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Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin

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Schwartz, Uwe ; Németh, Attila ; Diermeier, Sarah ; Exler, Josef H. ; Hansch, Stefan ; Maldonado, Rodrigo ; Heizinger, Leonhard ; Merkl, Rainer ; Längst, Gernot
Date of publication of this fulltext: 29 Jan 2019 09:45


Packaging of DNA into chromatin regulates DNA accessibility and consequently all DNA-dependent processes. The nucleosome is the basic packaging unit of DNA forming arrays that are suggested, by biochemical studies, to fold hierarchically into ordered higher-order structures of chromatin. This organization has been recently questioned using microscopy techniques, proposing an irregular structure. ...


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