Anzahl der Einträge: 185.
Grätz, Lukas,
Müller, Christoph,
Pegoli, Andrea ,
Schindler, Lisa,
Bernhardt, Günther und
Littmann, Timo
(2022)
Insertion of Nanoluc into the Extracellular Loops as a Complementary Method To Establish BRET-Based Binding Assays for GPCRs.
ACS Pharmacology & Translational Science 5 (11), S. 1142-1155.
Schindler, Lisa,
Moosbauer, Jutta,
Schmidt, Daniel ,
Spruss, Thilo,
Grätz, Lukas,
Lüdeke, Steffen,
Hofheinz, Frank,
Meister, Sebastian,
Echtenacher, Bernd,
Bernhardt, Günther,
Pietzsch, Jens ,
Hellwig, Dirk und
Keller, Max
(2022)
Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors.
Cancers 14 (19), S. 4922.
Biselli, Sabrina,
Bresinsky, Merlin,
Tropmann, Katharina,
Forster, Lisa ,
Honisch, Claudia ,
Buschauer, Armin,
Bernhardt, Günther und
Pockes, Steffen
(2021)
Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R.
European Journal of Medicinal Chemistry 214, S. 113190.
Volltext nicht vorhanden.
Littmann, Timo,
Ozawa, Takeaki und
Bernhardt, Günther
(2021)
7. Quantitative Determination and Imaging of Gαq Signaling in Live Cells via Split-Luciferase Complementation.
In:
Kim, Dung-Bae, (ed.)
Live Cell Imaging: Methods and Protocols.
Methods in Molecular Biology, 2274 (7).
Humana, Springer Science+Business Media, LLC, part of Springer Nature 2021, New York, S. 69-78.
ISBN 978-1-0716-1257-6.
Volltext nicht vorhanden.
Höring, Carina ,
Seibel, Ulla ,
Tropmann, Katharina,
Grätz, Lukas ,
Mönnich, Denise ,
Pitzl, Sebastian,
Bernhardt, Günther ,
Pockes, Steffen und
Strasser, Andrea
(2020)
A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes.
International Journal of Molecular Sciences 21 (22), S. 8440.
Grätz, Lukas,
Tropmann, Katharina,
Bresinsky, Merlin,
Müller, Christoph,
Bernhardt, Günther und
Pockes, Steffen
(2020)
NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells.
Scientific Reports 10, S. 13288.
Bartole, Edith,
Grätz, Lukas,
Littmann, Timo,
Wifling, David ,
Seibel, Ulla,
Buschauer, Armin und
Bernhardt, Günther
(2020)
UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors.
Journal of Medicinal Chemistry 63 (10), S. 5297-5311.
Volltext nicht vorhanden.
Spinnler, Katrin,
von Krüchten, Lara,
Konieczny, Adam,
Schindler, Lisa,
Bernhardt, Günther und
Keller, Max
(2020)
An Alkyne-functionalized Arginine for Solid-Phase Synthesis Enabling “Bioorthogonal” Peptide Conjugation.
ACS Medicinal Chemistry Letters 11 (3), S. 334-339.
Volltext nicht vorhanden.
Keller, Max,
Mahuroof, Shahani A.,
Hong Yee, Vivyanne,
Carpenter, Jessica,
Schindler, Lisa,
Littmann, Timo,
Pegoli, Andrea,
Hübner, Harald,
Bernhardt, Günther,
Gmeiner, Peter und
Holliday, Nicholas D.
(2020)
Fluorescence Labeling of Neurotensin(8–13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity.
ACS Medicinal Chemistry Letters 11 (1), S. 16-22.
Volltext nicht vorhanden.
Biselli, Sabrina,
Alencastre, Inês,
Tropmann, Katharina,
Erdmann, Daniela,
Chen, Mengya,
Littmann, Timo,
Maia, André F. ,
Gomez-Lazaro, Maria,
Tanaka, Miho,
Ozawa, Takeaki,
Keller, Max,
Lamghari, Meriem,
Buschauer, Armin und
Bernhardt, Günther
(2020)
Fluorescent H2 Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications.
ACS Medicinal Chemistry Letters 11 (8), S. 1521-1528.
Volltext nicht vorhanden.
She, Xueke,
Pegoli, Andrea,
Gruber, Corinna G.,
Wifling, David ,
Carpenter, Jessica,
Hübner, Harald,
Chen, Mengya,
Wan, Jianfei,
Bernhardt, Günther,
Gmeiner, Peter ,
Holliday, Nicholas D. und
Keller, Max
(2020)
Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor.
Journal of Medicinal Chemistry 63 (8), S. 4133-4154.
Volltext nicht vorhanden.
Antoni, Frauke,
Bause, Manuel,
Scholler, Matthias,
Bauer, Stefanie,
Stark, Simone Alexandra,
Jackson, Scott M.,
Manolaridis, Ioannis,
Locher, Kaspar P.,
König, Burkhard ,
Buschauer, Armin und
Bernhardt, Günther
(2020)
Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP).
European Journal of Medicinal Chemistry 191.
Volltext nicht vorhanden.
Maschauer, Simone,
Ott, Julian J. ,
Bernhardt, Günther,
Kuwert, Torsten,
Keller, Max und
Prante, Olaf
(2019)
18F-labelled triazolyl-linked argininamides targeting the neuropeptide Y Y1R for PET Imaging of mammary carcinoma.
Scientific Reports 9, S. 12990.
Pegoli, Andrea,
Wifling, David ,
Gruber, Corinna G.,
Xueke, She,
Hübner, Harald,
Bernhardt, Günther,
Gmeiner, Peter und
Keller, Max
(2019)
Conjugation of Short Peptides to Dibenzodiazepinone-Type
Muscarinic Acetylcholine Receptor Ligands Determines M2R
Selectivity.
Journal of Medicinal Chemistry 62, S. 5358-5369.
Volltext nicht vorhanden.
