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Einträge von Wifling, David auf dem Publikationsserver
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Anzahl der Einträge: 19.
2021
Weinhart, Corinna. G., Wifling, David, Schmidt, Maximilian. F., Neu, Eduard, Höring, Carina, Clark, Timothy, Gmeiner, Peter und Keller, Max
(2021)
Dibenzodiazepinone-type muscarinic receptor antagonists conjugated to basic peptides: Impact of the linker moiety and unnatural amino acids on M2R selectivity.
European Journal of Medicinal Chemistry 213, S. 113159.
Volltext nicht vorhanden.
Konieczny, Adam, Conrad, Marcus, Ertl, Fabian J., Gleixner, Jakob, Gattor, Albert O., Grätz, Lukas, Schmidt, Maximilian F., Neu, Eduard, Horn, Anselm H. C., Wifling, David, Gmeiner, Peter, Clark, Timothy, Sticht, Heinrich und Keller, Max
(2021)
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants.
Journal of Medicinal Chemistry 64 (22), S. 16746-16769.
Volltext nicht vorhanden.
2020
Antoni, Frauke 
, Wifling, David und Bernhardt, Günther
(2020)
Water-soluble inhibitors of ABCG2 (BCRP) – A fragment-based and computational approach.
European Journal of Medicinal Chemistry, S. 112958.
Volltext nicht vorhanden.
, Wifling, David und Bernhardt, Günther
(2020)
Water-soluble inhibitors of ABCG2 (BCRP) – A fragment-based and computational approach.
European Journal of Medicinal Chemistry, S. 112958.
Volltext nicht vorhanden.
Bartole, Edith, Grätz, Lukas, Littmann, Timo, Wifling, David , Seibel, Ulla, Buschauer, Armin und Bernhardt, Günther
(2020)
UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors.
Journal of Medicinal Chemistry 63 (10), S. 5297-5311.
Volltext nicht vorhanden.
, Seibel, Ulla, Buschauer, Armin und Bernhardt, Günther
(2020)
UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors.
Journal of Medicinal Chemistry 63 (10), S. 5297-5311.
Volltext nicht vorhanden.
Buschmann, Jonas, Seiler, Theresa, Bernhardt, Günther, Keller, Max und Wifling, David
(2020)
Argininamide-type neuropeptide Y Y1 receptor antagonists: the nature of Nω-carbamoyl substituents determines Y1R binding mode and affinity.
RSC Medicinal Chemistry 11 (2), S. 274-282.
Volltext nicht vorhanden.
Konieczny, Adam, Braun, Diana, Wifling, David , Bernhardt, Günther und Keller, Max
(2020)
Oligopeptides as Neuropeptide Y Y4 Receptor Ligands: Identification of a High-Affinity Tetrapeptide Agonist and a Hexapeptide Antagonist.
Journal of Medicinal Chemistry 63 (15), S. 8198-8215.
Volltext nicht vorhanden.
, Bernhardt, Günther und Keller, Max
(2020)
Oligopeptides as Neuropeptide Y Y4 Receptor Ligands: Identification of a High-Affinity Tetrapeptide Agonist and a Hexapeptide Antagonist.
Journal of Medicinal Chemistry 63 (15), S. 8198-8215.
Volltext nicht vorhanden.
She, Xueke, Pegoli, Andrea, Gruber, Corinna G., Wifling, David , Carpenter, Jessica, Hübner, Harald, Chen, Mengya, Wan, Jianfei, Bernhardt, Günther, Gmeiner, Peter , Holliday, Nicholas D. und Keller, Max
(2020)
Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor.
Journal of Medicinal Chemistry 63 (8), S. 4133-4154.
Volltext nicht vorhanden.
, Carpenter, Jessica, Hübner, Harald, Chen, Mengya, Wan, Jianfei, Bernhardt, Günther, Gmeiner, Peter , Holliday, Nicholas D. und Keller, Max
(2020)
Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor.
Journal of Medicinal Chemistry 63 (8), S. 4133-4154.
Volltext nicht vorhanden.
2019
Pegoli, Andrea, Wifling, David , Gruber, Corinna G., Xueke, She, Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter und Keller, Max
(2019)
Conjugation of Short Peptides to Dibenzodiazepinone-Type
Muscarinic Acetylcholine Receptor Ligands Determines M2R
Selectivity. Journal of Medicinal Chemistry 62, S. 5358-5369. Volltext nicht vorhanden.
, Gruber, Corinna G., Xueke, She, Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter und Keller, Max
(2019)
Conjugation of Short Peptides to Dibenzodiazepinone-Type
Muscarinic Acetylcholine Receptor Ligands Determines M2R
Selectivity. Journal of Medicinal Chemistry 62, S. 5358-5369. Volltext nicht vorhanden.
Pockes, Steffen, Wifling, David , Buschauer, Armin und Elz, Sigurd
(2019)
Structure‐Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands †.
ChemistryOpen 8 (3), S. 285-297.
Wifling, David , Pfleger, Christopher, Kaindl, Jonas, Ibrahim, Passainte, Kling, Ralf C., Buschauer, Armin, Gohlke, Holger und Clark, Timothy
(2019)
Basal Histamine H4Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif.
Chemistry – A European Journal 25 (64), S. 14613-14624.
Volltext nicht vorhanden.
