Einträge von Strasser, Andrea auf dem Publikationsserver

Höring, Carina , Conrad, Marcus, Söldner, Christian A. , Wang, Jinan , Sticht, Heinrich , Strasser, Andrea und Miao, Yinglong (2021) Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations. International Journal of Molecular Sciences 22 (18), S. 1-21.

Seibel-Ehlert, Ulla , Plank, Nicole, Inoue, Asuka, Bernhardt, Guenther und Strasser, Andrea (2021) Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors. International Journal of Molecular Sciences 22 (18), S. 1-33.

Tropmann, Katharina, Bresinsky, Merlin, Forster, Lisa, Mönnich, Denise, Buschauer, Armin , Wittmann, Hans-Joachim, Hübner, Harald, Gmeiner, Peter, Pockes, Steffen und Strasser, Andrea (2021) Abolishing Dopamine D2long/D3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2 Receptor Agonists. Journal of Medicinal Chemistry 64 (12), S. 8684-8709. Volltext nicht vorhanden.

Tropmann, Katharina, Seibel-Ehlert, Ulla, Littmann, Timo und Strasser, Andrea (2021) Shining light on the histamine H2 receptor: Synthesis of carbamoylguanidine-type agonists as a pharmacological tool to study internalization. Bioorganic & Medicinal Chemistry Letters 52, S. 128388. Volltext nicht vorhanden.

Höring, Carina , Seibel, Ulla , Tropmann, Katharina, Grätz, Lukas , Mönnich, Denise , Pitzl, Sebastian, Bernhardt, Günther , Pockes, Steffen und Strasser, Andrea (2020) A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes. International Journal of Molecular Sciences 21 (22), S. 8440.

Dolles, Dominik, Hoffmann, Matthias, Gunesch, Sandra, Marinelli, Oliviero, Möller, Jan , Santoni, Giorgio, Chatonnet, Arnaud, Lohse, Martin J. , Wittmann, Hans-Joachim, Strasser, Andrea, Nabissi, Massimo, Maurice, Tangui und Decker, Michael (2018) Structure–Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. Journal of Medicinal Chemistry 61 (4), S. 1646-1663. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim und Seifert, Roland (2017) Binding kinetics and pathways of ligands to GPCRs. Trends in Pharmacological Sciences. (Im Druck) Volltext nicht vorhanden.

Wittmann, Hans-Joachim und Strasser, Andrea (2017) Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions? Naunyn-Schmiedeberg's Archives of Pharmacology. (Im Druck) Volltext nicht vorhanden.

Wittmann, Hans-Joachim und Strasser, Andrea (2017) Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions? Naunyn-Schmiedeberg's Archives of Pharmacology 390 (6), S. 595-612. Volltext nicht vorhanden.

Naporra, Franziska, Gobleder, Susanne, Wittmann, Hans-Joachim, Spindler, Julia, Bodensteiner, Michael, Bernhardt, Günther, Hübner, Harald, Gmeiner, Peter, Elz, Sigurd und Strasser, Andrea (2016) Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs. Pharmacological Research 113, S. 610-625. (Im Druck) Volltext nicht vorhanden.

Geyer, Roland, Nordemann, Uwe, Strasser, Andrea, Wittmann, Hans-Joachim und Buschauer, Armin (2016) Conformational restriction and enantioseparation increase potency and selectivity of cyanoguanidine-type histamine H4 receptor agonists. Journal of Medicinal Chemistry 59 (7), S. 3452-3470. Volltext nicht vorhanden.

Hammer, Sebastian, Gobleder, Susanne, Naporra, Franziska, Wittmann, Hans-Joachim, Elz, Sigurd, Heinrich, Markus und Strasser, Andrea (2016) 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity. Bioorganic & Medicinal Chemistry Letters 26, S. 292-300. Volltext nicht vorhanden.

Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea und Decker, Michael (2016) Aminobenzimidazoles and structural isomers as templates for dual-acting butyrylcholinesterase inhibitors and hCB2R ligands to combat neurodegenerative disorders. ChemMedChem 11 (12), S. 1270-1283. Volltext nicht vorhanden.

Naporra, Franziska, Gobleder, Susanne, Wittmann, Hans-Joachim, Spindler, Julia, Bodensteiner, Michael, Bernhardt, Günther, Hübner, Harald, Gmeiner, Peter , Elz, Sigurd und Strasser, Andrea (2016) Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs. Pharmacological Research 113, S. 610-625. Volltext nicht vorhanden.

Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios , Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea und Decker, Michael (2015) Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors andhCB2R Ligands To Combat Neurodegenerative Disorders. ChemMedChem 11 (12), S. 1270-1283. Volltext nicht vorhanden.

