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The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men

Sarubin, Nina, Hilbert, Sven, Naumann, Felix, Zill, Peter, Wimmer, Anna-Maria, Nothdurfter, Caroline, Rupprecht, Rainer, Baghai, Thomas C., Bühner, Markus and Schüle, Cornelius (2017) The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men. European Archives of Psychiatry and Clinical Neuroscience 267 (2), pp. 123-133.

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Other URL: http://doi.org/10.1007/s00406-016-0722-5


Abstract

Genetic variations in the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) have been associated with maladaptive stress responses and major depressive disorder (MDD). In a case-control study design, we examined whether single nucleotide polymorphisms (SNPs) and haploid genotype (haplotype) associations of MR gene NR3C2, GR gene NR3C1 and genes of GR chaperone molecules FK506 ...

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Item type:Article
Date:2017
Institutions:Psychology and Pedagogy > Institut für Psychologie
Psychology and Pedagogy > Institut für Pädagogik
Psychology and Pedagogy > Institut für Sportwissenschaft
Identification Number:
ValueType
10.1007/s00406-016-0722-5DOI
Keywords:MINERALOCORTICOID RECEPTOR; HORMONE-RECEPTOR; TREATMENT RESPONSE; CRHR1 GENE; ANTIDEPRESSANT TREATMENT; CHILDHOOD MALTREATMENT; ADULT DEPRESSION; MOOD DISORDERS; STRESS; POLYMORPHISMS; Depression; Genetic variations; HPA axis; NR3C1
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
300 Social sciences > 370 Education
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38661
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