Anzahl der Einträge: 57.
Fiedler, Mathias ,
Off, Alisa,
Gärtner, Andreas,
Brockhoff, Gero ,
Eichberger, Jonas,
Gottsauner, Maximilian,
Schuderer, Johannes G. ,
Maurer, Michael ,
Bauer, Richard J. ,
Gerken, Michael,
Reichert, Torsten E.,
Ettl, Tobias und
Weber, Florian
(2024)
Increased PD‐1/PD‐L1 Immune Checkpoint Expression Is Associated With Oral Squamous Cell Carcinoma in Never‐Smokers and Never‐Drinkers.
Head & Neck.
Albert, Veruschka,
Bruss, Christina,
Tümen, Deniz,
Piendl, Gerhard,
Weber, Florian ,
Dahl, Edgar,
Seitz, Stephan,
Ortmann, Olaf ,
Wege, Anja K. und
Brockhoff, Gero
(2024)
HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice.
International Journal of Molecular Sciences 25 (13), S. 7475.
Rubenich, Dominique S. ,
Domagalski, Jordana L. ,
Gentil, Gabriela F. S. ,
Eichberger, Jonas,
Fiedler, Mathias,
Weber, Florian ,
Federlin, Marianne,
Poeck, Hendrik,
Reichert, Torsten E.,
Ettl, Tobias ,
Bauer, Richard J. ,
Braganhol, Elizandra und
Schulz, Daniela
(2024)
The immunomodulatory ballet of tumour‐derived extracellular vesicles and neutrophils orchestrating the dynamic CD73/PD‐L1 pathway in cancer.
Journal of Extracellular Vesicles 13 (7).
Dorn, Anna Rebecca,
Neff, Sara ,
Hupp, Sophia,
Engelhardt, Melissa,
Pion, Eric,
Lenze, Ulrich,
Knebel, Carolin ,
Duprée, Anna,
Schewe, Simone,
Weber, Markus ,
Wulbrand, Christian,
Hillmann, Axel,
Weber, Florian ,
Clarke, Phillip,
Kainz, Philipp ,
Aung, Thiha und
Haerteis, Silke
(2024)
Analysis of Osteosarcoma Cell Lines and Patient Tissue Using a 3D In Vivo Tumor Model—Possible Effects of Punicalagin.
Organoids 3 (1), S. 35-53.
Ettner-Sitter, Andreas,
Montagner, Agata,
Kuenzel, Jonas,
Brackmann, Kathrin,
Schäfer, Maximilian,
Schober, Robert,
Weber, Florian ,
Aung, Thiha,
Hackl, Christina und
Haerteis, Silke
(2024)
Visualization of Vascular Perfusion of Human Pancreatic Cancer Tissue in the CAM Model and Its Impact on Future Personalized Drug Testing.
Organoids 3 (1), S. 1-17.
Yang Zhou, Jordi,
Eder, Dominik,
Weber, Florian ,
Heumann, Philipp,
Kronenberg, Katharina,
Werner, Jens M. ,
Geissler, Edward K. ,
Schlitt, Hans J. ,
Hutchinson, James A. und
Bitterer, Florian
(2023)
Case report: Predictability of clinical response and rejection risk after immune checkpoint inhibition in liver transplantation.
Frontiers in Transplantation 2.
Kleber, Julia,
Yang Zhou, Jordi,
Weber, Florian ,
Bitterer, Florian ,
Hauer, Patricia,
Kupke, Paul ,
Kronenberg, Katharina,
Geissler, Edward K. ,
Schlitt, Hans J. ,
Hornung, Matthias ,
Hutchinson, James A. und
Werner, Jens M.
(2023)
Immune profile of patients with peritoneal carcinomatosis selected for CRS-HIPEC therapy.
Cancer Immunology, Immunotherapy 72, S. 3867-3873.
