Anzahl der Einträge in dieser Kategorie: 266.
Artikel
Schindler, Lisa,
Moosbauer, Jutta,
Schmidt, Daniel ,
Spruss, Thilo,
Grätz, Lukas,
Lüdeke, Steffen,
Hofheinz, Frank,
Meister, Sebastian,
Echtenacher, Bernd,
Bernhardt, Günther,
Pietzsch, Jens ,
Hellwig, Dirk und
Keller, Max
(2022)
Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors.
Cancers 14 (19), S. 4922.
Willkomm, Sarah ,
Jakob, Leonhard,
Kramm, Kevin,
Graus, Veronika,
Neumeier, Julia,
Meister, Gunter und
Grohmann, Dina
(2022)
Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2.
Nature Communications 13, art.no.3825.
Kuzin, Maxim ,
Haen, Ekkehard,
Hiemke, Christoph ,
Bochon, Benjamin,
Bochon, Karolina,
Gründer, Gerhard,
Paulzen, Michael und
Schoretsanitis, Georgios
(2021)
Body mass index as a determinant of clozapine plasma concentrations: A pharmacokinetic-based hypothesis.
Journal of Psychopharmacology 35 (3), S. 273-278.
Volltext nicht vorhanden.
Schoretsanitis, Georgios,
Haen, Ekkehard,
Piacentino, Daria,
Conca, Andreas,
Endres, Katharina,
Hiemke, Christoph,
Gründer, Gerhard und
Paulzen, Michael
(2021)
Clinical response in patients treated with once-monthly paliperidone palmitate: analysis of a therapeutic drug monitoring (TDM) database.
European Archives of Psychiatry and Clinical Neuroscience 271 (8), S. 1437-1443.
Volltext nicht vorhanden.
Wörle, Elisabeth,
Jakob, Leonhard,
Schmidbauer, Andreas,
Zinner, Gabriel und
Grohmann, Dina
(2021)
Decoupling the bridge helix of Cas12a results in a reduced trimming activity, increased mismatch sensitivity and impaired conformational transitions.
Nucleic Acids Research 49 (9), S. 5278-5293.
Volltext nicht vorhanden.
Schoretsanitis, Georgios,
Haen, Ekkehard,
Piacentino, Daria,
Conca, Andreas,
Endres, Katharina,
Carpi, Fabio,
Hiemke, Christoph,
Gründer, Gerhard und
Paulzen, Michael
(2021)
Pharmacokinetic Correlates of Once-Monthly Paliperidone Palmitate-Related Adverse Drug Reactions.
Clinical Pharmacokinetics 60 (12), S. 1583-1589.
Volltext nicht vorhanden.
Aldag, Pierre,
Welzel, Fabian,
Jakob, Leonhard,
Schmidbauer, Andreas,
Rutkauskas, Marius,
Fettes, Fergus,
Grohmann, Dina und
Seidel, Ralf
(2021)
Probing the stability of the SpCas9–DNA complex after cleavage.
Nucleic Acids Research 49 (21), S. 12411-12421.
Volltext nicht vorhanden.
Koehler, Katrin,
Hmida, Dorra,
Schlossmann, Jens,
Landgraf, Dana,
Reisch, Nicole,
Schuelke, Markus und
Huebner, Angela
(2020)
Homozygous mutation in murine retrovirus integration site 1 gene associated with a non‐syndromic form of isolated familial achalasia.
Neurogastroenterology & Motility 32 (12).
Volltext nicht vorhanden.
Biswas, Siladitta,
Kojonazarov, Baktybek,
Hadzic, Stefan,
Majer, Michael,
Bajraktari, Ganimete,
Novoyatleva, Tatyana,
Ghofrani, Hossein Ardeschir,
Grimminger, Friedrich,
Seeger, Werner,
Weissmann, Norbert,
Schlossmann, Jens und
Schermuly, Ralph Theo
(2020)
IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension.
Cells 9 (10), S. 2280.
Volltext nicht vorhanden.
Kuzin, Maxim ,
Schoretsanitis, Georgios ,
Haen, Ekkehard,
Dammann, Gerhard,
Hiemke, Christoph,
Gründer, Gerhard und
Paulzen, Michael
(2020)
The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism.
Pharmacopsychiatry 53 (02), S. 65-70.
Volltext nicht vorhanden.
Schramm, Andrea,
Schweda, Frank,
Sequeira-Lopez, Maria Luisa S.,
Hofmann, Franz,
Sandner, Peter und
Schlossmann, Jens
(2019)
Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion.
Frontiers in Pharmacology 2019 (10), S. 800.
Dorn, Christoph,
Petroff, David,
Neumann, Nancy,
Kratzer, Alexander,
El-Najjar, Nahed ,
Dietrich, Arne,
Kloft, Charlotte,
Zeitlinger, Markus ,
Kees, Martin,
Kees, Frieder,
Wrigge, Hermann und
Simon, Philipp
(2019)
Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial.
