Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin

URN to cite this document:: urn:nbn:de:bvb:355-epub-382737
DOI to cite this document:: 10.5283/epub.38273

Schwartz, Uwe ; Németh, Attila ; Diermeier, Sarah

; Exler, Josef H. ; Hansch, Stefan ; Maldonado, Rodrigo ; Heizinger, Leonhard

; Merkl, Rainer

; Längst, Gernot

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Date of publication of this fulltext: 29 Jan 2019 09:45

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Abstract

Packaging of DNA into chromatin regulates DNA accessibility and consequently all DNA-dependent processes. The nucleosome is the basic packaging unit of DNA forming arrays that are suggested, by biochemical studies, to fold hierarchically into ordered higher-order structures of chromatin. This organization has been recently questioned using microscopy techniques, proposing an irregular structure. ...