Gergs, U. ,
Bernhardt, Günther,
Buchwalow, I. B.,
Edler, H.,
Fröba, J.,
Keller, Max,
Kirchhefer, U.,
Köhler, F.,
Mißlinger, N.,
Wache, H. und
Neumann, J.
(2019)
Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors.
Journal of Pharmacology and Experimental Therapeutics 369 (1), S. 129-141.
Volltext nicht vorhanden.
Bartole, Edith,
Littmann, Timo,
Tanaka, Miho,
Ozawa, Takeaki,
Buschauer, Armin und
Bernhardt, Günther
(2019)
[3H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H4 Receptors.
Journal of Medicinal Chemistry 62 (17), S. 8338-8356.
Volltext nicht vorhanden.
Yang, Zhenlin,
Han, Shuo,
Keller, Max,
Kaiser, Anette,
Bender, Brain J.,
Bosse, Mathias,
Burkert, Kerstin,
Kögler, Lisa M.,
Wifling, David ,
Bernhardt, Günther,
Plank, Nicole,
Littmann, Timo,
Schmidt, Peter,
Yi, Cuiying,
Li, Beibei,
Ye, Sheng,
Zhang, Rongguang,
Xu, Bo,
Larhammar, Dan,
Stevens, Raymond C. ,
Huster, Daniel,
Meiler, Jens,
Zhao, Qiang,
Beck-Sickinger, Annette G.,
Buschauer, Armin und
Wu, Beili
(2018)
Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor.
Nature 556, S. 520-524.
Volltext nicht vorhanden.
Jackson, Scott M.,
Manolaridis, Ioannis,
Kowal, Julia ,
Zechner, Melanie,
Taylor, Nicholas M. I. ,
Bause, Manuel,
Bauer, Stefanie,
Bartholomaeus, Ruben,
Bernhardt, Günther,
König, Burkhard ,
Buschauer, Armin,
Stahlberg, Henning ,
Altmann, Karl-Heinz und
Locher, Kaspar P.
(2018)
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nature Structural & Molecular Biology 25 (4), S. 333-340.
Volltext nicht vorhanden.
Peña-Solórzano, Diana,
Scholler, Matthias,
Bernhardt, Günther,
Buschauer, Armin ,
König, Burkhard und
Ochoa-Puentes, Cristian
(2018)
Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators.
ACS Medicinal Chemistry Letters 9, S. 854-859.
Volltext nicht vorhanden.
She, Xueke,
Pegoli, Andrea,
Mayr, Judith,
Hübner, Harald,
Bernhardt, Günther ,
Gmeiner, Peter und
Keller, Max
(2017)
Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity.
ACS Omega 2 (10), S. 6741-6754.
Dukorn, Stefanie,
Littmann, Timo,
Keller, Max,
Kuhn, Kilian K.,
Cabrele, Chiara ,
Baumeister, Paul,
Bernhardt, Günther und
Buschauer, Armin
(2017)
Fluorescence- and radio-labeling of Lys4,Nle17,30hPP yields molecular tools for the NPY Y4 receptor.
Bioconjugate Chemistry.
Volltext nicht vorhanden.
Keller, Max ,
Maschauer, Simone,
Brennauer, Albert,
Tripal, Philipp,
Koglin, Norman,
Dittrich, Ralf,
Bernhardt, Günther,
Kuwert, Torsten,
Wester, Hans-Jürgen,
Buschauer, Armin und
Prante, Olaf
(2017)
Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma.
ACS Medicinal Chemistry Letters 8, S. 304-309.
Volltext nicht vorhanden.
Kuhn, Kilian K.,
Littmann, Timo,
Dukorn, Stefanie,
Tanaka, Miho,
Keller, Max,
Ozawa, Takeaki,
Bernhardt, Günther und
Buschauer, Armin
(2017)
In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists.
ACS Omega 2 (7), S. 3616-3631.
Pegoli, Andrea ,
She, Xueke,
Wifling, David ,
Hübner, Harald,
Bernhardt, Günther,
Gmeiner, Peter und
Keller, Max
(2017)
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor.
Journal of Medicinal Chemistry 60 (8), S. 3314-3334.
Volltext nicht vorhanden.
Lieb, Sebastian,
Littmann, Timo,
Plank, Nicole,
Felixberger, Johannes,
Tanaka, Miho,
Schäfer, Thorsten,
Krief, Stéphane,
Elz, Sigurd,
Friedland, Kristina,
Bernhardt, Günther,
Wegener, Joachim,
Ozawa, Takeaki und
Buschauer, Armin
(2016)
Label-free versus conventional cellular assays: functional investigations on the human histamine H1 receptor.
Pharmacological Research 114, S. 13-26.
Volltext nicht vorhanden.
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter,
Elz, Sigurd und
Strasser, Andrea
(2016)
Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs.
Pharmacological Research 113, S. 610-625.
(Im Druck)
Volltext nicht vorhanden.
Kuhn, Kilian K.,
Ertl, Thomas,
Dukorn, Stefanie,
Keller, Max,
Bernhardt, Günther,
Reiser, Oliver und
Buschauer, Armin
(2016)
High affinity agonists of the neuropeptide Y (NPY) Y4 receptor derived from the C-terminal pentapeptide of human pancreatic polypeptide (hPP): synthesis, stereochemical discrimination and radiolabeling.
Journal of Medicinal Chemistry 59 (13), S. 6045-6058.
Volltext nicht vorhanden.
Edalat, Lena,
Stegen, Benjamin,
Klumpp, Lukas,
Haehl, Erik,
Schilbach, Karin,
Lukowski, Robert,
Kühnle, Matthias,
Bernhardt, Günther,
Buschauer, Armin,
Zips, Daniel,
Ruth, Peter und
Huber, Stephan M.
(2016)
BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells.
Oncotarget 7 (12), S. 14259-14278.
Volltext nicht vorhanden.
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter ,
Elz, Sigurd und
Strasser, Andrea
(2016)
Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs.
Pharmacological Research 113, S. 610-625.
Volltext nicht vorhanden.
