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Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin

Schlossmann, Jens, Wetzl, Veronika, Schinner, Elisabeth, Kees, Frieder K., Hofmann, Franz and Faerber, Lothar (2016) Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin. Frontiers in Pharmacology 7 (195), pp. 1-27.

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Date of publication of this fulltext: 24 Jun 2016 08:50

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Other URL: http://journal.frontiersin.org/article/10.3389/fphar.2016.00195/abstract


Abstract

Introduction: Kidney fibrosis has shown to be ameliorated through the involvement of cyclic guanosine monophosphate (cGMP) and its dependent protein kinase I (cGKI). Serelaxin, the recombinant form of human relaxin-II, increases cGMP levels and has shown beneficial effects on kidney function in acute heart failure patients. Antifibrotic properties of serelaxin are supposed to be mediated via ...

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Item type:Article
Date:17 June 2016
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fphar.2016.00195DOI
Article-ID: 195Other
Keywords:Relaxin, Serelaxin, cGMP-dependent protein kinase, Kidney, interstitial fibrosis, signaling, Nitric Oxide
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33933
Owner only: item control page

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