Publikationen von Seifert, Roland

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Anzahl der Einträge: 130.

Artikel

Harloff, Manuela, Prüschenk, Sally, Seifert, Roland und Schlossmann, Jens

(2021) Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice. British Journal of Pharmacology 179, S. 2460-2475.

Scharrenbroich, Jessica, Kaever, Volkhard, Dove, Stefan, Seifert, Roland und Schneider, Erich H. (2019) Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode. Naunyn-Schmiedeberg's Archives of Pharmacology 392 (2), S. 199-208. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim und Seifert, Roland (2017) Binding kinetics and pathways of ligands to GPCRs. Trends in Pharmacological Sciences. (Im Druck) Volltext nicht vorhanden.

Dessauer, Carmen W., Watts, Val J., Ostrom, Rennolds S., Conti, Marco, Dove, Stefan und Seifert, Roland (2017) International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacological Reviews 69 (2), S. 93-139. Volltext nicht vorhanden.

Werner, Kristin, Kälble, Solveig, Wolter, Sabine, Schneider, Erich H., Buschauer, Armin, Neumann, Detlef und Seifert, Roland (2015) Flow cytometric analysis with a fluorescent formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2-receptor. Naunyn Schmiedebergs Archives of Pharmacology 388 (10), S. 1039-1052. Volltext nicht vorhanden.

Lübker, Carolin, Dove, Stefan, Tang, Wei-Jen, Bieber Urbauer, Ramona J., Moskovitz, Jackob, Urbauer, Jeffrey L. und Seifert, Roland (2015) Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor. Toxins 7 (7), S. 2598-2614.

Kagermeier, Nicole, Werner, Kristin, Keller, Max, Baumeister, Paul, Bernhardt, Günther, Seifert, Roland und Buschauer, Armin (2015) Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. Bioorganic & Medicinal Chemistry 23 (14), S. 3957-3969. Volltext nicht vorhanden.

Beermann, Silke, Bernhardt, Guenther, Seifert, Roland, Buschauer, Armin und Neumann, Detlef (2015) Histamine H1- and H4-receptor signaling cooperatively regulate MAPK activation. Biochemical Pharmacology 98 (3), S. 432-439. Volltext nicht vorhanden.

Lübker, Carolin, Bieber-Urbauer, Ramona J., Moskovitz, Jackob, Dove, Stefan, Weisemann, Jasmin, Fedorova, Maria, Urbauer, Jeffrey L. und Seifert, Roland (2015) Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin. Biochemical Pharmacology 93 (2), S. 196-209. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Schneider, Erich H. und Seifert, Roland (2015) Modulation of GPCRs by monovalent cations and anions. Naunyn-Schmiedeberg's Archives of Pharmacology 388, S. 363-380. Volltext nicht vorhanden.

Wifling, David, Löffel, Karolin, Nordemann, Uwe, Strasser, Andrea, Bernhardt, Günther, Dove, Stefan, Seifert, Roland und Buschauer, Armin (2015) Molecular determinants for the high constitutive activity of the human histamine H4 receptor: Functional studies on orthologs and mutants. British Journal of Pharmacology 172, S. 785-798. Volltext nicht vorhanden.

Reinartz, Michael T., Kälble, Solveig, Littmann, Timo, Ozawa, Takeaki, Dove, Stefan, Kaever, Volkhard, Wainer, Irving W. und Seifert, Roland (2015) Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor. Naunyn-Schmiedeberg's archives of pharmacology 388 (1), S. 51-65. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2014) Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor. In silico pharmacology 2.

Dove, Stefan, Danker, Kerstin Yvonne, Stasch, Johannes-Peter, Kaever, Volkhard und Seifert, Roland (2014) Structure/Activity Relationships of (M)ANT- and TNP-Nucleotides for Inhibition of Rat Soluble Guanylyl Cyclase alpha(1)beta(1). Molecular Pharmacology 85 (4), S. 598-607. Volltext nicht vorhanden.

