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Publications by Wittinghofer, A.

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Number of items: 23.

2010

Rosnizeck, I C., Graf, T., Spoerner, M., Tränkle, J., Filchtinski, D., Herrmann, C., Gremer, L., Vetter, I., Wittinghofer, A., König, Burkhard and Kalbitzer, H. R. (2010) Stabilizing a Weak Binding State for Effectors in the Human Ras Protein by Cyclen Complexes. Angewandte Chemie International Edition (49), pp. 3830-3833. Fulltext not available.

2005

Spörner, M., Nuehs, A., Ganser, P., Herrmann, C., Wittinghofer, A. and Kalbitzer, H. (2005) Conformational states of Ras complexed with the GTP-analogs GppNHp or GppCH2p: implications for the interaction with effector proteins. Biochemistry 44, pp. 2225-2236. Fulltext not available.

2001

Spoerner, M., Herrmann, C., Vetter, I. R., Kalbitzer, Hans Robert and Wittinghofer, A. (2001) Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proceedings of the National Academy of Sciences of the United States of America: PNAS 98 (9), pp. 4944-4949. Fulltext not available.

Rohrer, M., Prisner, T. F., Brügmann, O., Käss, H., Spoerner, M., Wittinghofer, A. and Kalbitzer, Hans Robert (2001) Structure of the metal-water complex in Ras x GDP studied by high-field EPR spectroscopy and ³¹P NMR spectroscopy. Biochemistry 40 (7), pp. 1884-1889. Fulltext not available.

2000

Huber, F., Gronwald, W., Wohlgemuth, S., Herrmann, C., Geyer, M., Wittinghofer, A. and Kalbitzer, Hans Robert (2000) Sequential NMR assignment of the RAS-binding domain of Byr2. Journal of Biomolecular NMR 16 (4), pp. 355-356. Fulltext not available.

1999

Geyer, M., Assheuer, R., Klebe, C., Kuhlmann, J., Becker, J., Wittinghofer, A. and Kalbitzer, Hans Robert (1999) Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1. Biochemistry 38 (35), pp. 11250-11260. Fulltext not available.

Vetter, I. R., Linnemann, T., Wohlgemuth, S., Geyer, M., Kalbitzer, Hans Robert, Herrmann, C. and Wittinghofer, A. (1999) Structural and biochemical analysis of Ras-effector signaling via RalGDS. FEBS letters 451 (2), pp. 175-180. Fulltext not available.

Linnemann, T., Geyer, M., Jaitner, B. K., Block, C., Kalbitzer, Hans Robert, Wittinghofer, A. and Herrmann, C. (1999) Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. The Journal of biological chemistry 274 (19), pp. 13556-13562. Fulltext not available.

1997

Geyer, M., Herrmann, C., Wohlgemuth, S., Wittinghofer, A. and Kalbitzer, Hans Robert (1997) Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. Nature structural biology 4 (9), pp. 694-699. Fulltext not available.

1996

Geyer, M., Schweins, T., Herrmann, C., Prisner, T., Wittinghofer, A. and Kalbitzer, Hans Robert (1996) Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP. Biochemistry 35 (32), pp. 10308-10320. Fulltext not available.

Schweins, T., Geyer, M., Kalbitzer, Hans Robert, Wittinghofer, A. and Warshel, A. (1996) Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras. Biochemistry 35 (45), pp. 14225-14231. Fulltext not available.

1995

Schweins, T., Geyer, M., Scheffzek, K., Warshel, A., Kalbitzer, Hans Robert and Wittinghofer, A. (1995) Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nature structural biology 2 (1), pp. 36-44. Fulltext not available.

1993

Franken, S. M., Scheidig, A. J., Krengel, U., Rensland, H., Lautwein, A., Geyer, M., Scheffzek, K., Goody, R. S., Kalbitzer, Hans Robert, Pai, E. F. and Wittinghofer, A. (1993) Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry 32 (33), pp. 8411-8420. Fulltext not available.

1992

Wolber, V., Rensland, H., Brandmeier, B., Sagemann, M., Hoffmann, R., Kalbitzer, Hans Robert and Wittinghofer, A. (1992) Expression, purification and biochemical characterisation of the human immunodeficiency virus 1 nef gene product. European journal of biochemistry: EJB (= The FEBS journal) 205 (3), pp. 1115-1121. Fulltext not available.

1991

Kalbitzer, Hans Robert, Maeda, K., Rösch, A., Maéda, Y., Geyer, M., Beneicke, W., Neidig, K. P. and Wittinghofer, A. (1991) C-terminal structure and mobility of rabbit skeletal muscle light meromyosin as studied by one- and two-dimensional ¹H NMR spectroscopy and X-ray small-angle scattering. Biochemistry 30 (32), pp. 8083-8091. Fulltext not available.

Maeda, K., Rösch, A., Maéda, Y., Kalbitzer, Hans Robert and Wittinghofer, A. (1991) Rabbit skeletal muscle myosin. Unfolded carboxyl-terminus and its role in molecular assembly. FEBS letters 281 (1-2), pp. 23-26. Fulltext not available.

Kalbitzer, Hans Robert and Wittinghofer, A. (1991) The effect of kirromycin on the metal ion coordination in complexes of elongation factor Tu from Bacillus stearothermophilus as inferred from the ¹⁷O-⁵⁵Mn superhyperfine interaction. Biochimica et biophysica acta 1078 (2), pp. 133-138. Fulltext not available.

1990

Kalbitzer, Hans Robert, Feuerstein, J., Goody, R. S. and Wittinghofer, A. (1990) Stereochemistry and lifetime of the GTP hydrolysis intermediate at the active site of elongation factor Tu from Bacillus stearothermophilus as inferred from the ¹⁷O-⁵⁵Mn superhyperfine interaction. European journal of biochemistry: EJB (= theFEBS journal) 188 (2), pp. 355-359. Fulltext not available.

1987

Feuerstein, J., Kalbitzer, Hans Robert, John, J., Goody, R. S. and Wittinghofer, A. (1987) Characterisation of the metal-ion-GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the ¹⁷O-Mn superhyperfine coupling and by kinetic methods. European journal of biochemistry (= the FEBS journal) 162 (1), pp. 49-55. Fulltext not available.

1985

Kalbitzer, Hans Robert, Lebermann, R. and Wittinghofer, A. (1985) ¹H-NMR spectroscopy on elongation factor Tu from Escherichia coli: Resolution enhancement by perdeuteration. FEBS letters 180 (1), pp. 40-42. Fulltext not available.

1984

Kalbitzer, Hans Robert, Goody, R. S. and Wittinghofer, A. (1984) Electron-paramagnetic-resonance studies of manganese(II) complexes with elongation factor Tu from Bacillus stearothermophilus. Observation of a GTP hydrolysis intermediate state complex. European journal of biochemistry / FEBS 141 (3), pp. 591-597. Fulltext not available.

1982

Wittinghofer, A., Goody, R. S., Roesch, P. and Kalbitzer, Hans Robert (1982) The structure of the EF-Tu.GDP.Me²⁺ complex. European journal of biochemistry: EJB = the FEBS journal 124 (1), pp. 109-115. Fulltext not available.

1981

Antonsson, B., Kalbitzer, Hans-Robert and Wittinghofer, A. (1981) The binding of nucleotides and metal ions to elongation factor Tu from Bacillus stearothermophilus as studied by equilibrium dialysis. Hoppe-Seyler's Zeitschrift für physiologische Chemie 362 (6), pp. 735-743. Fulltext not available.

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