, Pfleger, Christopher, Kaindl, Jonas, Ibrahim, Passainte, Kling, Ralf C., Buschauer, Armin, Gohlke, Holger und Clark, Timothy
(2019)
Basal Histamine H4Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif.
Chemistry – A European Journal 25 (64), S. 14613-14624.
Volltext nicht vorhanden.
Ibrahim, Passainte, Wifling, David und Clark, Timothy
(2019)
Universal Activation Index for Class A GPCRs.
Journal of Chemical Information and Modeling 59 (9), S. 3938-3945.
Volltext nicht vorhanden.
und Clark, Timothy
(2019)
Universal Activation Index for Class A GPCRs.
Journal of Chemical Information and Modeling 59 (9), S. 3938-3945.
Volltext nicht vorhanden.
2018
Yang, Zhenlin, Han, Shuo, Keller, Max, Kaiser, Anette, Bender, Brain J., Bosse, Mathias, Burkert, Kerstin, Kögler, Lisa M., Wifling, David , Bernhardt, Günther, Plank, Nicole, Littmann, Timo, Schmidt, Peter, Yi, Cuiying, Li, Beibei, Ye, Sheng, Zhang, Rongguang, Xu, Bo, Larhammar, Dan, Stevens, Raymond C. , Huster, Daniel, Meiler, Jens, Zhao, Qiang, Beck-Sickinger, Annette G., Buschauer, Armin und Wu, Beili
(2018)
Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor. Nature 556, S. 520-524. Volltext nicht vorhanden.
, Bernhardt, Günther, Plank, Nicole, Littmann, Timo, Schmidt, Peter, Yi, Cuiying, Li, Beibei, Ye, Sheng, Zhang, Rongguang, Xu, Bo, Larhammar, Dan, Stevens, Raymond C. , Huster, Daniel, Meiler, Jens, Zhao, Qiang, Beck-Sickinger, Annette G., Buschauer, Armin und Wu, Beili
(2018)
Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor. Nature 556, S. 520-524. Volltext nicht vorhanden.
Pockes, Steffen , Wifling, David , Keller, Max, Buschauer, Armin und Elz, Sigurd
(2018)
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists.
ACS Omega 2018 (3), S. 2865-2882.
2017
Pegoli, Andrea , She, Xueke, Wifling, David , Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter und Keller, Max
(2017)
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor.
Journal of Medicinal Chemistry 60 (8), S. 3314-3334.
Volltext nicht vorhanden.
, She, Xueke, Wifling, David , Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter und Keller, Max
(2017)
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor.
Journal of Medicinal Chemistry 60 (8), S. 3314-3334.
Volltext nicht vorhanden.
2016
Keller, Max, Kuhn, Kilian K., Einsiedel, Jürgen, Hübner, Harald, Biselli, Sabrina, Mollereau, Catherine , Wifling, David, Svobodova, Jaroslava, Bernhardt, Günther, Cabrele, Chiara , Vanderheyden, Patrick, Gmeiner, Peter und Buschauer, Armin
(2016)
Mimicking of arginine by functionalized Nω-carbamoylated arginine as a new broadly applicable approach to labeled bioactive peptides: high affinity angiotensin, neuropeptide Y, neuropeptide FF and neurotensin receptor ligands as examples.
Journal of Medicinal Chemistry 59 (5), S. 1925-1945.
Volltext nicht vorhanden.
, Wifling, David, Svobodova, Jaroslava, Bernhardt, Günther, Cabrele, Chiara , Vanderheyden, Patrick, Gmeiner, Peter und Buschauer, Armin
(2016)
Mimicking of arginine by functionalized Nω-carbamoylated arginine as a new broadly applicable approach to labeled bioactive peptides: high affinity angiotensin, neuropeptide Y, neuropeptide FF and neurotensin receptor ligands as examples.
Journal of Medicinal Chemistry 59 (5), S. 1925-1945.
Volltext nicht vorhanden.
2015
Wifling, David
(2015)
Constitutive activity of the human histamine H4 receptor: Molecular modelling, binding and functional studies on wild-type and mutant H4R orthologs.
Dissertation, Universität Regensburg.
Wifling, David , Bernhardt, Günther, Dove, Stefan und Buschauer, Armin
(2015)
The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity.
PLoS One 10 (1), S. 1-14.
Wifling, David , Löffel, Karolin, Nordemann, Uwe, Strasser, Andrea, Bernhardt, Günther, Dove, Stefan, Seifert, Roland und Buschauer, Armin
(2015)
Molecular determinants for the high constitutive activity of the human histamine H4 receptor: Functional studies on orthologs and mutants.
British Journal of Pharmacology 172, S. 785-798.
Volltext nicht vorhanden.
, Löffel, Karolin, Nordemann, Uwe, Strasser, Andrea, Bernhardt, Günther, Dove, Stefan, Seifert, Roland und Buschauer, Armin
(2015)
Molecular determinants for the high constitutive activity of the human histamine H4 receptor: Functional studies on orthologs and mutants.
British Journal of Pharmacology 172, S. 785-798.
Volltext nicht vorhanden.
2013
Nordemann, Uwe, Wifling, David , Schnell, David, Bernhardt, Günther, Stark, Holger , Seifert, Roland und Buschauer, Armin
(2013)
Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts.
PLoS One 8 (9), e73961.
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