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Bibliography of the Universität Regensburg

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Number of items at this level: 184.

Article

Schreiber, Rainer , Ousingsawat, Jiraporn and Kunzelmann, Karl (2025) Anoctamin 9 determines Ca2+ signals during activation of T-lymphocytes. Frontiers in Immunology 16.

Ousingsawat, Jiraporn , Talbi, Khaoula, Gómez-Martín, Hilario, Koy, Anne, Fernández-Jaén, Alberto, Tekgül, Hasan, Serdaroğlu, Esra, Ortigoza-Escobar, Juan Darío, Schreiber, Rainer and Kunzelmann, Karl (2025) Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1. BMC Medicine 23 (1).

Ousingsawat, Jiraporn , Schreiber, Rainer and Kunzelmann, Karl (2024) Functional Interdependence of Anoctamins May Influence Conclusions from Overexpression Studies. International Journal of Molecular Sciences 25 (18), p. 9998.

Kunzelmann, Karl , Ousingsawat, Jiraporn and Schreiber, Rainer (2024) Anoctamins in epithelial transport. Cell Calcium 120, p. 102888.

Ousingsawat, Jiraporn , Centeio, Raquel, Reyne, Nicole, McCarron, Alexandra, Cmielewski, Patricia, Schreiber, Rainer , diStefano, Gabriella, Römermann, Dorothee, Seidler, Ursula, Donnelley, Martin and Kunzelmann, Karl (2024) Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine. Scientific Reports 14 (1).

Ousingsawat, Jiraporn , Centeio, Raquel, Schreiber, Rainer and Kunzelmann, Karl (2023) Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract. Pflügers Archiv - European Journal of Physiology 476, pp. 211-227.

Kunzelmann, Karl , Ousingsawat, Jiraporn , Kraus, Andre, Park, Julien H., Marquardt, Thorsten, Schreiber, Rainer and Buchholz, Björn (2023) Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins. International Journal of Molecular Sciences 24 (17), p. 13278.

Talbi, Khaoula, Ousingsawat, Jiraporn , Centeio, Raquel, Schreiber, Rainer and Kunzelmann, Karl (2023) KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage dependent Cl- channel and is not expressed in renal proximal tubule. Pflügers Archiv - European Journal of Physiology 475, pp. 995-1007.

Centeio, Raquel, Cabrita, Inês , Schreiber, Rainer and Kunzelmann, Karl (2023) TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium. Frontiers in Physiology 14.

Hegyi, Peter, Seidler, Ursula and Kunzelmann, Karl (2023) CFTR-beyond the airways: Recent findings on the role of the CFTR channel in the pancreas, the intestine and the kidneys. Journal of Cystic Fibrosis 22, S17-S22. Fulltext not available.

Di Palma, Michael , Catalano, Myriam, Serpe, Carmela, De Luca, Mariassunta, Monaco, Lucia, Kunzelmann, Karl, Limatola, Cristina, Conti, Fiorenzo and Fattorini, Giorgia (2023) Lipopolysaccharide augments microglial GABA uptake by increasing GABA transporter‐1 trafficking and bestrophin‐1 expression. Glia 71 (11), pp. 2527-2540. Fulltext not available.

Lin, JinHeng, Gettings, Sean M. , Talbi, Khaoula, Schreiber, Rainer, Taggart, Michael J., Preller, Matthias , Kunzelmann, Karl, Althaus, Mike and Gray, Michael A. (2023) Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels. Pflügers Archiv - European Journal of Physiology 475 (2), pp. 167-179. Fulltext not available.

Kunzelmann, Karl , Centeio, Raquel, Ousingsawat, Jiraporn, Talbi, Khaoula, Seidler, Ursula and Schreiber, Rainer (2023) SLC26A9 in airways and intestine: secretion or absorption? Channels 17 (1). Fulltext not available.

Salari, Azam , Xiu, Renjie, Amiri, Mahdi , Pallenberg, Sophia Theres, Schreiber, Rainer , Dittrich, Anna-Maria , Tümmler, Burkhard, Kunzelmann, Karl and Seidler, Ursula (2023) The Anion Channel TMEM16a/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals. International Journal of Molecular Sciences 24 (18), p. 14214. Fulltext not available.

Schreiber, Rainer, Talbi, Khaoula, Ousingsawat, Jiraporn and Kunzelmann, Karl (2022) A TMEM16J variant leads to dysregulated cytosolic calcium which may lead to renal disease. The FASEB Journal 37 (1), e22683.

Jo, Sungwoo, Centeio, Raquel, Park, Jinhong, Ousingsawat, Jiraporn, Jeon, Dong‐kyu, Talbi, Khaoula, Schreiber, Rainer, Ryu, Kunhi, Kahlenberg, Kristin, Somoza, Veronika , Delpiano, Livia , Gray, Michael A., Amaral, Margarida D. , Railean, Violeta, Beekman, Jeffrey M., Rodenburg, Lisa W., Namkung, Wan and Kunzelmann, Karl (2022) The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion. The FASEB Journal 36 (11), e22534.

Schreiber, Rainer , Cabrita, Ines and Kunzelmann, Karl (2022) Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f. Gastro Hep Advances 1 (6), pp. 1088-1098.

Ousingsawat, Jiraporn , Centeio, Raquel, Schreiber, Rainer and Kunzelmann, Karl (2022) Expression of SLC26A9 in Airways and Its Potential Role in Asthma. International Journal of Molecular Sciences 23 (6), p. 2998.

Ousingsawat, Jiraporn , Centeio, Raquel, Cabrita, Inês , Talbi, Khaoula, Zimmer, Oliver , Graf, Moritz, Göpferich, Achim , Schreiber, Rainer and Kunzelmann, Karl (2022) Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease. International Journal of Molecular Sciences 23 (3), p. 1085.

Leitzke, Sinje, Seidel, Jana, Ahrens, Björn, Schreiber, Rainer, Kunzelmann, Karl, Sperrhacke, Maria, Bhakdi, Sucharit and Reiss, Karina (2022) Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function. Membranes 12 (2), p. 123. Fulltext not available.

Talbi, Khaoula, Ousingsawat, Jiraporn , Centeio, Raquel, Schreiber, Rainer and Kunzelmann, Karl (2021) Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells. Membranes 11 (9), pp. 1-14.

Talbi, Khaoula, Cabrita, Inês, Kraus, Andre, Hofmann, Sascha, Skoczynski, Kathrin, Kunzelmann, Karl , Buchholz, Bjoern and Schreiber, Rainer (2021) The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model. The FASEB Journal 35 (10), pp. 1-12.

Kunzelmann, Karl , Centeio, Raquel, Ousingsawat, Jiraporn , Cabrita, Inês , Schreiber, Rainer , Talbi, Khaoula, Benedetto, Roberta, Doušová, Tereza , Verbeken, Eric K., De Boeck, Kris and Cohen, Isaac (2021) Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease. International Journal of Molecular Sciences 22 (7852), pp. 1-18.

Kunzelmann, Karl , Talbi, Khaoula, Cabrita, Ines and Schreiber, Rainer (2021) Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals. International Journal of Molecular Sciences 2021 (22), p. 6019. (Submitted)

Kunzelmann, Karl , Centeio, Raquel, Ousingsawat, Jiraporn and Schreiber, Rainer (2021) CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A. International Journal of Molecular Sciences 2021 (22), p. 5133. (Submitted)

Grosch, Melanie, Brunner, Katrin, Ilyaskin, Alexandr V. , Schober, Michael, Staudner, Tobias, Schmied, Denise, Stumpp, Tina, Schmidt, Kerstin N., Madej, M. Gregor , Pessoa, Thaissa D., Othmen, Helga, Kubitza, Marion, Osten, Larissa, de Vries, Uwe, Mair, Magdalena M. , Somlo, Stefan, Moser, Markus, Kunzelmann, Karl, Ziegler, Christine , Haerteis, Silke, Korbmacher, Christoph and Witzgall, Ralph (2021) A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts. Journal of Cell Science 134 (16). Fulltext not available.

