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The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism

Kuzin, Maxim ; Schoretsanitis, Georgios ; Haen, Ekkehard ; Dammann, Gerhard ; Hiemke, Christoph ; Gründer, Gerhard ; Paulzen, Michael


Background Polypharmacy including somatic medications such as proton pump inhibitors is a common phenomenon in psychiatric care. The aim of this study was to evaluate the pantoprazole effects on clozapine metabolism. Methods A large therapeutic drug-monitoring database containing plasma concentrations of CLZ was analyzed. The results were stratified into four groups: a non-smoking (n = 250) and a ...


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