Lieb, Sebastian,
Michaelis, Stefanie,
Plank, Nicole,
Bernhardt, Günther,
Buschauer, Armin und
Wegener, Joachim
(2016)
Label-free analysis of GPCR-stimulation: The critical impact of cell adhesion.
Pharmacological Research 108 (June), S. 65-74.
Volltext nicht vorhanden.
Keller, Max,
Kuhn, Kilian K.,
Einsiedel, Jürgen,
Hübner, Harald,
Biselli, Sabrina,
Mollereau, Catherine ,
Wifling, David,
Svobodova, Jaroslava,
Bernhardt, Günther,
Cabrele, Chiara ,
Vanderheyden, Patrick,
Gmeiner, Peter und
Buschauer, Armin
(2016)
Mimicking of arginine by functionalized Nω-carbamoylated arginine as a new broadly applicable approach to labeled bioactive peptides: high affinity angiotensin, neuropeptide Y, neuropeptide FF and neurotensin receptor ligands as examples.
Journal of Medicinal Chemistry 59 (5), S. 1925-1945.
Volltext nicht vorhanden.
Baumeister, Paul,
Erdmann, Daniela,
Biselli, Sabrina,
Kagermeier, Nicole,
Elz, Sigurd,
Bernhardt, Günther und
Buschauer, Armin
(2015)
3HUR-DE257: Development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist.
ChemMedChem 10 (1), S. 83-93.
Volltext nicht vorhanden.
Kagermeier, Nicole,
Werner, Kristin,
Keller, Max,
Baumeister, Paul,
Bernhardt, Günther,
Seifert, Roland und
Buschauer, Armin
(2015)
Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists.
Bioorganic & Medicinal Chemistry 23 (14), S. 3957-3969.
Volltext nicht vorhanden.
Huber, Stefan,
Huettner, Johannes Philip,
Hacker, Kristina,
Bernhardt, Günther,
König, Jörg und
Buschauer, Armin
(2015)
Esters of bendamustine are by far more potent cytotoxic agents than the parent compound against human sarcoma and carcinoma cells.
PLoS One 10 (7), PLoSe0133743.
Keller, Max,
Tränkle, Christian,
She, Xueke,
Pegoli, Andrea,
Bernhardt, Günther,
Buschauer, Armin und
Read, Roger W.
(2015)
M2 subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: effect of chemical homo-dimerization on orthosteric (and allosteric?) binding.
Bioorganic & Medicinal Chemistry 23 (14), S. 3970-3990.
Volltext nicht vorhanden.
Wifling, David,
Löffel, Karolin,
Nordemann, Uwe,
Strasser, Andrea,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland und
Buschauer, Armin
(2015)
Molecular determinants for the high constitutive activity of the human histamine H4 receptor: Functional studies on orthologs and mutants.
British Journal of Pharmacology 172, S. 785-798.
Volltext nicht vorhanden.
Keller, Max,
Weiss, Stefan,
Hutzler, Christoph,
Kuhn, Kilian K.,
Mollereau, Catherine,
Dukorn, Stefanie,
Schindler, Lisa,
Bernhardt, Günther,
König, Burkhard und
Buschauer, Armin
(2015)
N(omega)-carbamoylation of the argininamide moiety: an avenue to insurmountable NPY Y1 receptor antagonists and a radiolabeled selective high affinity molecular tool ([3H]UR-MK299) with extended residence time.
Journal of Medicinal Chemistry 58 (22), S. 8834-8849.
Volltext nicht vorhanden.
Huber, Stefan,
Antoni, Frauke,
Schickaneder, Christian,
Schickaneder, Helmut,
Bernhardt, Günther und
Buschauer, Armin
(2015)
Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: Kinetic investigations by HPLC.
Journal of Pharmaceutical and Biomedical Analysis 104, S. 137-143.
Volltext nicht vorhanden.
Schickaneder, Helmut,
Buschauer, Armin,
Bernhardt, Günther,
Schickaneder, Christian,
Limmert, Michael,
Huber, Stefan,
Lubbe, Mathias und
Hofmeier, Harald
(2013)
Esters of bendamustine and related compounds, and medical use thereof.
Volltext nicht vorhanden.
Berlicki, Lukasz,
Kaske, Melanie,
Gutierrez-Abad, Raquel,
Bernhardt, Günther,
Illa, Ona,
Ortuño, Rosa,
Cabrele, Chiara,
Buschauer, Armin und
Reiser, Oliver
(2013)
Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane- and cis-cyclopentane β-amino acids shifts selectivity toward the Y4 receptor.
Journal of Medicinal Chemistry 56 (21), S. 8422-8431.
Volltext nicht vorhanden.
Nordemann, Uwe,
Wifling, David,
Schnell, David,
Bernhardt, Günther,
Stark, Holger,
Seifert, Roland und
Buschauer, Armin
(2013)
Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts.
PLoS One 8 (9), e73961.
Bauer, Stefanie,
Ochoa Puentes, Cristian,
Sun, Qiu,
Bause, Manuel,
Bernhardt, Günther,
König, Burkhard und
Buschauer, Armin
(2013)
Quinoline carboxamide-type ABCG2 modulators: Indole and quinoline moieties as anilide replacements.
ChemMedChem 8 (11), S. 1773-1778.
Volltext nicht vorhanden.
Ochoa-Puentes, Cristian,
Bauer, Stefanie,
Kühnle, Matthias,
Bernhardt, Günther,
Buschauer, Armin und
König, Burkhard
(2013)
Benzanilide – Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-type ABCG2 Modulators.
ACS Medicinal Chemistry Letters 4 (4), S. 393-396.
Volltext nicht vorhanden.
Memminger, Martin,
Keller, Max,
Lopuch, Miroslaw,
Pop, Nathalie,
Bernhardt, Günther,
von Angerer, Erwin und
Buschauer, Armin
(2012)
The Neuropeptide Y Y1 receptor: a diagnostic marker? Expression in MCF-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts.