Pereira, Catarina , Mazein, Alexander, Farinha, Carlos M., Gray, Michael A., Kunzelmann, Karl, Ostaszewski, Marek, Balaur, Irina, Amaral, Margarida D. and Falcao, Andre O. (2021) CyFi-MAP: an interactive pathway-based resource for cystic fibrosis. Scientific Reports 11 (1). Fulltext not available.

Cabrita, Ines, Talbi, Khaoula, Kunzelmann, Karl and Schreiber, Rainer (2021) Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling. Cell Calcium 97, p. 102413. Fulltext not available.

Cabrita, Inês, Benedetto, Roberta, Wanitchakool, Podchanart, Lerias, Joana, Centeio, Raquel, Ousingsawat, Jiraporn, Schreiber, Rainer and Kunzelmann, Karl (2021) TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 64 (1), pp. 50-58. Fulltext not available.

Berg, Peder , Svendsen, Samuel L., Sorensen, Mads Vaarby , Schreiber, Rainer, Kunzelmann, Karl and Leipziger, Jens (2021) The molecular mechanism of CFTR‐ and secretin‐dependent renal bicarbonate excretion. The Journal of Physiology 599 (12), pp. 3003-3011. Fulltext not available.

Centeio, Raquel, Ousingsawat, Jiraporn , Schreiber, Rainer and Kunzelmann, Karl (2020) Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels. Frontiers in Cell and Developmental Biology 8 (596879), pp. 1-14.

Cabrita, Ines, Kraus, Andre, Scholz, Julia Katharina, Skoczynski, Kathrin, Schreiber, Rainer, Kunzelmann, Karl and Buchholz, Björn (2020) Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo. Nature Communications 11, p. 4320.

Oliver, Paula M., Neubert, Patrick, Homann, Arne, Wendelborn, David, Bär, Anna-Lorena , Krampert, Luka , Trum, Maximilian, Schröder, Agnes, Ebner, Stefan, Weichselbaum, Andrea, Schatz, Valentin, Linz, Peter, Veelken, Roland, Schulte-Schrepping, Jonas , Aschenbrenner, Anna C., Quast, Thomas, Kurts, Christian, Geisberger, Sabrina, Kunzelmann, Karl, Hammer, Karin, Binger, Katrina J., Titze, Jens, Müller, Dominik N., Kolanus, Waldemar , Schultze, Joachim L., Wagner, Stefan and Jantsch, Jonathan (2020) NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLOS Biology 18 (6), e3000722.

Schreiber, Rainer, Ousingsawat, Jiraporn and Kunzelmann, Karl (2020) Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling. International Journal of Molecular Sciences 21 (11), p. 4065.

Pinto, Madalena C. , Schreiber, Rainer, Lerias, Joana, Ousingsawat, Jiraporn, Duarte, Aires, Amaral, Margarida and Kunzelmann, Karl (2020) Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation. Cells 9 (5), p. 1138.

Centeio, Raquel, Cabrita, Inês, Benedetto, Roberta, Talbi, Khaoula, Ousingsawat, Jiraporn, Schreiber, Rainer, Sullivan, John K. and Kunzelmann, Karl (2020) Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A. International Journal of Molecular Sciences 21 (7), p. 2557.

Silva, Iris A. L., Duarte, Aires, Marson, Fernando A. L. , Centeio, Raquel, Doušová, Tereza, Kunzelmann, Karl and Amaral, Margarida D. (2020) Assessment of Distinct Electrophysiological Parameters in Rectal Biopsies for the Choice of the Best Diagnosis/Prognosis Biomarkers for Cystic Fibrosis. Frontiers in Physiology 11. Fulltext not available.

Ormel, Lasse, Lauritzen, Knut H., Schreiber, Rainer, Kunzelmann, Karl and Gundersen, Vidar (2020) GABA, but Not Bestrophin-1, Is Localized in Astroglial Processes in the Mouse Hippocampus and the Cerebellum. Frontiers in Molecular Neuroscience 13. Fulltext not available.

Berg, Peder, Svendsen, Samuel L., Sorensen, Mads V. , Larsen, Casper K., Andersen, Jesper Frank, Jensen-Fangel, Søren, Jeppesen, Majbritt, Schreiber, Rainer, Cabrita, Ines, Kunzelmann, Karl and Leipziger, Jens (2020) Impaired Renal HCO3- Excretion in Cystic Fibrosis. Journal of the American Society of Nephrology 31 (8), pp. 1711-1727. Fulltext not available.

Sousa, Luis , Pankonien, Ines , Clarke, Luka A. , Silva, Iris , Kunzelmann, Karl and Amaral, Margarida D. (2020) KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway. Cells 9 (7), p. 1607. Fulltext not available.

Silva, Iris A.L., Doušová, Tereza, Ramalho, Sofia, Centeio, Raquel, Clarke, Luka A. , Railean, Violeta, Botelho, Hugo M., Holubová, Andrea, Valášková, Iveta, Yeh, Jiunn-Tyng, Hwang, Tzyh-Chang, Farinha, Carlos M., Kunzelmann, Karl and Amaral, Margarida D. (2020) Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 (11), p. 165905. Fulltext not available.

Park, Julien H, Ousingsawat, Jiraporn, Cabrita, Inês, Bettels, Ruth E, Große-Onnebrink, Jörg, Schmalstieg, Christian, Biskup, Saskia, Reunert, Janine, Rust, Stephan, Schreiber, Rainer, Kunzelmann, Karl and Marquardt, Thorsten (2020) TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents. Journal of Medical Genetics 58 (4), pp. 247-253. Fulltext not available.

Kunzelmann, Karl , Cabrita, Ines, Buchholz, Björn and Schreiber, Rainer (2020) TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells. Journal of Molecular Medicine 98, pp. 659-671.

Benedetto, Roberta, Centeio, Raquel, Ousingsawat, Jiraporn, Schreiber, Rainer, Kunzelmann, Karl and make_name_string expected hash reference (2020) Transport properties in CFTR−/− knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption. Pflügers Archiv - European Journal of Physiology 472, pp. 1507-1519.

Kunzelmann, Karl , Centeio, Raquel, Wanitchakool, Podchanart, Cabrita, Inês, Benedetto, Roberta, Saha, Tultul, Hoque, Kazi Mirajul and Schreiber, Rainer (2019) Control of Ion Transport by Tmem16a Expressed in Murine Intestine. Frontiers in Physiology 10 (1262), pp. 1-10.

Kunzelmann, Karl , Ousingsawat, Jiraporn , Benedetto, Roberta, Cabrita, Ines and Schreiber, Rainer (2019) Contribution of Anoctamins to Cell Survival and Cell Death. Cancers 11 (3), p. 382.

Bleibaum, Florian , Sommer, Anselm, Veit, Martin, Rabe, Björn, Andrä, Jörg, Kunzelmann, Karl, Nehls, Christian, Correa, Wilmar, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina and Fu, Haian (2019) ADAM10 sheddase activation is controlled by cell membrane asymmetry. Journal of Molecular Cell Biology 11 (11), pp. 979-993. Fulltext not available.

Nagy, Magdolna, van Geffen, Johanna P., Stegner, David , Adams, David J., Braun, Attila, de Witt, Susanne M., Elvers, Margitta, Geer, Mitchell J. , Kuijpers, Marijke J. E., Kunzelmann, Karl, Mori, Jun, Oury, Cécile, Pircher, Joachim, Pleines, Irina, Poole, Alastair W., Senis, Yotis A., Verdoold, Remco, Weber, Christian , Nieswandt, Bernhard, Heemskerk, Johan W. M. and Baaten, Constance C. F. M. J. (2019) Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Frontiers in Cardiovascular Medicine 6. Fulltext not available.