Wolter, Sabine, Dove, Stefan, Golombek, Marina, Schwede, Frank und Seifert, Roland (2014) N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo. Naunyn-Schmiedeberg's archives of pharmacology 387 (12), S. 1163-1175. Volltext nicht vorhanden.

Werner, Kristin, Neumann, Detlef, Buschauer, Armin und Seifert, Roland (2014) No evidence for histamine H4-receptor in human monocytes. Journal of Pharmacology and Experimental Therapeutics 351 (3), S. 519-526. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2014) Sodium binding to hH3R and hH4R - a molecular modelling study. Journal of Molecular Modeling 20, S. 2394. Volltext nicht vorhanden.

Nordemann, Uwe, Wifling, David, Schnell, David, Bernhardt, Günther, Stark, Holger, Seifert, Roland und Buschauer, Armin (2013) Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts. PLoS One 8 (9), e73961.

Brunskole Hummel, Irena, Kälble, Solveig, Burhenne, Heike, Reinartz, Michael T., Schwede, Frank, Buschauer, Armin und Seifert, Roland (2013) Dissociations in the effects of beta2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: Support for the concept of functional selectivity. PLoS One 8 (5), e64556.

Seifert, Roland, Strasser, Andrea, Schneider, Erich H., Neumann, Detlef, Dove, Stefan und Buschauer, Armin (2013) Molecular and cellular analysis of human histamine receptor subtypes. Trends in Pharmacological Sciences 34 (1), S. 33-58. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Buschauer, Armin, Schneider, Erich H. und Seifert, Roland (2013) Species-dependent activities of GPCR ligands: Lessons from histamine receptor orthologs. Trends in Pharmacological Sciences 34 (1), S. 13-32. Volltext nicht vorhanden.

Seifert, Roland und Dove, Stefan (2013) Inhibitors of Bacillus anthracis edema factor. Pharmacology & Therapeutics 140 (2), S. 200-212. Volltext nicht vorhanden.

Reher, Till M., Neumann, Detlef, Buschauer, Armin und Seifert, Roland (2012) Incomplete activation of human eosinophils via the histamine H(4)-receptor: Evidence for ligand-specific receptor conformations. Biochemical Pharmacology 84 (2), S. 192-203. Volltext nicht vorhanden.

Birnkammer, Tobias, Spickenreither, Anja, Brunskole, Irena, Lopuch, Miroslaw, Kagermeier, Nicole, Bernhardt, Günther, Dove, Stefan, Seifert, Roland, Elz, Sigurd und Buschauer, Armin (2012) The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. Journal of Medicinal Chemistry 55 (3), S. 1147-1160. Volltext nicht vorhanden.

Göttle, Martin, Dove, Stefan und Seifert, Roland (2012) Bacillus anthracis edema factor substrate specificity: evidence for new modes of action. Toxins 4 (7), S. 505-535.

Taha, Hesham, Dove, Stefan, Geduhn, Jens, König, Burkhard, Shen, Yuequan, Tang, Wei-Jen und Seifert, Roland (2012) Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 monoand bis-(M)ANT-substituted nucleoside 5′-triphosphates. Naunyn-Schmiedeberg's Archives of Pharmacology (385), S. 57-68. Volltext nicht vorhanden.

Appl, Heidrun, Holzammer, Tobias, Dove, Stefan, Haen, Ekkehard, Strasser, Andrea und Seifert, Roland (2012) Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics. Naunyn-Schmiedeberg's archives of pharmacology 385 (2), S. 145-170. Volltext nicht vorhanden.

Seifert, Roland und Dove, Stefan (2012) Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis. Trends in microbiology 20 (7), S. 343-351. Volltext nicht vorhanden.

Brunskole, Irena, Strasser, Andrea, Seifert, Roland und Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), S. 301-317. Volltext nicht vorhanden.

