Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase

URN to cite this document:: urn:nbn:de:bvb:355-epub-444029
DOI to cite this document:: 10.5283/epub.44402

Simeth, Nadja Anita

; Kinateder, Thomas ; Rajendran, Chitra ; Nazet, Julian ; Merkl, Rainer

; Sterner, Reinhard

; König, Burkhard

; Kneuttinger, Andrea C.

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Date of publication of this fulltext: 14 Jan 2021 08:56

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Abstract

Light regulation of drug molecules has gained growing interest in biochemical and pharmacological research in recent years. In addition, a serious need for novel molecular targets of antibiotics has emerged presently. Herein, the development of a photocontrollable, azobenzene-based antibiotic precursor towards tryptophan synthase (TS), an essential metabolic multienzyme complex in bacteria, is ...