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Cancer-associated cells release citrate to support tumour metastatic progression

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Drexler, Konstantin ; Schmidt, Katharina M. ; Jordan, Katrin ; Federlin, Marianne ; Milenkovic, Vladimir M. ; Liebisch, Gerhard ; Artati, Anna ; Schmidl, Christian ; Madej, Gregor ; Tokarz, Janina ; Cecil, Alexander ; Jagla, Wolfgang ; Haerteis, Silke ; Aung, Thiha ; Wagner, Christine ; Kolodziejczyk, Maria ; Heinke, Stefanie ; Stanton, Evan H. ; Schwertner, Barbara ; Riegel, Dania ; Wetzel, Christian H. ; Buchalla, Wolfgang ; Proescholdt, Martin ; Klein, Christoph A. ; Berneburg, Mark ; Schlitt, Hans J. ; Brabletz, Thomas ; Ziegler, Christine ; Parkinson, Eric K. ; Gaumann, Andreas ; Geissler, Edward K. ; Adamski, Jerzy ; Haferkamp, Sebastian ; Mycielska, Maria E.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jun 2021 19:14


Citrate is important for lipid synthesis and epigenetic regulation in addition to ATP production. We have previously reported that cancer cells import extracellular citrate via the pmCiC transporter to support their metabolism. Here, we show for the first time that citrate is supplied to cancer by cancer-associated stroma (CAS) and also that citrate synthesis and release is one of the latter’s ...


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