Miner, Kent, Labitzke, Katja, Liu, Benxian, Wang, Paul, Henckels, Kathryn, Gaida, Kevin, Elliott, Robin, Chen, Jian Jeffrey, Liu, Longbin, Leith, Anh, Trueblood, Esther, Hensley, Kelly, Xia, Xing-Zhong, Homann, Oliver, Bennett, Brian, Fiorino, Mike, Whoriskey, John, Yu, Gang, Escobar, Sabine, Wong, Min, Born, Teresa L., Budelsky, Alison, Comeau, Mike, Smith, Dirk, Phillips, Jonathan , Johnston, James A., McGivern, Joseph G., Weikl, Kerstin, Powers, David, Kunzelmann, Karl, Mohn, Deanna, Hochheimer, Andreas and Sullivan, John K. (2019) Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways. Frontiers in Pharmacology 10. Fulltext not available.

Schreiber, Rainer, Buchholz, Björn, Kraus, Andre, Schley, Gunnar, Scholz, Julia, Ousingsawat, Jiraporn and Kunzelmann, Karl (2019) Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A. Journal of the American Society of Nephrology 30 (2), pp. 228-242. Fulltext not available.

Cabrita, Inês, Benedetto, Roberta, Schreiber, Rainer and Kunzelmann, Karl (2019) Niclosamide repurposed for the treatment of inflammatory airway disease. JCI Insight 4 (15). Fulltext not available.

Benedetto, Roberta, Ousingsawat, Jiraporn, Cabrita, Inês, Pinto, Madalena, Lérias, Joana R., Wanitchakool, Podchanart, Schreiber, Rainer and Kunzelmann, Karl (2019) Plasma membrane–localized TMEM16 proteins are indispensable for expression of CFTR. Journal of Molecular Medicine 97 (5), pp. 711-722. Fulltext not available.

Benedetto, Roberta, Cabrita, Inês, Schreiber, Rainer and Kunzelmann, Karl (2019) TMEM16A is indispensable for basal mucus secretion in airways and intestine. The FASEB Journal 33 (3), pp. 4502-4512. Fulltext not available.

Ousingsawat, Jiraporn, Schreiber, Rainer and Kunzelmann, Karl (2019) TMEM16F/Anoctamin 6 in Ferroptotic Cell Death. Cancers 11, p. 625.

Lérias, Joana R., Pinto, Madalena C. , Botelho, Hugo M. , Awatade, Nikhil T., Quaresma, Margarida C., Silva, Iris A.L. , Wanitchakool, Podchanart, Schreiber, Rainer, Pepperkok, Rainer, Kunzelmann, Karl and Amaral, Margarida D. (2018) A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865 (2), pp. 421-431. Fulltext not available.

Veit, Martin, Koyro, Katharina Isabelle, Ahrens, Björn, Bleibaum, Florian, Munz, Martin, Rövekamp, Hagen, Andrä, Jörg, Schreiber, Rainer, Kunzelmann, Karl, Sommer, Anselm, Bhakdi, Sucharit and Reiss, Karina (2018) Anoctamin-6 regulates ADAM sheddase function. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865 (11), pp. 1598-1610. Fulltext not available.

Simões, Filipa, Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Fonseca, Ana , Cabrita, Inês, Benedetto, Roberta, Schreiber, Rainer and Kunzelmann, Karl (2018) CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6). Pflügers Archiv - European Journal of Physiology 470 (2), pp. 305-314. Fulltext not available.

Lérias, Joana , Pinto, Madalena , Benedetto, Roberta, Schreiber, Rainer, Amaral, Margarida , Aureli, Massimo and Kunzelmann, Karl (2018) Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1. Cellular Signalling 44, pp. 10-19. Fulltext not available.

Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Schreiber, Rainer and Kunzelmann, Karl (2018) Contribution of TMEM16F to pyroptotic cell death. Cell Death & Disease 9 (3). Fulltext not available.

Kraus, Andre, Peters, Dorien J.M., Klanke, Bernd, Weidemann, Alexander, Willam, Carsten, Schley, Gunnar, Kunzelmann, Karl, Eckardt, Kai-Uwe and Buchholz, Bjoern (2018) HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease. Kidney International 94 (5), pp. 887-899. Fulltext not available.

Schenk, Laura K., Buchholz, Bjoern, Henke, Sebastian F., Michgehl, Ulf, Daniel, Christoph , Amann, Kerstin, Kunzelmann, Karl and Pavenstädt, Hermann (2018) Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria. American Journal of Physiology-Renal Physiology 315 (6), F1777-F1786. Fulltext not available.

von Mässenhausen, Anne, Tonnus, Wulf, Himmerkus, Nina, Parmentier, Simon, Saleh, Danish, Rodriguez, Diego, Ousingsawat, Jiraporn, Ang, Rosalind L., Weinberg, Joel M., Sanz, Ana B. , Ortiz, Alberto, Zierleyn, Adrian, Becker, Jan Ulrich, Baratte, Blandine, Desban, Nathalie, Bach, Stéphane, Schiessl, Ina Maria , Nogusa, Shoko, Balachandran, Siddharth, Anders, Hans Joachim, Ting, Adrian T., Bleich, Markus , Degterev, Alexei, Kunzelmann, Karl, Bornstein, Stefan R., Green, Douglas R. , Hugo, Christian and Linkermann, Andreas (2018) Phenytoin inhibits necroptosis. Cell Death & Disease 9 (3). Fulltext not available.

Hagmann, Henning, Mangold, Nicole, Rinschen, Markus M. , Koenig, Tim, Kunzelmann, Karl, Schermer, Bernhard , Benzing, Thomas and Brinkkoetter, Paul T. (2018) Proline‐dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. The FASEB Journal 32 (1), pp. 208-219. Fulltext not available.

Schenk, Laura K., Ousingsawat, Jiraporn, Skryabin, Boris V. , Schreiber, Rainer, Pavenstädt, Hermann and Kunzelmann, Karl (2018) Regulation and Function of TMEM16F in Renal Podocytes. International Journal of Molecular Sciences 19, p. 1798.

Ousingsawat, Jiraporn, Cabrita, Inês, Wanitchakool, Podchanart, Sirianant, Lalida, Krautwald, Stefan, Linkermann, Andreas , Schreiber, Rainer and Kunzelmann, Karl (2017) Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis. Cellular and Molecular Life Sciences 74 (1), pp. 173-181. Fulltext not available.

Wanitchakool, Podchanart, Ousingsawat, Jiraporn, Sirianant, Lalida, Cabrita, Inês, Faria, Diana, Schreiber, Rainer and Kunzelmann, Karl (2017) Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling. Cellular Signalling 30, pp. 41-49. Fulltext not available.

Benedetto, Roberta, Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Zhang, Yong, Holtzman, Michael J., Amaral, Margarida , Rock, Jason R., Schreiber, Rainer and Kunzelmann, Karl (2017) Epithelial Chloride Transport by CFTR Requires TMEM16A. Scientific Reports 7 (1). Fulltext not available.

Schreiber, Rainer, Ousingsawat, Jiraporn , Wanitchakool, Podchanart, Sirianant, Lalida, Benedetto, Roberta, Reiss, Karina and Kunzelmann, Karl (2017) Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+and plasma membrane lipid. The Journal of Physiology 596 (2), pp. 217-229. Fulltext not available.

Sirianant, Lalida, Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Schreiber, Rainer and Kunzelmann, Karl (2016) Cellular volume regulation by anoctamin 6: Ca2+, phospholipase A2 and osmosensing. Pflügers Archiv - European Journal of Physiology 468 (2), pp. 335-349. Fulltext not available.

