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The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis

Ziegler, Christian, Graf, Johannes, Faderl, Stefan, Schedlbauer, Jessica, Strieder, Nicholas, Förstl, Bianca, Spang, Rainer, Bruckmann, Astrid, Merkl, Rainer , Hombach, Sonja and Kretz, Markus (2019) The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis. EMBO Rep., e46612.

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Other URL: http://embor.embopress.org/content/early/2019/01/08/embr.201846612.long


Abstract

Several long non-coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. ...

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Item type:Article
Date:8 January 2019
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Identification Number:
ValueType
30622217PubMed ID
10.15252/embr.201846612DOI
Keywords:LINC00941; SPRR5; differentiation; epidermis; long non‐coding RNA
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38179
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