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Schweihofer, Verena, Schulz, Daniela
, Blazquez, Raquel
, Brockhoff, Gero
, Ettl, Tobias
, Fiedler, Mathias
, Heimer, Sina, Schikora, Juliane, Bauer, Richard J.
und Wege, Anja Kathrin
(2025)
Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma.
Frontiers in Oncology 15.
Goerg, Alina, Piendl, Gerhard, Albert, Veruschka, Ortmann, Olaf
, Wege, Anja Kathrin
und Brockhoff, Gero
(2025)
Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition.
BMC Cancer 25 (1).
Schweihofer, Verena, Bruss, Christina, Seitz, Stephan, Glehr, Gunther
, Hetterich, Madeleine, Weber, Florian
, Hatzipanagiotou, Maria Eleni
, Fernández-Pacheco Álvarez, Miriam, Ortmann, Olaf
, Brockhoff, Gero
, Bauer, Richard J.
und Wege, Anja Kathrin
(2025)
Breast cancer scoring based on a multiplexed profiling of soluble and cell-associated (immune) markers facilitates the prediction of pembrolizumab therapy.
Cancer Cell International 25, S. 120.
Fiedler, Mathias
, Off, Alisa, Gärtner, Andreas, Brockhoff, Gero
, Eichberger, Jonas, Gottsauner, Maximilian, Schuderer, Johannes G.
, Maurer, Michael
, Bauer, Richard J.
, Gerken, Michael, Reichert, Torsten E., Ettl, Tobias
und Weber, Florian
(2024)
Increased PD‐1/PD‐L1 Immune Checkpoint Expression Is Associated With Oral Squamous Cell Carcinoma in Never‐Smokers and Never‐Drinkers.
Head & Neck.
Albert, Veruschka, Bruss, Christina, Tümen, Deniz, Piendl, Gerhard, Weber, Florian
, Dahl, Edgar, Seitz, Stephan, Ortmann, Olaf
, Wege, Anja K.
und Brockhoff, Gero
(2024)
HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice.
International Journal of Molecular Sciences 25 (13), S. 7475.
Bruss, Christina, Albert, Veruschka, Seitz, Stephan, Blaimer, Stephanie
, Kellner, Kerstin, Pohl, Fabian, Ortmann, Olaf
, Brockhoff, Gero
und Wege, Anja K.
(2024)
Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy.
Frontiers in Immunology 15.
Schulz, Daniela
, Feulner, Laura, Rubenich, Dominique S.
, Heimer, Sina, Rohrmüller, Sophia, Reinders, Yvonne, Falchetti, Marcelo, Wetzel, Martin, Braganhol, Elizandra
, Lummertz da Rocha, Edroaldo, Schäfer, Nicole, Stöckl, Sabine, Brockhoff, Gero
, Wege, Anja K.
, Fritsch, Jürgen
, Pohl, Fabian, Reichert, Torsten E., Ettl, Tobias
und Bauer, Richard J.
(2023)
Subcellular localization of PD‐L1 and cell‐cycle‐dependent expression of nuclear PD‐L1 variants: implications for head and neck cancer cell functions and therapeutic efficacy.
Molecular Oncology.
Brockhoff, Gero
(2023)
Complementary Tumor Diagnosis by Single Cell–Based Cytogenetics Using Multi‐marker Fluorescence In Situ Hybridization (mFISH).
Current Protocols 3 (11).
Bruss, Christina, Kellner, Kerstin, Albert, Veruschka, Hutchinson, James A.
, Seitz, Stephan, Ortmann, Olaf
, Brockhoff, Gero
und Wege, Anja K.
(2023)
Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion.
Cancers 15 (9), S. 2615.
Brockhoff, Gero
(2022)
“Shedding” light on HER4 signaling in normal and malignant breast tissues.
Cellular Signalling 97.
