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Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase

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Simeth, Nadja Anita ; Kinateder, Thomas ; Rajendran, Chitra ; Nazet, Julian ; Merkl, Rainer ; Sterner, Reinhard ; König, Burkhard ; Kneuttinger, Andrea C.
Date of publication of this fulltext: 14 Jan 2021 08:56

This publication is part of the DEAL contract with Wiley.


Light regulation of drug molecules has gained growing interest in biochemical and pharmacological research in recent years. In addition, a serious need for novel molecular targets of antibiotics has emerged presently. Herein, the development of a photocontrollable, azobenzene-based antibiotic precursor towards tryptophan synthase (TS), an essential metabolic multienzyme complex in bacteria, is ...


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