Einträge von Rümmele, Petra auf dem Publikationsserver

Elsner, Felix, Hoffmann, Martin, Fahrioglu‐Yamaci, Rezan, Czyz, Zbigniew, Feliciello, Giancarlo, Mederer, Tobias , Polzer, Bernhard, Treitschke, Steffi, Rümmele, Petra, Weber, Florian , Wiesinger, Hellmuth, Robold, Tobias, Sziklavari, Zsolt, Sienel, Wulf, Hofmann, Hans‐Stefan und Klein, Christoph A. (2022) Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution. The Journal of Pathology 258 (3), S. 250-263.

Spanier, Gerrit , Ugele, Ines, Nieberle, Felix , Symeou, Luisa, Schmidhofer, Sandra, Brand, Almut, Meier, Johannes, Spoerl, Steffen, Krupar, Rosemarie, Rümmele, Petra, Siska, Peter , Renner, Kathrin , Peter, Katrin, Gerken, Michael, Beckhove, Philipp, Reichert, Torsten E., Kreutz, Marina und Singer, Katrin (2021) The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients. Cancer Letters 499, S. 209-219. Volltext nicht vorhanden.

Werner-Klein, Melanie, Grujovic, Ana, Irlbeck, Christoph, Obradović, Milan, Hoffmann, Martin, Koerkel-Qu, Huiqin, Lu, Xin, Treitschke, Steffi, Köstler, Cäcilia, Botteron, Catherine, Weidele, Kathrin, Werno, Christian, Polzer, Bernhard, Kirsch, Stefan , Gužvić, Miodrag, Warfsmann, Jens, Honarnejad, Kamran, Czyz, Zbigniew, Feliciello, Giancarlo, Blochberger, Isabell, Grunewald, Sandra, Schneider, Elisabeth, Haunschild, Gundula, Patwary, Nina, Guetter, Severin, Huber, Sandra, Rack, Brigitte, Harbeck, Nadia, Buchholz, Stefan, Rümmele, Petra, Heine, Norbert, Rose-John, Stefan und Klein, Christoph A. (2020) Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency. Nature Communications 11, S. 4977.

Mycielska, Maria E., Mohr, Markus T. J., Schmidt, Katharina Maria, Drexler, Konstantin, Rümmele, Petra, Haferkamp, Sebastian, Schlitt, Hans J. , Gaumann, Andreas, Adamski, Jerzy und Geissler, Edward K. (2019) Potential Use of Gluconate in Cancer Therapy. Frontiers in Oncology 2019 (9), S. 1-7.

Werner-Klein, Melanie, Scheitler, Sebastian, Hoffmann, Martin, Hodak, Isabelle, Dietz, Klaus , Lehnert, Petra, Naimer, Veronika, Polzer, Bernhard , Treitschke, Steffi, Werno, Christian, Markiewicz, Aleksandra, Weidele, Kathrin, Czyz, Zbigniew, Hohenleutner, Ulrich, Hafner, Christian, Haferkamp, Sebastian, Berneburg, Mark, Rümmele, Petra, Ulmer, Anja und Klein, Christoph A. (2018) Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nature Communications 9 (595), S. 1-17.

Chatziantoniou, Christos , Bergler, Tobias, Jung, Bettina , Bourier, Felix, Kühne, Louisa, Banas, Miriam C., Rümmele, Petra, Wurm, Simone und Banas, Bernhard (2016) Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation. PLOS ONE 11 (6), e0156900. Volltext nicht vorhanden.

Giedl, Johannes, Rogler, Anja, Wild, Andreas, Riener, Marc-Oliver, Filbeck, Thomas, Burger, Maximilian, Rümmele, Petra, Hurst, Carolyn, Knowles, Margaret, Hartmann, Arndt, Zinnall, Ulrike und Stoehr, Robert (2016) TERT Core Promotor Mutations in Early-Onset Bladder Cancer. Journal of Cancer 7 (8), S. 915-920. Volltext nicht vorhanden.