Wanitchakool, Podchanart, Ousingsawat, Jiraporn, Sirianant, Lalida, MacAulay, Nanna , Schreiber, Rainer and Kunzelmann, Karl (2016) Cl− channels in apoptosis. European Biophysics Journal 45 (7), pp. 599-610. Fulltext not available.

Schreiber, Rainer and Kunzelmann, Karl (2016) Expression of anoctamins in retinal pigment epithelium (RPE). Pflügers Archiv - European Journal of Physiology 468 (11-12), pp. 1921-1929. Fulltext not available.

Kraus, Andre, Schley, Gunnar, Kunzelmann, Karl, Schreiber, Rainer, Peters, Dorien J. M., Stadler, Ruth, Eckardt, Kai-Uwe and Buchholz, Bjoern (2016) Glucose promotes secretion-dependent renal cyst growth. Journal of Molecular Medicine 94 (1), pp. 107-117. Fulltext not available.

Sirianant, Lalida, Wanitchakool, Podchanart, Ousingsawat, Jiraporn, Benedetto, Roberta, Zormpa, Anna, Cabrita, Ines, Schreiber, Rainer and Kunzelmann, Karl (2016) Non-essential contribution of LRRC8A to volume regulation. Pflügers Archiv - European Journal of Physiology 468 (5), pp. 805-816. Fulltext not available.

Sommer, Anselm, Kordowski, Felix, Büch, Joscha, Maretzky, Thorsten , Evers, Astrid, Andrä, Jörg, Düsterhöft, Stefan, Michalek, Matthias, Lorenzen, Inken, Somasundaram, Prasath, Tholey, Andreas , Sönnichsen, Frank D., Kunzelmann, Karl, Heinbockel, Lena, Nehls, Christian, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit and Reiss, Karina (2016) Phosphatidylserine exposure is required for ADAM17 sheddase function. Nature Communications 7 (1). Fulltext not available.

Benedetto, Roberta, Sirianant, Lalida, Pankonien, Ines , Wanitchakool, Podchanart, Ousingsawat, Jiraporn, Cabrita, Ines, Schreiber, Rainer, Amaral, Margarida and Kunzelmann, Karl (2016) Relationship between TMEM16A/anoctamin 1 and LRRC8A. Pflügers Archiv - European Journal of Physiology 468 (10), pp. 1751-1763. Fulltext not available.

Mattheij, Nadine J. A., Braun, Attila, Kruchten, Roger, Castoldi, Elisabetta, Pircher, Joachim, Baaten, Constance C. F. M. J., Wülling, Manuela, Kuijpers, Marijke J. E., Köhler, Ralf, Poole, Alastair W. , Schreiber, Rainer, Vortkamp, Andrea, Collins, Peter W., Nieswandt, Bernhard, Kunzelmann, Karl, Cosemans, Judith M. E. M and Heemskerk, Johan W. M. (2016) Survival protein anoctamin‐6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage. The FASEB Journal 30 (2), pp. 727-737. Fulltext not available.

Guoxing, Liu, Guilai, Liu, Hong, Chen, Borst, Oliver, Gawaz, Meinrad, Vortkamp, Andrea, Schreiber, Rainer , Kunzelmann, Karl and Lang, Florian (2015) Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis. Cellular Physiology and Biochemistry 37 (5), pp. 1934-1944.

Forschbach, V, Goppelt-Struebe, M, Kunzelmann, K, Schreiber, R, Piedagnel, R, Kraus, A, Eckardt, K-U and Buchholz, B (2015) Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation. Cell Death & Disease 6 (10), e1899-e1899. Fulltext not available.

Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Kmit, Arthur, Romao, Ana M., Jantarajit, Walailak, Schreiber, Rainer and Kunzelmann, Karl (2015) Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. Nature Communications 6 (1). Fulltext not available.

Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Schreiber, Rainer, Wuelling, Manuela, Vortkamp, Andrea and Kunzelmann, Karl (2015) Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1. Journal of Biological Chemistry 290 (10), pp. 6270-6280. Fulltext not available.

Schreiber, Rainer, Faria, Diana, Skryabin, Boris V., Wanitchakool, Podchanart, Rock, Jason R. and Kunzelmann, Karl (2015) Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Pflügers Archiv - European Journal of Physiology 467 (6), pp. 1203-1213. Fulltext not available.

Botelho, Hugo M. , Uliyakina, Inna , Awatade, Nikhil T. , Proença, Maria C., Tischer, Christian, Sirianant, Lalida, Kunzelmann, Karl, Pepperkok, Rainer and Amaral, Margarida D. (2015) Protein Traffic Disorders: an Effective High-Throughput Fluorescence Microscopy Pipeline for Drug Discovery. Scientific Reports 5 (1). Fulltext not available.

Schurek, Eva-Maria, Völker, Linus A., Tax, Judit, Lamkemeyer, Tobias, Rinschen, Markus M., Ungrue, Denise, Kratz, John E., Sirianant, Lalida, Kunzelmann, Karl, Chalfie, Martin, Schermer, Bernhard , Benzing, Thomas and Höhne, Martin (2014) A Disease-causing Mutation Illuminates the Protein Membrane Topology of the Kidney-expressed Prohibitin Homology (PHB) Domain Protein Podocin. Journal of Biological Chemistry 289 (16), pp. 11262-11271. Fulltext not available.

Buchholz, Bjoern, Faria, Diana , Schley, Gunnar, Schreiber, Rainer, Eckardt, Kai-Uwe and Kunzelmann, Karl (2014) Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells. Kidney International 85 (5), pp. 1058-1067. Fulltext not available.

Buchholz, Bjoern, Schley, Gunnar, Faria, Diana, Kroening, Sven, Willam, Carsten, Schreiber, Rainer, Klanke, Bernd, Burzlaff, Nicolai , Jantsch, Jonathan, Kunzelmann, Karl and Eckardt, Kai-Uwe (2014) Hypoxia-Inducible Factor-1α Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion. Journal of the American Society of Nephrology 25 (3), pp. 465-474. Fulltext not available.

Sirianant, Lalida, Ousingsawat, Jiraporn, Tian, Yuemin, Schreiber, Rainer and Kunzelmann, Karl (2014) TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl− currents. Cellular Signalling 26 (12), pp. 2826-2833. Fulltext not available.

Faria, Diana, Rock, Jason R., Romao, Ana M., Schweda, Frank, Bandulik, Sascha, Witzgall, Ralph , Schlatter, Eberhard, Heitzmann, Dirk, Pavenstädt, Hermann, Herrmann, Edwin, Kunzelmann, Karl and Schreiber, Rainer (2014) The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney International 85 (6), pp. 1369-1381. Fulltext not available.

Tosoni, Kendra, Stobbart, Michelle, Cassidy, Diane M., Venerando, Andrea, Pagano, Mario A. , Luz, Simão, Amaral, Margarida D. , Kunzelmann, Karl , Pinna, Lorenzo A. , Farinha, Carlos M. and Mehta, Anil (2013) CFTR mutations altering CFTR fragmentation. Biochemical Journal 449 (1), pp. 295-305. Fulltext not available.

Kmit, A, van Kruchten, R, Ousingsawat, J, Mattheij, N J A, Senden-Gijsbers, B, Heemskerk, J W M, Schreiber, R, Bevers, E M and Kunzelmann, K (2013) Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents. Cell Death & Disease 4 (4), e611-e611. Fulltext not available.

Tian, Yuemin, Schreiber, Rainer, Wanitchakool, Podchanart, Kongsuphol, Patthara, Sousa, Marisa, Uliyakina, Inna , Palma, Marta, Faria, Diana , Traynor‐Kaplan, Alexis E, Fragata, José I , Amaral, Margarida D and Kunzelmann, Karl (2013) Control of TMEM16A by INO‐4995 and other inositolphosphates. British Journal of Pharmacology 168 (1), pp. 253-265. Fulltext not available.

