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Label-free versus conventional cellular assays: functional investigations on the human histamine H1 receptor

Lieb, Sebastian, Littmann, Timo, Plank, Nicole, Felixberger, Johannes, Tanaka, Miho, Schäfer, Thorsten, Krief, Stéphane, Elz, Sigurd, Friedland, Kristina, Bernhardt, Günther, Wegener, Joachim, Ozawa, Takeaki and Buschauer, Armin (2016) Label-free versus conventional cellular assays: functional investigations on the human histamine H1 receptor. Pharmacological Research 114, pp. 13-26.

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Abstract

A set of histamine H1 receptor (H1R) agonists and antagonists was characterized in functional assays, using dynamic mass redistribution (DMR), electric cell-substrate impedance sensing (ECIS) and various signaling pathway specific readouts (Fura-2 and aequorin calcium assays, arrestin recruitment (luciferase fragment complementation) assay, luciferase gene reporter assay). Data were gained from ...

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Item type:Article
Date:11 October 2016
Additional Information (public):Supporting Information available
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Bioanalytik und Biosensorik (Prof. Joachim Wegener)
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands"
Identification Number:
ValueType
10.1016/j.phrs.2016.10.010DOI
27751876PubMed ID
Keywords:Histamine H1 receptor; Impedimetry; Dynamic mass redistribution; Calcium assay; beta-Arrestin recruitment; Reporter gene assay
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34702
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