Journal of Antimicrobial Chemotherapy.
Volltext nicht vorhanden.
Polykandriotis, Elias,
Horch, Raymund E.,
Jost, Matthias,
Arkudas, Andreas,
Kees, Frieder und
Schmitz, Marweh
(2019)
Can systemically administered antibiotics be detected in wound tissues and surfaces under negative pressure wound therapy?
International Wound Journal 16 (2), S. 503-510.
Volltext nicht vorhanden.
Shah, Nirav R.,
Bulitta, J. B. ,
Kinzig, M.,
Kees, Frieder,
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(2019)
Novel population pharmacokinetic approach to explain the differences between cystic fibrosis patients and healthy volunteers via protein binding.
Pharmaceutics 11, S. 286.
Schoretsanitis, Georgios ,
Haen, Ekkehard,
Hiemke, Christoph,
Endres, Katharina,
Ridders, Florian,
Veselinovic, Tanja,
Gründer, Gerhard und
Paulzen, Michael
(2019)
Pharmacokinetic correlates of venlafaxine: associated adverse reactions.
European Archives of Psychiatry and Clinical Neuroscience 269 (7), S. 851-857.
Volltext nicht vorhanden.
Schoretsanitis, Georgios ,
Haen, Ekkehard,
Gründer, Gerhard,
Hiemke, Christoph,
Endres, Katharina,
Ridders, Florian,
Correll, Christoph U. und
Paulzen, Michael
(2019)
Pharmacokinetics of venlafaxine in treatment responders and non-responders: a retrospective analysis of a large naturalistic database.
European Journal of Clinical Pharmacology 75 (8), S. 1109-1116.
Volltext nicht vorhanden.
Kratzer, Alexander,
Schießer, Selina,
Matzneller, Peter,
Wulkersdorfer, Beatrix,
Zeitlinger, Markus ,
Schlossmann, Jens ,
Kees, Frieder und
Dorn, Christoph
(2018)
Determination of Total and Free Ceftolozane and Tazobactam in Human Plasma and Interstitial Fluid by HPLC-UV.
Journal of Pharmaceutical and Biomedical Analysis.
Volltext nicht vorhanden.
Schramm, Andrea,
Mueller-Thuemen, Philip,
Littmann, Timo,
Harloff, Manuela,
Ozawa, Takeaki und
Schlossmann, Jens
(2018)
Establishing a Split Luciferase Assay for Proteinkinase G (PKG) Interaction Studies.
International Journal o f Molecular Sciences 19 (4), S. 1180.
Uchida, Hitoshi,
Matsumura, Shinji,
Katano, Tayo,
Watanabe, Masahiko ,
Schlossmann, Jens und
Ito, Seiji
(2018)
Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion.
Molecular Pain 14, S. 174480691879640.
Volltext nicht vorhanden.
Schlossmann, Jens,
Schinner, Elisabeth,
Wetzl, Veronika,
Schramm, Andrea,
Kees, Frieder,
Sandner, Peter,
Stasch, Johannes-Peter und
Hofmann, Franz
(2017)
Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis.
FEBS openbio 7 (4), S. 550-561.
Unholzer, S.,
Rothmund, A. und
Haen, E.
(2017)
Alleskönner Vitamin D?
Der Nervenarzt 88 (5), S. 489-494.
Volltext nicht vorhanden.
Wetzl, Veronika,
Schinner, Elisabeth,
Kees, Frieder,
Faerber, Lothar und
Schlossmann, Jens
(2017)
Differences in the renal antifibrotic cGMP/cGKI-dependent signaling of serelaxin, zaprinast, and their combination.
Naunyn-Schmiedeberg's Archives of Pharmacology 390 (9), S. 939-948.
Volltext nicht vorhanden.
Paulzen, Michael,
Schoretsanitis, Georgios ,
Stegmann, Benedikt,
Hiemke, Christoph,
Gründer, Gerhard,
Schruers, Koen R. J.,
Walther, Sebastian ,
Lammertz, Sarah E. und
Haen, Ekkehard
(2017)
Pharmacokinetic considerations in antipsychotic augmentation strategies: How to combine risperidone with low-potency antipsychotics.
Progress in Neuro-Psychopharmacology and Biological Psychiatry 76, S. 101-106.
Volltext nicht vorhanden.
Wetzl, Veronika,
Tiede, Svenja Lena,
Faerber, Lothar,
Weissmann, Norbert ,
Schermuly, Ralph Theo ,
Ghofrani, Hossein Ardeschir und
Gall, Henning
(2017)
Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension.
Lung 195 (4), S. 489-496.
Volltext nicht vorhanden.
Schlossmann, Jens,
Wetzl, Veronika,
Schinner, Elisabeth,
Kees, Frieder K.,
Hofmann, Franz und
Faerber, Lothar
(2016)
Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin.
