Einträge von Keller, Max auf dem Publikationsserver

Ertl, Fabian J., Kopanchuk, Sergei , Dijon, Nicola C., Veikšina, Santa, Tahk, Maris-Johanna , Laasfeld, Tõnis, Schettler, Franziska, Gattor, Albert O., Hübner, Harald, Archipowa, Nataliya , Köckenberger, Johannes, Heinrich, Markus R., Gmeiner, Peter , Kutta, Roger Jan , Holliday, Nicholas D. , Rinken, Ago und Keller, Max (2024) Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays. Journal of Medicinal Chemistry 67 (18), S. 16664-16691.

Wirth, Ulrike, Erl, Julia, Azzam, Saphia, Hoering, Carina, Skiba, Michael, Singh, Ritu, Hochmuth, Kathrin, Keller, Max , Wegener, Joachim und König, Burkhard (2023) Monitoring the Reversibility of GPCR Signaling by Combining Photochromic Ligands with Label-free Impedance Analysis. Angewandte Chemie International Edition, e202215547.

Schindler, Lisa, Moosbauer, Jutta, Schmidt, Daniel , Spruss, Thilo, Grätz, Lukas, Lüdeke, Steffen, Hofheinz, Frank, Meister, Sebastian, Echtenacher, Bernd, Bernhardt, Günther, Pietzsch, Jens , Hellwig, Dirk und Keller, Max (2022) Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors. Cancers 14 (19), S. 4922.

Tahk, Maris-Johanna , Torp, Jane , Ali, Mohammed A. S. , Fishman, Dmytro, Parts, Leopold , Grätz, Lukas , Müller, Christoph , Keller, Max , Veiksina, Santa , Laasfeld, Tõnis und Rinken, Ago (2022) Live-cell microscopy or fluorescence anisotropy with budded baculoviruses—which way to go with measuring ligand binding to M 4 muscarinic receptors? Open Biology 12 (6). Volltext nicht vorhanden.

Schindler, Lisa, Wohlfahrt, Katrin, Gluhacevic von Krüchten, Lara, Prante, Olaf, Keller, Max und Maschauer, Simone (2022) Neurotensin analogs by fluoroglycosylation at Nω-carbamoylated arginines for PET imaging of NTS1-positive tumors. Scientific Reports 12 (1). Volltext nicht vorhanden.

Tang, Tingting, Tan, Qiuxiang, Han, Shuo, Diemar, Anne, Löbner, Kristin, Wang, Hongyu, Schüß, Corinna, Behr, Victoria, Mörl, Karin, Wang, Mu, Chu, Xiaojing, Yi, Cuiying, Keller, Max, Kofoed, Jacob, Reedtz-Runge, Steffen, Kaiser, Anette, Beck-Sickinger, Annette G., Zhao, Qiang und Wu, Beili (2022) Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Science Advances 8 (18). Volltext nicht vorhanden.

Müller, Christoph, Gleixner, Jakob , Tahk, Maris-Johanna , Kopanchuk, Sergei , Laasfeld, Tõnis, Weinhart, Michael, Schollmeyer, Dieter, Betschart, Martin U., Lüdeke, Steffen, Koch, Pierre, Rinken, Ago und Keller, Max (2022) Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y1 Receptor. Journal of Medicinal Chemistry 65 (6), S. 4832-4853. Volltext nicht vorhanden.

Grätz, Lukas, Laasfeld, Tõnis, Allikalt, Anni , Gruber, Corinna G., Pegoli, Andrea, Tahk, Maris-Johanna, Tsernant, Mari-Liis, Keller, Max und Rinken, Ago (2021) BRET- and fluorescence anisotropy-based assays for real-time monitoring of ligand binding to M2 muscarinic acetylcholine receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868 (3), S. 118930. Volltext nicht vorhanden.

