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Article

Werner-Klein, Melanie and Proske, Judith and Werno, Christian and Schneider, Katharina and Hofmann, Hans-Stefan and Rack, Brigitte and Buchholz, Stefan and Ganzer, Roman and Blana, Andreas and Sellbach-Göbel, Birgit and Nitsche, Ulrich and Männel, Daniela N. and Klein, Christoph A. (2014) Immune Humanization of Immunodeficient Mice Using Diagnostic Bone Marrow Aspirates from Carcinoma Patients. PLoS ONE 9 (5), e97860.

Barth, Thomas and Schmidt, Dominic and Botteron, Catherine and Nguyen, Trang T. T. and Ritter, Uwe and Männel, Daniela N. and Lechner, Anja (2012) An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice. Plos One 7, e44499.

Echtenacher, Bernd and Männel, Daniela N. and Hültner, L. (1994) REDUCED EARLY TNF CORRELATES WITH INCREASED MORTALITY OF MAST CELL-DEFICIENT MICE AFTER EXPERIMENTAL PERITONITIS. Journal Of Investigative Dermatology 103 (4), p. 621.

Grau, G. E. and Männel, Daniela N. (1994) Strategies for inhibition of tumor necrosis factor in vivo. Trends in microbiology 2 (9), pp. 303-305.

PIGUET, P. F. and REMICK, D. and MUELLER, C. and RUDDLE, N.H. and Männel, Daniela N. (1993) TNF IN PATHOLOGY: OLD FACTS AND NEW QUESTIONS. DISCUSSION. Research in immunology 144 (5), pp. 385-387.

Westenfelder, U. and Schraven, B. and Männel, Daniela N. (1993) Characterization of monocyte-activating tumour cell membrane structures. Scandinavian journal of immunology 38 (4), pp. 388-394.

Orosz, P. and Echtenacher, Bernd and Falk, Werner and Rüschoff, J. and Weber, D. and Männel, Daniela N. (1993) Enhancement of experimental metastasis by tumor necrosis factor. The Journal of experimental medicine 177 (5), pp. 1391-1398.

Männel, Daniela N. and Rüschoff, J. and Orosz, P. (1993) The role of TNF in tumour growth and metastasis. Research in immunology 144 (5), pp. 364-369.

Stiemer, R. H. and Westenfelder, U. and Gausepohl, H. and Mirshahi, M. and Gundt, A. and Frank, R. W. and Männel, Daniela N. (1992) A common epitope on human tumor necrosis factor alpha and the autoantigen 'S-antigen/arrestin' induces TNF-alpha production. Journal of autoimmunity 5 (1), pp. 15-26.

Stiemer, R. H. and Westenfelder, U. and de Kozak, Y. and Gausepohl, H. and Mirshahi, M. and Frank, R. W. and Faure, J. P. and Männel, Daniela N. (1992) Cytokine induction by immunomodulatory epitopes in S-antigen and tumor necrosis factor alpha. Current eye research 11 Sup, pp. 197-202.

Ganter, S. and Northoff, H. and Männel, Daniela N. and Gebicke-Härter, P. J. (1992) Growth control of cultured microglia. Journal of neuroscience research 33 (2), pp. 218-230.

Müller-Quernheim, J. and Pfeifer, S. and Männel, Daniela N. and Strausz, J. and Ferlinz, R. (1992) Lung-restricted activation of the alveolar macrophage/monocyte system in pulmonary sarcoidosis. The American review of respiratory diseases 145 (1), pp. 187-192.

Schlehofer, J. R. and Rentrop, M. and Männel, Daniela N. (1992) Parvoviruses are inefficient in inducing interferon-beta, tumor necrosis factor-alpha, or interleukin-6 in mammalian cells. Medical microbiology and immunology 181 (3), pp. 153-164.

Männel, Daniela N. and Becker, H. and Gundt, A. and Kist, A. and Franz, H. (1991) Induction of tumor necrosis factor expression by a lectin from Viscum album. Cancer immunology, immunotherapy : CII 33 (3), pp. 177-182.

