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Einträge von Decker, Michael auf dem Publikationsserver
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Anzahl der Einträge: 32.
2019
Schramm, Simon, Agnetta, Luca, Bermudez, Marcel, Gerwe, Hubert, Irmen, Matthias, Holze, Janine, Littmann, Timo, Wolber, Gerhard 
, Tränkle, Christian und Decker, Michael
(2019)
Novel BQCA‐ and TBPB‐Derived M 1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
ChemMedChem 14 (14), S. 1349-1358.
Volltext nicht vorhanden.
, Tränkle, Christian und Decker, Michael
(2019)
Novel BQCA‐ and TBPB‐Derived M 1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
ChemMedChem 14 (14), S. 1349-1358.
Volltext nicht vorhanden.
Agnetta, Luca, Bermudez, Marcel , Riefolo, Fabio , Matera, Carlo , Claro, Enrique , Messerer, Regina, Littmann, Timo, Wolber, Gerhard , Holzgrabe, Ulrike und Decker, Michael
(2019)
Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties.
Journal of Medicinal Chemistry 62 (6), S. 3009-3020.
Volltext nicht vorhanden.
, Riefolo, Fabio , Matera, Carlo , Claro, Enrique , Messerer, Regina, Littmann, Timo, Wolber, Gerhard , Holzgrabe, Ulrike und Decker, Michael
(2019)
Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties.
Journal of Medicinal Chemistry 62 (6), S. 3009-3020.
Volltext nicht vorhanden.
2018
Dolles, Dominik, Hoffmann, Matthias, Gunesch, Sandra, Marinelli, Oliviero, Möller, Jan , Santoni, Giorgio, Chatonnet, Arnaud, Lohse, Martin J. , Wittmann, Hans-Joachim, Strasser, Andrea, Nabissi, Massimo, Maurice, Tangui und Decker, Michael
(2018)
Structure–Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.
Journal of Medicinal Chemistry 61 (4), S. 1646-1663.
Volltext nicht vorhanden.
, Santoni, Giorgio, Chatonnet, Arnaud, Lohse, Martin J. , Wittmann, Hans-Joachim, Strasser, Andrea, Nabissi, Massimo, Maurice, Tangui und Decker, Michael
(2018)
Structure–Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.
Journal of Medicinal Chemistry 61 (4), S. 1646-1663.
Volltext nicht vorhanden.
2017
Huang, Guozheng , Drakopoulos, Antonios , Saedtler, Marco, Zou, Huijuan, Meinel, Lorenz , Heilmann, Jörg und Decker, Michael
(2017)
Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility.
Bioorganic & Medicinal Chemistry Letters 27 (21), S. 4937-4941.
Volltext nicht vorhanden.
, Drakopoulos, Antonios , Saedtler, Marco, Zou, Huijuan, Meinel, Lorenz , Heilmann, Jörg und Decker, Michael
(2017)
Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility.
Bioorganic & Medicinal Chemistry Letters 27 (21), S. 4937-4941.
Volltext nicht vorhanden.
2016
Sadek, Bassem, Khan, Nadia, Darras, Fouad H., Pockes, Steffen und Decker, Michael
(2016)
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.
Physiology & Behavior 165, S. 383-391.
Volltext nicht vorhanden.
und Decker, Michael
(2016)
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.
Physiology & Behavior 165, S. 383-391.
Volltext nicht vorhanden.
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea und Decker, Michael
(2016)
Aminobenzimidazoles and structural isomers as templates for dual-acting butyrylcholinesterase inhibitors and hCB2R ligands to combat neurodegenerative disorders.
ChemMedChem 11 (12), S. 1270-1283.
Volltext nicht vorhanden.
Sawatzky, Edgar, Wehle, Sarah, Kling, Beata, Wendrich, Jan, Bringmann, Gerhard, Sotriffer, Christoph A., Heilmann, Jörg und Decker, Michael
(2016)
Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.
Journal of Medicinal Chemistry 59 (5), S. 2067-2082.
Volltext nicht vorhanden.
Khan, Nadia, Saad, Ali, Nurulain, Syed M., Darras, Fouad H., Decker, Michael und Sadek, Bassem
(2016)
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.
Behavioural Brain Research 297, S. 155-164.
Volltext nicht vorhanden.
Huang, Guozheng , Schramm, Simon, Heilmann, Jörg, Biedermann, David, Křen, Vladimír und Decker, Michael
(2016)
Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins.
Beilstein Journal of Organic Chemistry 12, S. 662-669.
Volltext nicht vorhanden.
, Schramm, Simon, Heilmann, Jörg, Biedermann, David, Křen, Vladimír und Decker, Michael
(2016)
Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins.
Beilstein Journal of Organic Chemistry 12, S. 662-669.
Volltext nicht vorhanden.
2015
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios , Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea und Decker, Michael
(2015)
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors andhCB2R Ligands To Combat Neurodegenerative Disorders.