Frontiers in Pharmacology 7 (195), S. 1-27.
Bucher, Felicitas ,
Walz, Johanna M.,
Bühler, Anima,
Aguilar, Edith,
Lange, Clemens,
Diaz-Aguilar, Sophia,
Martin, Gottfried,
Schlunck, Günther,
Agostini, Hansjürgen,
Friedlander, Martin und
Stahl, Andreas
(2016)
CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy.
Investigative Opthalmology & Visual Science 57 (10), S. 4017.
Volltext nicht vorhanden.
Schoretsanitis, Georgios,
Haen, Ekkehard,
Gründer, Gerhard,
Stegmann, Benedikt,
Schruers, Koen R. J.,
Hiemke, Christoph,
Lammertz, Sarah E. und
Paulzen, Michael
(2016)
Pharmacokinetic Drug-Drug Interactions of Mood Stabilizers and Risperidone in Patients Under Combined Treatment.
Journal of Clinical Psychopharmacology 36 (6), S. 554-561.
Volltext nicht vorhanden.
Walz, Johanna M.,
Bemme, Sebastian,
Pielen, Amelie,
Aisenbrey, Sabine,
Breuß, Helge,
Alex, Anne F.,
Wagenfeld, Lars,
Schiedel, Susanne,
Krohne, Tim U. und
Stahl, Andreas
(2016)
The German ROP Registry: data from 90 infants treated for retinopathy of prematurity.
Acta Ophthalmologica 94 (8), e744-e752.
Volltext nicht vorhanden.
Wolferstetter, Stefanie,
Reinders, Jörg,
Schwede, Frank,
Ruth, Peter,
Schinner, Elisabeth und
Schlossmann, Jens
(2015)
Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.
PLoS ONE 10 (5), e0126057.
Jenei-Lanzl, Zsuzsa,
Capellino, Silvia,
Kees, Frieder ,
Fleck, Martin,
Lowin, Torsten und
Straub, Rainer H.
(2015)
Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis.
Annals of the Rheumatic Diseases 74, S. 444-451.
Huber, Stefan,
Huettner, Johannes Philip,
Hacker, Kristina,
Bernhardt, Günther,
König, Jörg und
Buschauer, Armin
(2015)
Esters of bendamustine are by far more potent cytotoxic agents than the parent compound against human sarcoma and carcinoma cells.
PLoS One 10 (7), PLoSe0133743.
Kees, Martin Georg,
Schaeftlein, André,
Haeberle, Helene Anna,
Kees, Frieder K.,
Kloft, Charlotte und
Heininger, Alexandra
(2013)
Population pharmacokinetics and pharmacodynamic evaluation of intravenous and enteral moxifloxacin in surgical intensive care unit patients.
The Journal of antimicrobial chemotherapy.
Volltext nicht vorhanden.
Chen, W.,
Oberwinkler, H.,
Werner, F.,
Gaßner, B.,
Nakagawa, H,,
Feil, R.,
Hofmann, F.,
Schlossmann, Jens,
Dietrich, A.,
Gudermann, T.,
Nishida, M.,
Del Galdo, S.,
Wieland, T. und
Kuhn, M.
(2013)
ANP-mediated inhibition of microcirculatory endothelial Ca 2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.
Arteriosclerosis, Thrombosis, and Vascular Biology 33 (9), S. 2121-2129.
(Im Druck)
Volltext nicht vorhanden.
Dietrich, P.,
Moleda, Lukas,
Kees, Frieder K.,
Müller, M.,
Straub, R. H.,
Hellerbrand, C. und
Wiest, R.
(2013)
Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y.
Journal of hepatology 58 (2), S. 254-261.
Volltext nicht vorhanden.
Schlossmann, Jens und
Schinner, E.
(2012)
cGMP becomes a drug target.
Naunyn Schmiedeberg´s Archives of Pharmacology 385 (3), S. 243-252.
Taha, Hesham,
Dove, Stefan,
Geduhn, Jens,
König, Burkhard,
Shen, Yuequan,
Tang, Wei-Jen und
Seifert, Roland
(2012)
Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 monoand bis-(M)ANT-substituted nucleoside 5′-triphosphates.
Naunyn-Schmiedeberg's Archives of Pharmacology (385), S. 57-68.
Volltext nicht vorhanden.
Kees, Martin G.,
Steinke, T.,
Moritz, S.,
Rupprecht, K.,
Paulus, E. M.,
Kees, Frieder K.,
Bucher, M. und
Faerber, L.
(2012)
Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycophenolate sodium in healthy volunteers.
Journal of clinical pharmacology 52 (8), S. 1265-1272.
Volltext nicht vorhanden.