Urbaschek, R. and Männel, Daniela N. and Urbanczik, R. (1991) Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release. Antimicrobial agents and chemotherapy 35 (8), pp. 1666-1668.

Hass, R. and Lonnemann, G. and Männel, Daniela N. and Topley, N. and Hartmann, A. and Köhler, L. and Resch, K. and Goppelt-Strübe, M. (1991) Regulation of TNF-alpha, IL-1 and IL-6 synthesis in differentiating human monoblastoid leukemic U937 cells. Leukemia research 15 (5), pp. 327-339.

Strausz, J. and Männel, Daniela N. and Pfeifer, S. and Borkowski, A. and Ferlinz, R. and Müller-Quernheim, J. (1991) Spontaneous monokine release by alveolar macrophages in chronic sarcoidosis. International archives of allergy and applied immunology 96 (1), pp. 68-75.

Jänicke, R. and Männel, Daniela N. (1990) Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis. The Journal of Immunology 144 (3), pp. 1144-1150.

Ho, A. D. and Männel, Daniela N. and Wulf, G. and Kirchner, H. and Gundt, A. and Trede, I. and Rensch, K. and Hunstein, W. (1990) Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia. Leukemia 4 (8), pp. 584-589.

Männel, Daniela N. and Jänicke, R. and Westenfelder, U. and Echtenacher, Bernd and Falk, W. (1990) TUMOR-INDUCED TUMOR-NECROSIS-FACTOR PRODUCTION IN MACROPHAGES. Lymphokine research 9 (4), p. 562.

Männel, Daniela N. and Jänicke, R. (1989) Induction of monokine production by tumor cells. Lymphokine research 8 (3), pp. 257-261.

Flegel, W. A. and Wölpl, A. and Männel, Daniela N. and Northoff, H. (1989) Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins. Infection and immunity 57 (7), pp. 2237-2245.

Männel, Daniela N. and Kist, A. and Ho, A. D. and Räth, U. and Reichardt, P. and Wiedenmann, B. and Schlick, E. and Kirchner, H. (1989) Tumour necrosis factor production and natural killer cell activity in peripheral blood during treatment with recombinant tumour necrosis factor. British journal of cancer 60 (4), pp. 585-588.

Jänicke, R. and Männel, Daniela N. (1988) INDUCTION OF TNF-MRNA EXPRESSION AND TNF PRODUCTION IN HUMAN-MONOCYTES BY TUMOR-CELLS. Immunobiology 178 (1-2), p. 21.

Kojouharoff, G. and Männel, Daniela N. and Krammer, P.H. and Falk, W. (1988) PURIFICATION OF T-CELL-CYTOTOXICITY-INDUCING-FACTOR-1 (TCF-1), A LYMPHOKINE INVOLVED IN THE DIFFERENTIATION OF CYTO-TOXIC T-CELLS. Immunobiology 178 (1-2), p. 82.

Kist, A. and Ho, A. D. and Räth, U. and Wiedenmann, B. and Bauer, A. and Schlick, E. and Kirchner, H. and Männel, Daniela N. (1988) Decrease of natural killer cell activity and monokine production in peripheral blood of patients treated with recombinant tumor necrosis factor. Blood 72 (1), pp. 344-348.

Andus, T. and Northoff, H. and Bauer, J. and Ganter, U. and Männel, Daniela N. and Tran-Thi, T. A. and Decker, K. and Heinrich, P. C. (1988) Induction of the proteinase inhibitor alpha 2-macroglobulin in rat hepatocytes by a monocyte-derived factor. Advances in experimental medicine and biology 240, pp. 191-198.

Northoff, H. and Andus, T. and Geiger, T. and Bauer, J. and Männel, Daniela N. and Hirano, T. and Kishimoto, T. and Heinrich, P.C. (1987) INDUCTION IN RAT HEPATOCYTES HEPATOMA-CELLS OF THE ACUTE PHASE RESPONSE - EFFECTS OF DIFFERENT MEDIATORS. Journal of leukocyte biology 42 (5), pp. 566-567.