Servidoni, Maria F, Sousa, Marisa, Vinagre, Adriana M, Cardoso, Silvia R, Ribeiro, Maria A , Meirelles, Luciana R, de Carvalho, Rita B, Kunzelmann, Karl , Ribeiro, Antônio F , Ribeiro, José D and Amaral, Margarida D (2013) Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility. BMC Gastroenterology 13 (1). Fulltext not available.

Rahmati, Negah, Kunzelmann, Karl , Xu, Jie, Barone, Sharon, Sirianant, Lalida, De Zeeuw, Chris I. and Soleimani, Manoocher (2013) Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H+-ATPase. Pflügers Archiv - European Journal of Physiology 465 (11), pp. 1583-1597. Fulltext not available.

Kunzelmann, Karl , Tian, Yuemin, Martins, Joana Raquel , Faria, Diana , Kongsuphol, Patthara, Ousingsawat, Jiraporn, Wolf, Luisa and Schreiber, Rainer (2012) Airway epithelial cells—Functional links between CFTR and anoctamin dependent Cl− secretion. The International Journal of Biochemistry & Cell Biology 44 (11), pp. 1897-1900. Fulltext not available.

Kunzelmann, Karl and Schreiber, Rainer (2012) Airway epithelial cells—Hyperabsorption in CF? The International Journal of Biochemistry & Cell Biology 44 (8), pp. 1232-1235. Fulltext not available.

Tian, Yuemin, Schreiber, Rainer and Kunzelmann, Karl (2012) Anoctamins are a family of Ca2+ activated Cl− channels. Journal of Cell Science. Fulltext not available.

Ousingsawat, Jiraporn, Schreiber, Rainer and Kunzelmann, Karl (2012) Differential contribution of SLC26A9 to Cl− conductance in polarized and non‐polarized epithelial cells. Journal of Cellular Physiology 227 (6), pp. 2323-2329. Fulltext not available.

Lo, Anthony WI., Ruiz, Christian , Martins, Joana Raquel, Rudin, Florian, Schneider, Sandra, Dietsche, Tanja, Fischer, Claude A. , Tornillo, Luigi, Terracciano, Luigi M., Schreiber, Rainer, Bubendorf, Lukas and Kunzelmann, Karl (2012) Enhanced Expression of ANO1 in Head and Neck Squamous Cell Carcinoma Causes Cell Migration and Correlates with Poor Prognosis. PLoS ONE 7 (8), e43265. Fulltext not available.

Szteyn, K., Schmid, Evi, Nurbaeva, M.K., Wang, Wenting, Münzer, P., Kunzelmann, Karl , Lang, Florian and Shumilina, E. (2012) Expression and Functional Significance of the Ca2+-Activated Cl- Channel ANO6 in Dendritic Cells. Cellular Physiology and Biochemistry 30, pp. 13196-1332.

Kunzelmann, Karl , Schreiber, Rainer, Kmit, Arthur, Jantarajit, Walailak, Martins, Joana Raquel , Faria, Diana , Kongsuphol, Patthara, Ousingsawat, Jiraporn and Tian, Yuemin (2012) Expression and function of epithelial anoctamins. Experimental Physiology 97 (2), pp. 184-192. Fulltext not available.

Hartl, Dominik , Sousa, Marisa, Servidoni, Maria F., Vinagre, Adriana M. , Ramalho, Anabela S., Bonadia, Luciana C., Felício, Verónica , Ribeiro, Maria A. , Uliyakina, Inna , Marson, Fernando A., Kmit, Arthur, Cardoso, Silvia R. , Ribeiro, José D., Bertuzzo, Carmen S. , Sousa, Lisete , Kunzelmann, Karl , Ribeiro, Antônio F. and Amaral, Margarida D. (2012) Measurements of CFTR-Mediated Cl− Secretion in Human Rectal Biopsies Constitute a Robust Biomarker for Cystic Fibrosis Diagnosis and Prognosis. PLoS ONE 7 (10), e47708. Fulltext not available.

Faria, Diana , Lentze, Nicolas, Almaça, Joana , Luz, Simão, Alessio, Luisa, Tian, Yuemin, Martins, José Paulo , Cruz, Pedro , Schreiber, Rainer, Rezwan, Mandana, Farinha, Carlos Miguel , Auerbach, Daniel, Amaral, Margarida D. and Kunzelmann, Karl (2012) Regulation of ENaC biogenesis by the stress response protein SERP1. Pflügers Archiv - European Journal of Physiology 463 (6), pp. 819-827. Fulltext not available.

Deb, Sumitra, Oeggerli, Martin, Tian, Yuemin, Ruiz, Christian, Wijker, Barbara, Sauter, Guido, Obermann, Ellen, Güth, Uwe , Zlobec, Inti, Sausbier, Matthias , Kunzelmann, Karl and Bubendorf, Lukas (2012) Role of KCNMA1 in Breast Cancer. PLoS ONE 7 (8), e41664. Fulltext not available.

Duvvuri, Umamaheswar, Shiwarski, Daniel J. , Xiao, Dong, Bertrand, Carol, Huang, Xin, Edinger, Robert S., Rock, Jason R., Harfe, Brian D., Henson, Brian J., Kunzelmann, Karl , Schreiber, Rainer, Seethala, Raja S., Egloff, Ann Marie, Chen, Xing, Lui, Vivian W. , Grandis, Jennifer R. and Gollin, Susanne M. (2012) TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression. Cancer Research 72 (13), pp. 3270-3281. Fulltext not available.

Ruiz, Christian, Zlobec, Inti, Rudin, Florian, Schneider, Sandra, Rufle, Alex, Fischer, Claude, Tornillo, Luigi, Terracciano, Luigi M., Kunzelmann, Karl and Bubendorf, Lukas (2011) Abstract 1082: The amplification and overexpression of the calcium activated chloride channel TMEM16A (aka DOG1) has a prognostic role in patients with head and neck squamous cell carcinoma. Cancer Research 71 (8_Supp), p. 1082. Fulltext not available.

Martins, Joana Raquel , Faria, Diana , Kongsuphol, Patthara, Reisch, Barbara, Schreiber, Rainer and Kunzelmann, Karl (2011) Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proceedings of the National Academy of Sciences 108 (44), pp. 18168-18172. Fulltext not available.

Kunzelmann, Karl , Tian, Yuemin, Martins, Joana Raquel , Faria, Diana , Kongsuphol, Patthara, Ousingsawat, Jiraporn, Thevenod, Frank, Roussa, Eleni, Rock, Jason and Schreiber, Rainer (2011) Anoctamins. Pflügers Archiv - European Journal of Physiology 462 (2), pp. 195-208. Fulltext not available.

Ousingsawat, Jiraporn, Kongsuphol, Patthara, Schreiber, Rainer and Kunzelmann, Karl (2011) CFTR and TMEM16A are Separate but Functionally Related Cl<sup>-</sup> Channels. Cellular Physiology and Biochemistry 28 (4), pp. 715-724. Fulltext not available.

Kongsuphol, Patthara, Schreiber, Rainer, Kraidith, Kamonshanok and Kunzelmann, Karl (2011) CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca2+-activated Cl- conductance. Pflügers Archiv - European Journal of Physiology 462 (3), pp. 479-487. Fulltext not available.

Tian, Yuemin, Kongsuphol, Patthara, Hug, Martin, Ousingsawat, Jiraporn, Witzgall, Ralph , Schreiber, Rainer and Kunzelmann, Karl (2011) Calmodulin‐dependent activation of the epithelial calcium‐dependent chloride channel TMEM16A. The FASEB Journal 25 (3), pp. 1058-1068. Fulltext not available.

