Publikationen von 0000-0001-8177-8460
(ORCID: 0000-0001-8177-8460)

Drexler, Lukas, Fürtges, Torben F., Rudack, Till und Sterner, Reinhard (2025) On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily. Angewandte Chemie International Edition.

Kinateder, Thomas , Drexler, Lukas, Duran, Cristina, Osuna, Sílvia und Sterner, Reinhard (2025) A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase. Protein Science 34 (4), e70103.

Hiefinger, Caroline, Zinner, Gabriel, Fürtges, Torben F., Narindoshvili, Tamari, Schindler, Sebastian , Bruckmann, Astrid , Rudack, Till , Raushel, Frank M. und Sterner, Reinhard (2025) Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid. JACS Au 5 (2), S. 858-870.

Hiefinger, Caroline, Zinner, Gabriel, Fürtges, Torben F., Narindoshvili, Tamari, Schindler, Sebastian, Bruckmann, Astrid , Rudack, Till, Raushel, Frank M. und Sterner, Reinhard (2025) Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid. JACS Au 5 (2), S. 858-870.

Hupfeld, Enrico, Schlee, Sandra, Wurm, Jan Philip , Rajendran, Chitra, Yehorova, Dariia, Vos, Eva, Ravindra Raju, Dinesh, Kamerlin, Shina Caroline Lynn, Sprangers, Remco und Sterner, Reinhard (2024) Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF. JACS Au 4 (8), S. 3258-3276.

Kinateder, Thomas , Mayer, Carina, Nazet, Julian und Sterner, Reinhard (2024) Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases. Protein Science 33 (2).

Busch, Markus R., Rajendran, Chitra und Sterner, Reinhard (2023) Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli. Biochemistry 62 (3), S. 863-872. Volltext nicht vorhanden.

Kinateder, Thomas , Drexler, Lukas, Straub, Kristina , Merkl, Rainer und Sterner, Reinhard (2022) Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis. Protein Science 32 (1), e4536.

Wurm, Jan Philip , Sung, Sihyun , Kneuttinger, Andrea Christa, Hupfeld, Enrico, Sterner, Reinhard , Wilmanns, Matthias und Sprangers, Remco (2021) Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. Nature Communications 12 (1), S. 2748.

Simeth, Nadja Anita , Kinateder, Thomas, Rajendran, Chitra, Nazet, Julian, Merkl, Rainer , Sterner, Reinhard , König, Burkhard und Kneuttinger, Andrea C. (2020) Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase. Chemistry—A European Journal 27, S. 2439-2451.

Kneuttinger, Andrea C. , Rajendran, Chitra, Simeth, Nadja A., Bruckmann, Astrid, König, Burkhard und Sterner, Reinhard (2020) Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase. Biochemistry 59 (29), S. 2729-2742. Volltext nicht vorhanden.

Semmelmann, Florian, Hofferberth, John, Ruther, Joachim und Sterner, Reinhard (2019) Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia. Scientific Reports 9 (330), S. 1-7.

Semmelmann, Florian, Hupfeld, Enrico, Heizinger, Leonhard, Merkl, Rainer und Sterner, Reinhard (2019) A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases. Biochemistry 58 (22), S. 2584-2588. Volltext nicht vorhanden.

Schupfner, Michael, Straub, Kristina , Busch, Florian, Merkl, Rainer und Sterner, Reinhard (2019) Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction. Proceedings of the National Academy of Sciences 117 (1), S. 346-354. Volltext nicht vorhanden.

Schupfner, Michael, Busch, Florian, Wysocki, Vicki H. und Sterner, Reinhard (2019) Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint. ChemBioChem 20 (21), S. 2747-2751. Volltext nicht vorhanden.

Schlee, Sandra, Straub, Kristina , Schwab, Thomas, Kinateder, Thomas, Merkl, Rainer und Sterner, Reinhard (2019) Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases. Proteins: Structure, Function, and Bioinformatics 87 (10), S. 815-825. Volltext nicht vorhanden.

Kneuttinger, Andrea C., Winter, Martin, Simeth, Nadja Anita , Heyn, Kristina, Merkl, Rainer , König, Burkhard und Sterner, Reinhard (2018) Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand. ChemBioChem. Volltext nicht vorhanden.

Fleming, Jennifer R. , Schupfner, Michael, Busch, Florian, Baslé, Arnaud, Ehrmann, Alexander, Sterner, Reinhard und Mayans, Olga (2018) Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole. Journal of Molecular Biology 430 (24), S. 5066-5079. Volltext nicht vorhanden.

Linde, Mona, Heyn, Kristina, Merkl, Rainer , Sterner, Reinhard und Babinger, Patrick (2018) Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures. Biochemistry 57 (16), S. 2335-2348. Volltext nicht vorhanden.

