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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-445544
- DOI to cite this document:
- 10.5283/epub.44554
This publication is part of the DEAL contract with Wiley.
Abstract
Solid tumors exhibit an inversed pH gradient with increased intracellular pH (pH(i)) and decreased extracellular pH (pH(e)). This inside-out pH gradient is generated via sodium/hydrogen antiporter 1, vacuolar-type H + ATPases, monocarboxylate transporters, (bi)carbonate (co)transporters and carboanhydrases. Our knowledge on how pH(e)-signals are sensed and what the respective receptors induce ...
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