Kojouharoff, G. and Vonhoegen, I. and Männel, Daniela N. and Krammer, P.H. and Falk, Werner (1987) CHARACTERIZATION OF T-CELL-CYTOTOXICITY-INDUCING-FACTOR 1 (TCF-1), A T-CELL PRODUCT THAT INDUCES MURINE THYMOCYTE DIFFERENTIATION. Immunobiology 175 (4), pp. 313-314.

Falk, W. and Kyewski, B. and Männel, Daniela N. and Krammer, P.H. (1987) INTERLEUKIN-1 INDUCED GROWTH OF DOUBLE-NEGATIVE (L3T4- AND LYT2-) IMMATURE MOUSE THYMOCYTES IS INITIATED BY INDUCING THE SYNTHESIS OF INTERLEUKIN-2 RECEPTOR MESSENGER-RNA. Immunobiology 175 (4), p. 264.

Northoff, H. and Andus, T. and Tranthi, T. A. and Flegel, W. A. and Bauer, J. and Männel, Daniela N. and Heinrich, P. C. (1987) TUMOR-NECROSIS-FACTOR (TNF), INTERFERON-ALPHA, INTERFERON-GAMMA AND INTERFERON-BETA-1 DO NOT EXHIBIT HEPATOCYTE STIMULATING (HSF) ACTIVITY. Immunobiology 175 (4), pp. 315-316.

Urbaschek, R. and Männel, Daniela N. and Urbaschek, B. (1987) MEDIATION OF BENEFICIAL-EFFECTS OF ENDOTOXIN BY TUMOR-NECROSIS-FACTOR. Immunobiology 175 (1-2), p. 39.

Männel, Daniela N. and Urbaschek, R. (1987) BIOLOGICAL-ACTIVITY OF TUMOR-NECROSIS-FACTOR (TNF) IN MICE. European Journal of Pediatrics 146 (3), p. 340.

Männel, Daniela N. and Urbaschek, R. (1987) TUMOR-NECROSIS-FACTOR - A MEDIATOR OF ENDOTOXIC-SHOCK. Journal of clinical chemistry and clinical biochemistry 25 (4), pp. 228-229.

Hensel, G. and Männel, Daniela N. and Pfizenmaier, K. and Krönke, M. (1987) Autocrine stimulation of TNF-alpha mRNA expression in HL-60 cells. Lymphokine research 6 (2), pp. 119-125.

Andus, T. and Heinrich, P. C. and Bauer, J. and Tran-Thi, T. A. and Decker, K. and Männel, Daniela N. and Northoff, H. (1987) Discrimination of hepatocyte-stimulating activity from human recombinant tumor necrosis factor alpha. European journal of immunology 17 (8), pp. 1193-1197.

Falk, W. and Kyewski, B. and Männel, Daniela N. and Krammer, P.H. (1987) GROWTH OF DOUBLE-NEGATIVE (L3T4 AND LYT2) MOUSE THYMOCYTES IS INITIATED BY THE COMBINED ACTION OF INTERLEUKIN-1 (IL-1) AND INTERLEUKIN-2 (IL-2). Lymphokine research 6 (1), U77.

Esparza, I. and Männel, Daniela N. and Ruppel, A. and Falk, W. and Krammer, P.H. (1987) INTERFERON-Y (IFN-Y) AND LYMPHOTOXIN (LT) OR TUMOR-NECROSIS-FACTOR (TNF) SYNERGIZE TO ACTIVATE MACROPHAGES FOR TUMORICIDAL AND SCHISTOSOMULICIDAL FUNCTIONS. Lymphokine research 6 (1), U129.

Esparza, I. and Männel, Daniela N. and Ruppel, A. and Falk, Werner and Krammer, P.H. (1987) Interferon gamma and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni. The Journal of experimental medicine 166 (2), pp. 589-594.

Männel, Daniela N. and Falk, W. and Northoff, H. (1987) THERMOREGULATORY ACTIVITY OF TUMOR-NECROSIS-FACTOR INDEPENDENT OF MACROPHAGE IL1 PRODUCTION. Lymphokine Research 6 (1), U99.

