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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-445544
- DOI to cite this document:
- 10.5283/epub.44554
Abstract
Solid tumors exhibit an inversed pH gradient with increased intracellular pH (pH(i)) and decreased extracellular pH (pH(e)). This inside-out pH gradient is generated via sodium/hydrogen antiporter 1, vacuolar-type H + ATPases, monocarboxylate transporters, (bi)carbonate (co)transporters and carboanhydrases. Our knowledge on how pH(e)-signals are sensed and what the respective receptors induce ...

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