Entries of Lebek, Simon on the publication server

Seydel, Bettina, Hegner, Philipp , Lauerer, Anna-Maria, Schildt, Sönke, Bayram, Fatma, Tafelmeier, Maria , Wermers, Dominik, Rupprecht, Leopold , Schmid, Christof, Wagner, Stefan , Maier, Lars Siegfried , Arzt, Michael and Lebek, Simon (2025) Increased Myocardial MARK4 Expression in Patients with Heart Failure and Sleep-Disordered Breathing. International Journal of Molecular Sciences 26 (8), p. 3614.

Bayram, Fatma, Hegner, Philipp , Lauerer, Anna-Maria, Schildt, Sönke, Wermers, Dominik, Baier, Maria Johanna, Mustroph, Julian , Tafelmeier, Maria , Provaznik, Zdenek , Schmid, Christof, Maier, Lars Siegfried , Wagner, Stefan , Arzt, Michael and Lebek, Simon (2025) Myocardial DYRK1B Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing. Antioxidants 14 (2), p. 163.

Lauerer, Anna-Maria, Caravia, Xurde M., Maier, Lars S., Chemello, Francesco and Lebek, Simon (2024) Gene editing in common cardiovascular diseases. Pharmacology & Therapeutics 263, p. 108720.

Hegner, Philipp , Ofner, Florian, Schaner, Benedikt, Gugg, Mathias, Trum, Maximilian , Lauerer, Anna-Maria, Maier, Lars Siegfried , Arzt, Michael , Lebek, Simon and Wagner, Stefan (2024) CaMKIIδ-dependent dysregulation of atrial Na+ homeostasis promotes pro-arrhythmic activity in an obstructive sleep apnea mouse model. Frontiers in Pharmacology 15.

Hegner, Philipp , Wester, Michael , Tafelmeier, Maria , Provaznik, Zdenek , Klatt, Susanne, Schmid, Christof, Maier, Lars Siegfried , Arzt, Michael , Wagner, Stefan and Lebek, Simon (2024) Systemic inflammation predicts diastolic dysfunction in patients with sleep disordered breathing. European Respiratory Journal 63 (6), p. 2400579.

Trum, Maximilian , Riechel, Johannes, Schollmeier, Elisa, Lebek, Simon , Hegner, Philipp , Reuthner, Kathrin, Heers, Silvia, Keller, Karoline, Wester, Michael , Klatt, Susanne, Hamdani, Nazha, Provaznik, Zdenek , Schmid, Christof, Maier, Lars S. , Arzt, Michael and Wagner, Stefan (2024) Empagliflozin inhibits increased Na influx in atrial cardiomyocytes of patients with HFpEF. Cardiovascular Research.

Wester, Michael, Arzt, Michael, Sinha, Frederick, Maier, Lars S. and Lebek, Simon (2023) Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing. Biomedicines 11 (11), p. 3038.

Hegner, Philipp , Lebek, Simon , Schaner, Benedikt, Ofner, Florian, Gugg, Mathias, Maier, Lars Siegfried, Arzt, Michael and Wagner, Stefan (2023) CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea. Antioxidants 12 (2), p. 315.

Mustroph, Julian, Baier, Maria J., Unsin, Denise, Provaznik, Zdenek, Kozakov, Kostiantyn, Lebek, Simon , Tarnowski, Daniel, Schildt, Sönke , Voigt, Niels, Wagner, Stefan , Maier, Lars S. and Neef, Stefan (2023) Ethanol-Induced Atrial Fibrillation Results From Late I Na and Can Be Prevented by Ranolazine. Circulation 148 (8), pp. 698-700. Fulltext not available.

Lebek, Simon , Chemello, Francesco , Caravia, Xurde M., Tan, Wei, Li, Hui, Chen, Kenian, Xu, Lin , Liu, Ning , Bassel-Duby, Rhonda and Olson, Eric N. (2023) Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease. Science 379 (6628), pp. 179-185. Fulltext not available.

Lebek, Simon , Caravia, Xurde M., Chemello, Francesco, Tan, Wei, McAnally, John R., Chen, Kenian, Xu, Lin, Liu, Ning, Bassel-Duby, Rhonda and Olson, Eric N. (2023) Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice. Circulation 148 (19), pp. 1490-1504. Fulltext not available.