PLoS ONE 7 (12), e51032.
Birnkammer, Tobias,
Spickenreither, Anja,
Brunskole, Irena,
Lopuch, Miroslaw,
Kagermeier, Nicole,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd und
Buschauer, Armin
(2012)
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists.
Journal of Medicinal Chemistry 55 (3), S. 1147-1160.
Volltext nicht vorhanden.
Posavec, Damir,
Zabel, Manfred,
Bogner, Udo,
Bernhardt, Günther und
Knör, Günther
(2012)
Functionalized derivatives of 1,4-dimethylnaphthalene as precursors for biomedical applications: synthesis, structures, spectroscopy and photochemical activation in the presence of dioxygen.
Organic & biomolecular chemistry 10 (35), S. 7062-7069.
Braun, Stephan,
Botzki, Alexander,
Salmen, Sunnhild,
Textor, Christian,
Bernhardt, Günther,
Dove, Stefan und
Buschauer, Armin
(2011)
Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
European Journal of Medicinal Chemistry 46 (9), S. 4419-4429.
Volltext nicht vorhanden.
Pluym, Nikola,
Brennauer, Albert,
Keller, Max,
Ziemek, Ralf,
Pop, Nathalie,
Bernhardt, Günther und
Buschauer, Armin
(2011)
Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists.
ChemMedChem 6 (9), S. 1727-1738.
Volltext nicht vorhanden.
Pop, Nathalie,
Igel, Patrick,
Brennauer, Albert,
Cabrele, Chiara,
Bernhardt, Günther,
Seifert, Roland und
Buschauer, Armin
(2011)
Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells.
Journal of Receptors and Signal Transduction 31 (4), S. 271-285.
Volltext nicht vorhanden.
Keller, Max,
Erdmann, Daniela,
Teng, Shangjun,
Pop, Nathalie,
Pluym, Nikola,
Bernhardt, Günther und
Buschauer, Armin
(2011)
Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools.
Bioorganic & Medicinal Chemistry 19 (9), S. 2859-2878.
Volltext nicht vorhanden.
Ochoa Puentes, Cristian,
Höcherl, Peter,
Kühnle, Matthias,
Bauer, Stefanie,
Kürger, Kira,
Bernhardt, Günther,
Buschauer, Armin und
König, Burkhard
(2011)
Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).
Bioorganic & Medicinal Chemistry Letters 21 (12), S. 3654-3657.
Volltext nicht vorhanden.
Ghorai, Prasanta,
Kraus, Anja,
Birnkammer, Tobias,
Geyer, Roland,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd und
Buschauer, Armin
(2010)
Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity.
Bioorganic & Medicinal Chemistry Letters 20 (10), S. 3173-3176.
Volltext nicht vorhanden.
Kraus, Anja,
Ghorai, Prasanta,
Birnkammer, Tobias,
Schnell, David,
Elz, Sigurd,
Seifert, Roland,
Dove, Stefan,
Bernhardt, Günther und
Buschauer, Armin
(2009)
N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists.
ChemMedChem 4 (2), S. 232-240.
Volltext nicht vorhanden.
Igel, Patrick,
Schnell, David,
Bernhardt, Günther,
Seifert, Roland und
Buschauer, Armin
(2009)
Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand.
ChemMedChem 4 (2), S. 225-231.
Volltext nicht vorhanden.
Kühnle, Matthias,
Egger, Michael,
Müller, Christine,
Mahringer, Anne,
Bernhardt, Günther,
Fricker, Gert,
König, Burkhard und
Buschauer, Armin
(2009)
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
Journal of Medicinal Chemistry 52 (4), S. 1190-1197.
Volltext nicht vorhanden.
Keller, Max,
Pop, Nathalie,
Hutzler, Christoph,
Beck-Sickinger, Annette G.,
Bernhardt, Günther und
Buschauer, Armin
(2008)
Guanidine - acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist.
Journal of Medicinal Chemistry 51 (24), S. 8168-8172.
Volltext nicht vorhanden.
Ghorai, Prasanta,
Kraus, Anja,
Keller, Max,
Götte, Carsten,
Igel, Patrick,
Schneider, Erich,
Schnell, David,
Bernhardt, Günther,
Dove, Stefan,
Zabel, Manfred,
Elz, Sigurd,
Seifert, Roland und
Buschauer, Armin
(2008)
Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.
Journal of Medicinal Chemistry 51 (22), S. 7193-7204.
Volltext nicht vorhanden.
Hubensack, Martina,
Müller, Christine,
Höcherl, Höcherl,
Fellner, Stephan,
Spruss, Thilo,
Bernhardt, Günther und
Buschauer, Armin
(2008)
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.
Journal of Cancer Research and Clinical Oncology 134 (5), S. 597-607.
Zugang zum Volltext eingeschränkt.
Dai, Jisen,
Jian, Jinlong,
Bosland, Maarten,
Frenkel, Krystyna,
Bernhardt, Günther und
Huang, Xi
(2008)
Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status.
Breast (Edinburgh, Scotland) 17 (2), S. 172-179.
Volltext nicht vorhanden.
Bernhardt, Günther,
Biersack, Bernhard,
Bollwein, Susanne,
Schobert, Rainer und
Zoldakova, Miroslava
(2008)
Terpene conjugates of diaminedichloridoplatinum(II) complexes: antiproliferative effects in HL-60 leukemia, 518A2 melanoma, and HT-29 colon cancer cells.
Chemistry & biodiversity 5 (8), S. 1645-1659.
Volltext nicht vorhanden.
Ziemek, Ralf,
Schneider, Erich,
Kraus, Anja,
Cabrele, Chiara,
Beck-Sickinger, Annette G.,
Bernhardt, Günther und
Buschauer, Armin
(2007)
Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence.
Journal of Receptors and Signal Transduction 27 (4), S. 217-233.
Volltext nicht vorhanden.
