Startseite UR
Kinateder, Thomas
, Drexler, Lukas, Straub, Kristina
, Merkl, Rainer
und Sterner, Reinhard
(2022)
Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis.
Protein Science 32 (1), e4536.
Nazet, Julian Simon
(2022)
Design of Protein Interfaces Using Computer-Based Methods.
Dissertation, Universität Regensburg.
Heizinger, Leonhard Josef
(2021)
Exploring Early Stages of Protein Evolution.
Dissertation, Universität Regensburg.
Heizinger, Leonhard und Merkl, Rainer
(2021)
Evidence for the preferential reuse of sub‐domain motifs in primordial protein folds.
Proteins: Structure, Function, and Bioinformatics 89, S. 1167-1179.
Hoffmeister, Helen, Fuchs, Andreas
, Komives, Elizabeth, Groebner‐Ferreira, Regina, Strobl, Laura, Nazet, Julian, Heizinger, Leonhard, Merkl, Rainer, Dove, Stefan und Längst, Gernot
(2021)
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
The FEBS Journal 288, S. 4000-4023.
und Sterner, Reinhard
(2021)
Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design.
Structure 29 (3), 292-304.e3.
Volltext nicht vorhanden.
, Schmitz, Samuel, Ertelt, Moritz
, Merkl, Rainer
und Meiler, Jens
(2021)
Rosetta design with co-evolutionary information retains protein function.
PLOS Computational Biology 17 (1), e1008568.
Volltext nicht vorhanden.
Simeth, Nadja Anita
, Kinateder, Thomas, Rajendran, Chitra, Nazet, Julian, Merkl, Rainer
, Sterner, Reinhard
, König, Burkhard
und Kneuttinger, Andrea C.
(2020)
Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase.
Chemistry—A European Journal 27, S. 2439-2451.
Esch, Robert und Merkl, Rainer
(2020)
Conserved genomic neighborhood is a strong but no perfect indicator for a direct interaction of microbial gene products.
BMC Bioinformatics 21 (1), S. 1-8.
Kneuttinger, Andrea C.
, Zwisele, Stefanie, Straub, Kristina
, Bruckmann, Astrid, Busch, Florian, Kinateder, Thomas, Gaim, Barbara, Wysocki, Vicki H.
, Merkl, Rainer
und Sterner, Reinhard
(2019)
Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology.
International Journal of Molecular Sciences 20 (20), S. 5106.
Straub, Kristina
(2019)
Ancestral Sequence Reconstruction: Methods and Applications.
Dissertation, Universität Regensburg.
Ramchandran, Ramani, Plössl, Karolina
, Straub, Kristina, Schmid, Verena, Strunz, Franziska, Wild, Jens
, Merkl, Rainer, Weber, Bernhard H. F. und Friedrich, Ulrike
(2019)
Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.
PLOS ONE 14 (5), e0216320.
, Hombach, Sonja und Kretz, Markus
(2019)
The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis.
EMBO Rep., e46612.
Volltext nicht vorhanden.
(2019)
A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases.
Biochemistry 58 (22), S. 2584-2588.
Volltext nicht vorhanden.
, Malcicka, Miriama, Bruckmann, Astrid, Broschwitz, Bastian, Straub, Kristina, Merkl, Rainer, Monroig, Oscar, Sterner, Reinhard, Ruther, Joachim
und Ellers, Jacintha
(2019)
Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia.
Journal of Experimental Biology.
Volltext nicht vorhanden.
, Straub, Kristina
, Bittner, Philipp, Simeth, Nadja Anita, Bruckmann, Astrid, Busch, Florian, Rajendran, Chitra, Hupfeld, Enrico, Wysocki, Vicki H., Horinek, Dominik
, König, Burkhard
, Merkl, Rainer und Sterner, Reinhard
(2019)
Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.
Cell Chemical Biology 26, S. 1-14.
Volltext nicht vorhanden.
, Linde, Mona, Kropp, Cosimo, Blanquart, Samuel, Babinger, Patrick
und Merkl, Rainer
(2019)
Sequence selection by FitSS4ASR alleviates ancestral sequence reconstruction as exemplified for geranylgeranylglyceryl phosphate synthase.
Biological Chemistry 400 (3), S. 367-381.
Volltext nicht vorhanden.
Schwartz, Uwe, Németh, Attila, Diermeier, Sarah
, Exler, Josef H., Hansch, Stefan, Maldonado, Rodrigo, Heizinger, Leonhard
, Merkl, Rainer
und Längst, Gernot
(2018)
Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.