Rad, Roland, Rad, Lena, Wang, Wei, Strong, Alexander, Ponstingl, Hannes, Bronner, Iraad F, Mayho, Matthew, Steiger, Katja , Weber, Julia, Hieber, Maren , Veltkamp, Christian, Eser, Stefan, Geumann, Ulf, Öllinger, Rupert, Zukowska, Magdalena, Barenboim, Maxim, Maresch, Roman, Cadiñanos, Juan, Friedrich, Mathias, Varela, Ignacio , Constantino-Casas, Fernando, Sarver, Aaron, ten Hoeve, Jelle, Prosser, Haydn, Seidler, Barbara, Bauer, Judith, Heikenwälder, Mathias, Metzakopian, Emmanouil, Krug, Anne, Ehmer, Ursula, Schneider, Günter, Knösel, Thomas, Rümmele, Petra, Aust, Daniela, Grützmann, Robert, Pilarsky, Christian , Ning, Zemin , Wessels, Lodewyk, Schmid, Roland M, Quail, Michael A, Vassiliou, George , Esposito, Irene, Liu, Pentao, Saur, Dieter und Bradley, Allan (2015) A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nature Genetics 47 (1), S. 47-56. Volltext nicht vorhanden.

Bitter, Andreas, Rümmele, Petra, Klein, Kathrin, Kandel, Benjamin A., Rieger, Jessica K., Nüssler, Andreas K., Zanger, Ulrich M. , Trauner, Michael, Schwab, Matthias und Burk, Oliver (2015) Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms. Archives of Toxicology 89 (11), S. 2089-2103. Volltext nicht vorhanden.

Martin, Maria, Kesselring, Rebecca K., Saidou, Balam, Brunner, Stefan M., Schiechl, Gabriela, Mouris, Verena F., Wege, Anja K., Rümmele, Petra, Schlitt, Hans J., Geissler, Edward K. und Fichtner‐Feigl, Stefan (2015) RORγt+ hematopoietic cells are necessary for tumor cell proliferation during colitis‐associated tumorigenesis in mice. European Journal of Immunology 45 (6), S. 1667-1679. Volltext nicht vorhanden.

Benderska, Natalya, Dittrich, Anna-Lena, Knaup, Sabine, Rau, Tilman T., Neufert, Clemens, Wach, Sven, Fahlbusch, Fabian B. , Rauh, Manfred, Wirtz, Ralph M., Agaimy, Abbas, Srinivasan, Swetha , Mahadevan, Vijayalakshmi, Rümmele, Petra, Rapti, Emmanouela, Gazouli, Maria, Hartmann, Arndt und Schneider-Stock, Regine (2015) miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis. Inflammatory Bowel Diseases 21 (9), S. 2039-2051. Volltext nicht vorhanden.

Birner, Christoph, Hierl, S., Dietl, A., Hupf, J., Jungbauer, C., Schmid, Peter M., Rümmele, Petra, Deutzmann, Rainer, Riegger, Günter A. J. und Luchner, A. (2014) Experimental Heart Failure Induces Alterations of the Lung Proteome - Insight into Molecular Mechanisms. Cellular Physiology and Biochemistry 33 (3), S. 692-704.

Hoffmann, Ute, Bergler, Tobias , Jung, Bettina, Steege, Andreas, Pace, Claudia, Rümmele, Petra, Reinhold, Stephan, Krüger, Bernd, Krämer, Bernhard K. und Banas, Bernhard (2013) Comprehensive morphometric analysis of mononuclear cell infiltration during experimental renal allograft rejection. Transplant Immunology 28 (1), S. 24-31. Volltext nicht vorhanden.