ChemMedChem 11 (12), S. 1270-1283.
Volltext nicht vorhanden.
, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea und Decker, Michael
(2015)
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors andhCB2R Ligands To Combat Neurodegenerative Disorders.
ChemMedChem 11 (12), S. 1270-1283.
Volltext nicht vorhanden.
Chen, Xinyu, Klöckner, Jessika, Holze, Janine, Zimmermann, Cornelia, Seemann, Wiebke K., Schrage, Ramona, Bock, Andreas , Mohr, Klaus, Tränkle, Christian, Holzgrabe, Ulrike und Decker, Michael
(2015)
Rational Design of Partial Agonists for the Muscarinic M1 Acetylcholine Receptor.
Journal of Medicinal Chemistry 58 (2), S. 560-576.
Volltext nicht vorhanden.
, Mohr, Klaus, Tränkle, Christian, Holzgrabe, Ulrike und Decker, Michael
(2015)
Rational Design of Partial Agonists for the Muscarinic M1 Acetylcholine Receptor.
Journal of Medicinal Chemistry 58 (2), S. 560-576.
Volltext nicht vorhanden.
2014
Darras, Fouad, Pockes, Steffen, Huang, Guozheng , Wehle, Sarah, Strasser, Andrea, Wittmann, Hans-Joachim, Nimczick, Martin, Sotriffer, Christoph und Decker, Michael
(2014)
Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
ACS Chemical Neuroscience 5 (3), S. 225-242.
Volltext nicht vorhanden.
, Wehle, Sarah, Strasser, Andrea, Wittmann, Hans-Joachim, Nimczick, Martin, Sotriffer, Christoph und Decker, Michael
(2014)
Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
ACS Chemical Neuroscience 5 (3), S. 225-242.
Volltext nicht vorhanden.
Chen, Xinyu, Wehle, Sarah, Kuzmanovic, Natascha, Merget, Benjamin, Holzgrabe, Ulrike , König, Burkhard , Sotriffer, Christoph A. und Decker, Michael
(2014)
Acetylcholinesterase Inhibitors with Photoswitchable Inhibition of β‑Amyloid Aggregation.
ACS Chemical Neuroscience 5, S. 377-389.
Volltext nicht vorhanden.
, König, Burkhard , Sotriffer, Christoph A. und Decker, Michael
(2014)
Acetylcholinesterase Inhibitors with Photoswitchable Inhibition of β‑Amyloid Aggregation.
ACS Chemical Neuroscience 5, S. 377-389.
Volltext nicht vorhanden.
Darras, Fouad H., Wehle, Sarah, Huang, Guozheng , Sotriffer, Christoph A. und Decker, Michael
(2014)
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’ binding mode.
Bioorganic & Medicinal Chemistry 22 (17), S. 4867-4881.
Volltext nicht vorhanden.
, Sotriffer, Christoph A. und Decker, Michael
(2014)
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’ binding mode.
Bioorganic & Medicinal Chemistry 22 (17), S. 4867-4881.
Volltext nicht vorhanden.
Darras, Fouad H., Kling, Beata, Sawatzky, Edgar, Heilmann, Jörg und Decker, Michael
(2014)
Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.
Bioorganic & Medicinal Chemistry 22 (17), S. 5020-5034.
Volltext nicht vorhanden.
Huang, Guozheng , Pemp, Daniela, Stadtmüller, Patricia, Nimczick, Martin, Heilmann, Jörg und Decker, Michael
(2014)
Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.
Bioorganic & Medicinal Chemistry Letters 24 (17), S. 4209-4214.
Volltext nicht vorhanden.
, Pemp, Daniela, Stadtmüller, Patricia, Nimczick, Martin, Heilmann, Jörg und Decker, Michael
(2014)
Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.
Bioorganic & Medicinal Chemistry Letters 24 (17), S. 4209-4214.
Volltext nicht vorhanden.
Kling, Beata, Bücherl, Daniel, Palatzky, Peter, Matysik, Frank-Michael, Decker, Michael, Wegener, Joachim und Heilmann, Jörg
(2014)
Flavonoids, Flavonoid Metabolites, and Phenolic Acids Inhibit Oxidative Stress in the Neuronal Cell Line HT-22 Monitored by ECIS and MTT Assay: A Comparative Study.
Journal of Natural Products 77 (3), S. 446-454.
Volltext nicht vorhanden.
Huang, Guozheng , Kling, Beata, Darras, Fouad H., Heilmann, Jörg und Decker, Michael
(2014)
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.
European Journal of Medicinal Chemistry 81, S. 15-21.
Volltext nicht vorhanden.
, Kling, Beata, Darras, Fouad H., Heilmann, Jörg und Decker, Michael
(2014)
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.
European Journal of Medicinal Chemistry 81, S. 15-21.
Volltext nicht vorhanden.
