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Mei, Jian
, Schäfer, Nicole, Wei, Penghui, Kong, Zhiheng, Li, Shushan, Pann, Patrick, Ehrnsperger, Marianne, Johnstone, Brian, Matalova, Eva and Grässel, Susanne
(2025)
Targeting Caspase-1 in osteoarthritis: multi-omics insights into the effects of VX-765 on human chondrocyte function and phenotype.
Frontiers in Immunology 16.
Pann, Patrick, Kalke, Paul, Maier, Verena, Schäfer, Nicole, Clausen-Schaumann, Hauke, Schilling, Arndt F. and Grässel, Susanne
(2025)
Decoding the impact of exercise and αCGRP signaling on murine post-traumatic osteoarthritis progression.
Arthritis Research & Therapy 27 (1).
Stöckl, Sabine, Taheri, Shahed, Maier, Verena, Asid, Amir, Toelge, Martina, Clausen-Schaumann, Hauke, Schilling, Arndt and Grässel, Susanne
(2025)
Effects of intra-articular applied rat BMSCs expressing alpha-calcitonin gene-related peptide or substance P on osteoarthritis pathogenesis in a murine surgical osteoarthritis model.
Stem Cell Research & Therapy 16 (1).
Behn, Alissa, Brendle, Saskia, Ehrnsperger, Marianne, Zborilova, Magdalena, Grupp, Thomas M., Grifka, Joachim
, Schäfer, Nicole and Grässel, Susanne
(2025)
Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinical in vitro study.
Frontiers in Cell and Developmental Biology 13.
Ehrnsperger, Marianne, Taheri, Shahed, Pann, Patrick, Schilling, Arndt F. and Grässel, Susanne
(2024)
Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice.
Scientific Reports 14, p. 25026.
Wang, Chenglong, Stöckl, Sabine, Pattappa, Girish
, Schulz, Daniela
, Hofmann, Korbinian, Ilic, Jovana, Reinders, Yvonne, Bauer, Richard J., Sickmann, Albert and Grässel, Susanne
(2023)
Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia.
Biomedicines 11 (10), p. 2804.
Wank, Isabel, Niedermair, Tanja, Kronenberg, Daniel, Stange, Richard, Brochhausen, Christoph
, Hess, Andreas and Grässel, Susanne
(2022)
Influence of the Peripheral Nervous System on Murine Osteoporotic Fracture Healing and Fracture-Induced Hyperalgesia.
International Journal of Molecular Sciences 24 (1), p. 510.
Stöckl, Sabine, Reichart, Johanna, Zborilova, Magdalena, Johnstone, Brian and Grässel, Susanne
(2022)
Semaphorin 3A-Neuropilin-1 Signaling Modulates MMP13 Expression in Human Osteoarthritic Chondrocytes.
International Journal of Molecular Sciences 23 (22), p. 14180.
Wang, Chenglong, Stöckl, Sabine, Li, Shushan, Herrmann, Marietta, Lukas, Christoph, Reinders, Yvonne, Sickmann, Albert and Grässel, Susanne
(2022)
Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs.
Cells 11 (16), p. 2491.
Rösch, Gundula, Muschter, Dominique, Taheri, Shahed
, El Bagdadi, Karima, Dorn, Christoph, Meurer, Andrea, Zaucke, Frank, Schilling, Arndt F., Grässel, Susanne, Straub, Rainer H. and Jenei-Lanzl, Zsuzsa
(2022)
β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis.
Frontiers in Immunology 12.
, Muschter, Dominique, Farkas, Zsuzsanna, Grässel, Susanne, Aszodi, Attila
, Clausen-Schaumann, Hauke
and Alberton, Paolo
(2022)
Nano-Scale Mechanical Properties of the Articular Cartilage Zones in a Mouse Model of Post-Traumatic Osteoarthritis.
Applied Sciences 12 (5), p. 2596.
Fulltext not available.
, Taheri, Shahed, Dorn, Christoph
, Meurer, Andrea, Straub, Rainer H.
, Zaucke, Frank
, Schilling, Arndt F., Grässel, Susanne
and Jenei-Lanzl, Zsuzsa
(2021)
Sympathectomy aggravates subchondral bone changes during osteoarthritis progression in mice without affecting cartilage degeneration or synovial inflammation.
Osteoarthritis and Cartilage 30 (3), pp. 461-474.
Fulltext not available.
Grässel, Susanne
, Eitner, Annett, Bauer, Richard J., König, Matthias, Johnstone, Brian and Stöckl, Sabine
(2021)
Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes.
Frontiers in Immunology 12 (722884), pp. 1-16.