Lee, Ju-Seog, Overman, Michael J., Zhang, Jiexin , Kopetz, Scott, Davies, Michael, Zhi-Qin, Jiang , Stemke-Hale, Katherine, Rümmele, Petra , Pilarsky, Christian, Grützmann, Robert, Hamilton, Stanley, Hwang, Rosa, Abbruzzese, James L., Varadhachary, Gauri, Broom, Bradley und Wang, Huamin (2013) Gene Expression Profiling of Ampullary Carcinomas Classifies Ampullary Carcinomas into Biliary-Like and Intestinal-Like Subtypes That Are Prognostic of Outcome. PLoS ONE 8 (6), e65144. Volltext nicht vorhanden.

Beier, Christoph P., Kumar, Praveen, Meyer, Katharina, Leukel, Petra, Bruttel, Valentin , Aschenbrenner, Ines, Riemenschneider, Markus J., Fragoulis, Athanassios , Rümmele, Petra, Lamszus, Katrin, Schulz, Jörg B. , Weis, Joachim , Bogdahn, Ulrich, Wischhusen, Jörg, Hau, Peter, Spang, Rainer und Beier, Dagmar (2012) The cancer stem cell subtype determines immune infiltration of glioblastoma. Stem Cells and Development 21 (15), S. 2753-2761. Volltext nicht vorhanden.

Peters, Sebastian, Grunwald, Nicole, Rümmele, Petra, Endlicher, Esther, Lechner, Anja, Neumann, Inga D., Obermeier, Florian und Reber, Stefan O. (2012) Chronic psychosocial stress increases the risk for inflammation-related colon carcinogenesis in male mice. Stress 15 (4), S. 403-415. Volltext nicht vorhanden.

Piscuoglio, Salvatore , Lehmann, Frank S., Zlobec, I., Dietmaier, Wolfgang , Rümmele, Petra, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference und make_name_string expected hash reference (2012) Effect of EpCAM, CD44, CD133 and CD166 expression on patient survival in tumours of the ampulla of Vater. Journal of Clinical Pathology 65, S. 140-145.

Slonim, Donna K., Winter, Christof, Kristiansen, Glen , Kersting, Stephan, Roy, Janine, Aust, Daniela, Knösel, Thomas, Rümmele, Petra, Jahnke, Beatrix, Hentrich, Vera, Rückert, Felix, Niedergethmann, Marco, Weichert, Wilko, Bahra, Marcus, Schlitt, Hans J., Settmacher, Utz, Friess, Helmut, Büchler, Markus, Saeger, Hans-Detlev, Schroeder, Michael , Pilarsky, Christian und Grützmann, Robert (2012) Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes. PLoS Computational Biology 8 (5), e1002511. Volltext nicht vorhanden.

Eckey, Maren, Kuphal, Silke, Straub, Tobias , Rümmele, Petra, Kremmer, Elisabeth, Bosserhoff, Anja K. und Becker, Peter B. (2012) Nucleosome Remodeler SNF2L Suppresses Cell Proliferation and Migration and Attenuates Wnt Signaling. Molecular and Cellular Biology 32 (13), S. 2359-2371. Volltext nicht vorhanden.

Schnitzbauer, Andreas A., Lang, Sven A., Goessmann, Holger, Nadalin, Silvio, Baumgart, Janine, Farkas, Stefan A., Fichtner-Feigl, Stefan, Lorf, Thomas, Goralcyk, Armin, Hörbelt, Rüdiger, Kroemer, Alexander, Loss, Martin, Rümmele, Petra, Scherer, Marcus N., Padberg, Winfried, Königsrainer, Alfred, Lang, Hauke, Obed, Aiman und Schlitt, Hans J. (2012) Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings. Annals of Surgery 255 (3), S. 405-414. Volltext nicht vorhanden.

