Go to content
UR Home

Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists

Ghorai, Prasanta ; Kraus, Anja ; Keller, Max ; Götte, Carsten ; Igel, Patrick ; Schneider, Erich ; Schnell, David ; Bernhardt, Günther ; Dove, Stefan ; Zabel, Manfred ; Elz, Sigurd ; Seifert, Roland ; Buschauer, Armin



Abstract

N(1)-Aryl(heteroaryl)alkyl-N(2)-[3-(1H-imidazol-4-yl)propyl]guanidines are potent histamine H2-receptor (H2R) agonists, but their applicability is compromised by the lack of oral bioavailability and CNS penetration. To improve pharmacokinetics, we introduced carbonyl instead of methylene adjacent to the guanidine moiety, decreasing the basicity of the novel H2R agonists by 4-5 orders of ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 4239

Dissertations: dissertationen@ur.de
0941 943 3904

Research data: daten@ur.de
0941 943 4239

Contact persons