Weinhart, Corinna. G., Wifling, David, Schmidt, Maximilian. F., Neu, Eduard, Höring, Carina, Clark, Timothy, Gmeiner, Peter und Keller, Max (2021) Dibenzodiazepinone-type muscarinic receptor antagonists conjugated to basic peptides: Impact of the linker moiety and unnatural amino acids on M2R selectivity. European Journal of Medicinal Chemistry 213, S. 113159. Volltext nicht vorhanden.

Konieczny, Adam, Conrad, Marcus, Ertl, Fabian J., Gleixner, Jakob, Gattor, Albert O., Grätz, Lukas, Schmidt, Maximilian F., Neu, Eduard, Horn, Anselm H. C., Wifling, David, Gmeiner, Peter, Clark, Timothy, Sticht, Heinrich und Keller, Max (2021) N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants. Journal of Medicinal Chemistry 64 (22), S. 16746-16769. Volltext nicht vorhanden.

Spinnler, Katrin, von Krüchten, Lara, Konieczny, Adam, Schindler, Lisa, Bernhardt, Günther und Keller, Max (2020) An Alkyne-functionalized Arginine for Solid-Phase Synthesis Enabling “Bioorthogonal” Peptide Conjugation. ACS Medicinal Chemistry Letters 11 (3), S. 334-339. Volltext nicht vorhanden.

Buschmann, Jonas, Seiler, Theresa, Bernhardt, Günther, Keller, Max und Wifling, David (2020) Argininamide-type neuropeptide Y Y1 receptor antagonists: the nature of Nω-carbamoyl substituents determines Y1R binding mode and affinity. RSC Medicinal Chemistry 11 (2), S. 274-282. Volltext nicht vorhanden.

Gruber, Corinna G., Pegoli, Andrea, Müller, Christoph, Grätz, Lukas, She, Xueke und Keller, Max (2020) Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity. RSC Medicinal Chemistry 11 (7), S. 823-832. Volltext nicht vorhanden.

Keller, Max, Mahuroof, Shahani A., Hong Yee, Vivyanne, Carpenter, Jessica, Schindler, Lisa, Littmann, Timo, Pegoli, Andrea, Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter und Holliday, Nicholas D. (2020) Fluorescence Labeling of Neurotensin(8–13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity. ACS Medicinal Chemistry Letters 11 (1), S. 16-22. Volltext nicht vorhanden.

Biselli, Sabrina, Alencastre, Inês, Tropmann, Katharina, Erdmann, Daniela, Chen, Mengya, Littmann, Timo, Maia, André F. , Gomez-Lazaro, Maria, Tanaka, Miho, Ozawa, Takeaki, Keller, Max, Lamghari, Meriem, Buschauer, Armin und Bernhardt, Günther (2020) Fluorescent H2 Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications. ACS Medicinal Chemistry Letters 11 (8), S. 1521-1528. Volltext nicht vorhanden.

Konieczny, Adam, Braun, Diana, Wifling, David , Bernhardt, Günther und Keller, Max (2020) Oligopeptides as Neuropeptide Y Y4 Receptor Ligands: Identification of a High-Affinity Tetrapeptide Agonist and a Hexapeptide Antagonist. Journal of Medicinal Chemistry 63 (15), S. 8198-8215. Volltext nicht vorhanden.

She, Xueke, Pegoli, Andrea, Gruber, Corinna G., Wifling, David , Carpenter, Jessica, Hübner, Harald, Chen, Mengya, Wan, Jianfei, Bernhardt, Günther, Gmeiner, Peter , Holliday, Nicholas D. und Keller, Max (2020) Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor. Journal of Medicinal Chemistry 63 (8), S. 4133-4154. Volltext nicht vorhanden.

Maschauer, Simone, Ott, Julian J. , Bernhardt, Günther, Kuwert, Torsten, Keller, Max und Prante, Olaf (2019) 18F-labelled triazolyl-linked argininamides targeting the neuropeptide Y Y1R for PET Imaging of mammary carcinoma. Scientific Reports 9, S. 12990.