Wittmann, Hans-Joachim und Strasser, Andrea (2015) Binding pathway of histamine to the hH4R, observed by unconstrained molecular dynamics. Bioorganic & Medicinal Chemistry Letters 25, S. 1259-1268. Volltext nicht vorhanden.

Strasser, Andrea und Buschauer, Armin (2015) Histaminrezeptoren. Pharmakon 3 (2), S. 109-116. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Schneider, Erich H. und Seifert, Roland (2015) Modulation of GPCRs by monovalent cations and anions. Naunyn-Schmiedeberg's Archives of Pharmacology 388, S. 363-380. Volltext nicht vorhanden.

Wifling, David, Löffel, Karolin, Nordemann, Uwe, Strasser, Andrea, Bernhardt, Günther, Dove, Stefan, Seifert, Roland und Buschauer, Armin (2015) Molecular determinants for the high constitutive activity of the human histamine H4 receptor: Functional studies on orthologs and mutants. British Journal of Pharmacology 172, S. 785-798. Volltext nicht vorhanden.

Kirchhof, Susanne, Strasser, Andrea, Wittmann, Hans-Joachim, Messmann, Viktoria, Hammer, Nadine, Goepferich, Achim und Brandl, Ferdinand (2015) New insights into the cross-linking and degradation mechanism of Diels–Alder hydrogels. Journal of Materials Chemistry B 3, S. 449-457.

Untergehrer, Monika, Bücherl, Daniel, Wittmann, Hans-Joachim, Strasser, Andrea, Heilmann, Jörg und Jürgenliemk, Guido (2015) Structure-dependent deconjugation of flavonoid glucuronides by human beta-glucuronidase - in vitro and in silico analyses. Planta Med. 81 (12/13), S. 1182-1189. Volltext nicht vorhanden.

Cuboni, Serena, Devigny, Christian, Hoogeland, Bastiaan, Strasser, Andrea, Pomplun, Sebastian, Hauger, Barbara, Höfner, Georg, Wanner, Klaus, Eder, Matthias, Buschauer, Armin, Holsboer, Florian und Hausch, Felix (2014) Loratadine and analogs: Discovery and preliminary SAR of inhibitors of the amino acid transporter B0AT2. Journal of Medicinal Chemistry 57 (22), S. 9473-9479. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2014) Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor. In silico pharmacology 2.

Darras, Fouad, Pockes, Steffen , Huang, Guozheng, Wehle, Sarah, Strasser, Andrea, Wittmann, Hans-Joachim, Nimczick, Martin, Sotriffer, Christoph und Decker, Michael (2014) Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS Chemical Neuroscience 5 (3), S. 225-242. Volltext nicht vorhanden.

Wager, Eva, Wittmann, Hans-Joachim, Elz, Sigurd und Strasser, Andrea (2014) Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor - H1/H4 receptor selectivity. Naunyn-Schmiedeberg's Archives of Pharmacology 387, S. 235-250. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2014) Sodium binding to hH3R and hH4R - a molecular modelling study. Journal of Molecular Modeling 20, S. 2394. Volltext nicht vorhanden.

Seifert, Roland, Strasser, Andrea, Schneider, Erich H., Neumann, Detlef, Dove, Stefan und Buschauer, Armin (2013) Molecular and cellular analysis of human histamine receptor subtypes. Trends in Pharmacological Sciences 34 (1), S. 33-58. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Buschauer, Armin, Schneider, Erich H. und Seifert, Roland (2013) Species-dependent activities of GPCR ligands: Lessons from histamine receptor orthologs. Trends in Pharmacological Sciences 34 (1), S. 13-32. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2013) Molecular modelling studies give hint for the existence of a symmetric hb2R-Gabg-homodimer. J Mol Model 19, S. 4443-4457. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2012) Binding of Ligands to GPCRs – How Valid is a Thermodynamic
Discrimination of Antagonists and Agonists? Journal of Physical Chemistry & Biophysics 2012.

Appl, Heidrun, Holzammer, Tobias, Dove, Stefan, Haen, Ekkehard, Strasser, Andrea und Seifert, Roland (2012) Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics. Naunyn-Schmiedeberg's archives of pharmacology 385 (2), S. 145-170. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2012) hb2R-Gas-complex: Prediction versus crystal structure - How valuable are predictions based on molecular modelling studies? Journal of Molecular Modeling : J Mol Model 18, S. 3439-3444. Volltext nicht vorhanden.

Brunskole, Irena, Strasser, Andrea, Seifert, Roland und Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), S. 301-317. Volltext nicht vorhanden.

Seifert, Roland, Schneider, Erich H., Dove, Stefan, Brunskole, Irena, Neumann, Detlef, Strasser, Andrea und Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), S. 631-638. Volltext nicht vorhanden.