Justinger, Christoph,
Schilling, Martin K.,
Kees, Martin G.,
Kauffels, Anne,
Hirschmann, Katrin,
Kopp, Berit,
Kees, Frieder K. und
Kollmar, Otto
(2012)
Penetration of moxifloxacin into liver tissue.
International journal of antimicrobial agents 39 (6), S. 505-509.
Volltext nicht vorhanden.
Luo, C.,
Gangadharan, V.,
Bali, K. K.,
Xie, R. G.,
Agarwal, N.,
Kurejova, M.,
Tappe-Theodor, A.,
Tegeder, I.,
Feil, S.,
Lewin, G.,
Polgar, E.,
Todd, A. J.,
Schlossmann, Jens,
Hofmann, F.,
Liu, D. L.,
Hu, S. J.,
Feil, R.,
Kuner, T. und
Kuner, R.
(2012)
Presynaptically localized cyclic GMP-dependent Protein Kinase I is a key determinant of spinal potentiation and pain hypersensitivity.
PLoS Biology 10 (3), 1e1001283.
Jaumann, M.,
Dettling, J.,
Gubelt, M.,
Zimmermann, U.,
Gerling, A.,
Paquet-Durand, F.,
Feil, S.,
Wolpert, S.,
Franz, C.,
Varakina, K.,
Xiong, H.,
Brandt, N.,
Kuhn, S.,
Geisler, H.-S.,
Rohbock, K.,
Ruth, P.,
Schlossmann, Jens,
Hütter, J.,
Sandner, P.,
Feil, R.,
Engel, J.,
Knipper, M. und
Rüttiger, L.
(2012)
cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and heraring function.
Nature Medicine 18, S. 252-259.
Volltext nicht vorhanden.
Hübner, Melanie,
Dixit, A.,
Mou, T.-C.,
Lushington, Gerald H.,
Pinto, Cibele S.,
Gille, A.,
Geduhn, Jens,
König, Burkhard,
Sprang, S. R. und
Seifert, Roland
(2011)
Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2`,3`-O-(N-Methylanthraniloyl)-Inosine 5`-Triphosphate.
Molecular Pharmacology 80 (1), S. 87-96.
Volltext nicht vorhanden.
Kellermann, K.,
Dertinger, N.,
Blobner, M.,
Kees, Frieder,
Kochs, E. F. und
Jungwirt, B.
(2011)
Perioperative moxifloxacin treatment in rats subjected to deep hypothermic circulatory arrest: reduction in cerebral inflammation but without improvement in cognitive performance.
Journal of Thoracic and Cardiovascular Surgery 141 (3), S. 796-802.
Volltext nicht vorhanden.
Schnell, David,
Brunskole, Irena,
Ladova, Katerina,
Schneider, Erich H.,
Igel, Patrick,
Dove, Stefan,
Buschauer, Armin und
Seifert, Roland
(2011)
Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells.
Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), S. 457-470.
Volltext nicht vorhanden.
Geduhn, Jens,
Dove, Stefan,
Shen, Yuequan,
Tang, Wei-Jen,
König, Burkhard und
Seifert, Roland
(2011)
Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5'-triphosphates as Potent and Selective Inhibitors of Bordetella pertussis CyaA.
The Journal of pharmacology and experimental therapeutics 336 (1), S. 104-115.
Volltext nicht vorhanden.
Ertl, C.,
Lukowski, R.,
Sigl, K.,
Schlossmann, Jens,
Hofmann, F. und
Wegener, Jörg W.
(2011)
Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle.
Eur J Pharmacol 670 (1), S. 266-271.
Volltext nicht vorhanden.
Pinto, Cibele S.,
Lushington, Gerald H.,
Richter, M.,
Gille, A.,
Geduhn, Jens,
König, Burkhard,
Mou, T.-C.,
Sprang, S. R. und
Seifert, Roland
(2011)
Structure–activity relationships for the interactions of 2`- and 3`-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases.
Biochemical Pharmacology 82 (4), S. 358-370.
Volltext nicht vorhanden.
Werder, A.,
Mayr, M.,
Schneider, G.,
Oesterle, D.,
Fritsch, R. M.,
Seidler, B.,
Schlossmann, Jens,
Hofmann, F.,
Schemann, M.,
Allescher, H. D.,
Schmid, R. M. und
Saur, D.
(2011)
Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction.
American Journal of Physiology - Cell Physiology : Am J Physiol Cell Physiol 301 (6), C1445-1457.
Volltext nicht vorhanden.
Mathar, I.,
Vennekens, R.,
Meissner, M.,
Kees, Frieder K.,
Van der Mieren, G. und
Camacho Londono, J.
(2010)
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice.
The Journal of Clinical Investigation 120 (9), S. 3267-3279.
Volltext nicht vorhanden.
Desch, Matthias,
Schinner, Elisabeth,
Kees, Frieder K.,
Hofmann, F.,
Seifert, Roland und
Schlossmann, Jens
(2010)
Cyclic cytidine 3´,5´-monophosphate (cCMP) signals via cGMP kinase I.
