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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-303990
- DOI to cite this document:
- 10.5283/epub.30399
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Mendoza, Ezequiel, Colomb, Julien, Raybak, Jürgen, Pflügler, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Drosophila FoxP Mutants Are Deficient in Operant Self-Learning. PLoS ONE 9 (6), e100648. [Currently displayed]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Conceptual architecture of operant feedback loops. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Insertion mutants of the Drosophila FoxP gene affect isoform expression and flight performance. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) The mutant line FoxP³⁹⁵⁵ was impaired in operant self- but not world-learning. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Deficiency ED5438 uncovers the FoxP³⁹⁵⁵ self-learning phenotype. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Drosophila FoxP full length isoform B is required for operant self-learning. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Subtle morphological alterations in the brains of FoxP³⁹⁵⁵ mutants. [Image]Preview
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![[img]](https://epub.uni-regensburg.de/style/images/fileicons/other.png)
Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn
(2014)
List of sequences used for the phylogenetic analysis of FoxP subfamily members.
[Dataset]
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Preview
Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn
(2014)
Drosophila FoxP Mutants Are Deficient in Operant Self-Learning.
[Image]
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | PLoS ONE | ||||
| Publisher: | Public Library of Science | ||||
| Volume: | 9 | ||||
| Number of Issue or Book Chapter: | 6 | ||||
| Page Range: | e100648 | ||||
| Date: | 25 June 2014 | ||||
| Institutions: | Biology, Preclinical Medicine > Institut für Zoologie > Neurogenetik (Prof. Dr. Björn Brembs) | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 30399 |
Abstract
Intact function of the Forkhead Box P2 (FOXP2) gene is necessary for normal development of speech and language. This important role has recently been extended, first to other forms of vocal learning in animals and then also to other forms of motor learning. The homology in structure and in function among the FoxP gene members raises the possibility that the ancestral FoxP gene may have evolved as ...
Abstract
Intact function of the Forkhead Box P2 (FOXP2) gene is necessary for normal development of speech and language. This important role has recently been extended, first to other forms of vocal learning in animals and then also to other forms of motor learning. The homology in structure and in function among the FoxP gene members raises the possibility that the ancestral FoxP gene may have evolved as a crucial component of the neural circuitry mediating motor learning. Here we report that genetic manipulations of the single Drosophila orthologue, dFoxP, disrupt operant self-learning, a form of motor learning sharing several conceptually analogous features with language acquisition. Structural alterations of the dFoxP locus uncovered the role of dFoxP in operant self-learning and habit formation, as well as the dispensability of dFoxP for operant world-learning, in which no motor learning occurs. These manipulations also led to subtle alterations in the brain anatomy, including a reduced volume of the optic glomeruli. RNAi-mediated interference with dFoxP expression levels copied the behavioral phenotype of the mutant flies, even in the absence of mRNA degradation. Our results provide evidence that motor learning and language acquisition share a common ancestral trait still present in extant invertebrates, manifest in operant self-learning. This ‘deep’ homology probably traces back to before the split between vertebrate and invertebrate animals.
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