Schlee, Sandra, Klein, Thomas, Schumacher, Magdalena, Nazet, Julian, Merkl, Rainer , Steinhoff, Heinz-Jürgen und Sterner, Reinhard (2018) Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase. Biochemistry 57 (23), S. 3265-3277. Volltext nicht vorhanden.

Plach, Maximilian G., Löffler, Patrick, Merkl, Rainer und Sterner, Reinhard (2015) Conversion of Anthranilate Synthase into Isochorismate Synthase: Implications for the Evolution of Chorismate‐Utilizing Enzymes. Angewandte Chemie International Edition 54 (38), S. 11270-11274. Volltext nicht vorhanden.

Ece, Selin, Evran, Serap , Janda, Jan-Oliver, Merkl, Rainer und Sterner, Reinhard (2015) Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design. Protein Engineering, Design and Selection 28 (6), S. 147-151. Volltext nicht vorhanden.

Sommer, Bettina, Waege, Ingrid, Pöllmann, David, Seitz, Tobias, Thomm, Michael, Sterner, Reinhard und Hausner, Winfried (2014) Activation of a chimeric Rpb5/RpoH subunit using library selection. Plos One 9.

Peterhoff, David, Beer, Barbara, Rajendran, Chitra, Kumpula, Esa‐Pekka , Kapetaniou, Evangelia, Guldan, Harald, Wierenga, Rik K., Sterner, Reinhard und Babinger, Patrick (2014) A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization. Molecular Microbiology 92 (4), S. 885-899. Volltext nicht vorhanden.

Reisinger, Bernd, Sperl, Josef, Holinski, Alexandra , Schmid, Veronika, Rajendran, Chitra, Carstensen, Linn, Schlee, Sandra, Blanquart, Samuel, Merkl, Rainer und Sterner, Reinhard (2014) Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era. Journal of the American Chemical Society 136 (1), S. 122-129. Volltext nicht vorhanden.

Reisinger, Bernd, Kuzmanovic, Natascha, Löffler, Patrick, Merkl, Rainer , König, Burkhard und Sterner, Reinhard (2014) Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors. Angewandte Chemie International Edition 53, S. 595-598. Volltext nicht vorhanden.

Busch, Florian, Rajendran, Chitra, Mayans, Olga , Löffler, Patrick, Merkl, Rainer und Sterner, Reinhard (2014) TrpB2 Enzymes are O-Phospho-l-serine Dependent Tryptophan Synthases. Biochemistry 53 (38), S. 6078-6083. Volltext nicht vorhanden.

Schlee, Sandra, Dietrich, Susanne, Kurćon, Tomasz, Delaney, Pamela, Goodey, Nina M. und Sterner, Reinhard (2013) Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase. Biochemistry 52 (1), S. 132-142. Volltext nicht vorhanden.

Meier, Monika M., Rajendran, Chitra, Malisi, Christoph, Fox, Nicholas G., Xu, Chengfu, Schlee, Sandra, Barondeau, David P. , Höcker, Birte, Sterner, Reinhard und Raushel, Frank M. (2013) Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template. Journal of the American Chemical Society 135 (31), S. 11670-11677. Volltext nicht vorhanden.

Dietrich, Susanne, Borst, Nadine, Schlee, Sandra, Schneider, Daniel, Janda, Jan-Oliver, Sterner, Reinhard und Merkl, Rainer (2012) Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments. Biochemistry. Volltext nicht vorhanden.

List, Felix, Vega, M. Cristina , Razeto, Adelia, Häger, Michaela C., Sterner, Reinhard und Wilmanns, Matthias (2012) Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site. Chemistry & Biology 19 (12), S. 1589-1599. Volltext nicht vorhanden.

List, Felix, Bocola, Marco, Haeger, Michaela C. und Sterner, Reinhard (2012) Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase. Biochemistry 51 (13), S. 2812-2818. Volltext nicht vorhanden.

Peterhoff, David, Zellner, Hermann, Guldan, Harald, Merkl, Rainer , Sterner, Reinhard und Babinger, Patrick (2012) Dimerization determines substrate specificity of a bacterial prenyltransferase. Chembiochem : a European journal of chemical biology 13 (9), S. 1297-1303. Volltext nicht vorhanden.

Guldan, Harald, Matysik, Frank-Michael, Bocola, Marco, Sterner, Reinhard und Babinger, Patrick (2011) Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria. Angewandte Chemie International Edition 50, S. 8188-8191. Volltext nicht vorhanden.

Schwab, Thomas und Sterner, Reinhard (2011) Stabilization of a Metabolic Enzyme by Library Selection in Thermus thermophilus. ChemBioChem 12 (10), S. 1581-1588. Volltext nicht vorhanden.