Hübner, Melanie, Dixit, A., Mou, T.-C., Lushington, Gerald H., Pinto, Cibele S., Gille, A., Geduhn, Jens, König, Burkhard, Sprang, S. R. und Seifert, Roland (2011) Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2`,3`-O-(N-Methylanthraniloyl)-Inosine 5`-Triphosphate. Molecular Pharmacology 80 (1), S. 87-96. Volltext nicht vorhanden.

Erdorf, Miriam und Seifert, Roland (2011) Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (4), S. 357-372. Volltext nicht vorhanden.

Pop, Nathalie, Igel, Patrick, Brennauer, Albert, Cabrele, Chiara, Bernhardt, Günther, Seifert, Roland und Buschauer, Armin (2011) Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells. Journal of Receptors and Signal Transduction 31 (4), S. 271-285. Volltext nicht vorhanden.

Schnell, David, Brunskole, Irena, Ladova, Katerina, Schneider, Erich H., Igel, Patrick, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), S. 457-470. Volltext nicht vorhanden.

Seifert, Roland, Schneider, Erich H., Dove, Stefan, Brunskole, Irena, Neumann, Detlef, Strasser, Andrea und Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), S. 631-638. Volltext nicht vorhanden.

Geduhn, Jens, Dove, Stefan, Shen, Yuequan, Tang, Wei-Jen, König, Burkhard und Seifert, Roland (2011) Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5'-triphosphates as Potent and Selective Inhibitors of Bordetella pertussis CyaA. The Journal of pharmacology and experimental therapeutics 336 (1), S. 104-115. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2011) Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H1R. Biochemical Pharmacology 12, S. 1910-1918. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Elz, Sigurd, Seifert, Roland und Strasser, Andrea (2011) Na-methylated phenylhistamines exhibit affinity to the hH4R - a pharmacological and molecular modelling study. Naunyn Schmiedeberg's Arch Pharmacol 384, S. 287-299. Volltext nicht vorhanden.

Pinto, Cibele S., Lushington, Gerald H., Richter, M., Gille, A., Geduhn, Jens, König, Burkhard, Mou, T.-C., Sprang, S. R. und Seifert, Roland (2011) Structure–activity relationships for the interactions of 2`- and 3`-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochemical Pharmacology 82 (4), S. 358-370. Volltext nicht vorhanden.

Schnell, David, Strasser, Andrea und Seifert, Roland (2010) Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. Biochemical Pharmacology 80 (9), S. 1437-1449. Volltext nicht vorhanden.

Desch, Matthias, Schinner, Elisabeth, Kees, Frieder K., Hofmann, F., Seifert, Roland und Schlossmann, Jens (2010) Cyclic cytidine 3´,5´-monophosphate (cCMP) signals via cGMP kinase I. FEBS Letters 584 (18), S. 3979-3984. Volltext nicht vorhanden.

Schneider, E. H., Strasser, Andrea, Thurmond, R. L. und Seifert, Roland (2010) Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands. Journal of Pharmacology and Experimental Therapeutics 334 (2), S. 513-521. Volltext nicht vorhanden.

Ghorai, Prasanta, Kraus, Anja, Birnkammer, Tobias, Geyer, Roland, Bernhardt, Günther, Dove, Stefan, Seifert, Roland, Elz, Sigurd und Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), S. 3173-3176. Volltext nicht vorhanden.

Schnell, David und Seifert, Roland (2010) Modulation of Histamine H(3) receptor function by monovalent ions. Neuroscience Letters 472 (2), S. 114-118. Volltext nicht vorhanden.

Schnell, David, Burleigh, Katrina, Seifert, Roland und Trick, Jonathan (2010) No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers. Journal of Pharmacology and Experimental Therapeutics . JPET 332 (3), S. 996-1005. Volltext nicht vorhanden.

Göttle, Martin, Dove, Stefan, Kees, Frieder K., Schlossmann, Jens, Geduhn, Jens, König, Burkhard, Shen, Y., Tang, W. J., Kaever, V. und Seifert, Roland (2010) Citidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA. Biochemistry 49, S. 5494-5503. Volltext nicht vorhanden.

