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Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia

Semmelmann, Florian ; Kabeya, Naoki ; Malcicka, Miriama ; Bruckmann, Astrid ; Broschwitz, Bastian ; Straub, Kristina ; Merkl, Rainer ; Monroig, Oscar ; Sterner, Reinhard ; Ruther, Joachim ; Ellers, Jacintha


Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial for the biosynthesis of these chemical signals. Delta 12-desaturases catalyse the biosynthesis of linoleic acid by introducing a second double bond into oleic acid, but have been identified in only a fewanimal species. Here, we report the ...


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