Pegoli, Andrea, Wifling, David , Gruber, Corinna G., Xueke, She, Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter und Keller, Max (2019) Conjugation of Short Peptides to Dibenzodiazepinone-Type
Muscarinic Acetylcholine Receptor Ligands Determines M2R
Selectivity. Journal of Medicinal Chemistry 62, S. 5358-5369. Volltext nicht vorhanden.

Schindler, Lisa, Bernhardt, Günther und Keller, Max (2019) Modifications at Arg and Ile Give Neurotensin(8−13) Derivatives with High Stability and Retained NTS1 Receptor Affinity. ACS Medicinal Chemistry Letters 10 (6), S. 960-965. Volltext nicht vorhanden.

Gergs, U. , Bernhardt, Günther, Buchwalow, I. B., Edler, H., Fröba, J., Keller, Max, Kirchhefer, U., Köhler, F., Mißlinger, N., Wache, H. und Neumann, J. (2019) Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors. Journal of Pharmacology and Experimental Therapeutics 369 (1), S. 129-141. Volltext nicht vorhanden.

Lachmann, Daniel, Konieczny, Adam, Keller, Max und König, Burkhard (2019) Photochromic peptidic NPY Y4-receptor ligands. Organic & Biomolecular Chemistry 17, S. 2467-2478. Volltext nicht vorhanden.

Yang, Zhenlin, Han, Shuo, Keller, Max, Kaiser, Anette, Bender, Brain J., Bosse, Mathias, Burkert, Kerstin, Kögler, Lisa M., Wifling, David , Bernhardt, Günther, Plank, Nicole, Littmann, Timo, Schmidt, Peter, Yi, Cuiying, Li, Beibei, Ye, Sheng, Zhang, Rongguang, Xu, Bo, Larhammar, Dan, Stevens, Raymond C. , Huster, Daniel, Meiler, Jens, Zhao, Qiang, Beck-Sickinger, Annette G., Buschauer, Armin und Wu, Beili (2018) Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor. Nature 556, S. 520-524. Volltext nicht vorhanden.

Pockes, Steffen , Wifling, David , Keller, Max, Buschauer, Armin und Elz, Sigurd (2018) Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists. ACS Omega 2018 (3), S. 2865-2882.

She, Xueke, Pegoli, Andrea, Mayr, Judith, Hübner, Harald, Bernhardt, Günther , Gmeiner, Peter und Keller, Max (2017) Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity. ACS Omega 2 (10), S. 6741-6754.

Dukorn, Stefanie, Littmann, Timo, Keller, Max, Kuhn, Kilian K., Cabrele, Chiara , Baumeister, Paul, Bernhardt, Günther und Buschauer, Armin (2017) Fluorescence- and radio-labeling of Lys4,Nle17,30hPP yields molecular tools for the NPY Y4 receptor. Bioconjugate Chemistry. Volltext nicht vorhanden.

Keller, Max , Maschauer, Simone, Brennauer, Albert, Tripal, Philipp, Koglin, Norman, Dittrich, Ralf, Bernhardt, Günther, Kuwert, Torsten, Wester, Hans-Jürgen, Buschauer, Armin und Prante, Olaf (2017) Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma. ACS Medicinal Chemistry Letters 8, S. 304-309. Volltext nicht vorhanden.

Kuhn, Kilian K., Littmann, Timo, Dukorn, Stefanie, Tanaka, Miho, Keller, Max, Ozawa, Takeaki, Bernhardt, Günther und Buschauer, Armin (2017) In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists. ACS Omega 2 (7), S. 3616-3631.

Pegoli, Andrea , She, Xueke, Wifling, David , Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter und Keller, Max (2017) Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor. Journal of Medicinal Chemistry 60 (8), S. 3314-3334. Volltext nicht vorhanden.

