Einträge von Wittmann, Hans-Joachim auf dem Publikationsserver

Tropmann, Katharina, Bresinsky, Merlin, Forster, Lisa, Mönnich, Denise, Buschauer, Armin , Wittmann, Hans-Joachim, Hübner, Harald, Gmeiner, Peter, Pockes, Steffen und Strasser, Andrea (2021) Abolishing Dopamine D2long/D3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2 Receptor Agonists. Journal of Medicinal Chemistry 64 (12), S. 8684-8709. Volltext nicht vorhanden.

Dolles, Dominik, Hoffmann, Matthias, Gunesch, Sandra, Marinelli, Oliviero, Möller, Jan , Santoni, Giorgio, Chatonnet, Arnaud, Lohse, Martin J. , Wittmann, Hans-Joachim, Strasser, Andrea, Nabissi, Massimo, Maurice, Tangui und Decker, Michael (2018) Structure–Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. Journal of Medicinal Chemistry 61 (4), S. 1646-1663. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim und Seifert, Roland (2017) Binding kinetics and pathways of ligands to GPCRs. Trends in Pharmacological Sciences. (Im Druck) Volltext nicht vorhanden.

Wittmann, Hans-Joachim und Strasser, Andrea (2017) Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions? Naunyn-Schmiedeberg's Archives of Pharmacology. (Im Druck) Volltext nicht vorhanden.

Wittmann, Hans-Joachim und Strasser, Andrea (2017) Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions? Naunyn-Schmiedeberg's Archives of Pharmacology 390 (6), S. 595-612. Volltext nicht vorhanden.

Naporra, Franziska, Gobleder, Susanne, Wittmann, Hans-Joachim, Spindler, Julia, Bodensteiner, Michael, Bernhardt, Günther, Hübner, Harald, Gmeiner, Peter, Elz, Sigurd und Strasser, Andrea (2016) Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs. Pharmacological Research 113, S. 610-625. (Im Druck) Volltext nicht vorhanden.

Geyer, Roland, Nordemann, Uwe, Strasser, Andrea, Wittmann, Hans-Joachim und Buschauer, Armin (2016) Conformational restriction and enantioseparation increase potency and selectivity of cyanoguanidine-type histamine H4 receptor agonists. Journal of Medicinal Chemistry 59 (7), S. 3452-3470. Volltext nicht vorhanden.

Hammer, Sebastian, Gobleder, Susanne, Naporra, Franziska, Wittmann, Hans-Joachim, Elz, Sigurd, Heinrich, Markus und Strasser, Andrea (2016) 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity. Bioorganic & Medicinal Chemistry Letters 26, S. 292-300. Volltext nicht vorhanden.

Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea und Decker, Michael (2016) Aminobenzimidazoles and structural isomers as templates for dual-acting butyrylcholinesterase inhibitors and hCB2R ligands to combat neurodegenerative disorders. ChemMedChem 11 (12), S. 1270-1283. Volltext nicht vorhanden.

Naporra, Franziska, Gobleder, Susanne, Wittmann, Hans-Joachim, Spindler, Julia, Bodensteiner, Michael, Bernhardt, Günther, Hübner, Harald, Gmeiner, Peter , Elz, Sigurd und Strasser, Andrea (2016) Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs. Pharmacological Research 113, S. 610-625. Volltext nicht vorhanden.

Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios , Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea und Decker, Michael (2015) Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors andhCB2R Ligands To Combat Neurodegenerative Disorders. ChemMedChem 11 (12), S. 1270-1283. Volltext nicht vorhanden.

Wittmann, Hans-Joachim und Strasser, Andrea (2015) Binding pathway of histamine to the hH4R, observed by unconstrained molecular dynamics. Bioorganic & Medicinal Chemistry Letters 25, S. 1259-1268. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Schneider, Erich H. und Seifert, Roland (2015) Modulation of GPCRs by monovalent cations and anions. Naunyn-Schmiedeberg's Archives of Pharmacology 388, S. 363-380. Volltext nicht vorhanden.

Kirchhof, Susanne, Strasser, Andrea, Wittmann, Hans-Joachim, Messmann, Viktoria, Hammer, Nadine, Goepferich, Achim und Brandl, Ferdinand (2015) New insights into the cross-linking and degradation mechanism of Diels–Alder hydrogels. Journal of Materials Chemistry B 3, S. 449-457.

Untergehrer, Monika, Bücherl, Daniel, Wittmann, Hans-Joachim, Strasser, Andrea, Heilmann, Jörg und Jürgenliemk, Guido (2015) Structure-dependent deconjugation of flavonoid glucuronides by human beta-glucuronidase - in vitro and in silico analyses. Planta Med. 81 (12/13), S. 1182-1189. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2014) Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor. In silico pharmacology 2.

