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Development and validation of new approaches for quantitative intermolecular interaction analysis by MicroScale Thermophoresis under near-native experimental conditions

Bartoschik, Tanja Astrid (2019) Development and validation of new approaches for quantitative intermolecular interaction analysis by MicroScale Thermophoresis under near-native experimental conditions. PhD, Universität Regensburg.

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Date of publication of this fulltext: 19 Jun 2019 05:03

Abstract (English)

The analysis of molecular binding events is of great importance for both basic research and drug development. Several biophysical methods can be applied for the characterization of interactions, regarding affinity, kinetics or thermodynamic parameters. One commonly applied biophysical method is label-free MicroScale Thermophoresis (MST), which provides Kd determination under label-free and ...

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Translation of the abstract (German)

Die Analyse molekularer Interaktionen ist von großer Bedeutung für die Grundlagenforschung und für die Entwicklung neuer Arzneistoffe. Für ihre Charakterisierung stehen verschiedene Methoden zur Verfügung, mit denen Affinität, Kinetik oder auch thermodynamische Parameter analysiert werden können. Eine dieser Methoden ist markierungsfreie mikroskalierte Thermophorese (MST), mit der Kds ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:19 June 2019
Referee:Prof. Dr. Gernot Längst
Date of exam:19 June 2018
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Keywords:MicroScale Thermophoresis, dissociation constant, affinity
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37442
Owner only: item control page

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