Pérez-Mancera, Pedro A., Rust, Alistair G. , van der Weyden, Louise, Kristiansen, Glen, Li, Allen, Sarver, Aaron L., Silverstein, Kevin A. T., Grützmann, Robert, Aust, Daniela, Rümmele, Petra, Knösel, Thomas, Herd, Colin, Stemple, Derek L., Kettleborough, Ross, Brosnan, Jacqueline A., Li, Ang, Morgan, Richard, Knight, Spencer, Yu, Jun, Stegeman, Shane, Collier, Lara S., ten Hoeve, Jelle J., de Ridder, Jeroen, Klein, Alison P., Goggins, Michael, Hruban, Ralph H., Chang, David K. , Biankin, Andrew V. , Grimmond, Sean M. , Wessels, Lodewyk F. A., Wood, Stephen A. , Iacobuzio-Donahue, Christine A., Pilarsky, Christian , Largaespada, David A., Adams, David J. und Tuveson, David A. (2012) The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 486 (7402), S. 266-270. Volltext nicht vorhanden.

Ehehalt, Florian, Rümmele, Petra, Kersting, Stephan , Lang-Schwarz, Corinna, Rückert, Felix, Hartmann, Arndt, Dietmaier, Wolfgang, Terracciano, Luigi, Aust, Daniela E., Jahnke, Beatrix, Saeger, Hans-Detlev, Pilarsky, Christian und Grützmann, Robert (2011) Hepatocyte Nuclear Factor (HNF) 4α Expression Distinguishes Ampullary Cancer Subtypes and Prognosis After Resection. Annals of Surgery 254 (2), S. 302-310. Volltext nicht vorhanden.

Hoffmann, Ute, Bergler, Tobias , Segerer, Stephan , Rümmele, Petra, Krüger, Bernd, Banas, Miriam C., Reinhold, Stephan, Banas, Bernhard und Krämer, Bernhard K. (2010) Impact of chemokine receptor CX3CR1 in human renal allograft rejection. Transplant Immunology 23 (4), S. 204-208. Volltext nicht vorhanden.

Wismeth, Caecilia, Dudel, Christine, Pascher, Christina, Ramm, Paul, Pietsch, Torsten, Hirschmann, Birgit, Reinert, Christiane , Proescholdt, Martin A., Rümmele, Petra, Schuierer, Gerhard, Bogdahn, Ulrich und Hau, Peter (2010) Transcranial electro-hyperthermia combined with alkylating chemotherapy in patients with relapsed high-grade gliomas: phase I clinical results. Journal of neuro-oncology 98 (3), S. 395-405. Volltext nicht vorhanden.

Beier, Christoph P., Schmid, Christina, Gorlia, Thierry, Kleinletzenberger, Christine, Beier, Dagmar, Grauer, Oliver, Steinbrecher, Andreas, Hirschmann, Birgit, Brawanski, Alexander, Dietmaier, Christopher, Jauch-Worley, Tanja, Kölbl, Oliver, Pietsch, Torsten, Proescholdt, Martin A., Rümmele, Petra, Muigg, Armin, Stockhammer, Günther, Hegi, Monika , Bogdahn, Ulrich und Hau, Peter (2009) RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study. BMC cancer 9, S. 308.

Gelbmann, Cornelia M, Rümmele, Petra, Wimmer, Monika, Hofstädter, Ferdinand, Göhlmann, Björn, Endlicher, Esther, Kullmann, Frank, Langgartner, Julia und Schölmerich, Jürgen (2007) Ischemic-Like Cholangiopathy With Secondary Sclerosing Cholangitis in Critically Ill Patients. The American Journal of Gastroenterology 102 (6), S. 1221-1229. Volltext nicht vorhanden.

Agaimy, Abbas, Wünsch, Peter H., Hofstaedter, Ferdinand, Blaszyk, Hagen, Rümmele, Petra, Gaumann, Andreas, Dietmaier, Wolfgang und Hartmann, Arndt (2007) Minute Gastric Sclerosing Stromal Tumors (GIST Tumorlets) Are Common in Adults and Frequently Show c-KIT Mutations. American Journal of Surgical Pathology 31 (1), S. 113-120. Volltext nicht vorhanden.