Schuderer, Johannes G. ,
Dinh, Huong,
Spoerl, Steffen,
Taxis, Jürgen,
Fiedler, Mathias,
Gottsauner, Josef Maximilian,
Maurer, Michael ,
Reichert, Torsten E.,
Meier, Johannes K.,
Weber, Florian und
Ettl, Tobias
(2023)
Risk Factors for Flap Loss: Analysis of Donor and Recipient Vessel Morphology in Patients Undergoing Microvascular Head and Neck Reconstructions.
Journal of Clinical Medicine 12 (16), S. 5206.
Zugang zum Volltext eingeschränkt.
Treitschke, Steffi,
Weidele, Kathrin,
Varadarajan, Adithi Ravikumar,
Feliciello, Giancarlo,
Warfsmann, Jens,
Vorbeck, Sybille,
Polzer, Bernhard,
Botteron, Catherine,
Hoffmann, Martin,
Dechand, Vadim,
Mederer, Tobias ,
Weber, Florian ,
Werner‐Klein, Melanie,
Robold, Tobias,
Hofmann, Hans‐Stefan,
Werno, Christian und
Klein, Christoph A.
(2023)
Ex vivo expansion of lung cancer‐derived disseminated cancer cells from lymph nodes identifies cells associated with metastatic progression.
International Journal of Cancer.
Fiedler, Mathias,
Off, Alisa,
Eichberger, Jonas,
Spoerl, Steffen,
Schuderer, Johannes G. ,
Taxis, Juergen ,
Bauer, Richard J.,
Schreml, Stephan ,
Reichert, Torsten E.,
Ettl, Tobias und
Weber, Florian
(2023)
OSCC in Never-Smokers and Never-Drinkers Is Associated with Increased Expression of Tumor-Infiltrating Lymphocytes and Better Survival.
Cancers 15 (10), S. 2688.
Zugang zum Volltext eingeschränkt.
Scheiter, Alexander ,
Hierl, Frederik,
Lüke, Florian ,
Keil, Felix ,
Heudobler, Daniel ,
Einhell, Sabine,
Klier-Richter, Margit,
Konstandin, Nikola P.,
Weber, Florian ,
Scheiter, Andrea,
Kandulski, Arne,
Schlosser, Sophie ,
Cosma, Lidia-Sabina,
Tews, Hauke,
Weiss, Andreas R. R. ,
Grube, Matthias,
Bumes, Elisabeth ,
Hau, Peter ,
Proescholdt, Martin A. ,
Steger, Felix,
Troeger, Anja,
Haferkamp, Sebastian ,
Reibenspies, Lucas E.,
Schnabel, Marco J.,
Schulz, Christian ,
Drexler, Konstantin,
Hatzipanagiotou, Maria E.,
Seitz, Stephan,
Klinkhammer-Schalke, Monika,
Unberath, Philipp,
Calvisi, Diego F. ,
Pukrop, Tobias ,
Dietmaier, Wolfgang,
Evert, Matthias und
Utpatel, Kirsten
(2022)
Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre.
British Journal of Cancer.
Eichberger, Jonas,
Weber, Florian ,
Spanier, Gerrit,
Gerken, Michael,
Schreml, Stephan ,
Schulz, Daniela,
Fiedler, Mathias,
Ludwig, Nils,
Bauer, Richard J.,
Reichert, Torsten E. und
Ettl, Tobias
(2022)
Loss of MMP-27 Predicts Mandibular Bone Invasion in Oral Squamous Cell Carcinoma.
Cancers 14 (16), S. 4044.
Elsner, Felix,
Hoffmann, Martin,
Fahrioglu‐Yamaci, Rezan,
Czyz, Zbigniew,
Feliciello, Giancarlo,
Mederer, Tobias ,
Polzer, Bernhard,
Treitschke, Steffi,
Rümmele, Petra,
Weber, Florian ,
Wiesinger, Hellmuth,
Robold, Tobias,
Sziklavari, Zsolt,
Sienel, Wulf,
Hofmann, Hans‐Stefan und
Klein, Christoph A.
(2022)
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution.
The Journal of Pathology 258 (3), S. 250-263.