Geiger, Sarah, Nickl, Kathrin, Schneider, Erich H., Seifert, Roland und Heilmann, Jörg (2010) Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands. Naunyn-Schmiedebergs Archiv für Pharmakologie 382 (2), S. 177-191. Volltext nicht vorhanden.

Schneider, Erich H., Schnell, David, Strasser, Andrea, Dove, Stefan und Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. Journal of Pharmacology and Experimental Therapeutics 333 (2), S. 382-392. Volltext nicht vorhanden.

Schneider, Erich, Schnell, David, Strasser, Andrea, Dove, Stefan und Seifert, Roland (2010) Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 333 (2), S. 382-392. Volltext nicht vorhanden.

Igel, Patrick, Geyer, Roland, Straßer, Andrea, Dove, Stefan, Seifert, Roland und Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), S. 6297-6313. Volltext nicht vorhanden.

Igel, Patrick, Schneider, Erich, Schnell, David, Elz, Sigurd, Seifert, Roland und Buschauer, Armin (2009) N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. Journal of Medicinal Chemistry 52 (8), S. 2623-2627. Volltext nicht vorhanden.

Kraus, Anja, Ghorai, Prasanta, Birnkammer, Tobias, Schnell, David, Elz, Sigurd, Seifert, Roland, Dove, Stefan, Bernhardt, Günther und Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), S. 232-240. Volltext nicht vorhanden.

Igel, Patrick, Schnell, David, Bernhardt, Günther, Seifert, Roland und Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), S. 225-231. Volltext nicht vorhanden.

Wittmann, Hans-Joachim, Seifert, Roland und Strasser, Andrea (2009) Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H1-receptor. Molecular Pharmacology 76, S. 25-37. Volltext nicht vorhanden.

Seifert, Roland und Dove, Stefan (2009) Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities. Mol. Pharmacol. 75 (1), S. 13-18. Volltext nicht vorhanden.

Deml, Karl-Friedrich, Beermann, S, Neumann, Detlef, Strasser, Andrea und Seifert, Roland (2009) Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Mol Pharmacol : Molecular pharmacology 76 (5), S. 1019-1030. Volltext nicht vorhanden.

Taha, H. M., Schmidt, J., Göttle, M., Suryanarayana, S., Shen, Y., Tang, W.-J., Gille, A., Geduhn, Jens, König, Burkhard, Dove, Stefan und Seifert, Roland (2009) Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides. Mol. Pharmacol. 75 (3), S. 693-703. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim, Kunze, Marc, Elz, Sigurd und Seifert, Roland (2009) Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea-pig H1-receptor. Mol Pharmacol : Molecular pharmacology 75, S. 454-465. Volltext nicht vorhanden.

Egger, Michael, Maity, Prantik, Hübner, Melanie, Seifert, Roland und König, Burkhard (2009) Synthesis and pharmacological properties of new tetracyclic forskolin analogues. European Journal of Organic Chemistry 2009 (21), S. 3613-3618. Volltext nicht vorhanden.

Ghorai, Prasanta, Kraus, Anja, Keller, Max, Götte, Carsten, Igel, Patrick, Schneider, Erich, Schnell, David, Bernhardt, Günther, Dove, Stefan, Zabel, Manfred, Elz, Sigurd, Seifert, Roland und Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), S. 7193-7204. Volltext nicht vorhanden.

Strasser, Andrea, Striegl, Birgit, Wittmann, Hans-Joachim und Seifert, Roland (2008) Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms. Journal of Pharmacology and Experimental Therapeutics 324, S. 60-71. Volltext nicht vorhanden.

Nickl, Kathrin, Gardner, Eric E., Geiger, Sarah, Heilmann, Jörg und Seifert, Roland (2008) Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Galpha i2beta 1gamma 2. Neuroscience letters 447 (1), S. 68-72. Volltext nicht vorhanden.