Müller, Christine,
Gross, Dietmar,
Sarli, Vasiliki,
Gartner, Michael,
Giannis, Athanassios,
Bernhardt, Günther und
Buschauer, Armin
(2007)
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Cancer Chemotherapy and Pharmacology 59 (2), S. 157-164.
Volltext nicht vorhanden.
Hofinger, Edith S. A.,
Spickenreither, Martin,
Oschmann, Jan,
Bernhardt, Günther,
Rudolph, Rainer und
Buschauer, Armin
(2007)
Recombinant human hyaluronidase Hyal-1: insect cells versus E. coli as expression system and identification of low molecular weight inhibitors.
Glycobiology 17 (4), S. 444-453.
Volltext nicht vorhanden.
Schobert, Rainer,
Bernhardt, Günther,
Biersack, Bernhard,
Bollwein, Susanne,
Fallahi, Magid,
Grotemeier, Antje und
Hammond, Geoffrey L.
(2007)
Steroid conjugates of dichloro(6-aminomethylnicotinate)platinum(II): effects on DNA, sex hormone binding globulin, the estrogen receptor, and various breast cancer cell lines.
ChemMedChem 2 (3), S. 333-342.
Volltext nicht vorhanden.
Schneider, Erich,
Keller, Max,
Brennauer, Albert,
Hoefelschweiger, Bianca K.,
Gross, Dietmar,
Wolfbeis, Otto S.,
Bernhardt, Günther und
Buschauer, Armin
(2007)
Synthesis and Characterization of the First Fluorescent Nonpeptide NPY Y1 Receptor Antagonist.
ChemBioChem 8 (16), S. 1981-1988.
Zugang zum Volltext eingeschränkt.
Egger, Michael,
Li, Xuqin,
Müller, Christine,
Bernhardt, Günther,
Buschauer, Armin und
König, Burkhard
(2007)
Tariquidar analogues: synthesis by Cu(I)-catalysed N/O–aryl coupling and inhibitory activity against the ABCB1 transporter.
European Journal of Organic Chemistry 2007 (16), S. 2643-2649.
Volltext nicht vorhanden.
Schneider, Erich,
Mayer, Matthias,
Ziemek, Ralf,
Li, Liantao,
Hutzler, Christoph,
Bernhardt, Günther und
Buschauer, Armin
(2006)
A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G-Protein-coupled Receptor Subtypes.
ChemBioChem 7 (9), S. 1400-1409.
Volltext nicht vorhanden.
Rigden, Daniel J.,
Botzki, Alexander,
Nukui, Masatoshi,
Mewbourne, R. Brandon,
Lamani, Ejvis,
Braun, Stephan,
von Angerer, Erwin,
Bernhardt, Günther,
Dove, Stefan,
Buschauer, Armin und
Jedrzejas, Mark J.
(2006)
Design of new benzoxazole-2-thione derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.
Glycobiology 16 (8), S. 757-765.
Volltext nicht vorhanden.
Ziemek, Ralf,
Brennauer, Albert,
Schneider, Erich,
Cabrele, Chiara,
Beck-Sickinger, Annette G.,
Bernhardt, Günther und
Buschauer, Armin
(2006)
Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y(2) receptor ligands.
European Journal of Pharmacology 551 (1-3), S. 10-8.
Volltext nicht vorhanden.
Xie, Sheng-Xue,
Petrache, Georgiana,
Schneider, Erich,
Ye, Qi-Zhuang,
Bernhardt, Günther,
Seifert, Roland und
Buschauer, Armin
(2006)
Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine.
Bioorganic & Medicinal Chemistry Letters 16 (15), S. 3886-3890.
Volltext nicht vorhanden.
Botzki, Alexander,
Salmen, Sunnhild,
Bernhardt, Günther,
Buschauer, Armin und
Dove, Stefan
(2005)
Structure-Based Design Of Bacterial Hyaluronan Lyase Inhibitors,.
QSAR & Combinatorial Science 24 (4), S. 458-469.
Volltext nicht vorhanden.
Salmen, Sunnhild,
Hoechstetter, Julia,
Käsbauer, Christian,
Paper, Dieter H.,
Bernhardt, Günther und
Buschauer, Armin
(2005)
Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae.
Planta Med. 71, S. 727-732.
Volltext nicht vorhanden.
Bernhardt, Günther,
Brunner, Henri,
Gruber, Nick,
Lottner, Christian,
Pushpan, Simi K.,
Tsuno, Takashi und
Zabel, Manfred
(2004)
Carboplatin derivatives with superior antitumor activity compared to the parent compound.
Inorganica Chimica Acta 357 (15), S. 4452-4466.
Volltext nicht vorhanden.
Dittmar, Michael,
Kiourkenidis, Georgios,
Horn, Markus,
Bollwein, Susanne und
Bernhardt, Günther
(2004)
Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity.
Stroke 35 (7), e338-e340.
Volltext nicht vorhanden.
Gürtler, Ulrich,
Fuchs, Peter,
Stangelmayer, Achim,
Bernhardt, Günther,
Buschauer, Armin und
Spruss, Thilo
(2004)
Construction and validation of a microprocessor controlled extracorporal circuit in rats for the optimization of isolated limb perfusion.
Archiv der Pharmazie 33 (12), S. 672-681.
Volltext nicht vorhanden.
Botzki, Alexander,
Rigden, Daniel J.,
Braun, Stephan,
Nukui, Masatoshi,
Salmen, Sunnhild,
Hoechstetter, Julia,
Bernhardt, Günther,
Dove, Stefan,
Buschauer, Armin und
Jedrzejas, Mark J.
(2004)
L-ascorbic acid-6-hexadecanoate, a potent hyaluronidase inhibitor: X-ray structure and molecular modeling of enzyme-inhibitor complexes.
The Journal of Biological Chemistry 279 (44), S. 45990-45997.
Volltext nicht vorhanden.
Schertl, Sabine,
Hartmann, Rolf W.,
Batzl-Hartmann, Christine,
Bernhardt, Günther,
Spruß, Thilo,
Beckenlehner, Karin,
Koch, Marion,
Krauser, Rudolf,
Schlemmer, Richard,
Gust, Ronald und
Schönenberger, Helmut
(2004)
[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action I: antitumor activity due to the reduction of the endogenous estrogen level.