Böger, Carsten A., Rümmele, Petra, Mihatsch, Michael J., Banas, Bernhard und Krämer, Bernhard K. (2006) Reverse diastolic intrarenal flow due to calcineurin inhibitor (CNI) toxicity. American journal of transplantation 6 (8), S. 1963-1967. Zugang zum Volltext eingeschränkt.

Bataille, Frauke, Troppmann, Sabine, Klebl, Frank, Rogler, Gerhard , Stoelcker, Benjamin, Hofstaedter, Ferdinand, Bosserhoff, Anja-Katrin und Rümmele, Petra (2006) Multiparameter immunofluorescence on paraffin-embedded tissue sections. Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 14 (2), S. 225-228. Zugang zum Volltext eingeschränkt.

Dietmaier, Wolfgang, Bettstetter, Marcus, Wild, Peter J., Woenckhaus, Matthias, Rümmele, Petra, Hartmann, Arndt, Dechant, Stefan, Blaszyk, Hagen, Pauer, Armin, Klinkhammer-Schalke, Monika und Hofstädter, Ferdinand (2006) Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer. International journal of cancer. Journal international du cancer 118 (9), S. 2247-2254. Zugang zum Volltext eingeschränkt.

Dietmaier, Wolfgang, Bettstetter, Marcus, Wild, Peter J., Woenckhaus, Matthias, Rümmele, Petra, Hartmann, Arndt, Dechant, Stefan, Blaszyk, Hagen, Pauer, Armin, Klinkhammer-Schalke, Monika und Hofstädter, Ferdinand (2006) Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer. International journal of cancer. Journal international du cancer 118 (9), S. 2247-2254. Volltext nicht vorhanden.

Hoffmann, Ute, Segerer, Stephan, Rümmele, Petra, Krüger, Bernd, Pietrzyk, Miriam, Hofstädter, Ferdinand, Banas, Bernhard und Krämer, Bernhard K. (2006) Expression of the chemokine receptor CXCR3 in human renal allografts--a prospective study. Nephrology, dialysis, transplantation 21 (5), S. 1373-1381. Zugang zum Volltext eingeschränkt.

Hoffmann, Ute, Banas, Bernhard, Krüger, Bernd, Pietrzyk, Miriam, Obed, Aiman, Segerer, Stephan , Kammerl, Martin, Rümmele, Petra, Riegger, Günter A. J. und Krämer, Bernhard K. (2006) Expression of cyclooxygenase-1 and cyclooxygenase-2 in human renal allograft rejection-- a prospective study. Transplant international 19 (3), S. 203-212. Zugang zum Volltext eingeschränkt.

Hau, Peter, Kunz-Schughart, Leoni A., Rümmele, Petra, Arslan, Füsun, Dörfelt, Anett, Koch, Horst, Lohmeier, Annette, Hirschmann, Birgit , Müller, Adolf, Bogdahn, Ulrich und Bosserhoff, Anja-Katrin (2006) Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas. Journal of neuro-oncology 77 (1), S. 1-7. Zugang zum Volltext eingeschränkt.

Engel, Christoph , Forberg, Jochen, Holinski‐Feder, Elke, Pagenstecher, Constanze, Plaschke, Jens, Kloor, Matthias, Poremba, Christopher, Pox, Christian P., Rüschoff, Josef, Keller, Gisela, Dietmaier, Wolfgang, Rümmele, Petra, Friedrichs, Nicolaus, Mangold, Elisabeth, Buettner, Reinhard, Schackert, Hans K., Kienle, Peter, Stemmler, Susanne, Moeslein, Gabriela und Loeffler, Markus (2006) Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer. International Journal of Cancer 118 (1), S. 115-122. Volltext nicht vorhanden.

Hoffmann, Ute, Banas, Bernhard, Krüger, Bernd, Banas, Miriam, Bergler, Tobias , Böger, Carsten, Kammerl, Martin, Obed, Aiman, Rümmele, Petra, Segerer, Stephan , Riegger, Günter A. J. und Krämer, Bernhard K. (2006) SDF-1 expression is elevated in chronic human renal allograft rejection. Clinical transplantation 20 (6), S. 712-718. Zugang zum Volltext eingeschränkt.