Dove, Stefan, Seifert, Roland, Elz, Sigurd und Buschauer, Armin (2008) Frontiers in medicinal chemistry in Regensburg. ChemMedChem 3 (8), S. 1181-1184. Volltext nicht vorhanden.

Strasser, Andrea, Wittmann, Hans-Joachim und Seifert, Roland (2008) Ligand-specific contribution of the N-terminus and E2-loop to pharmacological properties of the histamine H1-receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 326 (3), S. 783-791. Volltext nicht vorhanden.

Egger, Michael, Pellett, Patrina, Nickl, Kathrin, Geiger, Sarah, Graetz, Stephanie, Seifert, Roland, Heilmann, Jörg und Koenig, Burkhard (2008) Synthesis and cannabinoid receptor activity of ketoalkenes from echinacea pallida and nonnatural analogues. Chemistry: a European journal 14 (35), S. 10978-10987. Volltext nicht vorhanden.

Göttle, Martin, Dove, Stefan, Steindel, Phillip, Shen, Yuequan, Tang, Wei-Jen, Geduhn, Jens, König, Burkhard und Seifert, Roland (2007) Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides. Molecular Pharmacology 72 (3), S. 526-535.

Lorenz, Veronika, Pinto, Cibele S. und Seifert, Roland (2007) Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. Neuroscience Letters 420 (1), S. 6-11.

Wang, Jenna L., Guo, Jian-Xin, Zhang, Qi-Yuan, Wu, Jay J.-Q., Seifert, Roland und Lushington, Gerald H. (2007) A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified
and unmodified nucleotide inhibitors. Bioorganic & Medicinal Chemistry 15 (8), S. 2993-3002.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2007) Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors. Journal of Pharmacology and Experimental Therapeutics 321 (3), S. 983-995.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2007) Mutations of Cys-17 and Ala-271 in the Human Histamine H₂
Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity. Journal of Pharmacology and Experimental Therapeutics 321 (3), S. 975-982.

Xie, Sheng-Xue, Schalkhausser, Fabian, Ye, Qi-Zhuang, Seifert, Roland und Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), S. 9-16.

Rottlaender, Dennis, Matthes, Jan, Vatner, Stephen F., Seifert, Roland und Herzig, Stefan (2007) Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate. Journal of Pharmacology and Experimental Therapeutics 321 (2), S. 608-615.

Schlegel, Birgit, Laggner, Christian, Meier, Rene, Langer, Thierry, Schnell, David, Seifert, Roland, Stark, Holger, Höltje, Hans-Dieter und Sippl, Wolfgang (2007) Generation of a homology model of the human histamine H₃ receptor for ligand docking and pharmacophore-based screening. Journal of Computer-Aided Molecular Design.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2007) Point Mutations in the Second Extracellular Loop of the Histamine H2 Receptor do not affect the Species-Selective Activity of Guanidine-Type Agonists. Naunyn Schmiedebergs Arch. Pharmacol. 376 (4), S. 253-264. Zugang zum Volltext eingeschränkt.

Xie, Sheng-Xue, Kraus, Anja, Ghorai, Prasanta, Ye, Qi-Zhuang, Elz, Sigurd, Buschauer, Armin und Seifert, Roland (2006) N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors. Journal of Pharmacology and Experimental Therapeutics 317 (3), S. 1262-1268. Zugang zum Volltext eingeschränkt.

Xie, Sheng-Xue, Ghorai, Prasanta, Ye, Qi-Zhuang, Buschauer, Armin und Seifert, Roland (2006) Probing Ligand-Specific Histamine H1- and H2-Receptor
Conformations with NG-Acylated Imidazolylpropylguanidines. The Journal of Pharmacology and Experimental Therapeutics 317 (1), S. 139-146. Zugang zum Volltext eingeschränkt.

