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pH sensing in skin tumors: Methods to study the involvement of GPCRs, acid‐sensing ion channels and transient receptor potential vanilloid channels

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Schreml, Stephan ; Stolwijk, Judith A. ; Sauer, Lisa ; Ackermann, Kirsten ; Nassios, Anaïs ; Aung, Thiha ; Haerteis, Silke ; Bäumner, Antje J. ; Wegener, Joachim
Date of publication of this fulltext: 26 Jan 2021 17:56


Solid tumors exhibit an inversed pH gradient with increased intracellular pH (pHi) and decreased extracellular pH (pHe). This inside‐out pH gradient is generated via sodium/hydrogen antiporter 1, vacuolar‐type H + ATPases, monocarboxylate transporters, (bi)carbonate (co)transporters and carboanhydrases. Our knowledge on how pHe‐signals are sensed and what the respective receptors induce inside ...


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