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Cancer-associated cells release citrate to support tumour metastatic progression

URN to cite this document:
urn:nbn:de:bvb:355-epub-461727
DOI to cite this document:
10.5283/epub.46172
Drexler, Konstantin ; Schmidt, Katharina M. ; Jordan, Katrin ; Federlin, Marianne ; Milenkovic, Vladimir M. ; Liebisch, Gerhard ; Artati, Anna ; Schmidl, Christian ; Madej, Gregor ; Tokarz, Janina ; Cecil, Alexander ; Jagla, Wolfgang ; Haerteis, Silke ; Aung, Thiha ; Wagner, Christine ; Kolodziejczyk, Maria ; Heinke, Stefanie ; Stanton, Evan H. ; Schwertner, Barbara ; Riegel, Dania ; Wetzel, Christian H. ; Buchalla, Wolfgang ; Proescholdt, Martin ; Klein, Christoph A. ; Berneburg, Mark ; Schlitt, Hans J. ; Brabletz, Thomas ; Ziegler, Christine ; Parkinson, Eric K. ; Gaumann, Andreas ; Geissler, Edward K. ; Adamski, Jerzy ; Haferkamp, Sebastian ; Mycielska, Maria E.
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Date of publication of this fulltext: 25 Jun 2021 19:14



Abstract

Citrate is important for lipid synthesis and epigenetic regulation in addition to ATP production. We have previously reported that cancer cells import extracellular citrate via the pmCiC transporter to support theirmetabolism. Here, we showfor thefirst time that citrate is supplied to cancer by cancer-associated stroma (CAS) and also that citrate synthesis and release is one of the ...

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