FEBS Letters 584 (18), S. 3979-3984.
Volltext nicht vorhanden.
Desch, Matthias,
Sigl, K.,
Hieke, Bernhard,
Salb, Katharina,
Kees, F. und
Bernhard, D.
(2010)
IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation.
Cardiovascular Research 86 (3), S. 496-505.
Volltext nicht vorhanden.
Göttle, Martin,
Dove, Stefan,
Kees, Frieder K.,
Schlossmann, Jens,
Geduhn, Jens,
König, Burkhard,
Shen, Y.,
Tang, W. J.,
Kaever, V. und
Seifert, Roland
(2010)
Citidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.
Biochemistry 49, S. 5494-5503.
Volltext nicht vorhanden.
Desch, M.,
Sigl, K.,
Hieke, B.,
Salb, Katharina,
Kees, Frieder,
Bernhard, D.,
Jochim, A.,
Spiessberger, B.,
Höcherl, K.,
Feil, R.,
Lukowski, R.,
Wegener, Jörg W.,
Hofmann, F. und
Schlossmann, Jens
(2010)
IRAG determines NO- and ANP-mediated smooth muscle relaxation.
Cardiovascular Research 86 (3), S. 496-505.
Volltext nicht vorhanden.
Igel, Patrick,
Geyer, Roland,
Straßer, Andrea,
Dove, Stefan,
Seifert, Roland und
Buschauer, Armin
(2009)
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists.
Journal of Medicinal Chemistry 52 (20), S. 6297-6313.
Volltext nicht vorhanden.
Igel, Patrick,
Schneider, Erich,
Schnell, David,
Elz, Sigurd,
Seifert, Roland und
Buschauer, Armin
(2009)
N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Journal of Medicinal Chemistry 52 (8), S. 2623-2627.
Volltext nicht vorhanden.
Kraus, Anja,
Ghorai, Prasanta,
Birnkammer, Tobias,
Schnell, David,
Elz, Sigurd,
Seifert, Roland,
Dove, Stefan,
Bernhardt, Günther und
Buschauer, Armin
(2009)
N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists.
ChemMedChem 4 (2), S. 232-240.
Volltext nicht vorhanden.
Igel, Patrick,
Schnell, David,
Bernhardt, Günther,
Seifert, Roland und
Buschauer, Armin
(2009)
Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand.
ChemMedChem 4 (2), S. 225-231.
Volltext nicht vorhanden.
Frei, E.,
Huster, M.,
Smital, P.,
Schlossmann, Jens,
Hofmann, F. und
Wegener, Jörg W.
(2009)
Calcium-dependent and Calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle.
American Journal of Physiology 297, G834-839.
Volltext nicht vorhanden.
Taha, H. M.,
Schmidt, J.,
Göttle, M.,
Suryanarayana, S.,
Shen, Y.,
Tang, W.-J.,
Gille, A.,
Geduhn, Jens,
König, Burkhard,
Dove, Stefan und
Seifert, Roland
(2009)
Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides.
Mol. Pharmacol. 75 (3), S. 693-703.
Volltext nicht vorhanden.
Schlossmann, Jens und
Desch, M.
(2009)
cGK substrates.
Handbook of Experimental Pharmacology 191, S. 163-193.
Volltext nicht vorhanden.
Ghorai, Prasanta,
Kraus, Anja,
Keller, Max,
Götte, Carsten,
Igel, Patrick,
Schneider, Erich,
Schnell, David,
Bernhardt, Günther,
Dove, Stefan,
Zabel, Manfred,
Elz, Sigurd,
Seifert, Roland und
Buschauer, Armin
(2008)
Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.
Journal of Medicinal Chemistry 51 (22), S. 7193-7204.
Volltext nicht vorhanden.
Schmidtko, A.,
Gao, W.,
König, P.,
Heine, S.,
Motterlini, R.,
Ruth, P.,
Schlossmann, Jens,
Koesling, D.,
Niederberger, E.,
Tegeder, I.,
Friebe, A. und
Geisslinger, G.
(2008)
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.
Journal of Neuroscience 28, S. 8568-8576.
Volltext nicht vorhanden.
Göttle, Martin,
Dove, Stefan,
Steindel, Phillip,
Shen, Yuequan,
Tang, Wei-Jen,
Geduhn, Jens,
König, Burkhard und
Seifert, Roland
(2007)
Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides.
Molecular Pharmacology 72 (3), S. 526-535.
Wang, Jenna L.,
Guo, Jian-Xin,
Zhang, Qi-Yuan,
Wu, Jay J.-Q.,
Seifert, Roland und
Lushington, Gerald H.
(2007)
A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified
and unmodified nucleotide inhibitors.
Bioorganic & Medicinal Chemistry 15 (8), S. 2993-3002.
