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Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin

URN to cite this document:
urn:nbn:de:bvb:355-epub-382737
DOI to cite this document:
10.5283/epub.38273
Schwartz, Uwe ; Németh, Attila ; Diermeier, Sarah ; Exler, Josef H. ; Hansch, Stefan ; Maldonado, Rodrigo ; Heizinger, Leonhard ; Merkl, Rainer ; Längst, Gernot
Date of publication of this fulltext: 29 Jan 2019 09:45


Abstract

Packaging of DNA into chromatin regulates DNA accessibility and consequently all DNA-dependent processes. The nucleosome is the basic packaging unit of DNA forming arrays that are suggested, by biochemical studies, to fold hierarchically into ordered higher-order structures of chromatin. This organization has been recently questioned using microscopy techniques, proposing an irregular structure. ...

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