Silva, Maria Elena, Heim, Ralf, Strasser, Andrea, Elz, Sigurd und Dove, Stefan (2011) Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor. Journal of computer-aided molecular design 25 (1), S. 51-66. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2011) Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H1R. Biochemical Pharmacology 12, S. 1910-1918. Volltext nicht vorhanden.

Wagner, Eva, Wittmann, Hans-Joachim, Elz, Sigurd und Strasser, Andrea (2011) Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH1R, but low affinity to hH4R. Bioorganic & Medicinal Chemistry Letters 21, S. 6274-9280. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Elz, Sigurd, Seifert, Roland und Strasser, Andrea (2011) Na-methylated phenylhistamines exhibit affinity to the hH4R - a pharmacological and molecular modelling study. Naunyn Schmiedeberg's Arch Pharmacol 384, S. 287-299. Volltext nicht vorhanden.

Ferstl, Matthias, Strasser, Andrea, Wittmann, Hans-Joachim, Drechsler, Markus, Rischer, M., Engl, J. und Goepferich, Achim (2011) Nanofibres Resulating from Cooperative Electrostatic and Hydrophobic Interactions between Peptides and Polyelectrolytes of Opposite Charge. Langmuir 27, S. 14450-14459. Volltext nicht vorhanden.

Schnell, David, Strasser, Andrea und Seifert, Roland (2010) Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. Biochemical Pharmacology 80 (9), S. 1437-1449. Volltext nicht vorhanden.

Schneider, E. H., Strasser, Andrea, Thurmond, R. L. und Seifert, Roland (2010) Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands. Journal of Pharmacology and Experimental Therapeutics 334 (2), S. 513-521. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2010) 3D-QSAR CoMFA study to predict orientation of suprahistaprodifens and phenoprodifens in the binding-pocket of four histamine H1-receptor species. Molecular Informatics 29, S. 333-341. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2010) Distinct interactions between the human adrenergic b2 receptor and Gas - an in silico study. J Mol Model 16, S. 1307-1318. Volltext nicht vorhanden.

Schneider, Erich H., Schnell, David, Strasser, Andrea, Dove, Stefan und Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. Journal of Pharmacology and Experimental Therapeutics 333 (2), S. 382-392. Volltext nicht vorhanden.

Schneider, Erich, Schnell, David, Strasser, Andrea, Dove, Stefan und Seifert, Roland (2010) Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 333 (2), S. 382-392. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2010) In silico analysis of the histaprodifen induced pathway of the guinea-pig histamine H1 receptor. Journal of computer- aided molecular design : J Comput Aided Mol Des 24, S. 759-769. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2009) Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H1-receptor. Molecular Pharmacology 76, S. 25-37. Volltext nicht vorhanden.

Deml, Karl-Friedrich, Beermann, S, Neumann, Detlef, Strasser, Andrea und Seifert, Roland (2009) Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Mol Pharmacol : Molecular pharmacology 76 (5), S. 1019-1030. Volltext nicht vorhanden.

Strasser, Andrea (2009) Molecular Modelling and QSAR-based design of histamine receptor ligands. Expert Opinion on Drug Discovery (4), S. 1061-1075. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Kunze, Marc, Elz, Sigurd und Seifert, Roland (2009) Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea-pig H1-receptor. Mol Pharmacol : Molecular pharmacology 75, S. 454-465. Volltext nicht vorhanden.

Strasser, Andrea, Striegl, Birgit, Wittmann, Hans-Joachim und Seifert, Roland (2008) Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms. Journal of Pharmacology and Experimental Therapeutics 324, S. 60-71. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim und Seifert, Roland (2008) Ligand-specific contribution of the N-terminus and E2-loop to pharmacological properties of the histamine H1-receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 326 (3), S. 783-791. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2007) Analysis of the activation mechanism of the guinea-pig histamine H1-receptor. J Comput Aided Mol Des : Journal of computer aided molecular design 21, S. 499-509. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2007) LigPath: A module for predictive calculation of a ligands pathway into a receptor - application to the gpH1-receptor. J Mol Model : Journal of molecular modeling 13, S. 209-218. Volltext nicht vorhanden.

Krienke, Hartmut, Schmeer, Georg und Strasser, Andrea (2004) Thermodynamic properties of water from combined quantum and statistical mechanics in the temperature range from 273.16 to 423.15 K. J Mol Liq : Journal of molecular liquids 113 (1-3), S. 115-124. Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2016) Molecular Modelling Approaches for the Analysis of Histamine Receptors and Their Interaction with Ligands. In: Handbook of Experimental Pharmacology. (Im Druck) Volltext nicht vorhanden.

Strasser, Andrea und Wittmann, Hans-Joachim (2013) Modelling of GPCRs - A Practical Handbook. Springer. Volltext nicht vorhanden.