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Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs

Tahedl, Marlene ; Li Hi Shing, Stacey ; Finegan, Eoin ; Chipika, Rangariroyashe H. ; Lope, Jasmin ; Hardiman, Orla ; Bede, Peter


Motor neuron diseases encompass a divergent group of conditions with considerable differences in clinical manifestations, survival, and genetic vulnerability. One of the key aspects of clinical heterogeneity is the preferential involvement of upper (UMN) and lower motor neurons (LMN). While longitudinal imaging patters are relatively well characterized in ALS, progressive cortical changes in ...


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