Schwan, Franziska E. ,
Künzel, Julian ,
Weber, Florian,
Vielsmeier, Veronika ,
Bohr, Christopher und
Andorfer, Kornelia E. C.
(2022)
Lateral neck cyst surgery without ipsilateral tonsillectomy: a retrospective analysis.
European Archives of Oto-Rhino-Laryngology 280, S. 315-320.
Treeck, Oliver ,
Weber, Florian ,
Fritsch, Juergen ,
Skrzypczak, Maciej,
Schüler-Toprak, Susanne,
Buechler, Christa und
Ortmann, Olaf
(2022)
DSCAM-AS1 Long Non-Coding RNA Exerts Oncogenic Functions in Endometrial Adenocarcinoma via Activation of a Tumor-Promoting Transcriptome Profile.
Biomedicines 10 (7), S. 1727.
Wege, Anja Kathrin,
Rom‐Jurek, Eva‐Maria,
Jank, Paul,
Denkert, Carsten,
Ugocsai, Peter,
Solbach, Christine,
Blohmer, Jens‐Uwe,
Sinn, Bruno,
Mackelenbergh, Marion,
Möbus, Volker,
Trumpp, Andreas,
Marangoni, Elisabetta,
Pfarr, Nicole,
Irlbeck, Christoph ,
Warfsmann, Jens,
Polzer, Bernhard ,
Weber, Florian,
Ortmann, Olaf ,
Loibl, Sibylle,
Vladimirova, Valentina und
Brockhoff, Gero
(2021)
mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease.
International Journal of Cancer 150, S. 1357-1372.
Eckstein, Markus,
Kimmel, Charlotte,
Bruendl, Johannes,
Weber, Florian,
Denzinger, Stefan,
Gierth, Michael,
Burger, Maximilian,
Hartmann, Arndt,
Otto, Wolfgang und
Breyer, Johannes
(2021)
Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer.
Scientific Reports 11 (1), S. 17981.
Wertheimer, Tobias ,
Pausch, Antonia-Maria,
Kammerer, Sylvia,
Weber, Florian,
Herr, Wolfgang,
Stroszczynski, Christian ,
Holler, Ernst,
Edinger, Matthias,
Wolff, Daniel ,
Weber, Daniela und
Jung, Ernst-Michael
(2021)
Parametric Imaging of Contrast-Enhanced Ultrasound (CEUS) for the Evaluation of Acute Gastrointestinal Graft-Versus-Host Disease.
Cells 10 (5), S. 1092.
(Eingereicht)
Promm, Martin,
Otto, Wolfgang,
Weber, Florian,
Götz, Stefanie,
Burger, Maximilian,
Müller, Karolina,
Rubenwolf, Peter,
Neuhuber, Winfried und
Roesch, Wolfgang H.
(2021)
Expression of Low Affinity Nerve Growth Factor Receptor p75 in Classic Bladder Exstrophy.
Frontiers in Pediatrics 9 (634343), S. 1-7.
Lubnow, Matthias ,
Schmidt, Barbara,
Fleck, Martin,
Salzberger, Bernd,
Müller, Thomas,
Peschel, Georg,
Schneckenpointner, Roland,
Lange, Tobias,
Hitzenbichler, Florian ,
Kieninger, Martin,
Lunz, Dirk,
Graf, Bernhard,
Brochhausen, Christoph,
Weber, Florian,
Lüke, Florian,
Peterhoff, David,
Schuster, Philipp,
Hiergeist, Andreas,
Offner, Robert,
Hehr, Ute,
Wallner, Stefan,
Hanses, Frank ,
Schmid, Stephan,
Weigand, Kilian,
Geismann, Florian ,
Poeck, Hendrik,
Pukrop, Tobias,
Evert, Matthias,
Gessner, Andre,
Burkhardt, Ralph ,
Herr, Wolfgang,
Maier, Lars S. und
Heudobler, Daniel
(2021)
Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson’s disease: Balancing immunosuppression.
International Journal of Infectious Diseases 103 (2021), S. 624-627.
