Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy

URN to cite this document:: urn:nbn:de:bvb:355-epub-780687
DOI to cite this document:: 10.5283/epub.78068

Krammer, Thomas ; Baier, Maria J.

; Lutz, Vanessa ; Hübner, Anna‐Christina ; Zschiedrich, Tilman ; Lukas, David ; Le Phu, Christian ; Wolf, Matthias ; Maassen, Claire ; Wester, Michael

; Neef, Stefan ; Schach, Christian

; Sag, Can‐Martin ; Evert, Katja

; Paulus, Michael

; Meindl, Christine

; Tafelmeier, Maria

; Debl, Kurt ; Maier, Lars S.

; Wagner, Stefan

; Röcken, Christoph ; Mustroph, Julian

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Nov 2025 06:26

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Abstract

Aims Transthyretin amyloid cardiomyopathy (ATTR-CM) is marked by deposition of transthyretin amyloid in the myocardium. Patients present with symptoms of heart failure, left ventricular (LV) hypertrophy, diastolic dysfunction, and arrhythmias. Echocardiographic apical sparing, quantified via the relative apical sparing (RELAPS) pattern, is a hallmark imaging feature but its histopathological and ...