Archiv der Pharmazie 337 (6), S. 335-348.
Volltext nicht vorhanden.
Schertl, Sabine,
Hartmann, Rolf W.,
Batzl-Hartmann, Christine,
Bernhardt, Günther,
Spruss, Thilo,
Beckenlehner, Karin,
Koch, Marion,
Krauser, Rudolf,
Schlemmer, Richard,
Gust, Ronald und
Schönenberger, Helmut
(2004)
[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action II: contribution of drug inactivation, cellular drug uptake and sterical factors in the drug-target interaction to the antitumor activity.
Archiv der Pharmazie 337 (6), S. 349-359.
Volltext nicht vorhanden.
Li, Liantao,
Mayer, Matthias,
Schneider, Erich,
Schreiber, Elvira,
Bernhardt, Günther,
Peng, Shiqi und
Buschauer, Armin
(2003)
Preparation of fluorescent nonpeptidic neuropeptide Y receptor ligands: analogues of the quinazoline-type anti-obesity Y5 antagonist CGP 71683A.
Arch Pharm (Weinheim) 336 (12), S. 585-590.
Volltext nicht vorhanden.
Li, Liantao,
Kracht, Julia,
Peng, Shiqi,
Bernhardt, Günther,
Elz, Sigurd und
Buschauer, Armin
(2003)
Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,.
Bioorganic & Medicinal Chemistry Letters 13 (10), 0960-894.
Volltext nicht vorhanden.
Li, Liantao,
Kracht, Julia,
Peng, Shiqi,
Bernhardt, Günther und
Buschauer, Armin
(2003)
Synthesis and pharmacological activity of fluorescent histamine H1 receptor antagonists related to mepyramine,.
Bioorganic & Medicinal Chemistry Letters 13 (7), S. 1245-1248.
Volltext nicht vorhanden.
Vogelhuber, Werner,
Spruß, Thilo,
Bernhardt, Günther,
Buschauer, Armin und
Göpferich, Achim
(2002)
Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts,.
International Journal of Pharmaceutics 238 (1-2), S. 111-121.
Volltext nicht vorhanden.
Bernhardt, Günther,
Beckenlehner, Karin,
Spruss, Thilo,
Schlemmer, Richard,
Reile, Herta und
Schönenberger, Helmut
(2002)
Establishment and Characterization of New Murine Breast Cancer Cell Lines.
Archiv der Pharmazie 335 (2), S. 55-68.
Volltext nicht vorhanden.
Bernhardt, Günther,
Beckenlehner, Karin,
Spruss, Thilo,
Schlemmer, Richard,
Reile, Herta und
Schönenberger, Helmut
(2002)
Establishment and characterization of new murine breast cancer cell lines.
Archiv der Pharmazie 335 (2-3), S. 55-68.
Volltext nicht vorhanden.
Weiss, Thomas S.,
Bernhardt, Günther,
Buschauer, Armin,
Thasler, Wolfgang E.,
Dolgner, Doris,
Zirngibl, Hubert und
Jauch, Karl-Walter
(2002)
Polyamine levels of human colorectal adenocarcinomas are correlate with tumor stage and grade,.
International Journal of Colorectal Disease 17 (6), S. 381-387.
Volltext nicht vorhanden.
Fellner, Stephan,
Bauer, Björn,
Miller, David S.,
Schaffrick, Martina,
Fankhänel, Martina,
Spruß, Thilo,
Bernhardt, Günther,
Graeff, Claudia,
Färber, Lothar,
Gschaidmeier, Harald,
Buschauer, Armin und
Fricker, Gert
(2002)
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo.
The Journal of Clinical Investigation 110 (9), S. 1309-1318.
Schertl, Sabine,
Hartmann, Rolf W.,
Batzl-Hartmann, Christine,
Schlemmer, Richard,
Spruß, Thilo,
Bernhardt, Günther,
Gust, Ronald und
Schönenberger, Helmut
(2001)
1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties.
Archiv der Pharmazie 334 (4), S. 125-137.
Volltext nicht vorhanden.
Schlemmer, Richard,
Spruß, Thilo,
Bernhardt, Günther und
Schönenberger, Helmut
(2001)
Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) act as an immune response modifier? IV. Inhibition of the proliferation-increasing effect of progressively growing MXT-M-3,2 breast cancer on phagocytes by the title compound.
Archiv der Pharmazie 334 (10), S. 309-317.
Volltext nicht vorhanden.
Vogelhuber, W.,
Rutunno, P.,
Magni, E.,
Gazzaniga, A.,
Spruss, Thilo,
Bernhardt, Günther,
Buschauer, Armin und
Goepferich, Achim
(2001)
Programmable biodegradable implants.
Journal of Controlled Release 73 (1), S. 75-88.
Volltext nicht vorhanden.
Schlemmer, Richard,
Spruß, Thilo,
Bernhardt, Günther und
Schönenberger, Helmut
(2000)
Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloro-platinum(II) act as an immune response modifier? Part III: Progressively growing MXT-M-3,2 breast cancer stimulates the proliferation of phagocytes in B6D2F1 mice.
Archiv der Pharmazie 333 (12), S. 404-414.
Volltext nicht vorhanden.
Schlemmer, Richard,
Spruß, Thilo,
Bernhardt, Günther und
Schönenberger, Helmut
(2000)
Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part 1: The MXT-M-3.2 breast cancer stimulates the growth of an identical second graft; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplat inum (II) inhibits this process.
Archiv der Pharmazie 333 (2-3), S. 69-71.
Volltext nicht vorhanden.
Schlemmer, Richard,
Spruß, Thilo,
Bernhardt, Günther und
Schönenberger, Helmut
(2000)
Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice.
Archiv der Pharmazie 333 (12), S. 397-403.
Volltext nicht vorhanden.