Lüttgenau, Simona Mareike,
Emming, Christin,
Wagner, Thomas,
Harms, Julia,
Guske, Justine,
Weber, Katrin,
Neugebauer, Ute,
Schröter, Rita,
Panichkina, Olga,
Pethő, Zoltán ,
Weber, Florian,
Schwab, Albrecht,
Wege, Anja Kathrin,
Nedvetsky, Pavel und
Krahn, Michael P.
(2021)
Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6.
Molecular Cancer 20 (1).
Volltext nicht vorhanden.
Reiß, Julian,
Kälble, Sebastian,
Bründl, Johannes,
Rosenhammer, Bernd,
Gierth, Michael,
Weber, Florian,
Eckstein, Markus,
Wirtz, Ralph Markus,
Denzinger, Stefan,
Burger, Maximilian,
Otto, Wolfgang und
Breyer, Johannes
(2021)
Prognostic Role of mRNA-Expression of Aquaporins (AQP) 3, 4, 7 and 9 in Stage pT1 Non-Muscle-Invasive Bladder Cancer.
Bladder Cancer 7 (1), S. 71-78.
Volltext nicht vorhanden.
Babel, Maximilian,
Mamilos, Andreas,
Seitz, Stephan,
Niedermair, Tanja,
Weber, Florian,
Anzeneder, Tobias,
Ortmann, Olaf ,
Dietmaier, Wolfgang und
Brochhausen, Christoph
(2020)
Compared DNA and RNA quality of breast cancer biobanking samples after long-term storage protocols in − 80 °C and liquid nitrogen.
Scientific Reports 10, S. 14404.
Fiedler, Mathias ,
Weber, Florian,
Hautmann, Matthias G. ,
Bohr, Christopher,
Reichert, Torsten E. und
Ettl, Tobias
(2020)
Infiltrating immune cells are associated with radiosensitivity and favorable survival in head and neck cancer treated with definitive radiotherapy.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129 (6), S. 612-620.
Volltext nicht vorhanden.
Spachmann, Philipp J.,
Azzolina, Vanessa,
Weber, Florian,
Evert, Matthias,
Eckstein, Markus,
Denzinger, Stefan,
Burger, Maximilian,
Otto, Wolfgang und
Breyer, Johannes
(2020)
Loss of CHEK2 Predicts Progression in Stage pT1 Non-Muscle-Invasive Bladder Cancer (NMIBC).
Pathology & Oncology Research 26 (3), S. 1625-1632.
Volltext nicht vorhanden.
Weber, Florian,
Junger, Henrik,
Werner, Jens M.,
Vélez Char, Natalia,
Rejas, Carolina,
Schlitt, Hans J. und
Hornung, Matthias
(2019)
Increased cytoplasmatic expression of cancer immune surveillance receptor CD1d in anaplastic thyroid carcinomas.
Cancer Medicine 8 (16), S. 7065-7073.
Bitzinger, Diane I.,
Gruber, Michael ,
Tümmler, Simon,
Malsy, Manuela,
Seyfried, Timo,
Weber, Florian,
Redel, Andreas,
Graf, Bernhard M. und
Zausig, York A.
(2019)
In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimental Sepsis in Rats.
Mediators of Inflammation 2019, S. 1-12.
Dechant, Franz-Xaver,
Dechant, Rebecca,
Kandulski, Arne,
Selgrad, Michael,
Weber, Florian,
Reischl, Udo,
Wilczek, Wolf,
Mueller, Martina und
Weigand, Kilian
(2019)
Accuracy of Different Rapid Urease Tests in Comparison with Histopathology in Patients with Endoscopic Signs of Gastritis.
Digestion 101 (2), S. 184-190.
Volltext nicht vorhanden.
Bründl, Johannes,
Neppl, Christina,
Hommer, Thomas,
Otto, Wolfgang,
Breyer, Johannes,
Brookman-May, Sabine,
Weber, Florian,
Burger, Maximilian,
May, Matthias und
Eichelberg, Christian
(2019)
Bedeutung von p16(INK4A) hinsichtlich des Nachweises von HPV-DNA und in der Stratifizierung der tumorspezifischen Mortalität bei 34 Patienten mit invasivem Peniskarzinom in Langzeit-Nachbeobachtung.