Preuss, Hendrik,
Ghorai, Prasanta,
Kraus, Anja,
Dove, Stefan,
Buschauer, Armin und
Seifert, Roland
(2007)
Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors.
Journal of Pharmacology and Experimental Therapeutics 321 (3), S. 983-995.
Preuss, Hendrik,
Ghorai, Prasanta,
Kraus, Anja,
Dove, Stefan,
Buschauer, Armin und
Seifert, Roland
(2007)
Mutations of Cys-17 and Ala-271 in the Human Histamine H₂
Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity.
Journal of Pharmacology and Experimental Therapeutics 321 (3), S. 975-982.
Antl, M.,
von Brühl, M. L.,
Eiglsperger, C.,
Werner, M.,
Konrad, I.,
Köcher, T.,
Wilm, M.,
Hofmann, F.,
Massberg, S. und
Schlossmann, Jens
(2007)
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.
Blood 109 (2), S. 552-559.
Volltext nicht vorhanden.
Kees, F.,
Bucher, M.,
Schweda, F.,
Gschaidmeier, H.,
Faerber, L. und
Seifert, R.
(2007)
Neoimmun versus Neoral: a bioequivalence study in healthy volunteers and influence of a fat-rich meal on the bioavailability of Neoimmun.
Naunyn-Schmiedeberg's Archives of Pharmacology 375 (6), S. 393-399.
Preuss, Hendrik,
Ghorai, Prasanta,
Kraus, Anja,
Dove, Stefan,
Buschauer, Armin und
Seifert, Roland
(2007)
Point Mutations in the Second Extracellular Loop of the Histamine H2 Receptor do not affect the Species-Selective Activity of Guanidine-Type Agonists.
Naunyn Schmiedebergs Arch. Pharmacol. 376 (4), S. 253-264.
Zugang zum Volltext eingeschränkt.
Sausbier, M.,
Zhou, X. B.,
Beier, C.,
Sausbier, U.,
Wolpers, D.,
Maget, S.,
Martin, C.,
Dietrich, A.,
Ressmeyer, A. R.,
Schlossmann, Jens,
Hofmann, F.,
Neuhuber, W.,
Gudermann, T.,
Uhlig, S.,
Korth, M. und
Ruth, P.
(2007)
Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+channel.
FASEB Journal 21, S. 812-822.
Volltext nicht vorhanden.
Weber, S.,
Bernhard, D.,
Lukowski, R.,
Weinmeister, P.,
Wörner, R.,
Wegener, J. W.,
Valtcheva, N.,
Feils, S.,
Schlossmann, Jens,
Hofmann, F. und
Feil, R.
(2007)
Rescue of cGMP Kinase I knockout mice by smooth muscle specific expression of either isozyme.
Circulation Research 101, S. 1096-1103.
Volltext nicht vorhanden.
Kees, Frieder,
Bucher, Michael,
Schweda, Frank,
Gschaidmeier, Harald,
Burhenne, Juergen,
Mikus, Gerd und
Faerber, Lothar
(2006)
Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers.
Therapeutic drug monitoring 28 (3), S. 312-320.
Zugang zum Volltext eingeschränkt.
Xie, Sheng-Xue,
Kraus, Anja,
Ghorai, Prasanta,
Ye, Qi-Zhuang,
Elz, Sigurd,
Buschauer, Armin und
Seifert, Roland
(2006)
N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), S. 1262-1268.
Zugang zum Volltext eingeschränkt.
Feil, S.,
Zimmermann, P.,
Knorn, A.,
Brummer, S.,
Schlossmann, Jens,
Hofmann, F. und
Feil, R.
(2005)
Distribution of cGMP-dependent protein kinase type 1 and its isoforms in the mouse brain and retina.
Neuroscience 135, S. 863-868.
Volltext nicht vorhanden.
Werner, C. G.,
Godrey, V.,
Arnold, R. R.,
Featherstone, G. L.,
Bender, D.,
Schlossmann, Jens,
Schiemann, M.,
Hofmann, F. und
Pryzwansky, K. B.
(2005)
Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice.
Journal of Immunology 175, S. 1919-1929.
Volltext nicht vorhanden.
Geiselhöringer, A.,
Werner, M.,
Sigl, K.,
Smital, P.,
Wörner, R.,
Acheo, L.,
Stieber, J.,
Weinmeister, P.,
Feil, R.,
Feil, S.,
Wegener, J.,
Hofmann, F. und
Schlossmann, Jens
(2004)
IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP Kinase.
EMBO Journal 23, S. 4222-4231.
Volltext nicht vorhanden.
Fritsch, R. M.,
Saur, D.,
Kurjak, M.,
Oesterle, D.,
Schlossmann, Jens,
Geiselhöringer, A.,
Hofmann, F. und
Allescher, H. D.
(2004)
InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle.
