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Pharmacokinetics of risperidone in different application forms – Comparing long-acting injectable and oral formulations

Schoretsanitis, Georgios ; de Leon, Jose ; Haen, Ekkehard ; Stegmann, Benedikt ; Hiemke, Christoph ; Gründer, Gerhard ; Paulzen, Michael



Abstract

We aimed to explore the differences in the pharmacokinetics of risperidone between oral and long-acting injectable (LAI) formulations using a large database of therapeutic drug monitoring (TDM). Plasma concentrations of risperidone (RIS), its active metabolite (9-OH-RIS) and the active moiety (AM) (RIS+9-OH-RIS), their concentration-to-dose (C/D) ratios and ratio of RIS/9OH-RIS (an index of ...

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