| Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (1MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-303990
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.30399
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Mendoza, EzequielVorschau
, Colomb, Julien
, Raybak, Jürgen
, Pflügler, Hans-Joachim, Zars, Troy
, Scharff, Constance und Brembs, Björn
(2014)
Drosophila FoxP Mutants Are Deficient in Operant Self-Learning.
PLoS ONE 9 (6), e100648.
[Gegenwärtig angezeigt]-
Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn (2014) Conceptual architecture of operant feedback loops. [Bild]Vorschau
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn (2014) Insertion mutants of the Drosophila FoxP gene affect isoform expression and flight performance. [Bild]Vorschau
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn (2014) The mutant line FoxP³⁹⁵⁵ was impaired in operant self- but not world-learning. [Bild]Vorschau
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn (2014) Deficiency ED5438 uncovers the FoxP³⁹⁵⁵ self-learning phenotype. [Bild]Vorschau
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn (2014) Drosophila FoxP full length isoform B is required for operant self-learning. [Bild]Vorschau
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn (2014) Subtle morphological alterations in the brains of FoxP³⁹⁵⁵ mutants. [Bild]Vorschau
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Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn
(2014)
List of sequences used for the phylogenetic analysis of FoxP subfamily members.
[Datensatz]
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Vorschau
Mendoza, Ezequiel, Colomb, Julien, Rybak, Jürgen, Pflüger, Hans-Joachim, Zars, Troy, Scharff, Constance und Brembs, Björn
(2014)
Drosophila FoxP Mutants Are Deficient in Operant Self-Learning.
[Bild]
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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Open Access Art: | Gold (mit APC - bezahlt UR) | ||||
| Titel eines Journals oder einer Zeitschrift: | PLoS ONE | ||||
| Verlag: | PUBLIC LIBRARY SCIENCE | ||||
| Ort der Veröffentlichung: | SAN FRANCISCO | ||||
| Band: | 9 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 6 | ||||
| Seitenbereich: | e100648 | ||||
| Datum: | 25 Juni 2014 | ||||
| Institutionen: | Biologie und Vorklinische Medizin > Institut für Zoologie > Neurogenetik (Prof. Dr. Björn Brembs) | ||||
| Sonstige Projekte: | Open Access Publizieren (DFG) | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | BASAL GANGLIA CIRCUITS; SONG CONTROL NUCLEI; PROTEIN-KINASE-C; ADENYLYL-CYCLASE; ZEBRA FINCH; MOTOR COORDINATION; LANGUAGE DISORDERS; FLIGHT ORIENTATION; VISUAL-SYSTEM; SEVERE SPEECH; | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 590 Tiere (Zoologie) 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 30399 |

Zusammenfassung
Intact function of the Forkhead Box P2 (FOXP2) gene is necessary for normal development of speech and language. This important role has recently been extended, first to other forms of vocal learning in animals and then also to other forms of motor learning. The homology in structure and in function among the FoxP gene members raises the possibility that the ancestral FoxP gene may have evolved as ...

Zusammenfassung
Intact function of the Forkhead Box P2 (FOXP2) gene is necessary for normal development of speech and language. This important role has recently been extended, first to other forms of vocal learning in animals and then also to other forms of motor learning. The homology in structure and in function among the FoxP gene members raises the possibility that the ancestral FoxP gene may have evolved as a crucial component of the neural circuitry mediating motor learning. Here we report that genetic manipulations of the single Drosophila orthologue, dFoxP, disrupt operant self-learning, a form of motor learning sharing several conceptually analogous features with language acquisition. Structural alterations of the dFoxP locus uncovered the role of dFoxP in operant self-learning and habit formation, as well as the dispensability of dFoxP for operant world-learning, in which no motor learning occurs. These manipulations also led to subtle alterations in the brain anatomy, including a reduced volume of the optic glomeruli. RNAi-mediated interference with dFoxP expression levels copied the behavioral phenotype of the mutant flies, even in the absence of mRNA degradation. Our results provide evidence that motor learning and language acquisition share a common ancestral trait still present in extant invertebrates, manifest in operant self-learning. This 'deep' homology probably traces back to before the split between vertebrate and invertebrate animals.
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