Luz, Simão, Kongsuphol, Patthara, Mendes, Ana Isabel, Romeiras, Francisco, Sousa, Marisa, Schreiber, Rainer, Matos, Paulo , Jordan, Peter , Mehta, Anil, Amaral, Margarida D. , Kunzelmann, Karl and Farinha, Carlos M. (2011) Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity. Molecular and Cellular Biology 31 (22), pp. 4392-4404. Fulltext not available.

Faria, Diana , Dahimène, Shehrazade, Alessio, Luisa, Scott-Ward, Toby, Schreiber, Rainer, Kunzelmann, Karl and Amaral, Margarida D. (2011) Effect of Annexin A5 on CFTR: regulated traffic or scaffolding? Molecular Membrane Biology 28 (1), pp. 14-29. Fulltext not available.

Martins, Joana Raquel , Kongsuphol, Patthara, Sammels, Eva, Dahimène, Shehrazade, AlDehni, Fadi, Clarke, Luka Alexander , Schreiber, Rainer, de Smedt, Humbert, Amaral, Margarida D. and Kunzelmann, Karl (2011) F508del-CFTR increases intracellular Ca2+ signaling that causes enhanced calcium-dependent Cl− conductance in cystic fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812 (11), pp. 1385-1392. Fulltext not available.

Kunzelmann, Karl , Kongsuphol, Patthara, Chootip, Krongkarn, Toledo, Caio, Martins, Joana R. , Almaca, Joana , Tian, Yuemin, Witzgall, Ralph , Ousingsawat, Jiraporn and Schreiber, Rainer (2011) Role of the Ca2+-activated Cl- channels bestrophin and anoctamin in epithelial cells. Biological Chemistry 392 (1-2). Fulltext not available.

Ousingsawat, Jiraporn, Mirza, Myriam, Tian, Yuemin, Roussa, Eleni, Schreiber, Rainer, Cook, David I. and Kunzelmann, Karl (2011) Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflügers Archiv - European Journal of Physiology 461 (5), pp. 579-589. Fulltext not available.

Barro-Soria, René, Aldehni, Fadi, Almaça, Joana , Witzgall, Ralph , Schreiber, Rainer and Kunzelmann, Karl (2010) ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel. Pflügers Archiv - European Journal of Physiology 459 (3), pp. 485-497. Fulltext not available.

Almaça, Joana , Kongsuphol, Patthara, Hieke, Bernhard, Ousingsawat, Jiraporn, Viollet, Benoit , Schreiber, Rainer, Amaral, Margarida D. and Kunzelmann, Karl (2010) Erratum to: AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated. Pflügers Archiv - European Journal of Physiology 460 (6), pp. 1105-1106. Fulltext not available.

Skals, Marianne, Jensen, Uffe B. , Ousingsawat, Jiraporn, Kunzelmann, Karl , Leipziger, Jens and Praetorius, Helle A. (2010) Escherichia coli α-Hemolysin Triggers Shrinkage of Erythrocytes via KCa3.1 and TMEM16A Channels with Subsequent Phosphatidylserine Exposure. Journal of Biological Chemistry 285 (20), pp. 15557-15565. Fulltext not available.

Schreiber, Rainer, Uliyakina, Inna , Kongsuphol, Patthara, Warth, Richard , Mirza, Myriam, Martins, Joana R. and Kunzelmann, Karl (2010) Expression and Function of Epithelial Anoctamins. Journal of Biological Chemistry 285 (10), pp. 7838-7845. Fulltext not available.

Carota, I. , Theilig, F., Oppermann, M., Kongsuphol, P., Rosenauer, A. , Schreiber, R., Jensen, B. L., Walter, S., Kunzelmann, K. and Castrop, H. (2010) Localization and functional characterization of the human NKCC2 isoforms. Acta Physiologica 199 (3), pp. 327-338. Fulltext not available.

Kongsuphol, Patthara, Cassidy, Diane, Romeiras, Francisco, Schreiber, Rainer, Mehta, Anil and Kunzelmann, Karl (2010) Metformin Treatment of Diabetes Mellitus Increases the Risk for Pancreatitis in Patients Bearing the CFTR-mutation S573C. Cellular Physiology and Biochemistry 25 (4-5), pp. 389-396. Fulltext not available.

Duning, Kerstin, Rosenbusch, Deike, Schlüter, Marc A., Tian, Yuemin, Kunzelmann, Karl , Meyer, Nina, Schulze, Ulf, Markoff, Arseni, Pavenstädt, Hermann and Weide, Thomas (2010) Polycystin-2 Activity Is Controlled by Transcriptional Coactivator with PDZ Binding Motif and PALS1-associated Tight Junction Protein. Journal of Biological Chemistry 285 (44), pp. 33584-33588. Fulltext not available.

Koehl, G E, Spitzner, M, Ousingsawat, J, Schreiber, R, Geissler, E K and Kunzelmann, K (2010) Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice. Oncogene 29 (10), pp. 1553-1560. Fulltext not available.

Almaça, Joana , Kongsuphol, Patthara, Hieke, Bernhard, Ousingsawat, Jiraporn, Viollet, Benoit , Schreiber, Rainer, Amaral, Margarida D. and Kunzelmann, Karl (2009) AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated. Pflügers Archiv - European Journal of Physiology 458 (4), pp. 713-721. Fulltext not available.

Rotte, Anand, Bhandaru, Madhuri, Föller, Michael, Biswas, Raja, Mack, Andreas F., Friedrich, Björn, Rexhepaj, Rexhep, Nasir, Omaima, Ackermann, Teresa F., Boini, Krishna M., Kunzelmann, Karl , Behrens, Jürgen and Lang, Florian (2009) APC Sensitive Gastric Acid Secretion. Cellular Physiology and Biochemistry 23 (1-3), pp. 133-142. Fulltext not available.

Aldehni, Fadi, Spitzner, Melanie, Martins, Joana Raquel , Barro-Soria, René, Schreiber, Rainer and Kunzelmann, Karl (2009) Bestrophin 1 Promotes Epithelial-to-mesenchymal Transition of Renal Collecting Duct Cells. Journal of the American Society of Nephrology 20 (7), pp. 1556-1564. Fulltext not available.

Barro Soria, René, Spitzner, Melanie, Schreiber, Rainer and Kunzelmann, Karl (2009) Bestrophin-1 Enables Ca2+-activated Cl− Conductance in Epithelia. Journal of Biological Chemistry 284 (43), pp. 29405-29412. Fulltext not available.

Faria, Diana , Schreiber, Rainer and Kunzelmann, Karl (2009) CFTR is activated through stimulation of purinergic P2Y2 receptors. Pflügers Archiv - European Journal of Physiology 457 (6), pp. 1373-1380. Fulltext not available.

Milenkovic, Vladimir M., Soria, René Barro, Aldehni, Fadi, Schreiber, Rainer and Kunzelmann, Karl (2009) Functional assembly and purinergic activation of bestrophins. Pflügers Archiv - European Journal of Physiology 458 (2), pp. 431-441. Fulltext not available.

Treharne, Kate J., Xu, Zhe, Chen, Jeng-Haur, Best, O. Giles , Cassidy, Diane M., Gruenert, Dieter C., Hegyi, Péter, Gray, Michael A., Sheppard, David N., Kunzelmann, Karl and Mehta, Anil (2009) Inhibition of Protein Kinase CK2 Closes the CFTR Cl<sup>-</sup> Channel, but has no Effect on the Cystic Fibrosis Mutant ΔF508-CFTR. Cellular Physiology and Biochemistry 24 (5-6), pp. 347-360. Fulltext not available.

Ousingsawat, Jiraporn, Martins, Joana R. , Schreiber, Rainer, Rock, Jason R., Harfe, Brian D. and Kunzelmann, Karl (2009) Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport. Journal of Biological Chemistry 284 (42), pp. 28698-28703. Fulltext not available.