Darras, Fouad, Pockes, Steffen , Huang, Guozheng, Wehle, Sarah, Strasser, Andrea, Wittmann, Hans-Joachim, Nimczick, Martin, Sotriffer, Christoph und Decker, Michael (2014) Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS Chemical Neuroscience 5 (3), S. 225-242. Volltext nicht vorhanden.

Wager, Eva, Wittmann, Hans-Joachim, Elz, Sigurd und Strasser, Andrea (2014) Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor - H1/H4 receptor selectivity. Naunyn-Schmiedeberg's Archives of Pharmacology 387, S. 235-250. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2014) Sodium binding to hH3R and hH4R - a molecular modelling study. Journal of Molecular Modeling 20, S. 2394. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Buschauer, Armin, Schneider, Erich H. und Seifert, Roland (2013) Species-dependent activities of GPCR ligands: Lessons from histamine receptor orthologs. Trends in Pharmacological Sciences 34 (1), S. 13-32. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2013) Molecular modelling studies give hint for the existence of a symmetric hb2R-Gabg-homodimer. J Mol Model 19, S. 4443-4457. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2012) Binding of Ligands to GPCRs – How Valid is a Thermodynamic
Discrimination of Antagonists and Agonists? Journal of Physical Chemistry & Biophysics 2012.

Strasser, Andrea und Wittmann, Hans-Joachim (2012) hb2R-Gas-complex: Prediction versus crystal structure - How valuable are predictions based on molecular modelling studies? Journal of Molecular Modeling : J Mol Model 18, S. 3439-3444. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2011) Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H1R. Biochemical Pharmacology 12, S. 1910-1918. Volltext nicht vorhanden.

Wagner, Eva, Wittmann, Hans-Joachim, Elz, Sigurd und Strasser, Andrea (2011) Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH1R, but low affinity to hH4R. Bioorganic & Medicinal Chemistry Letters 21, S. 6274-9280. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Elz, Sigurd, Seifert, Roland und Strasser, Andrea (2011) Na-methylated phenylhistamines exhibit affinity to the hH4R - a pharmacological and molecular modelling study. Naunyn Schmiedeberg's Arch Pharmacol 384, S. 287-299. Volltext nicht vorhanden.

Ferstl, Matthias, Strasser, Andrea, Wittmann, Hans-Joachim, Drechsler, Markus, Rischer, M., Engl, J. und Goepferich, Achim (2011) Nanofibres Resulating from Cooperative Electrostatic and Hydrophobic Interactions between Peptides and Polyelectrolytes of Opposite Charge. Langmuir 27, S. 14450-14459. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2010) 3D-QSAR CoMFA study to predict orientation of suprahistaprodifens and phenoprodifens in the binding-pocket of four histamine H1-receptor species. Molecular Informatics 29, S. 333-341. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2010) Distinct interactions between the human adrenergic b2 receptor and Gas - an in silico study. J Mol Model 16, S. 1307-1318. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2010) In silico analysis of the histaprodifen induced pathway of the guinea-pig histamine H1 receptor. Journal of computer- aided molecular design : J Comput Aided Mol Des 24, S. 759-769. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2009) Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H1-receptor. Molecular Pharmacology 76, S. 25-37. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Kunze, Marc, Elz, Sigurd und Seifert, Roland (2009) Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea-pig H1-receptor. Mol Pharmacol : Molecular pharmacology 75, S. 454-465. Volltext nicht vorhanden.

Strasser, Andrea, Striegl, Birgit, Wittmann, Hans-Joachim und Seifert, Roland (2008) Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms. Journal of Pharmacology and Experimental Therapeutics 324, S. 60-71. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim und Seifert, Roland (2008) Ligand-specific contribution of the N-terminus and E2-loop to pharmacological properties of the histamine H1-receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 326 (3), S. 783-791. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2007) Analysis of the activation mechanism of the guinea-pig histamine H1-receptor. J Comput Aided Mol Des : Journal of computer aided molecular design 21, S. 499-509. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2007) LigPath: A module for predictive calculation of a ligands pathway into a receptor - application to the gpH1-receptor. J Mol Model : Journal of molecular modeling 13, S. 209-218. Volltext nicht vorhanden.

Barthel, Josef, Buchner, Richard und Wittmann, Hans-Joachim (1984) Conductivity and dielectric properties of aqueous cadmium sulfate solutions. Zeitschrift fuer Physikalische Chemie (Muenchen, Germany) 139, S. 23-37. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2016) Molecular Modelling Approaches for the Analysis of Histamine Receptors and Their Interaction with Ligands. In: Handbook of Experimental Pharmacology. (Im Druck) Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2013) Modelling of GPCRs - A Practical Handbook. Springer. Volltext nicht vorhanden.