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Cortical progression patterns in individual ALS patients across multiple timepoints: a mosaic-based approach for clinical use

Tahedl, Marlene ; Chipika, Rangariroyashe H. ; Lope, Jasmin ; Li Hi Shing, Stacey ; Hardiman, Orla ; Bede, Peter


Introduction The majority of imaging studies in ALS infer group-level imaging signatures from group comparisons, as opposed to estimating disease burden in individual patients. In a condition with considerable clinical heterogeneity, the characterisation of individual patterns of pathology is hugely relevant. In this study, we evaluate a strategy to track progressive cortical involvement in ...


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