Kongsuphol, Patthara, Cassidy, Diane, Hieke, Bernhard, Treharne, Kate J., Schreiber, Rainer, Mehta, Anil and Kunzelmann, Karl (2009) Mechanistic Insight into Control of CFTR by AMPK. Journal of Biological Chemistry 284 (9), pp. 5645-5653. Fulltext not available.

Kongsuphol, Patthara, Hieke, Bernhard, Ousingsawat, Jiraporn, Almaca, Joana , Viollet, Benoit , Schreiber, Rainer and Kunzelmann, Karl (2009) Regulation of Cl− secretion by AMPK in vivo. Pflügers Archiv - European Journal of Physiology 457 (5), pp. 1071-1078. Fulltext not available.

Almaça, Joana , Tian, Yuemin, Aldehni, Fadi, Ousingsawat, Jiraporn, Kongsuphol, Patthara, Rock, Jason R., Harfe, Brian D., Schreiber, Rainer and Kunzelmann, Karl (2009) TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A. Journal of Biological Chemistry 284 (42), pp. 28571-28578. Fulltext not available.

Schreiber, Rainer, Castrop, Hayo and Kunzelmann, Karl (2008) Allergen-induced airway hyperresponsiveness is absent in ecto-5′-nucleotidase (CD73)-deficient mice. Pflügers Archiv - European Journal of Physiology 457 (2), pp. 431-440. Fulltext not available.

Barro-Soria, René, Schreiber, Rainer and Kunzelmann, Karl (2008) Bestrophin 1 and 2 are components of the Ca2+ activated Cl− conductance in mouse airways. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783 (10), pp. 1993-2000. Fulltext not available.

Hennig, B., Schultheiss, G., Kunzelmann, K. and Diener, M. (2008) Ca 2+ -Induced Cl− Efflux at Rat Distal Colonic Epithelium. Journal of Membrane Biology 221 (2), pp. 61-72. Fulltext not available.

Illek, Beate, Maurisse, Rosalie, Wahler, Logan, Kunzelmann, Karl , Fischer, Horst and Gruenert, Dieter (2008) Cl Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA Expression Levels. Cellular Physiology and Biochemistry 22 (1-4), 057-068. Fulltext not available.

Grangeia, Ana , Barro-Soria, Ren&eacute;, Carvalho, Filipa , Damas, Ana, Maur&iacute;cio, Ana , Kunzelmann, Karl , Barros, Alberto and Sousa, M&aacute;rio (2008) Molecular and Functional Characterization of CBAVD-Causing Mutations Located in CFTR Nucleotide-Binding Domains. Cellular Physiology and Biochemistry 22 (1-4), 079-092. Fulltext not available.

Milenkovic, Vladimir M., Langmann, Thomas, Schreiber, Rainer, Kunzelmann, Karl and Weber, Bernhard H. F. (2008) Molecular evolution and functional divergence of the bestrophin protein family. BMC Evolutionary Biology 8, p. 72.

Bachhuber, Tanja, Almaça, Joana , Aldehni, Fadi, Mehta, Anil, Amaral, Margarida D. , Schreiber, Rainer and Kunzelmann, Karl (2008) Regulation of the Epithelial Na+ Channel by the Protein Kinase CK2. Journal of Biological Chemistry 283 (19), pp. 13225-13232. Fulltext not available.

Ousingsawat, Jiraporn, Spitzner, Melanie, Schreiber, Rainer and Kunzelmann, Karl (2008) Upregulation of colonic ion channels in APC Min/+ mice. Pflügers Archiv - European Journal of Physiology 456 (5), pp. 847-855. Fulltext not available.

Schreiber, Rainer, Sorria, René Barro, Milenkovic, Vladimir, Spitzner, Melanie, Hieke, Bernhard and Kunzelmann, Karl (2007) ATP induced Ca 2+ activated Cl − conductance is dependent on VMD2 (bestrophin‐1) expression. The FASEB Journal 21 (6). Fulltext not available.

Kunzelmann, Karl , Sun, Jane, Meanger, Jayesh, King, Nicholas J. and Cook, David I. (2007) Inhibition of Airway Na + Transport by Respiratory Syncytial Virus. Journal of Virology 81 (8), pp. 3714-3720. Fulltext not available.

Kunzelmann, Karl , Milenkovic, Vladimir M., Spitzner, Melanie, Soria, René Barro and Schreiber, Rainer (2007) Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin? Pflügers Archiv - European Journal of Physiology 454 (6), pp. 879-889. Fulltext not available.

Puntheeranurak, Supaporn, Schreiber, Rainer, Spitzner, Melanie, Ousingsawat, Jiraporn, Krishnamra, Nateetip and Kunzelmann, Karl (2007) Control of Ion Transport in Mouse Proximal and Distal Colon by Prolactin. Cellular Physiology and Biochemistry 19 (1-4), pp. 77-88. Fulltext not available.

Ousingsawat, Jiraporn, Spitzner, Melanie, Puntheeranurak, Supaporn, Terracciano, Luigi, Tornillo, Luigi , Bubendorf, Lukas, Kunzelmann, Karl and Schreiber, Rainer (2007) Expression of Voltage-Gated Potassium Channels in Human and Mouse Colonic Carcinoma. Clinical Cancer Research 13 (3), pp. 824-831. Fulltext not available.

Milenkovic, Vladimir M., Rivera, A., Horling, F. and Weber, Bernhard H. F. (2007) Insertion and topology of normal and mutant bestrophin-1 in the endoplasmic reticulum membrane. The Journal of Biological Chemistry 282, pp. 1313-1321. Fulltext not available.

Bloch, M, Ousingsawat, J, Simon, R, Schraml, P, Gasser, T C, Mihatsch, M J, Kunzelmann, K and Bubendorf, L (2007) KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Oncogene 26 (17), pp. 2525-2534. Fulltext not available.

Amaral, Margarida D. and Kunzelmann, Karl (2007) Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis. Trends in Pharmacological Sciences 28 (7), pp. 334-341. Fulltext not available.

Spitzner, Melanie, Ousingsawat, Jiraporn, Scheidt, Kerstin, Kunzelmann, Karl and Schreiber, Rainer (2007) Voltage‐gated K channels support proliferation of colonic carcinoma cells. The FASEB Journal 21 (1), pp. 35-44. Fulltext not available.

Kunzelmann, Karl , Scheidt, Kerstin, Scharf, Birgit, Ousingsawat, Jiraporn, Schreiber, Rainer, Wainwright, Brandon and McMorran, Brendan (2006) Flagellin of Pseudomonas aeruginosa inhibits Na
transport in airway epithelia.
The FASEB Journal 20 (3), pp. 545-546. Fulltext not available.

Sousa, Marisa, Ousingsawat, Jiraporn, Seitz, Roswitha, Puntheeranurak, Supaporn, Regalado, Ana , Schmidt, André, Grego, Tiago , Jansakul, Chaweewan, Amaral, Margarida D. , Schreiber, Rainer and Kunzelmann, Karl (2006) An Extract from the Medicinal PlantPhyllanthus acidusand Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis. Molecular Pharmacology 71 (1), pp. 366-376. Fulltext not available.

Stumpf, Astrid, Almaca, Joana , Kunzelmann, Karl , Wenners-Epping, Kerstin, Huber, Stephan, Haberle, Johannes, Falk, Sabine, Duebbers, Angelika, Walte, Mike, Oberleithner, Hans and Schillers, Hermann (2006) IADS, a Decomposition Product of DIDS Activates a Cation Conductance in <i>Xenopus</i> Oocytes and Human Erythrocytes: New Compound for the Diagnosis of Cystic Fibrosis. Cellular Physiology and Biochemistry 18 (4-5), pp. 243-252. Fulltext not available.