Aiglstorfer, Iris,
Hendrich, Ingo,
Moser, Christiane,
Bernhardt, Günther,
Dove, Stefan und
Buschauer, Armin
(2000)
Structure-Activity Relationships of Neuropeptide Y Y_1 Receptor Antagonists Related to BIBP 3226,.
Bioorganic & Medicinal Chemistry Letters 10 (14), S. 1597-1600.
Volltext nicht vorhanden.
Schlemmer, Richard,
Spruß, Thilo,
Bernhardt, Günther und
Schönenberger, Helmut
(1999)
[meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II), a compound with a specific activity on hormone-sensitive breast cancers--evidence for a diethylstilbestrol-like mode of action.
Archiv der Pharmazie 332 (2), S. 59-69.
Volltext nicht vorhanden.
Bernhardt, Günther,
Koch, Marion,
Spruss, Thilo,
Gust, Ronald,
Krauser, Rudolf,
Schlemmer, Richard,
Hollstein, Michael,
Lux, Franz und
Schönenberger, Helmut
(1999)
[meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] sulfatoplatinum(II)--pharmacokinetic studies.
Archiv der Pharmazie 332 (6), S. 195-200.
Volltext nicht vorhanden.
Schuster, Andreas,
Bernhardt, Günther,
Eibler, Ernst,
Buschauer, Armin und
Hesselink, Willy
(1998)
Chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, and analogous guanidines and guanidine-N-carboxylic acid esters with HPLC and CZE.
Journal of Chromatography A 793 (1), S. 77-90.
Volltext nicht vorhanden.
Pillwein, Konrad,
Fuiko, R.,
Slavc, I.,
Czech, T.,
Hawliczek, G.,
Bernhardt, Günther,
Nirnberger, Gunther und
Koller, U.
(1998)
Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors.
Cancer Letters (Shannon, Ireland) 131 (1), S. 101-108.
Volltext nicht vorhanden.
Aiglstorfer, Iris,
Uffrecht, Anka,
Geßele, K.,
Moser, Christiane,
Schuster, Andreas,
Merz, S.,
Malawska, B.,
Bernhardt, Günther,
Dove, Stefan und
Buschauer, Armin
(1998)
NPY Y_1 antagonists: structure-activity relationships of arginine derivatives and hybrid compounds with arpromidine-like partial structures.
Regul. Pept. 75, S. 75-76.
Volltext nicht vorhanden.
Gust, Ronald,
Schnurr, Beate,
Krauser, Rudolf,
Bernhardt, Günther,
Koch, Marion,
Schmid, Beate,
Hummel, Evelyn und
Schönenberger, Helmut
(1998)
Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative.
Journal of Cancer Research and Clinical Oncology 124 (11), S. 585-597.
Volltext nicht vorhanden.
Schuster, Andreas,
Bollwein, Susanne,
Uffrecht, Anka,
Krey, Volker,
Götte, Carsten,
Bernhardt, Günther und
Buschauer, Armin
(1998)
Stereochemical Investigations on Intermediates for the Synthesis of Histamine H_2 Receptor Agonists and Neuropeptide Y Y_1 Antagonists: Chiral Separation of Phenyl(pyridyl)alkanoic Acids by HPLC and CE.
Sci. Pharm 66, S. 263-278.
Volltext nicht vorhanden.
Müller, Manfred,
Knieps, Sebastian,
Geßele, Karin,
Dove, Stefan,
Bernhardt, Günther und
Buschauer, Armin
(1997)
Synthesis and neuropeptide Y Y1 receptor antagonistic activity of N,N-disubstituted w -guanidino- and w -aminoalkanoic acid amides.
Arch. Pharm. - Pharm. Med. Chem. (Weinheim) 330, S. 333-342.
Volltext nicht vorhanden.
Lux, Franz,
Hollstein, Michael,
Reile, Herta,
Bernhardt, Günther und
Schönenberger, Helmut
(1996)
Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin.
Biological Trace Element Research 53 (1-3), S. 113-128.
Volltext nicht vorhanden.
Knieps, Sebastian,
Dove, Stefan,
Michel, Martin C.,
Rottmeier, Karin,
Wernet, W.,
Bernhardt, Günther und
Buschauer, Armin
(1996)
w -Phenyl-w -(2-pyridyl)alkyl-substituted bisguanidines are moderate neuropeptide Y antagonists.
Pharm. Pharmacol. Lett. 6, S. 27-30.
Volltext nicht vorhanden.
Gust, Ronald,
Bernhardt, Günther,
Spruss, Thilo,
Krauser, Rudolf,
Koch, Marion,
Schönenberger, Helmut,
Bauer, Kurt H.,
Schertl, Sabine und
Lu, Zhi
(1995)
Development of a parenterally administrable hydrosol preparation of the "third generation platinum complex" [(+/-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity.
Archiv der Pharmazie 328 (9), S. 645-653.
Volltext nicht vorhanden.
Gust, Ronald,
Bernhardt, Günther,
Spruss, Thilo,
Krauser, Rudolf,
Koch, Marion,
Schönenberger, Helmut,
Bauer, Kurt-Heinz,
Schertl, Sabine und
Lu, Zhi
(1995)
Development of a parenterally administrable hydrosol preparation of the third generation platinum complex [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity.
Archiv der Pharmazie (Weinheim, Germany) 328 (9), S. 645-653.
Volltext nicht vorhanden.
Beck, E.,
Hofmann, M.,
Bernhardt, Günther,
Jäger, W.,
Wildt, L. und
Lang, N.
(1994)
In vitro activity of immunoconjugates between cisplatin and an anti-CA125 monoclonal antibody on ovarian cancer cell lines.
Cell biophysics 24-25, S. 163-173.
Volltext nicht vorhanden.
Kritzenberger, J.,
Bernhardt, Günther,
Gust, Ronald,
Pistor, Petra,
Schönenberger, Helmut und
Yersin, Hartmut
(1993)
Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line.