J. Biol. Chem. 279, S. 12551-12559.
Volltext nicht vorhanden.
Koller, A.,
Schlossmann, Jens,
Ashman, K.,
Uttenweiler-Joseph, S.,
Ruth, P. l. und
Hofmann, F.
(2003)
Association of phospholamban with a cGMP kinase signaling complex.
Biochemical and Biophysical Research Communications : Biochem. Biophys. Res. Commun. 300, S. 155-160.
Volltext nicht vorhanden.
Seifert, Roland,
Wenzel-Seifert, Katharina,
Bürckstümmer, Tilmann,
Pertz, Heinz H.,
Schunack, Walter,
Dove, Stefan,
Buschauer, Armin und
Elz, Sigurd
(2003)
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,.
Journal of Pharmacology and Experimental Therapeutics 305, S. 1104-1115.
Volltext nicht vorhanden.
Feil, R.,
Gappa, N.,
Rutz, M.,
Schlossmann, Jens,
Rose, C. R.,
Konnerth, A.,
Brummer, S. und
Hofmann, F.
(2002)
Functional Reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms.
Circulation Research : Circ. Res. 90, S. 1080-1086.
Volltext nicht vorhanden.
Kelley, Melissa T.,
Bürckstümmer, Tilmann,
Wenzel-Seifert, Katharina,
Dove, Stefan,
Buschauer, Armin und
Seifert, Roland
(2001)
Distinct interaction of human and guinea pig histamine H_2-Receptor with guanidine-type agonists,.
Molecular Pharmacology 60 (6), S. 1210-1225.
Volltext nicht vorhanden.
Schlossmann, Jens,
Ammendola, A.,
Ashman, K.,
Zong, X,
Huber, A.,
Neubauer, G.,
Wang, G. X.,
Allescher, H. D.,
Korth, M.,
Wilm, M.,
Hofmann, F. und
Ruth, P.
(2000)
Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.
Nature 404, S. 197-201.
Volltext nicht vorhanden.
Hagelüken, Astrid,
Burde, Rahel,
Nürnberg, Bernd,
Harhammer, Rainer,
Buschauer, Armin und
Seifert, Roland
(1995)
Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism.
Naunyn Schmiedeberg's Arch. Pharmacol. 351, S. 305-308.
Volltext nicht vorhanden.
Hagelüken, A.,
Grünbaum, L.,
Nürnberg, B.,
Harhammer, R.,
Schunack, W. und
Seifert, Roland
(1994)
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
Biochemical pharmacology 47 (10), S. 1789-1795.
Klinker, J. F.,
Hagelüken, A.,
Grünbaum, L.,
Heilmann, I.,
Nürnberg, B.,
Harhammer, R.,
Offermanns, S.,
Schwaner, I.,
Ervens, J.,
Wenzel-Seifert, K.,
Müller, T. und
Seifert, Roland
(1994)
Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase.
The Biochemical journal 304 ( Pt 2, S. 377-383.
Seifert, Roland,
Hagelüken, A.,
Höer, A.,
Höer, D.,
Grünbaum, L.,
Offermanns, S.,
Schwaner, I.,
Zingel, V.,
Schunack, W. und
Schultz, Günter
(1994)
The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.
Molecular Pharmacology 45 (4), S. 578-586.
Tsang, K. W.,
Roberts, P.,
Read, R. C.,
Kees, Frieder,
Wilson, R. und
Cole, P. J.
(1994)
The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration.
The Journal of antimicrobial chemotherapy 33 (2), S. 289-297.
Klinker, J. F.,
Höer, A.,
Schwaner, I.,
Offermanns, S.,
Wenzel-Seifert, Katharina und
Seifert, Roland
(1993)
Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells.
The Biochemical journaL 296 ( Pt 1, S. 245-251.
Dietmeier, K.,
Zara, V.,
Voos, W.,
Schlossmann, Jens,
Moczko, M. und
Pfanner, N.
(1993)
Targeting and translocation of the phosphate carrier/p32 to the inner membrane of yeast mitochondria.
The journal of biological chemistry : J. Biol. Chem. 268, S. 25958-25964.
Volltext nicht vorhanden.
Klinz, F. J.,
Seifert, Roland,
Schwaner, I.,
Gausepohl, H.,
Frank, R. und
Schultz, Günter
(1992)
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells.
European journal of biochemistry 207 (1), S. 207-213.
Seifert, Roland,
Serke, S.,
Huhn, D.,
Bessler, W. G.,
Hauschildt, S.,
Metzger, J.,
Wismüller, K. H. und
Jung, G.
(1992)
Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation.
European journal of biochemistry / FEBS 203 (1-2), S. 143-151.
Offermanns, S.,
Seifert, Roland,
Metzger, J. W.,
Jung, G.,
Lieberknecht, A.,
Schmidt, U. und
Schultz, Günter
(1992)
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
Biochemical Journal 282 ( Pt 2, S. 551-7.