Urbaschek, R. and Männel, Daniela N. and Urbaschek, B. (1987) Tumor necrosis factor induced stimulation of granulopoiesis and radioprotection. Lymphokine research 6 (3), pp. 179-186.

Bauss, F. and Dröge, W. and Männel, Daniela N. (1987) Tumor necrosis factor mediates endotoxic effects in mice. Infection and immunity 55 (7), pp. 1622-1625.

Männel, Daniela N. and Northoff, H. and Bauss, F. and Falk, Werner (1987) Tumor necrosis factor: a cytokine involved in toxic effects of endotoxin. Reviews of infectious diseases 9 Suppl 5, S602-S606.

Esparza, I. and Männel, Daniela N. and Ruppel, A. and Falk, W. and Krammer, P.H. (1986) GAMMA-INTERFERON (IFN-GAMMA) AND LYMPHOTOXIN OR TUMOR-NECROSIS-FACTOR SYNERGIZE TO ACTIVATE MACROPHAGES FOR TUMORICIDAL AND SCHISTOSOMULICIDAL FUNCTIONS. Immunobiology 173 (2-5), p. 244.

Hensel, G. and Männel, Daniela N. and Hofsommer, A. and Pfizenmaier, K. and Kronke, M. (1986) RECOMBINANT TUMOR-NECROSIS-FACTOR (RTNF) INDUCES TNF MESSENGER-RNA ACCUMULATION IN HL60 CELLS. Immunobiology 173 (2-5), p. 120.

Bauss, F. and Männel, Daniela N. (1986) TUMOR NECROSIS FACTOR-INDUCED HYPERREACTIVITY AND TOLERANCE TO HYPOTHERMIA IN MICE. Immunobiology 173 (2-5), p. 112.

Männel, Daniela N. (1986) Biological aspects of tumor necrosis factor. Immunobiology 172 (3-5), pp. 283-290.

Männel, Daniela N. and Dröge, W. and Falk, Werner (1986) REGULATION OF T-CELL FUNCTION WITH MONOCLONAL ANTI-THY-1 ANTIBODIES. Journal of Cellular Biochemistry (Suppl. 10A), p. 79.

Männel, Daniela N. and Droge, W. and Falk, W. (1985) BIOLOGICAL EFFECTS OF MONOCLONAL-ANTIBODIES DIRECTED AGAINST A MURINE T-CELL SURFACE PROTEIN. Immunobiology 170 (1-2), pp. 57-58.

Daum, L. and Falk, W. and Dröge, W. and Männel, Daniela N. (1984) DOES THE DIFFERENTIATION OF CYTO-TOXIC LYMPHOCYTES-T REQUIRE IFN-GAMMA? Immunobiology 168 (1-2), p. 30.

Männel, Daniela N. and Falk, W. (1984) INDUCTION OF IL2 RESPONSIVENESS BY A T-CELL DERIVED LYMPHOKINE. Immunobiology 167 (1-3), p. 261.

Männel, Daniela N. and Falk, Werner and Herrmann, T. and Osawa, H. and Diamantstein, T. (1984) INDUCTION OF T-CELL DIFFERENTIATION BY A SOLUBLE MEDIATOR. Immunobiology 168 (1-2), p. 7.

ORBACHYLIRUKA, E. and Männel, Daniela N. and Dröge, W. and Falk, W. (1984) T-CELL CYTO-TOXICITY INDUCING FACTOR-I (TCF-1) IS A PRODUCT OF ACTIVATED T-CELLS. Immunobiology 168 (1-2), pp. 35-36.

Männel, Daniela N. and Falk, W. (1984) T-CELL CYTO-TOXICITY INDUCING FACTOR-I (TCF1) IS A T-CELL PRODUCT THAT INDUCES THYMOCYTE DIFFERENTIATION. Lymphokine research 3 (4), p. 257.