Monatshefte fuer Chemie 124 (5), S. 587-604.
Meyer, Thomas,
Goehl, Jonas,
Hohenberger, Werner,
Christl, Claudia,
Bernhardt, Günther,
Spruss, Thilo und
Schönenberger, Helmut
(1993)
The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines.
Chirurgisches Forum fuer Experimentelle und Klinische Forschung, S. 89-94.
Volltext nicht vorhanden.
Reile, Herta,
Bernhardt, Günther,
Koch, Marion,
Schönenberger, Helmut,
Hollstein, Michael und
Lux, Franz
(1992)
Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and specific platinum accumulation.
Cancer chemotherapy and pharmacology 30 (2), S. 113-122.
Bernhardt, Günther,
Müller, Richard,
Gust, Ronald,
Reile, Herta,
Keller, Christoph,
Spruss, Thilo und
Schönenberger, Helmut
(1992)
Dichloro-[1-(hydroxyphenyl)-2-phenylethylenediamine]platinum(II) complexes: testing on the human ovarian cancer cell lines NIH: OVCAR3 and SK OV 3.
Archiv der Pharmazie 325 (2), S. 93-99.
Grimm, Daniela,
Hofstädter, Ferdinand,
Bauer, Johann,
Spruss, Thilo,
Steinbach, Pia,
Bernhardt, Günther und
Menze, Rita
(1992)
Establishment and characterization of a human papillary thyroid carcinoma cell line with oxyphilic differentiation (ONCO-DG 1).
Virchows Archiv. B, Cell pathology including molecular pathology 62 (2), S. 97-104.
Beckenlehner, Karin,
Bannke, Silke,
Spruss, Thilo,
Bernhardt, Günther,
Schönenberger, Helmut und
Schiess, Wilfried
(1992)
Hyaluronidase enhances the activity of adriamycin in breast cancer models in vitro and in vivo.
Journal of cancer research and clinical oncology 118 (8), S. 591-596.
Bernhardt, Günther,
Gust, Ronald,
Reile, Herta,
vom Orde, Hans Dieter,
Müller, Richard,
Keller, Christoph,
Spruß, Thilo,
Schönenberger, Helmut,
Burgemeister, Thomas,
Mannschreck, Albrecht,
Range, Klaus-Jürgen und
Klement, Ulrich
(1992)
[1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. II. Synthesis and preliminary testing of the enantiomeric complexes.
Journal of cancer research and clinical oncology 118 (3), S. 201-208.
Bernhardt, Günther,
Gust, Ronald,
Reile, Herta,
vom Orde, Hans Dieter,
Müller, Richard,
Keller, Christoph,
Spruß, Thilo,
Schönenberger, Helmut,
Burgemeister, Thomas,
Mannschreck, Albrecht,
Range, Klaus Jürgen und
Klement, Ulrich
(1992)
[1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. III. Detailed evaluation of the antitumor activity of the enantiomeric complexes on the human NIH:OVCAR-3 ovarian cancer cell line.
Journal of cancer research and clinical oncology 118 (3), S. 209-215.
Bernhardt, Günther,
Reile, Herta,
Spruss, Thilo,
Koch, Marion,
Gust, Ronald,
Schönenberger, Helmut,
Hollstein, Michael,
Lux, Franz und
Engel, Jürgen
(1991)
D-17446.
Drugs of the Future 16 (10), S. 899-903.
Reile, Herta,
Spruß, Thilo,
Bernhardt, Günther,
Müller, Richard,
Gust, Ronald und
Schönenberger, Helmut
(1991)
Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part IV: Biological evaluation--in vivo studies on the P 388 leukemia.
Archiv der Pharmazie 324 (7), S. 405-409.
Reile, Herta,
Spruß, Thilo,
Müller, Richard,
Gust, Ronald,
Bernhardt, Günther,
Schönenberger, Helmut und
Engel, Jürgen
(1990)
Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes, III: Evaluation of the mammary tumor inhibiting properties.
Archiv der Pharmazie 323 (5), S. 301-306.
Reile, Herta,
Müller, Richard,
Gust, Ronald,
Laske, Reiner,
Krischke, Walter,
Bernhardt, Günther,
Spruss, Thilo,
Jennerwein, Margaretha,
Engel, Jürgen und
Seeber, Siegfried
(1990)
Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part II: Biological evaluation-in vitro studies on the P 388 D1 leukemia cell line.
Archiv der Pharmazie 323 (3), S. 133-140.
vom Orde, Hans Dieter,
Reile, Herta,
Müller, Richard,
Gust, Ronald,
Bernhardt, Günther,
Spruß, Thilo,
Schönenberger, Helmut,
Burgemeister, Thomas und
Mannschreck, Albrecht
(1990)
Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes.
Journal of cancer research and clinical oncology 116 (5), S. 434-438.
Müller, Richard,
Gust, Ronald,
Bernhardt, Günther,
Keller, Christoph,
Schönenberger, Helmut,
Seeber, Siegfried,
Osieka, Reinhardt,
Eastman, Alan und
Jennerwein, Margaretha
(1990)
[DL-1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer.
Journal of cancer research and clinical oncology 116 (3), S. 237-244.
Mueller, Richard,
Gust, Ronald,
Jennerwein, Margaretha,
Reile, Herta,
Laske, Reiner,
Krischke, Walter,
Bernhardt, Günther,
Spruss, Thilo,
Engel, Juergen und
Schönenberger, Helmut
(1989)
Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis.
European Journal of Medicinal Chemistry 24 (4), S. 341-348.
Bernhardt, Günther,
Disteche, A.,
Jaenicke, Rainer,
Koch, B.,
Lüdemann, Hans-Dietrich und
Stetter, Karl Otto
(1988)
EFFECT OF CARBON-DIOXIDE AND HYDROSTATIC-PRESSURE ON THE PH OF CULTURE MEDIA AND THE GROWTH OF METHANOGENS AT ELEVATED-TEMPERATURE.
Applied Microbiology and Biotechnology 28 (2), S. 176-181.
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