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Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1

Hoffmeister, Helen ; Fuchs, Andreas ; Strobl, Laura ; Sprenger, Frank ; Gröbner-Ferreira, Regina ; Michaelis, Stefanie ; Hoffmann, Petra ; Nazet, Julian ; Merkl, Rainer ; Längst, Gernot


The Snf2 proteins, comprising 53 different enzymes in humans, belong to the SF2 family. Many Snf2 enzymes possess chromatin-remodeling activity, requiring a functional ATPase domain consisting of conserved motifs named Q and I-VII. These motifs form two recA-like domains, creating an ATP-binding pocket. Little is known about the function of the conserved motifs in chromatin-remodeling enzymes. ...


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