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Pharmacokinetic correlates of venlafaxine: associated adverse reactions

Schoretsanitis, Georgios ; Haen, Ekkehard ; Hiemke, Christoph ; Endres, Katharina ; Ridders, Florian ; Veselinovic, Tanja ; Gründer, Gerhard ; Paulzen, Michael



Abstract

To address the potential correlation between plasma concentrations of venlafaxine (VEN), its active metabolite O-desmethylvenlafaxine (ODVEN) and the active moiety, AM, (ODVEN + VEN) and adverse drug reactions (ADR) in a large naturalistic sample of in- and outpatients. We compared plasma concentrations of VEN, ODVEN and AM and dose-adjusted (C/D) levels as well the ODVEN/VEN ratios between ...

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