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The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis

Ziegler, Christian ; Graf, Johannes ; Faderl, Stefan ; Schedlbauer, Jessica ; Strieder, Nicholas ; Förstl, Bianca ; Spang, Rainer ; Bruckmann, Astrid ; Merkl, Rainer ; Hombach, Sonja ; Kretz, Markus



Abstract

Several long non-coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. ...

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