Aktuelle Urologie 50 (05), S. 491-501.
Volltext nicht vorhanden.
Spachmann, Philipp Julian,
Breyer, Johannes,
Kalogirou, Charis,
Lausenmeyer, Eva-Maria,
Weber, Florian,
Prohaska, Sandra,
Denzinger, Stefan,
Burger, Maximilian,
Kübler, Hubert,
Otto, Wolfgang und
Vergho, Daniel
(2019)
Impact of E-Cadherin and β-Catenin as Prognostic Factor in Renal Cell Carcinoma with Tumor Thrombus of the Vena Cava.
Urologia Internationalis 102 (4), S. 413-420.
Volltext nicht vorhanden.
Stöhr, Christine G. ,
Steffens, Sandra,
Polifka, Iris,
Jung, Rudolf,
Kahlmeyer, Andreas,
Ivanyi, Philipp ,
Weber, Florian,
Hartmann, Arndt,
Wullich, Bernd,
Wach, Sven und
Taubert, Helge
(2019)
Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients.
Scientific Reports 9 (1).
Volltext nicht vorhanden.
Fiedler, Mathias,
Renner, Patty,
Schubert, Jürgen,
Weber, Florian,
Hartmann, Arndt,
Iro, Heinrich,
Vielsmeier, Veronika,
Bohr, Christopher,
Gerken, Michael,
Reichert, Torsten E. und
Ettl, Tobias
(2019)
Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study.
Clinical Oral Investigations 23 (10), S. 3801-3809.
Volltext nicht vorhanden.
Bründl, Johannes ,
Wallinger, Sabine,
Breyer, Johannes,
Weber, Florian,
Evert, Matthias,
Georgopoulos, Nikolaos Theodoros,
Rosenhammer, Bernd,
Burger, Maximilian,
Otto, Wolfgang und
Rubenwolf, Peter
(2018)
Expression, localisation and potential significance of aquaporins in benign and malignant human prostate tissue.
BMC Urology 18 (75), S. 1-9.
Fiedler, Mathias,
Weber, Florian,
Hautmann, Matthias G.,
Haubner, Frank,
Reichert, Torsten E.,
Klingelhöffer, Christoph,
Schreml, Stephan,
Meier, Johannes K.,
Hartmann, Arndt und
Ettl, Tobias
(2018)
Biological predictors of radiosensitivity in head and neck squamous cell carcinoma.
Clinical Oral Investigations 22 (1), S. 189-200.
Volltext nicht vorhanden.
Brockhoff, Gero,
Seitz, Stephan,
Weber, Florian,
Zeman, Florian,
Klinkhammer-Schalke, Monika,
Ortmann, Olaf und
Wege, Anja Kathrin
(2018)
The presence of PD-1 positive tumor infiltrating lymphocytes in triple negative breast cancers is associated with a favorable outcome of disease.
Oncotarget 2018 (9), S. 6201-6212.
Ulmer, Anja,
Dietz, Klaus ,
Werner-Klein, Melanie,
Häfner, Hans-Martin,
Schulz, Claudia,
Renner, Philipp,
Weber, Florian,
Breuninger, Helmut,
Röcken, Martin,
Garbe, Claus ,
Fierlbeck, Gerhard und
Klein, Christoph A.
(2018)
The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival.
European Journal of Cancer 91, S. 1-10.
Volltext nicht vorhanden.
Wege, Anja K.,
Weber, Florian,
Kroemer, Alexander,
Ortmann, Olaf,
Nimmerjahn, Falk und
Brockhoff, Gero
(2016)
IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM).
Oncotarget 8 (2), S. 2731-2744.
Cidlinsky, Natascha,
Dogliotti, Giada,
Pukrop, Tobias,
Jung, Rudolf,
Weber, Florian und
Krahn, Michael P.