(Submitted)
Nazet, Ute
, Neubert, Patrick, Schatz, Valentin, Grässel, Susanne
, Proff, Peter
, Jantsch, Jonathan, Schröder, Agnes
and Kirschneck, Christian
(2021)
Differential gene expression response of synovial fibroblasts from temporomandibular joints and knee joints to dynamic tensile stress.
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie.
Grässel, Susanne
, Zaucke, Frank
and Madry, Henning
(2021)
Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology.
Journal of Clinical Medicine 10 (9), p. 1938.
Li, Shushan, Stöckl, Sabine, Lukas, Christoph, Herrmann, Marietta
, Brochhausen, Christoph
, König, Matthias A., Johnstone, Brian
and Grässel, Susanne
(2021)
Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1β-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p.
Stem Cell Research & Therapy 12 (1), p. 252.
Nazet, Ute
, Feulner, Laura, Muschter, Dominique
, Neubert, Patrick, Schatz, Valentin, Grässel, Susanne
, Jantsch, Jonathan, Proff, Peter, Schröder, Agnes
and Kirschneck, Christian
(2021)
Mechanical stress induce PG-E2 in murine synovial fibroblasts originating from the temporomandibular joint.
Cells 2021 (10), p. 298.
(Submitted)
, Melnik, Svitlana, Riegger, Jana
, Trivanović, Drenka, Li, Shushan, Jenei-Lanzl, Zsuzsa, Brenner, Rolf E., Huber-Lang, Markus, Zaucke, Frank, Schildberg, Frank A. and Grässel, Susanne
(2021)
Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration.
Frontiers in Bioengineering and Biotechnology 8.
Fulltext not available.
, Zaucke, Frank
and Madry, Henning
(2021)
Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology.
Journal of Clinical Medicine 10 (9), p. 1938.
Fulltext not available.
, Bernstein, Anke, Docheva, Denitsa
, Kauther, Max Daniel, Katthagen, Jan Christoph, Bader, Rainer, van Griensven, Martijn
, Wirtz, Dieter C., Raschke, Michael J. and Huber-Lang, Markus
(2021)
The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?
European Journal of Medical Research 26 (1).
Fulltext not available.
Niedermair, Tanja, Lukas, Christoph, Li, Shushan
, Stöckl, Sabine, Craiovan, Benjamin, Brochhausen, Christoph
, Federlin, Marianne, Herrmann, Marietta and Grässel, Susanne
(2020)
Influence of Extracellular Vesicles Isolated From Osteoblasts of Patients With Cox-Arthrosis and/or Osteoporosis on Metabolism and Osteogenic Differentiation of BMSCs.
Frontiers in Bioengineering and Biotechnology 8 (615520), pp. 1-15.
Li, Shushan, Stöckl, Sabine, Lukas, Christoph, Götz, Julia, Herrmann, Marietta, Federlin, Marianne and Grässel, Susanne
(2020)
hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways.
Frontiers in Bioengineering and Biotechnology 8 (603598), pp. 1-24.
Stöckl, Sabine, Lindner, Georg, Li, Shushan
, Schuster, Philipp, Haferkamp, Sebastian, Wagner, Ferdinand, Prodinger, Peter M., Multhoff, Gabriele, Boxberg, Melanie, Hillmann, Axel, Bauer, Richard J. and Grässel, Susanne
(2020)
SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line.
International Journal of Molecular Sciences 21 (20), p. 7627.
Nazet, Ute, Grässel, Susanne, Jantsch, Jonathan, Proff, Peter, Schröder, Agnes and Kirschneck, Christian
(2020)
Early OA Stage Like Response Occurs after Dynamic Stretching of Human Synovial Fibroblasts.
International Journal of Molecular Sciences 21 (11), p. 3874.
Niedermair, Tanja, Straub, Rainer H.
, Brochhausen, Christoph and Grässel, Susanne
(2020)
Impact of the Sensory and Sympathetic Nervous System on Fracture Healing in Ovariectomized Mice.
International Journal of Molecular Sciences 21 (405), pp. 1-18.
and Grässel, Susanne
(2020)
Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way.
Mechanisms of Ageing and Development 189, p. 111265.
Fulltext not available.
Niedermair, Tanja, Straub, Rainer H.
, Brochhausen, Christoph and Grässel, Susanne
(2020)
Impact of the Sensory and Sympathetic Nervous System on Fracture Healing in Ovariectomized Mice.
International Journal of Molecular Sciences 21, p. 405.
, Zaucke, Frank
and Jenei-Lanzl, Zsuzsa
(2020)
Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation.
International Journal of Molecular Sciences 21 (11), p. 3924.
Fulltext not available.
, Taheri, Shahed, Schilling, Arndt F., Clausen-Schaumann, Hauke
and Grässel, Susanne
(2020)
Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model.
Bone 133, p. 115181.
Fulltext not available.