Kuhn, Kilian K., Ertl, Thomas, Dukorn, Stefanie, Keller, Max, Bernhardt, Günther, Reiser, Oliver und Buschauer, Armin (2016) High affinity agonists of the neuropeptide Y (NPY) Y4 receptor derived from the C-terminal pentapeptide of human pancreatic polypeptide (hPP): synthesis, stereochemical discrimination and radiolabeling. Journal of Medicinal Chemistry 59 (13), S. 6045-6058. Volltext nicht vorhanden.

Keller, Max, Kuhn, Kilian K., Einsiedel, Jürgen, Hübner, Harald, Biselli, Sabrina, Mollereau, Catherine , Wifling, David, Svobodova, Jaroslava, Bernhardt, Günther, Cabrele, Chiara , Vanderheyden, Patrick, Gmeiner, Peter und Buschauer, Armin (2016) Mimicking of arginine by functionalized Nω-carbamoylated arginine as a new broadly applicable approach to labeled bioactive peptides: high affinity angiotensin, neuropeptide Y, neuropeptide FF and neurotensin receptor ligands as examples. Journal of Medicinal Chemistry 59 (5), S. 1925-1945. Volltext nicht vorhanden.

Keller, Max, Schindler, Lisa, Bernhardt, Günther und Buschauer, Armin (2015) Towards labeled argininamide-type NPY Y1 receptor antagonists: Identification of a favorable propionylation site in BIBO3304. Archiv der Pharmazie 348 (6), S. 390-398. Volltext nicht vorhanden.

Kagermeier, Nicole, Werner, Kristin, Keller, Max, Baumeister, Paul, Bernhardt, Günther, Seifert, Roland und Buschauer, Armin (2015) Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. Bioorganic & Medicinal Chemistry 23 (14), S. 3957-3969. Volltext nicht vorhanden.

Keller, Max, Tränkle, Christian, She, Xueke, Pegoli, Andrea, Bernhardt, Günther, Buschauer, Armin und Read, Roger W. (2015) M2 subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: effect of chemical homo-dimerization on orthosteric (and allosteric?) binding. Bioorganic & Medicinal Chemistry 23 (14), S. 3970-3990. Volltext nicht vorhanden.

Keller, Max, Weiss, Stefan, Hutzler, Christoph, Kuhn, Kilian K., Mollereau, Catherine, Dukorn, Stefanie, Schindler, Lisa, Bernhardt, Günther, König, Burkhard und Buschauer, Armin (2015) N(omega)-carbamoylation of the argininamide moiety: an avenue to insurmountable NPY Y1 receptor antagonists and a radiolabeled selective high affinity molecular tool ([3H]UR-MK299) with extended residence time. Journal of Medicinal Chemistry 58 (22), S. 8834-8849. Volltext nicht vorhanden.

Keller, Max, Kaske, Melanie, Holzammer, Tobias, Bernhardt, Günther und Buschauer, Armin (2013) Dimeric argininamide-type neuropeptide Y receptor antagonists: chiral discrimination between Y1 and Y4 receptors. Bioorganic and Medicinal Chemistry 21 (21), S. 6303-6322. Volltext nicht vorhanden.

Pluym, Nikola, Baumeister, Paul, Keller, Max, Bernhardt, Günther und Buschauer, Armin (2013) [3H]UR-PLN196: A Selective Nonpeptide Radioligand and Insurmountable Antagonist for the Neuropeptide Y Y2 Receptor. ChemMedChem 8 (4), S. 587-593. Volltext nicht vorhanden.

Memminger, Martin, Keller, Max, Lopuch, Miroslaw, Pop, Nathalie, Bernhardt, Günther, von Angerer, Erwin und Buschauer, Armin (2012) The Neuropeptide Y Y1 receptor: a diagnostic marker? Expression in MCF-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts. PLoS ONE 7 (12), e51032.