Nucleic Acids Research 2018 (1), S. 1-16.
, Heyn, Kristina, Merkl, Rainer
, König, Burkhard
und Sterner, Reinhard
(2018)
Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.
ChemBioChem.
Volltext nicht vorhanden.
, Mickert, Matthias J.
, Nazet, Julian, Merkl, Rainer
, Gorris, Hans H.
und König, Burkhard
(2018)
Development of photoswitchable inhibitors for β-galactosidase.
Organic & Biomolecular Chemistry 16, S. 7430-7437.
Volltext nicht vorhanden.
Löffler, Patrick
(2017)
Computationally modeling interactions and dynamics to promote the understanding of protein function.
Dissertation, Universität Regensburg.
Merkl, Rainer, Löffler, Patrick
, Schmitz, Samuel, Hupfeld, Enrico und Sterner, Reinhard
(2017)
Rosetta:MSF: a modular framework for multi-state computational protein design.
PLOS Computational Biology 13 (6), e1005600.
Kandlinger, Florian, Plach, Maximilian G. und Merkl, Rainer
(2017)
AGeNNT: annotation of enzyme families by means of refined neighborhood networks.
BMC Bioinformatics 18 (1), S. 1-13.
Merkl, Rainer, Verprinsky, Valery, Plach, Maximilian G. und Heizinger, Leonhard
(2017)
Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism.
BMC Evolutionary Biology 17 (36), S. 1-15.
Merkl, Rainer, Plach, Maximilian G., Reisinger, Bernd und Sterner, Reinhard
(2016)
Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation.
PLoS Genetics 12 (1), S. 1-14.
und Sterner, Reinhard
(2016)
Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes.
Cell Chemical Biology 23 (6), S. 709-715.
Volltext nicht vorhanden.
Merkl, Rainer, Žváček, Clemens, Heizinger, Leonhard
und Friedrichs, Gerald
(2015)
An assessment of catalytic residue 3D ensembles for the prediction of enzyme function.
BMC Bioinformatics 16 (359), S. 1-8.
, Janda, Jan-Oliver, Merkl, Rainer
und Sterner, Reinhard
(2015)
Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design.
Protein Engineering, Design and Selection 28 (6), S. 147-151.
Volltext nicht vorhanden.
Diermeier, Sarah Daniela Helena
, Kolovos, Petros
, Heizinger, Leonhard, Schwartz, Uwe, Georgomanolis, Theodore, Zirkel, Anne, Wedemann, Gero
, Grosveld, Frank, Knoch, Tobias A., Merkl, Rainer, Cook, Peter R., Längst, Gernot und Papatonis, Argyris
(2014)
TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.
Genome Biology 15 (12).
Janda, Jan-Oliver
(2014)
Data mining for important amino acid residues in multiple sequence alignments and protein structures.
Dissertation, Universität Regensburg.
Janda, Jan-Oliver, Popal, Ajmal, Bauer, Jochen, Busch, Markus, Klocke, Michael, Spitzer, Wolfgang, Keller, Jörg und Merkl, Rainer
(2014)
H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments.
BMC Bioinformatics 15 (118).
, Schmid, Veronika, Rajendran, Chitra, Carstensen, Linn, Schlee, Sandra, Blanquart, Samuel, Merkl, Rainer
und Sterner, Reinhard
(2014)
Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era.
Journal of the American Chemical Society 136 (1), S. 122-129.
Volltext nicht vorhanden.
, König, Burkhard
und Sterner, Reinhard
(2014)
Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors.
Angewandte Chemie International Edition 53, S. 595-598.
Volltext nicht vorhanden.
und Meister, Gunter
(2014)
Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage.
RNA 20 (10), S. 1532-1538.
Volltext nicht vorhanden.
, Löffler, Patrick, Längst, Gernot, Merkl, Rainer
, Urlaub, Henning und Meister, Gunter
(2014)
The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.
Genes & Development 28 (7), S. 749-764.
Volltext nicht vorhanden.
Birzer, Dietmar
(2013)
Entwicklung von Enzymdesignalgorithmen mit flexibler Ligandenpositionierung.
Dissertation, Universität Regensburg.
(2013)
CLIPS-4D: a classifier that distinguishes structurally and functionally important residue-positions based on sequence and 3D data.
Bioinformatics 29 (23), S. 3029-3035.
Volltext nicht vorhanden.
und Meister, Gunter
(2013)
Turning catalytically inactive human Argonaute proteins into active slicer enzymes.