Lebek, Simon , Hegner, Philipp , Hultsch, Rosa, Rohde, Jonas, Rupprecht, Leopold, Schmid, Christof, Sossalla, Samuel, Maier, Lars Siegfried, Arzt, Michael and Wagner, Stefan (2022) Voltage-Gated Sodium Channel NaV1.8 Dysregulates Na and Ca, Leading to Arrhythmias in Patients with Sleep-Disordered Breathing. American Journal of Respiratory and Critical Care Medicine 206 (11). Fulltext restricted.

Lebek, Simon , Hegner, Philipp, Hultsch, Rosa, Rohde, Jonas, Rupprecht, Leopold , Schmid, Christof, Sossalla, Samuel , Maier, Lars Siegfried , Arzt, Michael and Wagner, Stefan (2022) Supplemental Material for "NaV1.8 dysregulates Na and Ca leading to arrhythmias in patients with sleep-disordered breathing". (Unpublished) Fulltext restricted.

Wester, Michael, Pec, Jan , Lebek, Simon , Fisser, Christoph, Debl, Kurt, Hamer, Okka W., Poschenrieder, Florian, Buchner, Stefan, Maier, Lars S., Arzt, Michael and Wagner, Stefan (2022) Sleep-Disordered Breathing Is Associated With Reduced Left Atrial Strain Measured by Cardiac Magnetic Resonance Imaging in Patients After Acute Myocardial Infarction. Frontiers in Medicine 2022 (9), p. 759361.

Arzt, Michael, Drzymalski, Marzena A., Ripfel, Sarah, Meindl, Sebastian, Biedermann, Alexander, Durczok, Melanie, Keller, Karoline, Mustroph, Julian, Katz, Sylvia, Tafelmeier, Maria, Lebek, Simon , Flörchinger, Bernhard, Camboni, Daniele, Wittmann, Sigrid, Backs, Johannes, Schmid, Christof, Maier, Lars S. and Wagner, Stefan (2022) Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing. Antioxidants 11 (2), p. 331.

Islam, M. M. Towhidul, Tarnowski, Daniel, Zhang, Min , Trum, Maximilian , Lebek, Simon, Mustroph, Julian, Daniel, Henriette, Moellencamp, Johanna, Pabel, Steffen, Sossalla, Samuel, El‐Armouche, Ali, Nikolaev, Viacheslav O., Shah, Ajay M., Eaton, Philip J. , Maier, Lars S., Sag, Can Martin and Wagner, Stefan (2021) Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice. Journal of the American Heart Association 10 (19), 021985.

Hegner, Philipp, Lebek, Simon, Maier, Lars Siegfried, Arzt, Michael and Wagner, Stefan (2021) The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea. Frontiers in Physiology 2121 (12), pp. 1-8.

Lebek, Simon , Wester, Michael , Pec, Jan, Poschenrieder, Florian, Tafelmeier, Maria, Fisser, Christoph, Provaznik, Zdenek, Schopka, Simon, Debl, Kurt, Schmid, Christof, Buchner, Stefan, Maier, Lars S., Arzt, Michael and Wagner, Stefan (2021) Abnormal P‐wave terminal force in lead V 1 is a marker for atrial electrical dysfunction but not structural remodelling. ESC Heart Failure 8 (5), pp. 4055-4066.

Wagner, Stefan, Lebek, Simon, Hegner, Philipp, Tafelmeier, Maria, Rupprecht, Leopold, Schmid, Christof, Maier, Lars Siegfried and Arzt, Michael (2021) Female Patients With Sleep-Disordered Breathing Display More Frequently Heart Failure With Preserved Ejection Fraction. Medicine 2021 (8), p. 675987. (Submitted)

Hegner, Philipp, Lebek, Simon, Tafelmeier, Maria, Camboni, Daniele, Schopka, Simon, Schmid, Christof, Maier, Lars Siegfried, Arzt, Michael and Wagner, Stefan (2021) Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression. Heart Rhythm 18 (12), pp. 2187-2194. Fulltext not available.