Männel, Daniela N. and Falk, W. and Dröge, W. (1983) EFFECTS OF LYMPHOKINES ON THE SPECIFICITY OF CYTO-TOXIC LYMPHOCYTE-T RESPONSES. Immunobiology 165 (3-4), p. 314.

Männel, Daniela N. and Falk, Werner (1983) Interferon-gamma is required in activation of macrophages for tumor cytotoxicity. Cellular immunology 79 (2), pp. 396-402.

Falk, W. and Männel, Daniela N. and Dröge, W. (1982) A MINIMUM OF 3 DIFFERENT LYMPHOKINES IS REQUIRED FOR THE GENERATION OF CYTO-TOXIC T-CELL RESPONSES. Immunobiology 162 (4-5), p. 348.

Männel, Daniela N. and De Maeyer, E. and Kemler, R. and Cachard, A. and De Maeyer-Guignard, J. (1982) A rat monoclonal antibody against mouse alpha and beta interferon of all molecular weight species. Nature (London) 296 (5858), pp. 664-665.

Männel, Daniela N. and Falk, W. and Droege, W. (1982) GENERATION OF CYTO-TOXIC T-CELL RESPONSES REQUIRES AT LEAST 2 EARLY ACTING HELPER FACTORS AND ONE LATE ACTING HELPER FACTOR. Immunobiology 162 (4-5), p. 387.

Männel, Daniela N. (1982) Possible role of endotoxin in mediating host resistance. Klinische Wochenschrift 60 (14), pp. 752-753.

Männel, Daniela N. and Falk, Werner (1982) Requirement for γ-interferon in activation of macrophages for tumor cytotoxicity. Cellular Immunology 70 (2), p. 389.

Männel, Daniela N. and Meltzer, M. S. and Mergenhagen, S. E. (1980) Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells. Infection and immunity 28 (1), pp. 204-211.

Männel, Daniela N. (1980) SOLUBLE CYTO-TOXIC FACTOR FROM MURINE MACROPHAGES. Federation Proceedings 39 (3), p. 451.

Männel, Daniela N. and Farrar, J. J. and Mergenhagen, S. E. (1980) Separation of a serum-derived tumoricidal factor from a helper factor for plaque-forming cells. Journal of immunology 124 (3), pp. 1106-1110.

Männel, Daniela N. and FARRAR, J .J. and MERGENHAGEN, S.E. (1979) CHARACTERIZATION OF A CYTOTOXIC SERUM FACTOR FROM MICE - MODE OF PRODUCTION, SPECIFICITY AND PHYSICOCHEMICAL PROPERTIES. Federation proceedings 38 (3), p. 1455.

Männel, Daniela N. and Mäkelä, P. H. and Mayer, H. (1978) Enterobacterial common antigen in mutant strains of Salmonella. Journal of bacteriology 135 (2), pp. 348-353.

Männel, Daniela N. and Mayer, H. (1978) Isolation and chemical characterization of the enterobacterial common antigen. European journal of biochemistry: the FEBS Journal 86 (2), pp. 361-370.

Männel, Daniela N. and Mayer, H. (1978) Serological and immunological properties of isolated enterobacterial common antigen. European journal of biochemistry: the FEBS Journal 86 (2), pp. 371-379.

Schmidt, G. and Männel, Daniela N. and Mayer, H. and Whang, H. Y. and Neter, E. (1976) Role of a lipopolysaccharide gene for immunogenicity of the enterobacterial common antigen. Journal of bacteriology 126 (2), pp. 579-586.

Book Section

Männel, Daniela N. and Falk, Werner (1983) Requirement of g-interferon in activation of macrophages for tumour cytotoxicity. In: Oppenheim, J. .J. and Cohen, S., (eds.) Interleukins, Lymphokines and Cytokines: Proceedings of the Third International Lymphokine Workshop. Academic Press, New York, pp. 287-290. ISBN 0125275404; 978-0125275408 .

Thesis

Männel, Daniela N. (1985) Untersuchungen über die Struktur-Wirkungsmechanismen bei der Endotoxin-verursachten Tumornekrose. Habilitation, Heidelberg, Univ..

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