Pinto, Cibele S. und Seifert, Roland (2006) Decreased GTP-stimulated adenylyl cyclase activity in
HPRT-deficient human and mouse fibroblast and rat
B103 neuroblastoma cell membranes. Journal of Neurochemistry 96 (2), S. 454-459. Zugang zum Volltext eingeschränkt.

Xie, Sheng-Xue, Petrache, Georgiana, Schneider, Erich, Ye, Qi-Zhuang, Bernhardt, Günther, Seifert, Roland und Buschauer, Armin (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters 16 (15), S. 3886-3890. Volltext nicht vorhanden.

Dove, Stefan, Elz, Sigurd, Seifert, Roland und Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), S. 941-954. Volltext nicht vorhanden.

Seifert, Roland, Wenzel-Seifert, Katharina, Bürckstümmer, Tilmann, Pertz, Heinz H., Schunack, Walter, Dove, Stefan, Buschauer, Armin und Elz, Sigurd (2003) Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,. Journal of Pharmacology and Experimental Therapeutics 305, S. 1104-1115. Volltext nicht vorhanden.

Kelley, Melissa T., Bürckstümmer, Tilmann, Wenzel-Seifert, Katharina, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2001) Distinct interaction of human and guinea pig histamine H_2-Receptor with guanidine-type agonists,. Molecular Pharmacology 60 (6), S. 1210-1225. Volltext nicht vorhanden.

Wenzel-Seifert, Katharina, Kelley, Melissa T., Buschauer, Armin und Seifert, Roland (2001) Similar apparent constitutive activity of human histamine H_2-receptor fused to long and short splice variants of Gsa,. Journal of Pharmacology and Experimental Therapeutics 299 (3), S. 1013-1020. Volltext nicht vorhanden.

Hagelüken, Astrid, Burde, Rahel, Nürnberg, Bernd, Harhammer, Rainer, Buschauer, Armin und Seifert, Roland (1995) Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism. Naunyn Schmiedeberg's Arch. Pharmacol. 351, S. 305-308. Volltext nicht vorhanden.

Klinker, J. F., Schwaner, I., Offermanns, S., Hagelüken, A. und Seifert, Roland (1994) Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants. Biochemical pharmacology 48 (10), S. 1857-1864.

Wenzel-Seifert, K., Schächtele, C., Hummel, R., Grünbaum, L. und Seifert, Roland (1994) Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Biochemical pharmacology 48 (5), S. 859-864.

Seifert, Roland, Grünbaum, L. und Schultz, Günter (1994) Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores. Naunyn-Schmiedeberg's archives of pharmacology 349 (4), S. 355-361.

Musgrave, I. F. und Seifert, Roland (1994) Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors. Biochemical pharmacology 47 (2), S. 233-239.

Hagelüken, A., Grünbaum, L., Nürnberg, B., Harhammer, R., Schunack, W. und Seifert, Roland (1994) Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. Biochemical pharmacology 47 (10), S. 1789-1795.

Musgrave, I. F., Seifert, Roland und Schultz, Günter (1994) Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. The Biochemical journal 301 ( Pt 2, S. 437-441.

Klinker, J. F., Hagelüken, A., Grünbaum, L., Heilmann, I., Nürnberg, B., Harhammer, R., Offermanns, S., Schwaner, I., Ervens, J., Wenzel-Seifert, K., Müller, T. und Seifert, Roland (1994) Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. The Biochemical journal 304 ( Pt 2, S. 377-383.

Wenzel-Seifert, K., Schächtele, C. und Seifert, Roland (1994) N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. Biochemical and biophysical research communications 200 (3), S. 1536-1543.

Naim, M., Seifert, Roland, Nürnberg, B., Grünbaum, L. und Schultz, Günter (1994) Some taste substances are direct activators of G-proteins. The Biochemical journal 297 ( Pt 3, S. 451-454.

Berger, M., Offermanns, S., Seifert, Roland und Schultz, Günter (1994) Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. The American journal of physiology 266 (6 Pt 1), C1684-C1691.