Nature Structural & Molecular Biology 20 (7), S. 814-817.
Volltext nicht vorhanden.
und Merkl, Rainer
(2012)
Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments.
Biochemistry.
Volltext nicht vorhanden.
Zellner, Hermann Josef
(2012)
PresCont: Vorhersage von Protein-Protein Interaktionsflächen unter Verwendung struktureller und evolutionärer Eigenschaften.
Dissertation, Universität Regensburg.
Janda, Jan-Oliver, Busch, Markus, Kück, Fabian, Porfenenko, Mikhail und Merkl, Rainer
(2012)
CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure.
BMC Bioinformatics 13, S. 55.
Hain, Torsten, Ghai, Rohit
, Billion, Andre, Kuenne, Carsten Tobias
, Steinweg, Christiane, Izar, Benjamin, Mohamed, Walid, Mraheil, Mobarak, Domann, Eugen, Schaffrath, Silke, Kärst, Uwe, Goesmann, Alexander
, Oehm, Sebastian, Pühler, Alfred, Merkl, Rainer
, Vorwerk, Sonja, Glaser, Philippe, Garrido, Patricia, Rusniok, Christophe, Buchrieser, Carmen
, Goebel, Werner und Chakraborty, Trinad
(2012)
Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes.
BMC genomics 13 (1), S. 144.
, Sterner, Reinhard
und Babinger, Patrick
(2012)
Dimerization determines substrate specificity of a bacterial prenyltransferase.
Chembiochem : a European journal of chemical biology 13 (9), S. 1297-1303.
Volltext nicht vorhanden.
(2011)
Prescont: Predicting protein-protein interfaces utilizing four residue properties.
Proteins.
Volltext nicht vorhanden.
, Merkl, Rainer
und Tamm, Ernst R.
(2011)
Focus on Molecules: Norrin.
Experimental eye research.
Volltext nicht vorhanden.
und Gronwald, Wolfram
(2011)
PROCOS: Computational analysis of protein–protein complexes.
Journal of Computational Chemistry 32 (12), S. 2575-2586.
Volltext nicht vorhanden.
und Bocola, Marco
(2011)
A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein.
ChemBioChem.
Volltext nicht vorhanden.
Dietrich, Susanne
(2011)
Mutationsanalyse und kinetische Untersuchungen zum Reaktionsmechanismus der Indolglycerinphosphat-Synthase aus Sulfolobus solfataricus.
Dissertation, Universität Regensburg.
von Mandach, Conrad und Merkl, Rainer
(2010)
Genes optimized by evolution for accurate and fast translation encode in Archaea and Bacteria a broad and characteristic spectrum of protein functions.
BMC genomics 11 (1), S. 617.
, Dachauer, Karoline, Brehm, Alexander, Grummt, Ingrid und Längst, Gernot
(2010)
DNA sequence encoded repression of rRNA gene transcription in chromatin.
Nucleic acids research 38 (16), S. 5304-5314.
Volltext nicht vorhanden.
und Sterner, Reinhard
(2010)
Computational and Experimental Evidence for the Evolution of a (βα)8-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds.
Journal of Molecular Biology 398 (5), S. 763-773.
Volltext nicht vorhanden.
, Matheisl, Sarah, Straub, Tobias
, Merkl, Rainer
, Leonhardt, Heinrich, Kremmer, Elisabeth, Schermelleh, Lothar
und Hake, Sandra B.
(2010)
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y.
The Journal of cell biology 190 (5), S. 777-791.
Volltext nicht vorhanden.
und Wiezer, Arnim
(2009)
GO4genome: A prokaryotic phylogeny based on genome organisation.
Journal of Molecular Evolution 68 (5), S. 550-562.
Volltext nicht vorhanden.
Fischer, André, Enkler, Nils, Neudert, Gerd, Bocola, Marco, Sterner, Reinhard
und Merkl, Rainer
(2009)
TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis.
BMC Bioinformatics 10, S. 54.
Fischer, André
(2008)
TRANSCENT - ein Enzymdesignprogramm zum Transfer aktiver Zentren unter Wahrung Katalyse-relevanter Rahmenbedingungen.
Dissertation, Universität Regensburg.
Merkl, Rainer
und Zwick, Matthias
(2007)
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments.
BMC Bioinformatics 9, S. 151.
Merkl, Rainer
(2007)
Modelling the evolution of the archeal tryptophan synthase.