Keller, Max, Bhadbhade, Mohan M. und Read, Roger W. (2012) Two dibenzodiazepinone molecules with dissimilar dimeric associations and apparent different tautomeric forms. Acta Crystallogr. C 68 (6), o240-o246. Volltext nicht vorhanden.

Pluym, Nikola, Brennauer, Albert, Keller, Max, Ziemek, Ralf, Pop, Nathalie, Bernhardt, Günther und Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), S. 1727-1738. Volltext nicht vorhanden.

Keller, Max, Bernhardt, Günther und Buschauer, Armin (2011) [3H]UR-MK136 - a highly potent and selective radioligand for neuropeptide Y Y1 receptors. ChemMedChem 6 (9), S. 1566-1571. Volltext nicht vorhanden.

Keller, Max, Erdmann, Daniela, Teng, Shangjun, Pop, Nathalie, Pluym, Nikola, Bernhardt, Günther und Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), S. 2859-2878. Volltext nicht vorhanden.

Hild, Wolfgang, Pollinger, Klaus, Caporale, Andrea, Cabrele, Chiara, Keller, Max, Pluym, Nicola, Buschauer, Armin , Rachel, Reinhard , Tessmar, Joerg, Breunig, Miriam und Goepferich, Achim (2010) G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake. Proceedings of the National Academy of Sciences USA: PNAS 107 (23), S. 10667-10672. Volltext nicht vorhanden.

Kleinmaier, Roland, Igel, Patrick, Keller, Max, Buschauer, Armin und Gschwind, Ruth M. (2010) Conformations, Conformational Preferences, and Conformational Exchange of N'-Substituted N-Acylguanidines: Intermolecular Interactions Hold the Key. J. Am. Chem. Soc. 132 (32), S. 11223-11233. Volltext nicht vorhanden.

Weiss, Stefan, Keller, Max, Bernhardt, G., Buschauer, Armin und König, Burkhard (2010) N(G)-Acyl-argininamides as NPY Y (1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity. Bioorganic & Medicinal Chemistry (18), S. 6292-6304. Volltext nicht vorhanden.

Keller, Max, Teng, Shangjun, Bernhardt, Günther und Buschauer, Armin (2009) Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation. ChemMedChem 4 (10), S. 1733-1745. Volltext nicht vorhanden.

Keller, Max (2009) Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes. Dissertation, Universität Regensburg.

Keller, Max, Pop, Nathalie, Hutzler, Christoph, Beck-Sickinger, Annette G., Bernhardt, Günther und Buschauer, Armin (2008) Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. Journal of Medicinal Chemistry 51 (24), S. 8168-8172. Volltext nicht vorhanden.

Ghorai, Prasanta, Kraus, Anja, Keller, Max, Götte, Carsten, Igel, Patrick, Schneider, Erich, Schnell, David, Bernhardt, Günther, Dove, Stefan, Zabel, Manfred, Elz, Sigurd, Seifert, Roland und Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), S. 7193-7204. Volltext nicht vorhanden.

Weiss, Stefan, Keller, Max, Bernhardt, Günther, Buschauer, Armin und König, Burkhard (2008) Modular synthesis of non-peptidic bivalent NPY Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry 16 (22), S. 9858-9866. Volltext nicht vorhanden.

Brennauer, Albert, Keller, Max, Freund, Matthias, Bernhardt, Günther und Buschauer, Armin (2007) Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions. Tetrahedron Letters 48 (39), S. 6996-6999. Volltext nicht vorhanden.

Schneider, Erich, Keller, Max, Brennauer, Albert, Hoefelschweiger, Bianca K., Gross, Dietmar, Wolfbeis, Otto S., Bernhardt, Günther und Buschauer, Armin (2007) Synthesis and Characterization of the First Fluorescent Nonpeptide NPY Y1 Receptor Antagonist. ChemBioChem 8 (16), S. 1981-1988. Zugang zum Volltext eingeschränkt.