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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-315447
- DOI to cite this document:
- 10.5283/epub.31544
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Mendoza, Ezequiel, Colomb, Julien, Raybak, Jürgen, Pflügler, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Drosophila FoxP Mutants Are Deficient in Operant Self-Learning. PLoS ONE 9 (6), e100648.Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Conceptual architecture of operant feedback loops. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Insertion mutants of the Drosophila FoxP gene affect isoform expression and flight performance. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) The mutant line FoxP³⁹⁵⁵ was impaired in operant self- but not world-learning. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Deficiency ED5438 uncovers the FoxP³⁹⁵⁵ self-learning phenotype. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Drosophila FoxP full length isoform B is required for operant self-learning. [Image] [Currently displayed]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Subtle morphological alterations in the brains of FoxP³⁹⁵⁵ mutants. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) List of sequences used for the phylogenetic analysis of FoxP subfamily members. [Dataset]
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Drosophila FoxP Mutants Are Deficient in Operant Self-Learning. [Image]
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Item type: | Image | ||||
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Date: | 25 June 2014 | ||||
Institutions: | Biology, Preclinical Medicine > Institut für Zoologie > Neurogenetik (Prof. Dr. Björn Brembs) | ||||
Identification Number: |
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Keywords: | anatomy, nervous system, Motor system, neuroanatomy, Evolutionary biology, genetics, Gene function, neuroscience, cognitive science, cognition, Animal cognition, Decision making, Behavioral neuroscience, Cognitive neuroscience, Learning and memory, Neuroethology, neuropsychology, psychology, behavior, habits, Verbal behavior, Experimental psychology, Zoology, Animal behavior, linguistics, speech, isoform, operant | ||||
Dewey Decimal Classification: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Partially | ||||
Item ID: | 31544 |
Abstract
a, Flies expressing an RNAi construct targeting the FoxP isoform B were impaired in operant self-learning, compared to the genetic controls (pooled, see Materials and Methods; Mann-Whitney U-Test, U = 378.5, p<0.03) in a 2-minute test immediately after eight minutes of training. See raw data or Fig. S2 for separated control groups. b, Both flies expressing an RNAi construct targeting the FoxP ...

Abstract
a, Flies expressing an RNAi construct targeting the FoxP isoform B were impaired in operant self-learning, compared to the genetic controls (pooled, see Materials and Methods; Mann-Whitney U-Test, U = 378.5, p<0.03) in a 2-minute test immediately after eight minutes of training. See raw data or Fig. S2 for separated control groups.
b, Both flies expressing an RNAi construct targeting the FoxP isoform B, as well as genetic control flies performed well in operant world-learning (Mann-Whitney U-Test, U = 420.5, P<0.2).
c, No reduction in the expression of isoform B mRNA using qRT-PCR in flies expressing an RNAi construct targeting the FoxP isoform B. Canton S data are identical to those in Fig. 2c, as experiments were performed simultaneously.
d, Mutant FoxP³⁹⁵⁵ flies were impaired in habit formation. In a 2-minute self-learning test (i.e. without colors) after 16 minutes of training in world-learning (i.e. with colors), FoxP³⁹⁵⁵ flies showed a significantly reduced preference for the previously unpunished turning-maneuvers, compared to wild type control animals (Mann-Whitney U-Test, U = 186.0, p<0.04). However, the mutant flies nevertheless showed a significant performance index (t-test against zero: df: 23; t = 2.54; p<0.02).
Metadata last modified: 29 Sep 2021 07:40