Brueckl, Wolfgang M. , Grombach, Jens, Wein, Axel, Ruckert, Stefan, Porzner, Marc, Dietmaier, Wolfgang, Rümmele, Petra, Croner, Roland S., Boxberger, Frank, Kirchner, Thomas, Hohenberger, Werner, Hahn, Eckhart G. und Jung, Andreas (2005) Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal tumours displaying either microsatellite stability (MSS) or instability (MSI). Cancer Letters 223 (1), S. 137-142. Volltext nicht vorhanden.

Bettstetter, Marcus, Woenckhaus, Matthias, Wild, Peter J, Rümmele, Petra, Blaszyk, Hagen, Hartmann, Arndt, Hofstädter, Ferdinand und Dietmaier, Wolfgang (2005) Elevated nuclear maspin expression is associated with microsatellite instability and high tumour grade in colorectal cancer. The Journal of Pathology 205 (5), S. 606-614. Volltext nicht vorhanden.

Iesalnieks, Igors, Rümmele, Petra, Dietmaier, Wolfgang, Jantsch, Thomas, Zülke, Carl, Schlitt, Hans J., Hofstädter, Ferdinand und Anthuber, Matthias (2005) Factors Associated With Disease Progression in Patients With Gastrointestinal Stromal Tumors in the Pre-Imatinib Era. American Journal of Clinical Pathology 124 (5), S. 740-748. Volltext nicht vorhanden.

Endlicher, Esther, Rümmele, Petra, Hausmann, Florian, Rath, Heiko C., Knüchel, Ruth, Krieg, Rene C., Schölmerich, Jürgen und Messmann, Helmut (2004) Detection of Dysplastic Lesions by Fluorescence in a Model of Chronic Colitis in Rats After Local Application of 5-Aminolevulinic Acid and its Esterified Derivatives ¶. Photochemistry and Photobiology 79 (2), S. 189. Volltext nicht vorhanden.

Hau, Peter, Fabel, Klaus, Baumgart, Ulrike, Rümmele, Petra, Grauer, Oliver, Bock, Annekatrin, Dietmaier, Christopher, Dietmaier, Wolfgang, Dietrich, Jörg, Dudel, Christine, Hübner, Franz, Jauch, Tanya, Drechsel, Elisabeth, Kleiter, Ingo, Wismeth, Cäcile, Zellner, Anton, Brawanski, Alexander, Steinbrecher, Andreas, Marienhagen, Jörg und Bogdahn, Ulrich (2004) Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma. Cancer 100 (6), S. 1199-1207. Volltext nicht vorhanden.

Przkora, Rene, Bruns, Christiane, Zülke, Carl, Heinkelein, Jürgen, Rümmele, Petra, Schalhorn, Andreas und Jauch, Karl Walter (2003) Castleman's disease causing obstructive jaundice. Journal of Hepatology 38 (4), S. 548-549. Volltext nicht vorhanden.

Bataille, Frauke, Klebl, Frank, Rümmele, Petra, Straub, Rainer H. , Wild, Peter, Schölmerich, Jürgen und Hofstädter, Ferdinand (2003) Histopathological parameters as predictors for the course of Crohn's disease. Virchows Archiv: an international journal of pathology 443 (4), S. 501-507. Volltext nicht vorhanden.

Schönberger, Johann, Rüschoff, J., Grimm, Daniela, Marienhagen, Jörg, Rümmele, Petra, Meyringer, Rotraud, Kossmehl, Peter, Hofstaedter, Ferdinand und Eilles, Christoph (2002) Glucose transporter 1 gene expression is related to thyroid neoplasms with an unfavorable prognosis: an immunohistochemical study. Thyroid 12 (9), S. 747-754. Volltext nicht vorhanden.