent protein kinase I (cGKI). Serelaxin, the recombinant form of human relaxin-II, increases cGMP levels and has shown beneficial effects on kidney function in acute heart failure patients. Antifibrotic properties of serelaxin are supposed to be mediated via ...