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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-315472
- DOI to cite this document:
- 10.5283/epub.31547
-
Mendoza, EzequielPreview
, Colomb, Julien , Raybak, Jürgen , Pflügler, Hans-Joachim, Zars, Troy , Scharff, Constance and Brembs, Björn
(2014)
Drosophila FoxP Mutants Are Deficient in Operant Self-Learning.
PLoS ONE 9 (6), e100648.
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Conceptual architecture of operant feedback loops. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Insertion mutants of the Drosophila FoxP gene affect isoform expression and flight performance. [Image] [Currently displayed]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) The mutant line FoxP³⁹⁵⁵ was impaired in operant self- but not world-learning. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Deficiency ED5438 uncovers the FoxP³⁹⁵⁵ self-learning phenotype. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Drosophila FoxP full length isoform B is required for operant self-learning. [Image]Preview
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn (2014) Subtle morphological alterations in the brains of FoxP³⁹⁵⁵ mutants. [Image]Preview
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![[img]](https://epub.uni-regensburg.de/style/images/fileicons/other.png)
Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn
(2014)
List of sequences used for the phylogenetic analysis of FoxP subfamily members.
[Dataset]
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Preview
Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance and Brembs, Björn
(2014)
Drosophila FoxP Mutants Are Deficient in Operant Self-Learning.
[Image]
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| Item type: | Image | ||||
|---|---|---|---|---|---|
| Date: | 25 June 2014 | ||||
| Institutions: | Biology, Preclinical Medicine > Institut für Zoologie > Neurogenetik (Prof. Dr. Björn Brembs) | ||||
| Identification Number: |
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| Keywords: | anatomy, nervous system, Motor system, neuroanatomy, Evolutionary biology, genetics, Gene function, neuroscience, cognitive science, cognition, Animal cognition, Decision making, Behavioral neuroscience, Cognitive neuroscience, Learning and memory, Neuroethology, neuropsychology, psychology, behavior, habits, Verbal behavior, Experimental psychology, Zoology, Animal behavior, linguistics, speech, mutants, isoform | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Partially | ||||
| Item ID: | 31547 |
Abstract
a, Rooted phylogenetic tree using the genomic sequence of the Drosophila FoxP gene (see Materials and Methods). The single invertebrate FoxP gene probably corresponds to the ancestral form from which the four vertebrate genes have arisen by serial duplication. b, Location of the three insertions (black triangles) and qRT-PCR primer pairs (grey arrows) on the genomic structure of the dFoxP gene ...
Abstract
a, Rooted phylogenetic tree using the genomic sequence of the Drosophila FoxP gene (see Materials and Methods). The single invertebrate FoxP gene probably corresponds to the ancestral form from which the four vertebrate genes have arisen by serial duplication.
b, Location of the three insertions (black triangles) and qRT-PCR primer pairs (grey arrows) on the genomic structure of the dFoxP gene (left). Structure of the three cloned transcripts (right). IR: intron retention; FH: Forkhead-Box Domain.
c, Expression levels of the three dFoxP isoform mRNAs in heads of Canton S wildtype flies and of the three insertion lines using qRT-PCR. Horizontal lines denote averages, individual circles, trinagles and squares constitute different biological replicates. * - p<0.05, ** - p<0.01, *** - p<0.001.
d, Flight performance of Canton S wildtype flies and the three insertion lines. Asterisk denotes statistical significance compared to Canton S control flies (Kruskal-Wallis ANOVA: H(3, N = 119) = 46.02 p<0.0001, 3955: R = 77.0, p<0.4; f03746: R = 50.9, p<0.00004; c03619: R = 37.0, p<0.00001). Number of animals: 18–37. For full flight performance data see Fig. S1.
Metadata last modified: 29 Sep 2021 07:40
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