Structure‐Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands †

URN to cite this document:: urn:nbn:de:bvb:355-epub-412846
DOI to cite this document:: 10.5283/epub.41284

Pockes, Steffen ; Wifling, David

; Buschauer, Armin

; Elz, Sigurd

Preview

License: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 16 Dec 2019 09:37

Alternative links to fulltext:DOI Publisher Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

New classes of alkylated hetarylpropylguanidines with different functionality and variation in spacer length were synthesized to determine their behavior at the four histamine receptor (H1R, H2R, H3R, H4R) subtypes. Alkylated guanidines with different terminal functional groups and varied basicity, like amine, guanidine and urea were developed, based on the lead structure SK&F 91486 (2). ...