Söllner, T.,
Rassow, J.,
Wiedmann, T.,
Schlossmann, Jens,
Neupert, W. und
Pfanner, N.
(1992)
Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates.
Nature 355, S. 84-87.
Volltext nicht vorhanden.
Seifert, Roland,
Schultz, Günter,
Richter-Freund, M.,
Metzger, J.,
Wiesmüller, K. H.,
Jung, G.,
Bessler, W. G. und
Hauschildt, S.
(1990)
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.
The Biochemical journal 267 (3), S. 795-802.
Naber, K. G.,
Sörgel, F.,
Kees, Frieder K.,
Schumacher, H.,
Sigl, G.,
Zürcher, J. und
Berger, S.
(1989)
Enoxacin-Konzentrationen in der Samenflüssigkeit, im Prostatasekret und im Prostataadenomgewebe nach oraler Gabe oder intravenöser Infusion [Enoxacin concentration in seminal fluid, in prostate secretions and in prostatic adenoma tissue following oral administration or intravenous infusion].
Infection 17 Suppl 1, S30-S66.
Rudolph, U.,
Koesling, D.,
Hinsch, K. D.,
Seifert, Roland,
Bigalke, M.,
Schultz, Günter und
Rosenthal, W.
(1989)
G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils.
Molecular and cellular endocrinology 63 (1-2), S. 143-153.
Naber, K. G.,
Sörgel, F.,
Kees, Frieder K.,
Jaehde, U. und
Schumacher, H.
(1989)
Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration.
The American journal of medicine 87 (5supl1), S57-S59.
Naber, K. G.,
Sörgel, F.,
Kees, Frieder K.,
Schumacher, H.,
Metz, R. und
Grobecker, H.
(1988)
In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue.
The Journal of antimicrobial chemotherapy 22 Suppl D, S. 199-207.
Seifert, Roland,
Rosenthal, W.,
Schultz, Günter,
Wieland, T.,
Gierschick, P. und
Jakobs, K. H.
(1988)
The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides.
European journal of biochemistry / FEBS 175 (1), S. 51-55.
Naber, K.,
Kees, Frieder K.,
Denk, K.,
Bauernfeind, A. und
Grobecker, H.
(1987)
Carumonam versus ceftazidime: in vitro activity, pharmacokinetics in elderly patients, safety and therapeutic efficacy in the treatment of complicated urinary tract infections.
Chemioterapia 6 (2 Supl), S. 517-518.
Volltext nicht vorhanden.
Grobecker, H.,
Kees, Frieder K.,
Linden, M.,
Schrader, E. und
Welte, S.
(1987)
Untersuchungen zur Bioverfügbarkeit von Midodrin und 2,5- Dimethoxyphenyl-ß-aminoethanol-hydrochlorid [The bioavailability of midodrin and alpha-2,5-dimethoxyphenyl-beta-aminoethanol hydrochloride].
Arzneimittel-Forschung 37 (4), S. 447-450.
Naber, K. G.,
Dette, G. A.,
Kees, Frieder K.,
Knothe, H. und
Grobecker, H.
(1986)
Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections.
The Journal of antimicrobial chemotherapy 17 (4), S. 517-527.
Grobecker, H.,
Gessler, I.,
Delius, W.,
Dominiak, P. und
Kees, Frieder K.
(1985)
Effect of ketanserin on hemodynamics, plasma-catecholamine concentrations, and serotonin uptake by platelets in volunteers and patients with congestive heart failure.
Journal of cardiovascular pharmacology 7, Suppl 7, S102-S104.
Kees, Frieder K.,
Naber, K. G.,
Bartoschik-Wich, B.,
Stockmann, P.,
Meyer, G. P. und
Grobecker, H.
(1985)
High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers.
Arzneimittel-Forschung 35 (7), S. 1099-1104.
Kees, Frieder K.,
Strehl, E.,
Dominiak, P.,
Grobecker, H.,
Seeger, K.,
Seidel, G.,
Neuhaus, B. und
Safrany, L.
(1983)
Cefotaxime and desacetyl cefotaxime in human bile.
Infection 11 (2), S. 118-120.
Kees, Frieder K.,
Strehl, E.,
Seeger, K.,
Seidel, G.,
Dominiak, P. und
Grobecker, H.
(1981)
Comparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography.
Arzneimittel-Forschung 31 (2), S. 362-365.
Buchkapitel
Schlossmann, Jens und
Hofmann, F.
(2008)
Receptor mediated mechanisms.
In:
Greim, H. und
Snyder, R., (eds.)
Toxicology and risk assessment : a comprehensive introduction.
Wiley, Chicester.
ISBN 978-0-470-86893-5.
Volltext nicht vorhanden.
Buch
Hochschulschrift der Universität Regensburg
Hochschulschrift
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