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Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability

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Hoffmeister, Helen ; Fuchs, Andreas ; Komives, Elizabeth ; Groebner‐Ferreira, Regina ; Strobl, Laura ; Nazet, Julian ; Heizinger, Leonhard ; Merkl, Rainer ; Dove, Stefan ; Längst, Gernot
Date of publication of this fulltext: 15 Mar 2021 07:36

This publication is part of the DEAL contract with Wiley.


Chromatin remodelers use the energy of ATP hydrolysis to regulate chromatin dynamics. Their impact for development and disease requires strict enzymatic control. Here, we address the differential regulability of the ATPase domain of hSNF2H and hCHD3, exhibiting similar substrate affinities and enzymatic activities. Both enzymes are comparably strongly inhibited in their ATP hydrolysis activity by ...


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