BMC Evolutionary Biology 7, S. 59.
Fink, Florian, Merkl, Rainer und Gronwald, Wolfram
(2007)
Verification of protein-protein interactions by use of docking techniques.
In: Hansmann, U. H. E. und Meinke, J. Mohanty S. und Zimmermann, O., (eds.)
From computational biophysics to systems biology (CBSB07). Proceedings of the NIC Workshop 2007.
NIC Series, 36.
John von Neumann Institute for Computing, Jülich, S. 125-127.
ISBN 978-3-9810843-2-0.
(2006)
A comparative categorization of protein function encoded in bacterial or archeal genomic islands.
J Mol Evol 62 (1), S. 1-14.
Volltext nicht vorhanden.
Waack, Stephan, Keller, Oliver, Asper, Roman, Brodag, Thomas, Damm, Carsten, Fricke, Wolfgang Florian
, Surovcik, Katharina, Meinicke, Peter und Merkl, Rainer
(2006)
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models.
BMC Bioinformatics 7, S. 142.
(2005)
A comparative categorization of gene flux in diverse microbial species.
Genomics 86 (4), S. 462-475.
Zugang zum Volltext eingeschränkt.
Meinicke, Peter, Tech, Maike, Morgenstern, Burkhard und Merkl, Rainer
(2004)
Oligo kernels for datamining on biological sequences: a case study on prokaryotic translation initiation sites.
BMC Bioinformatics 5 (1), S. 169.
Merkl, Rainer
(2004)
SIGI: score-based identification of genomic islands.
BMC Bioinformatics 5, S. 22.
Brüggemann, Holger, Baumer, Sebastian, Fricke, Wolfgang Florian, Wiezer, Arnim, Liesegang, Heiko, Decker, Ivona, Herzberg, Christina, Martinez-Arias, Rosa, Merkl, Rainer, Henne, Anke und Gottschalk, Gerhard
(2003)
The genome sequence of Clostridium tetani, the causative agent of tetanus disease.
Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490.
Larbig, Karen D., Christmann, Andreas, Johann, André, Klockgether, Jens, Hartsch, Thomas, Merkl, Rainer, Wiehlmann, Lotz, Fritz, Hans Joachim und Tümmler, Burkhard
(2002)
Gene Islands Integrated into tRNA(Gly) Genes Confer Genome Diversity on a Pseudomonas aeruginosa Clone.
Journal of Bacteriology 184 (23), S. 6665-6680.
Merkl, Rainer und Fritz, Hans Joachim
(1996)
Statistical evidence for a biochemical pathway of natural, sequence-targeted G/C to C/G transversion mutagenesis in Haemophilus influenzae Rd.
Nucleic Acids Research 24 (21), S. 4146-4151.
Merkl, Rainer, Kröger, Manfred, Rice, Peter und Fritz, Hans Joachim
(1992)
Statistical evaluation and biological interpretation of non-random abundance in the E. coli K-12 genome of tetra- and pentanucleotide sequences related to VSP DNA mismatch repair.
Nucleic Acids Research 20 (7), S. 1657-1662.
Fisher, P. R., Merkl, Rainer und Gerisch, G.
(1989)
Quantitative Analysis of Cell Motility and Chemotaxis in Dictyostelium discoideum by Using an Image Processing System and a Novel Chemotaxis Chamber Providing Stationary Chemical Gradients.
The Journal of Cell Biology (JCB) 108 (3), S. 973-984.
Francis, D., Toda, K., Merkl, Rainer, Hatfield, T. und Gerisch, G.
(1985)
Mutants of Polysphondylium pallidum altered in cell aggregation and in the expression of a carbohydrate epitope on cell surface glycoproteins.
EMBO Journal 4 (10), S. 2525-2532.
Noegel, A., Harloff, C., Hirth, P., Merkl, Rainer, Modersitzki, M., Stadler, J., Weinhart, U., Westphal, M. und Gerisch, G.
(1985)
Probing an adhesion mutant of Dictyostelium discoideum with cDNA clones and monoclonal antibodies indicates a specific defect in the contact site A glycoprotein.
EMBO Journal 4 (13B), S. 3805-3810.
Ochiai, H., Stadler, J., Westphal, M., Wagle, G., Merkl, Rainer und Gerisch, G.
(1982)
Monoclonal antibodies against contact sites A of Dictyostelium discoideum: detection of modifications of the glycoprotein in tunicamycin-treated cells.
EMBO Journal 1 (8), S. 1011-1016.
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