Nazet, Ute
, Schröder, Agnes, Grässel, Susanne
, Muschter, Dominique
, Proff, Peter and Kirschneck, Christian
(2019)
Housekeeping gene validation for RT-qPCR studies on synovial fibroblasts derived from healthy and osteoarthritic patients with focus on mechanical loading.
PLOS ONE 14 (12), e0225790.
Schröder, Agnes, Nazet, Ute, Muschter, Dominique, Grässel, Susanne
, Proff, Peter and Kirschneck, Christian
(2019)
Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis.
International Journal of Molecular Sciences 20 (3), p. 585.
(2019)
A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma.
Acta Biomaterialia 89, pp. 372-381.
Fulltext not available.
, Waltera, Anna, Reichert, Torsten E., Stöckl, Sabine, Grässel, Susanne and Bauer, Richard J.
(2019)
Induction of ALP and MMP9 activity facilitates invasive behavior in heterogeneous human BMSC and HNSCC 3D spheroids.
The FASEB Journal 33 (11), pp. 11884-11893.
Fulltext not available.
Grässel, Susanne
and Aszodi, A.
(2019)
Osteoarthritis and Cartilage Regeneration: Focus on Pathophysiology and Molecular Mechanisms.
International Journal of Molecular Sciences 20 (24), p. 6156.
, Schröder, Agnes and Grässel, Susanne
(2019)
Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages.
International Journal of Molecular Sciences 20, p. 503.
Fulltext not available.
Niedermair, Tanja, Schirner, Stephan, Seebröker, Raphael, Straub, Rainer H.
and Grässel, Susanne
(2018)
Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts.
Scientific Reports 8 (9199), pp. 1-15.
Grässel, Susanne and Muschter, Dominique
(2018)
Do Neuroendocrine Peptides and Their Receptors Qualify as Novel Therapeutic Targets in Osteoarthritis?
International Journal of Molecular Sciences 19 (2), p. 367.
Mayer, Ute, Benditz, Achim and Grässel, Susanne
(2017)
miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment.
Scientific Reports 7 (13297), pp. 1-14.
Grässel, Susanne
and Muschter, Dominique
(2017)
Peripheral Nerve Fibers and Their Neurotransmitters in Osteoarthritis Pathology.
International Journal of Molecular Sciences 18, p. 931.
, Dosoki, Heba, Luger, Thomas A., Straub, Rainer H. and Grässel, Susanne
(2016)
α-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients.
Biochemical Pharmacology 116, pp. 89-99.
Fulltext not available.
Grässel, Susanne, Muschter, Dominique, Schäfer, Nicole, Stangl, Hubert and Straub, Rainer H.
(2015)
Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis.
PLoS ONE 2015 (10), e0139726.
Grässel, Susanne, Mutscher, Dominique, Göttl, Claudia, Vogel, Mandy, Grifka, Joachim and Straub, Rainer H.
(2015)
Reactivity of rat bone marrow-derived macrophages to neurotransmitter stimulation in the context of collagen II-induced arthritis.
Arthritis Research & Therapy 17 (169), pp. 1-15.
Leyh, Michaela, Seitz, Andreas
, Dürselen, Lutz, Schaumburger, Jens, Ignatius, Anita
, Grifka, Joachim and Grässel, Susanne
(2014)
Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes.
Arthritis Research & Therapy 16 (453).
Lorenz, Julia, Seebach, Elisabeth, Hackmeyer, Gerit, Greth, Carina, Bauer, Richard J., Kleinschmidt, Kerstin, Bettenworth, Dominik
, Böhm, Markus, Grifka, Joachim and Grässel, Susanne
(2014)
Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis.
PLOS ONE 9 (9), e105858.
Lehy, Michaela, Seitz, Andreas
, Dürselen, Lutz, Springorum, Hans-Robert, Angele, Peter, Ignatius, Anita
, Grifka, Joachim and Grässel, Susanne
(2014)
Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes.
Stem Cell Research & therapy 5 (3).
Bedal, Konstanze B., Grässel, Susanne, Oefner, Peter J.
, Reinders, Jörg, Reichert, Torsten E. and Bauer, Richard
(2014)
Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma.
Plos One 9 (1), e86777.
, Kees, Frieder, Miosge, Nicolai, Angele, Peter and Straub, Rainer H.
(2014)
Norepinephrine Inhibition of Mesenchymal Stem Cell and Chondrogenic Progenitor Cell Chondrogenesis and Acceleration of Chondrogenic Hypertrophy.
Arthritis & Rheumatology 66 (9), pp. 2472-2481.
Fulltext not available.
Pongratz, Georg, Anthofer, Judith M., Melzer, Madlen, Anders, Sven, Grässel, Susanne and Straub, Rainer H.
(2013)
IL-7 receptor α expressing B cells act proinflammatory in collagen-induced arthritis and are inhibited by sympathetic neurotransmitters.