Lebek, Simon, Hegner, Philipp, Schach, Christian, Reuthner, Katrin, Tafelmeier, Maria , Maier, Lars S., Arzt, Michael and Wagner, Stefan (2020) A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction. PLoS One 15 (12), e0243844. (In Press)

Lebek, Simon, Tafelmeier, Maria, Messmann, Rebecca, Provaznik, Zdenek, Schmid, Christof, Maier, Lars S., Birner, Christoph, Arzt, Michael and Wagner, Stefan (2020) Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin-converting enzyme 2 in patients with cardiovascular disease. European Journal of Heart Failure 22, pp. 2248-2257.

Trum, Maximilian , Riechel, Johannes, Lebek, Simon, Pabel, Steffen, Sossalla, Samuel T., Hirt, Stephan, Arzt, Michael, Maier, Lars S. and Wagner, Stefan (2020) Empagliflozin inhibits Na + /H + exchanger activity in human atrial cardiomyocytes. ESC Heart Failure 2020, pp. 1-9.

Trum, Maximilian, Islam, Towhidul, Lebek, Simon, Baier, Maria, Hegner, Philipp, Eaton, Phil, Maier, Lars Siegfried and Wagner, Stefan (2020) Supplemental Figures S1 and S2. [Image] (Submitted)

Lebek, Simon, Pichler, Konstantin, Reuthner, Kathrin, Trum, Maximillian, Tafelmeier, Maria, Mustroph, Julian , Camboni, Daniele, Rupprecht, Leopold, Schmid, Christof, Maier, Lars S., Arzt, Michael and Wagner, Stefan (2020) Enhanced CaMKII-Dependent Late I Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing. Circulation Research 126 (5), pp. 603-615. Fulltext not available.

Bader, Michael, Lebek, Simon, Hegner, Philipp, Schach, Christian, Reuthner, Kathrin, Tafelmeier, Maria, Maier, Lars Siegfried, Arzt, Michael and Wagner, Stefan (2020) A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction. PLOS ONE 15 (12), e0243844. Fulltext not available.

Sossalla, Samuel, Maier, Lars S. , Neef, Stefan, Wagner, Stefan, Rupprecht, Leopold, Keyser, Andreas, Dybkova, Nataliya, Lebek, Simon, Stehle, Thea, Mustroph, Julian and Pabel, Steffen (2020) Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias. EP Europace 22 (7), pp. 1111-1118. Fulltext not available.

Tafelmeier, Maria, Knapp, Marvin, Lebek, Simon, Floerchinger, Bernhard, Camboni, Daniele, Creutzenberg, Marcus, Wittmann, Sigrid, Zeman, Florian, Schmid, Christof, Maier, Lars Siegfried, Wagner, Stefan and Arzt, Michael (2019) Predictors of delirium after cardiac surgery in patients with sleep disordered breathing. European Respiratory Journal 54 (2), p. 1900354. Fulltext not available.

Mustroph, Julian, Wagemann, Olivia, Lücht, Charlotte M., Trum, Maximilian, Hammer, Karin P., Sag, Can Martin, Lebek, Simon, Tarnowski, Daniel, Reinders, Jörg, Perbellini, Filippo, Terracciano, Cesare, Schmid, Christof, Schopka, Simon, Hilker, Michael, Zausig, York, Pabel, Steffen, Sossalla, Samuel T., Schweda, Frank, Maier, Lars S. and Wagner, Stefan (2018) Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes. ESC Heart Failure 5 (4), pp. 642-648.

Neef, Stefan, Steffens, Alexander, Pellicena, Patricia, Mustroph, Julian, Lebek, Simon, Ort, Katharina R., Schulman, Howard and Maier, Lars S. (2018) Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor. Journal of Molecular and Cellular Cardiology 115, pp. 73-81. Fulltext not available.

Mustroph, Julian, Wagemann, Olivia, Lebek, Simon, Tarnowski, Daniel, Ackermann, Jasmin, Drzymalski, Marzena, Pabel, Steffen, Schmid, Christof, Wagner, Stefan , Sossalla, Samuel, Maier, Lars S. and Neef, Stefan (2018) SR Ca 2+ -leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure. Journal of Molecular and Cellular Cardiology 116, pp. 81-90. Fulltext not available.