Seifert, Roland, Hagelüken, A., Höer, A., Höer, D., Grünbaum, L., Offermanns, S., Schwaner, I., Zingel, V., Schunack, W. und Schultz, Günter (1994) The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. Molecular Pharmacology 45 (4), S. 578-586.

Wenzel-Seifert, Katharina und Seifert, Roland (1993) Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. The Journal of Immunology 150 (10), S. 4591-4599.

Klinker, J. F., Höer, A., Schwaner, I., Offermanns, S., Wenzel-Seifert, Katharina und Seifert, Roland (1993) Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. The Biochemical journaL 296 ( Pt 1, S. 245-251.

Wenzel-Seifert, Katharina und Seifert, Roland (1993) Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. Naunyn-Schmiedeberg's archives of pharmacology 348 (1), S. 7-13.

Musgrave, I. F., Genieser, H. G., Maronde, E. und Seifert, Roland (1993) Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS letters 318 (3), S. 227-230.

Krautwurst, D., Seifert, Roland, Hescheler, J. und Schultz, Günter (1992) Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. The Biochemical journal 288 ( Pt 3, S. 1025-1035.

Klinz, F. J., Seifert, Roland, Schwaner, I., Gausepohl, H., Frank, R. und Schultz, Günter (1992) Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells. European journal of biochemistry 207 (1), S. 207-213.

Seifert, Roland, Höer, Ariane, Offermann, Stefan, Buschauer, Armin und Schunack, Walter (1992) Histamine increases Ca^2+ in dibutyryl cyclic AMP-differentiated HL-60 cells via H_1-receptors and is an incomplete secretagogue. Mol. Pharmacol. 42, S. 227-234.

Seifert, Roland, Höer, Ariane, Schwaner, Ingo und Buschauer, Armin (1992) Histamine increases cytosolic Ca^2+ in HL-60 promyelocytes predominantly via H_2-receptors with an unique agonist/antagonist profile and induces functional differentiation. Molecular Pharmacology 42, S. 235-241.

Seifert, Roland, Serke, S., Huhn, D., Bessler, W. G., Hauschildt, S., Metzger, J., Wismüller, K. H. und Jung, G. (1992) Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation. European journal of biochemistry / FEBS 203 (1-2), S. 143-151.

Offermanns, S., Seifert, Roland, Metzger, J. W., Jung, G., Lieberknecht, A., Schmidt, U. und Schultz, Günter (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochemical Journal 282 ( Pt 2, S. 551-7.

Ervens, J. und Seifert, Roland (1992) Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism. Biochemical pharmacology 44 (4), S. 637-644.

Schwaner, I., Seifert, Roland und Schultz, Günter (1992) Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. The Biochemical journal 281 ( Pt 2, S. 301-307.

Schwaner, I., Seifert, Roland und Schultz, Günter (1992) The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. Eicosanoids 5 Suppl, S10-512. Volltext nicht vorhanden.

Seifert, Roland, Schultz, Günter, Richter-Freund, M., Metzger, J., Wiesmüller, K. H., Jung, G., Bessler, W. G. und Hauschildt, S. (1990) Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. The Biochemical journal 267 (3), S. 795-802.

Jungblut, P. R. und Seifert, Roland (1990) Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells. Journal of biochemical and biophysical methods 21 (1), S. 47-58.

Burde, Rahel, Buschauer, Armin und Seifert, Roland (1990) Characterization of histamine H_2-receptors in human neutrophils with a series of guanidine analogues of impromidine: Are cell type-specific H_2-receptors involved in the regulation of NADPH oxidase? Naunyn-Schmiedeberg's Archives of Pharmacology 341, S. 455-461.

Wenzel-Seifert, Katharina und Seifert, Roland (1990) Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells. Immunobiology 181 (4-5), S. 298-316.