Bruss, Christina, Kellner, Kerstin, Ortmann, Olaf
, Seitz, Stephan, Brockhoff, Gero
, Hutchinson, James A.
und Wege, Anja Kathrin
(2022)
Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice.
Cancers 14 (9), S. 2214.
Albert, Veruschka, Piendl, Gerhard, Yousseff, Dali, Lammert, Hedwig, Hummel, Michael, Ortmann, Olaf
, Jagla, Wolfgang, Gaumann, Andreas, Wege, Anja K.
und Brockhoff, Gero
(2022)
Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects.
Archives of Gynecology and Obstetrics.
Wege, Anja Kathrin, Rom‐Jurek, Eva‐Maria, Jank, Paul, Denkert, Carsten, Ugocsai, Peter, Solbach, Christine, Blohmer, Jens‐Uwe, Sinn, Bruno, Mackelenbergh, Marion, Möbus, Volker, Trumpp, Andreas, Marangoni, Elisabetta, Pfarr, Nicole, Irlbeck, Christoph
, Warfsmann, Jens, Polzer, Bernhard
, Weber, Florian, Ortmann, Olaf
, Loibl, Sibylle, Vladimirova, Valentina und Brockhoff, Gero
(2021)
mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease.
International Journal of Cancer 150, S. 1357-1372.
Schulz, Daniela, Wetzel, Martin, Eichberger, Jonas, Piendl, Gerhard, Brockhoff, Gero
, Wege, Anja K.
, Reichert, Torsten, Ettl, Tobias und Bauer, Richard J.
(2021)
Differential Expression of PD-L1 during Cell Cycle Progression of Head and Neck Squamous Cell Carcinoma.
International Journal of Molecular Sciences 22 (23), S. 1-18.
, Piendl, Gerhard, Brockhoff, Gero
, Eichberger, Jonas, Menevse, Ayse N., Beckhove, Philipp
, Hautmann, Matthias G.
, Reichert, Torsten E., Ettl, Tobias
und Bauer, Richard J.
(2020)
Buparlisib modulates PD-L1 expression in head and neck squamous cell carcinoma cell lines.
Experimental Cell Research 396 (1), S. 112259.
Volltext nicht vorhanden.
, Streller, Melanie, Piendl, Gerhard, Brockhoff, Gero
, Reichert, Torsten E., Menevse, Ayse N., Beckhove, Philipp
, Hautmann, Matthias G.
, Bauer, Richard J.
und Ettl, Tobias
(2019)
Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma.
Carcinogenesis 41 (7), S. 984-992.
Volltext nicht vorhanden.
Schulz, Daniela
, Stancev, Irene, Sorrentino, Antonio, Menevse, Ayse N., Beckhove, Philipp
, Brockhoff, Gero
, Hautmann, Matthias G.
, Reichert, Torsten E., Bauer, Richard J.
und Ettl, Tobias
(2019)
Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta.
Oncotarget 10 (5), S. 573-583.
Wege, Anja Kathrin, Chittka, Dominik, Buchholz, Stefan, Klinkhammer-Schalke, Monika, Diermeier-Daucher, Simone, Zeman, Florian, Ortmann, Olaf und Brockhoff, Gero
(2018)
HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women.
Breast Cancer Research 20 (1), S. 1-15.
(2017)
HER2 FISH results in breast cancers with increased CEN17 signals using alternative chromosome 17 probes - reclassifying cases in the equivocal category.
Histopathology 71 (4), S. 610-625.
Volltext nicht vorhanden.
Gehmert, Sebastian
, Wenzel, Carina, Loibl, Markus
, Brockhoff, Gero
, Huber, Michaela, Krutsch, Werner, Nerlich, Michael, Gosau, Martin, Klein, Silvan, Schreml, Stephan, Prantl, Lukas und Gehmert, Sanga
(2014)
Adipose tissue-derived Stem Cell (ASC) secreted IGF-1 protects myoblasts from the negative effect of Myostatin.
BioMed Research International 2014.
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