Richter, Markus, Bosnali, Manal, Carstensen, Linn, Seitz, Tobias, Durchschlag, Helmut, Blanquart, Samuel, Merkl, Rainer und Sterner, Reinhard (2010) Computational and Experimental Evidence for the Evolution of a (βα)8-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds. Journal of Molecular Biology 398 (5), S. 763-773. Volltext nicht vorhanden.

Drzewiecki, Katharina, Angelov, Angel , Ballschmiter, Meike, Tiefenbach, Klaus-Jürgen, Sterner, Reinhard und Liebl, Wolfgang (2010) Hyperthermostable acetyl xylan esterase. Microbial biotechnology 3 (1), S. 84-92. Volltext nicht vorhanden.

Liebold, Christoph, List, Felix, Kalbitzer, Hans Robert, Sterner, Reinhard und Brunner, Eike (2010) The interaction of ammonia and xenon with the imidazole glycerol phosphate synthase from Thermotoga maritima as detected by NMR spectroscopy. Protein science : a publication of the Protein Society 19 (9), S. 1774-1782. Volltext nicht vorhanden.

Schlee, Sandra, Deuss, Miriam, Bruning, Marc, Ivens, Andreas, Schwab, Thomas, Hellmann, Nadja, Mayans, Olga und Sterner, Reinhard (2009) Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release. Biochemistry 48 (23), S. 5199-209. Volltext nicht vorhanden.

Claren, Jörg, Malisi, Christoph, Höcker, Birte und Sterner, Reinhard (2009) Establishing wild-type levels of catalytic activity on natural and artificial (beta alpha)8-barrel protein scaffolds. Proceedings of the National Academy of Sciences of the United States of America 106 (10), S. 3704-9. Volltext nicht vorhanden.

Xiang, Dao Feng, Kolb, Peter , Fedorov, Alexander A., Meier, Monika M., Fedorov, Lena V., Nguyen, T. Tinh, Sterner, Reinhard , Almo, Steven C., Shoichet, Brian K. und Raushel, Frank M. (2009) Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily. Biochemistry 48 (10), S. 2237-47. Volltext nicht vorhanden.

Höcker, Birte, Lochner, Adriane, Seitz, Tobias, Claren, Jörg und Sterner, Reinhard (2009) High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels. Biochemistry 48 (6), S. 1145-7. Volltext nicht vorhanden.

Fischer, André, Enkler, Nils, Neudert, Gerd, Bocola, Marco, Sterner, Reinhard und Merkl, Rainer (2009) TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis. BMC Bioinformatics 10, S. 54.

Schwab, Thomas, Skegro, Darko, Mayans, Olga und Sterner, Reinhard (2008) A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable. Journal of molecular biology 376 (2), S. 506-16. Volltext nicht vorhanden.

Reetz, Manfred T., Rentzsch, Martin, Pletsch, Andreas, Taglieber, Andreas, Hollmann, Frank , Mondière, Régis J. G., Dickmann, Norbert, Höcker, Birte, Cerrone, Simona, Haeger, Michaela C. und Sterner, Reinhard (2008) A robust protein host for anchoring chelating ligands and organocatalysts. Chembiochem : a European journal of chemical biology 9 (4), S. 552-64. Volltext nicht vorhanden.

Guldan, Harald, Sterner, Reinhard und Babinger, Patrick (2008) Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis. Biochemistry 47 (28), S. 7376-84. Volltext nicht vorhanden.

Marino, Marco, Deuss, Miriam, Svergun, Dmitri I. , Konarev, Petr V., Sterner, Reinhard und Mayans, Olga (2006) Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus. The Journal of Biological Chemistry 281 (30), S. 21410-21421. Zugang zum Volltext eingeschränkt.

Leopoldseder, Sonja, Hettwer, Stefan und Sterner, Reinhard (2006) Evolution of multi-enzyme complexes: the case of tryptophan synthase. Biochemistry 45 (47), S. 14111-9. Volltext nicht vorhanden.

Schneider, Birgit, Knöchel, Thorsten, Darimont, Beatrice, Hennig, Michael, Dietrich, Susanne, Babinger, Karin, Kirschner, Kasper und Sterner, Reinhard (2005) Role of the N-terminal extension of the (betaalpha)8-barrel enzyme indole-3-glycerol phosphate synthase for its fold, stability, and catalytic activity. Biochemistry 44 (50), S. 16405-12. Volltext nicht vorhanden.

Höcker, Birte , Claren, Jörg und Sterner, Reinhard (2004) Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels. Proceedings of the National Academy of Sciences of the United States of America 101 (47), S. 16448-53. Volltext nicht vorhanden.