Huber, Tobias B., Schermer, Bernhard , Müller, Roman Ulrich, Höhne, Martin, Bartram, Malte, Calixto, Andrea, Hagmann, Henning, Reinhardt, Christian, Koos, Fabienne, Kunzelmann, Karl , Shirokova, Elena, Krautwurst, Dietmar, Harteneck, Christian, Simons, Matias , Pavenstädt, Hermann, Kerjaschki, Dontscho, Thiele, Christoph, Walz, Gerd, Chalfie, Martin and Benzing, Thomas (2006) Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proceedings of the National Academy of Sciences 103 (46), pp. 17079-17086. Fulltext not available.

da Paula, Ana, Ramalho, Anabela , Farinha, Carlos , Cheung, Judy, Maurisse, Rosalie, Gruenert, Dieter, Ousingsawat, Jiraporn, Kunzelmann, Karl and Amaral, Margarida (2005) Characterization of Novel Airway Submucosal Gland Cell Models for Cystic Fibrosis. Cellular Physiology and Biochemistry 15 (6), pp. 251-262. Fulltext not available.

Bachhuber, Tanja, König, Jens, Voelcker, Thilo, Mürle, Bettina, Schreiber, Rainer and Kunzelmann, Karl (2005) Cl– Interference with the Epithelial Na+ Channel ENaC. Journal of Biological Chemistry 280 (36), pp. 31587-31594. Fulltext not available.

Kunzelmann, Karl , Sun, Jane, Markovich, Daniel, König, Jens, Mürle, Bettina, Mall, Marcus and Schreiber, Rainer (2005) Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR‐2). The FASEB Journal 19 (8), pp. 969-970. Fulltext not available.

Mendes, Filipa , Wakefield, John, Bachhuber, Tanja, Barroso, Margarida , Bebok, Zsuzsa, Penque, Deborah , Kunzelmann, Karl and Amaral, Margarida D. (2005) Establishment and Characterization of a Novel Polarized MDCK Epithelial Cellular Model for CFTR Studies. Cellular Physiology and Biochemistry 16 (4-6), pp. 281-290. Fulltext not available.

Adam, Gabriele, Ousingsawat, Jiraporn, Schreiber, Rainer and Kunzelmann, Karl (2005) Increase in intracellular Cl? concentration by cAMP- and Ca2+-dependent stimulation of M1 collecting duct cells. Pfl�gers Archiv - European Journal of Physiology 449 (5), pp. 470-478. Fulltext not available.

Kunzelmann, Karl (2005) Ion Channels and Cancer. The Journal of Membrane Biology 205 (3). Fulltext not available.

Schreiber, Rainer and Kunzelmann, Karl (2005) Purinergic P2Y<sub>6</sub> Receptors Induce Ca<sup>2+</sup> and CFTR Dependent Cl<sup>-</sup> Secretion in Mouse Trachea. Cellular Physiology and Biochemistry 16 (1-3), pp. 99-108. Fulltext not available.

Kunzelmann, K. , Bachhuber, T., Regeer, R., Markovich, D., Sun, J. and Schreiber, R. (2005) Purinergic inhibition of the epithelial Na+transport via hydrolysis of PIP2. The FASEB Journal 19 (1), pp. 142-143. Fulltext not available.

Hirtz, Stephanie, Gonska, Tanja, Seydewitz, Hans H., Thomas, Jörg, Greiner, Peter, Kuehr, Joachim, Brandis, Matthias, Eichler, Irmgard, Rocha, Herculano, Lopes, Ana—Isabel, Barreto, Celeste, Ramalho, Anabela , Amaral, Margarida D. , Kunzelmann, Karl and Mall, Marcus (2004) CFTR Cl− channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. Gastroenterology 127 (4), pp. 1085-1095. Fulltext not available.

Schreiber, R., Boucherot, A., Mürle, B., Sun, J. and Kunzelmann, K. (2004) Control of Epithelial Ion Transport by Cl− and PDZ Proteins. Journal of Membrane Biology 199 (2), pp. 85-98. Fulltext not available.

Mall, Marcus and Kunzelmann, Karl (2004) Correction of the CF defect by curcumin: hypes and disappointments. BioEssays 27 (1), pp. 9-13. Fulltext not available.

Kunzelmann, Karl , Sun, J, Schreiber, R and König, Jens (2004) Effects of dietary lectins on ion transport in epithelia. British Journal of Pharmacology 142 (8), pp. 1219-1226. Fulltext not available.

Kunzelmann, Karl and McMorran, Brendan (2004) First Encounter: How Pathogens Compromise Epithelial Transport. Physiology 19 (5), pp. 240-244. Fulltext not available.

Mall, Marcus, Kreda, Silvia M., Mengos, April, Jensen, Timothy J., Hirtz, Stephanie, Seydewitz, Hans H., Yankaskas, James, Kunzelmann, Karl , Riordan, John R. and Boucher, Richard C. (2004) The ΔF508 mutation results in loss of CFTR function and mature protein in native human colon. Gastroenterology 126 (1), pp. 32-41. Fulltext not available.

Schreiber, Rainer, Bartoszyk, Gerd D. and Kunzelmann, Karl (2004) The κ-opioid receptor agonist asimadoline inhibits epithelial transport in mouse trachea and colon. European Journal of Pharmacology 503 (1-3), pp. 185-190. Fulltext not available.

Schreiber, R., K�nig, J., Sun, J., Markovich, D. and Kunzelmann, K. (2003) Effects of Purinergic Stimulation, CFTR and Osmotic Stress on Amiloride-sensitive Na + Transport in Epithelia and Xenopus Oocytes. Journal of Membrane Biology 192 (2), pp. 101-110. Fulltext not available.

Oceandy, D. , McMorran, B., Schreiber, R., Wainwright, B. J. and Kunzelmann, K. (2003) GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon. Journal of Membrane Biology 192 (3), pp. 159-167. Fulltext not available.

Thesis of the University of Regensburg

Talbi, Khaoula (2023) Ion channels and calcium signaling in kidney disease. PhD, Universität Regensburg.

Martins Centeio, Raquel (2023) Restoring airway function in muco-obstructive diseases by modulating TMEM16A and SLC26A9. PhD, Universität Regensburg.

Benedetto, Roberta (2019) Modulation of TMEM16 proteins: a novel therapeutic approach to Cystic Fibrosis therapy. PhD, Universität Regensburg.

Wanitchakool, Podchanart (2017) Anoctamins in Volume Regulation, Proliferation and Apoptotic Cell Death. PhD, Universität Regensburg.

Sirianant, Lalida (2016) Volume regulations by Anoctamins, Bestrophin1 and
Transmembrane Channel like proteins.
PhD, Universität Regensburg.

Zormpa, Anna (2016) The role of LRRC8A for cellullar volume regulation and apoptosis. PhD, Universität Regensburg.

Tian, Yuemin (2012) Regulation and function of Anoctamins, a new family of Ca2+ activated Cl- channels. PhD, Universität Regensburg.

Kongsuphol, Patthara (2011) Regulation of CFTR and its contribution to other epithelial Cl- channels. PhD, Universität Regensburg.

Florian, Christian (2011) Die Rolle Langerin+ Zellen für die Induktion einer humoralen Immunantwort gegen Leishmania major. PhD, Universität Regensburg.

Hofmann-Sieber, Helga (2008) Etablierung des Equinen Herpesvirus Typ 1 (EHV-1) als neues virales Vektorsystem. PhD, Universität Regensburg.

Barro Soria, René (2008) Cellular role of the putative Ca2+-dependent Cl- channel bestrophin. PhD, Universität Regensburg.

Spitzner, Melanie (2008) Role of potassium ion channels (K+ channels) on proliferation and development of colonic cancer. PhD, Universität Regensburg.

Bachhuber, Tanja (2008) Control of epithelial Na+ channels by CFTR, receptors and kinases. PhD, Universität Regensburg.

This list was generated on Sat May 17 17:28:00 2025 CEST.
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