Seifert, Roland, Burde, R. und Schultz, Günter (1989) Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. The Biochemical journal 259 (3), S. 813-819.

Seifert, Roland, Jungblut, P. und Schultz, Günter (1989) Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells. Biochemical and biophysical research communications 161 (3), S. 1109-1117.

Schmidt, H. H., Seifert, Roland und Böhme, E. (1989) Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. FEBS letters 244 (2), S. 357-360.

Rudolph, U., Koesling, D., Hinsch, K. D., Seifert, Roland, Bigalke, M., Schultz, Günter und Rosenthal, W. (1989) G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. Molecular and cellular endocrinology 63 (1-2), S. 143-153.

Burde, Rahel, Seifert, Roland, Buschauer, Armin und Schultz, Günther (1989) Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H_2-receptors. Naunyn-Schmiedeberg's archives of pharmacology 340, S. 671-678.

Seifert, Roland und Schultz, Günter (1989) Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. Trends in pharmacological sciences 10 (9), S. 365-369.

Seifert, Roland, Burde, R. und Schultz, Günter (1989) Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. Naunyn-Schmiedeberg's archives of pharmacology 340 (1), S. 101-106.

Seifert, Roland, Wenzel, Katharina, Eckstein, F. und Schultz, Günter (1989) Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. European journal of biochemistry / FEBS 181 (1), S. 277-285.

Seifert, Roland, Schächtele, C., Rosenthal, W. und Schultz, Günter (1988) Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol. Biochemical and biophysical research communications 154 (1), S. 20-26.

Schächtele, C., Seifert, Roland und Osswald, H. (1988) Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochemical and biophysical research communications 151 (1), S. 542-547.

Seifert, Roland und Schächtele, C. (1988) Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase. Biochemical and biophysical research communications 152 (2), S. 585-592.

Seifert, Roland, Rosenthal, W., Schultz, Günter, Wieland, T., Gierschick, P. und Jakobs, K. H. (1988) The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. European journal of biochemistry / FEBS 175 (1), S. 51-55.

Seifert, Roland, Schächtele, C. und Schultz, Günter (1987) Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. Biochemical and biophysical research communications 149 (2), S. 762-768.

Seifert, Roland und Schultz, Günter (1987) Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides. European journal of biochemistry / FEBS 162 (3), S. 563-569.

Seifert, Roland und Schultz, Günter (1987) Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells. Biochemical and biophysical research communications 146 (3), S. 1296-1302.

Seifert, Roland, Rosenthal, W. und Schultz, Günter (1986) Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils. FEBS letters 205 (1), S. 161-165.

Buchkapitel

Dove, Stefan (2016) Mammalian Nucleotidyl Cyclases and Their Nucleotide Binding Sites. In: Seifert, Roland, (ed.) Non-canonical Cyclic Nucleotides. Handbook of Experimental Pharmacology, 238. Springer International Publishing, Cham, Switzerland, S. 49-66. ISBN 978-3-319-52673-7 (online), 978-3-319-52671-3 (print). Volltext nicht vorhanden.

Seifert, Roland und Dove, Stefan (2012) 3/14. Molecular analysis of agonist stereoisomers at β2-adrenoceptors. In: Jozwiak, Krzysztof und Lough, W. John und Wainer, Irving W., (eds.) Drug stereochemistry : Analytical methods and pharmacology. 3. ed. Informa Healthcare, New York, S. 274-293. ISBN 9781420092387. Volltext nicht vorhanden.

Buch

Seifert, Roland und Schultz, Günter (1991) The superoxide- forming NADPH oxidase of phagocytes: an enzyme system regulated by multiple mechanisms. Reviews of physiology, biochemistry, and pharmacology, 117. Springer, Berlin. ISBN 3-540-53663-9, 0-387-53663-9.

Hochschulschrift

Seifert, Roland (1986) Nikotinamidmethylierung in normalen Geweben und Tumorzellen von Ratte und Maus. Dissertation, Berlin, Freie Universität.

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