Annals of the Rheumatic Diseases 73, pp. 306-312.
, Anthofer, Judith M, Melzer, Madlen, Anders, Sven, Grässel, Susanne and Straub, Rainer H
(2013)
IL-7 receptor α expressing B cells act proinflammatory in collagen-induced arthritis and are inhibited by sympathetic neurotransmitters.
Annals of the Rheumatic Diseases 73 (1), pp. 306-312.
Fulltext not available.
Stöckl, Sabine, Göttl, Claudia, Grifka, Joachim and Grässel, Susanne
(2013)
Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC).
Cell. Physiol. Biochem. 31, pp. 703-717.
, Göttl, Claudia, Grifka, Joachim and Grässel, Susanne
(2013)
Sox9 modulates cell survival and adipogenic differentiation of multipotent adult rat mesenchymal stem cells.
Journal of Cell Science.
Fulltext not available.
, Pasoldt, Anja, Grifka, Joachim and Grässel, Susanne
(2012)
Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis.
Arthritis & Rheumatism 64 (3), pp. 729-739.
Fulltext not available.
Bauer, Richard, Ratzinger, Sabine, Wales, Lynn, Bosserhoff, Anja
, Senner, V., Grifka, Joachim and Grässel, Susanne
(2011)
Inhibition of Collagen XVI Expression Reduces Glioma Cell Invasiveness.
Cellular Physiology and Biochemistry 27, pp. 217-226.
Lechler, Philipp, Balakrishnan, Sanjeevi, Schaumburger, Jens, Grässel, Susanne, Baier, Clemens, Grifka, Joachim, Straub, Rainer H.
and Renkawitz, Tobias
(2011)
The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro.
BMC musculoskeletal disorders 12, p. 150.
, Grifka, Joachim and Grässel, Susanne
(2010)
Collagen XVI induces formation of focal contacts on intestinal myofibroblasts isolated from the normal and inflamed intestinal tract.
Matrix Biology 29 (3), pp. 177-193.
Fulltext not available.
, Dienstknecht, Thomas, Huber, Marion, Hager, Markus, Grässel, Susanne, Kujat, Richard, Angele, Martin K., Nerlich, Michael and Angele, Peter
(2010)
Estradiol inhibits chondrogenic differentiation of mesenchymal stem cells via nonclassic signaling.
Arthritis & Rheumatism 62 (4), pp. 1088-1096.
Fulltext not available.
and Bosserhoff, Anja-Katrin
(2010)
Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP).
Experimental and Molecular Medicine 42 (3), p. 166.
Fulltext not available.
(2010)
Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis.
Arthritis Research & Therapy 12 (3).
Fulltext not available.
(2009)
The cartilage‐specific transcription factor Sox9 regulates AP‐2ε expression in chondrocytes.
The FEBS Journal 276 (9), pp. 2494-2504.
Fulltext not available.
, Grifka, Joachim, Luger, Thomas A. and Böhm, Markus
(2009)
The melanocortin system in articular chondrocytes: Melanocortin receptors, pro‐opiomelanocortin, precursor proteases, and a regulatory effect of α‐melanocyte–stimulating hormone on proinflammatory cytokines and extracellular matrix components.
Arthritis & Rheumatism 60 (10), pp. 3017-3027.
Fulltext not available.
, Grässel, Susanne and Paulus, Werner
(2008)
Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion.
FEBS Letters 582 (23-24), pp. 3293-3300.
Fulltext not available.
, Probst, Axel and Grässel, Susanne
(2007)
Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice.
Matrix Biology 26 (2), pp. 85-95.
Fulltext not available.
, Zaucke, Frank, Ehlen, Harald W. A., Wagener, Raimund, Ala-Kokko, Leena, Paulsson, Mats, Bruckner, Peter
and Grässel, Susanne
(2005)
Altered Integration of Matrilin-3 into Cartilage Extracellular Matrix in the Absence of Collagen IX.
Molecular and Cellular Biology 25 (23), pp. 10465-10478.
Fulltext not available.
, Schaefer, Liliana
, Thanos, Solon, Grässel, Susanne, Oldberg, Åke, Iozzo, Renato V.
, Young, Marian F. and Kresse, Hans
(2004)
Decorin Deficiency Leads to Impaired Angiogenesis in Injured Mouse Cornea.
Journal of Vascular Research 41 (6), pp. 499-508.
Fulltext not available.
, Chu, Mon-Li, Bruckner, Peter
and Grässel, Susanne
(2004)
Molecular Structure and Interaction of Recombinant Human Type XVI Collagen.
Journal of Molecular Biology 339 (4), pp. 835-853.
Fulltext not available.
(2004)
Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade.
Experimental Cell Research 297 (2), pp. 303-312.
Fulltext not available.
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