Nimczick, Martin, Pemp, Daniela, Darras, Fouad H., Chen, Xinyu, Heilmann, Jörg und Decker, Michael
(2014)
Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB2R selective benzimidazoles reveal unexpected intrinsic properties.
Bioorganic & Medicinal Chemistry 22 (15), S. 3938-3946.
Volltext nicht vorhanden.
2013
Decker, Michael und Wehle, Sarah
(2013)
Alzheimer mit Hybridmolekülen in die Zange nehmen.
Nachrichten aus der Chemie 61 (9), S. 871-875.
Volltext nicht vorhanden.
Zenger, Katharina, Chen, Xinyu, Decker, Michael und Kraus, Birgit
(2013)
In-vitro stability and metabolism of a tacrine–silibinin codrug.
Journal of Pharmacy and Pharmacology 65 (12), S. 1765-1772.
Volltext nicht vorhanden.
2012
Decker, Michael und Holzgrabe, Ulrike
(2012)
M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease.
MedChemComm 3 (7), S. 752.
Volltext nicht vorhanden.
(2012)
M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease.
MedChemComm 3 (7), S. 752.
Volltext nicht vorhanden.
Darras, Fouad H., Kling, Beata, Heilmann, Jörg und Decker, Michael
(2012)
Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.
ACS Medicinal Chemistry Letters 3 (11), S. 914-919.
Volltext nicht vorhanden.
Chen, Xinyu, Zenger, Katharina, Lupp, Amelie, Kling, Beata, Heilmann, Jörg, Fleck, Christian, Kraus, Birgit und Decker, Michael
(2012)
Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effects in Vitro and Pro-Cognitive and Hepatoprotective Effects in Vivo.
Journal of Medicinal Chemistry 55 (11), S. 5231-5242.
Volltext nicht vorhanden.
2011
Macabeo, Allan Patrick G., Vidar, Warren S., Chen, Xinyu, Decker, Michael, Heilmann, Jörg, Wan, Baojie, Franzblau, Scott G. , Galvez, Elano V., Aguinaldo, Ma. Alicia M. und Cordell, Geoffrey A.
(2011)
Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.
European Journal of Medicinal Chemistry 46 (7), S. 3118-3123.
Volltext nicht vorhanden.
, Galvez, Elano V., Aguinaldo, Ma. Alicia M. und Cordell, Geoffrey A.
(2011)
Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.
European Journal of Medicinal Chemistry 46 (7), S. 3118-3123.
Volltext nicht vorhanden.
Chen, Xinyu, Tikhonova, Irina G. und Decker, Michael
(2011)
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.
Bioorganic & Medicinal Chemistry 19 (3), S. 1222-1235.
Volltext nicht vorhanden.
2008
Fang, Lei, Kraus, Birgit, Lehmann, Jochen, Heilmann, Jörg, Zhang, Yihua und Decker, Michael
(2008)
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
Bioorganic & medicinal chemistry letters 18 (9), S. 2905-2909.
Volltext nicht vorhanden.
Fang, Lei, Kraus, Birgit, Lehmann, Jochen, Heilmann, Joerg, Zhang, Yihua und Decker, Michael
(2008)
Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
Bioorganic & Medicinal Chemistry Letters 18 (9), S. 2905-2909.
Volltext nicht vorhanden.
Decker, Michael, Kraus, Birgit und Heilmann, Jörg
(2008)
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.
Bioorganic & medicinal chemistry 16 (8), S. 4252-4261.
Volltext nicht vorhanden.
Decker, Michael, Kraus, Birgit und Heilmann, Jörg
(2008)
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.
Bioorganic & Medicinal Chemistry 16 (8), S. 4252-4261.
Volltext nicht vorhanden.
2002
El-Subbagh, Hussein, Wittig, Thomas, Decker, Michael, Elz, Sigurd, Nieger, Martin und Lehmann, Jochen
(2002)
Dopamine/Serotonin Receptor Ligands. Part IV [1]: Synthesis and Pharmacology of Novel 3-Benzazecines and 3-Benzazonines as Potential 5-HT2A and Dopamine Receptor Ligands.
Archiv der Pharmazie 335 (9), S. 443-448.
Volltext nicht vorhanden.
und Lehmann, Jochen
(2002)
Dopamine/Serotonin Receptor Ligands. Part IV [1]: Synthesis and Pharmacology of Novel 3-Benzazecines and 3-Benzazonines as Potential 5-HT2A and Dopamine Receptor Ligands.
Archiv der Pharmazie 335 (9), S. 443-448.
Volltext nicht vorhanden.
Jordan, Wolfgang, Decker, Michael, Kamrowski, Heike, Brunner, Edgar, Ehrenreich, Hannelore und Hajak, Göran
(2002)
Effects of cerebrovascular challenges on plasma endothelin.
Neuroscience Research 43 (2), S. 127-134.
Volltext nicht vorhanden.
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