(2016)
Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report.
Cellular Oncology 39 (4), S. 389-396.
Volltext nicht vorhanden.
Ettl, Tobias,
El-Gindi, Alain,
Hautmann, Matthias,
Gosau, Martin,
Weber, Florian,
Rohrmeier, Christian,
Gerken, Michael,
Müller, Steffen,
Reichert, Torsten und
Klingelhöffer, Christoph
(2016)
Positive frozen section margins predict local recurrence in R0-resected squamous cell carcinoma of the head and neck.
Oral Oncology 55, S. 17-23.
Volltext nicht vorhanden.
Brunner, Stefan,
Weber, Florian,
Werner, Jens M. ,
Agha, Ayman,
Farkas, Stefan A.,
Schlitt, Hans-Jürgen und
Hornung, Matthias
(2015)
Neuroendocrine tumors of the pancreas: a retrospective single-center analysis using the ENETS TNM-classification and immunohistochemical markers for risk stratification.
BMC Surgery 15 (49), S. 1-10.
Ganzer, Roman,
Stolzenburg, Jens-Uwe,
Neuhaus, Jochen,
Weber, Florian,
Fuchshofer, Rudolf ,
Burger, Maximilian und
Bründl, Johannes
(2015)
Anatomical Study of Pelvic Nerves in Relation to Seminal Vesicles, Prostate and Urethral Sphincter: Immunohistochemical Staining, Computerized Planimetry and 3-Dimensional Reconstruction.
Journal of Urology 193 (4), S. 1205-1212.
Volltext nicht vorhanden.
Skrzypczak, Maciej ,
Merx, Isabel,
Schüler-Toprak, Susanne,
Weber, Florian,
Inwald, Elisabeth C.,
Ortmann, Olaf und
Treeck, Oliver
(2015)
Molecular profiling of estrogen receptor α and progesterone receptor transcript variants in endometrial cancer.
Steroids 104, S. 122-128.
Volltext nicht vorhanden.
Bründl, Johannes,
Schneider, Sebastian,
Weber, Florian,
Zeman, Florian,
Wieland, Wolf F. und
Ganzer, Roman
(2014)
Computerized Quantification and Planimetry of Prostatic Capsular Nerves in Relation to Adjacent Prostate Cancer Foci.
European Urology 65 (4), S. 802-808.
Volltext nicht vorhanden.
Ganzer, Roman,
Stolzenburg, Jens-Uwe,
Neuhaus, Jochen,
Weber, Florian,
Burger, Maximilian und
Bründl, Johannes
(2014)
Is the Striated Urethral Sphincter at Risk by Standard Suture Ligation of the Dorsal Vascular Complex in Radical Prostatectomy? An Anatomic Study.
Urology 84 (6), S. 1453-1460.
Volltext nicht vorhanden.
Seitz, Stephan,
Buchholz, Stefan,
Schally, Andrew Victor,
Weber, Florian,
Klinkhammer-Schalke, Monika,
Inwald, Elisabeth C,
Perez, Roberto,
Rick, Ferenc G,
Szalontay, Luca,
Hohla, Florian,
Segerer, Sabine,
Kwok, Chui Wai,
Ortmann, Olaf und
Engel, Jörg Bernhard
(2014)
Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125.
BMC Cancer 14 (1).
Volltext nicht vorhanden.
Seitz, Stephan,
Buchholz, Stefan,
Schally, Andrew V. ,
Jayakumar, Arumugam R.,
Weber, Florian,
Papadia, Andrea ,
Rick, Ferenc G. ,
Szalontay, Luca,
Treszl, Andrea,
Köster, Frank,
Ortmann, Olaf und
Hohla, Florian
(2013)
Targeting triple-negative breast cancer through the somatostatin receptor with the new cytotoxic somatostatin analogue AN-162 [AEZS-124].
Anti-Cancer Drugs 24 (2), S. 150-157.
Volltext nicht vorhanden.
Diese Liste wurde erzeugt am Sat Dec 21 19:36:55 2024 CET.